An article 1,5,7-Triazabicylodec-5-ene-Promoted Direct Vinylogous Aldol Reaction for the Synthesis of 3-Hydroxy-2-oxoindole Derivatives WOS:000460584600009 published article about CATALYTIC ASYMMETRIC-SYNTHESIS; ENANTIOSELECTIVE SYNTHESIS; DIASTEREOSELECTIVE SYNTHESIS; OXINDOLES; CONSTRUCTION; ISATINS; ALKALOIDS; ALDEHYDES; KETONES; ESTERS in [Zhang, Xianhui; Zhou, Li; Mahmood, Qaiser; Zhao, Mengmeng; Wang, Xiaowu; Wang, Qinggang] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Key Lab Biobased Mat, 189 Songling Rd, Qingdao 266101, Peoples R China; [Zhang, Xianhui; Zhou, Li] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 10049, Peoples R China in 2019.0, Cited 57.0. Application In Synthesis of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6
A simple and efficient method has been developed for the synthesis of 3-hydroxy-2-oxoindole derivatives through a direct vinylogous aldol reaction of allylic esters with isatins, catalyzed by 1,5,7-triazabicyclodec-5-ene. This method affords a variety of 3-hydroxy-2-oxoindole derivatives in moderate to excellent yields with high regioselectivities. An asymmetric version of this reaction catalyzed by Corey’s chiral guanidine proceeded with moderate enantioselectivity. The protocol can also be used to synthesize isatin spiro ethers.
Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Zhang, XH; Zhou, L; Mahmood, Q; Zhao, MM; Wang, XW; Wang, QG or concate me.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles