Authors Kaur, H; Singh, J; Narasimhan, B in BMC published article about STRUCTURE-BASED DESIGN; GLUTAMATE LIGASE; AZO DYES; CANCER; DERIVATIVES; ANTIBACTERIAL; RESISTANCE; INHIBITORS; PROTEIN; ASSAY in [Kaur, Harmeet; Narasimhan, Balasubramanian] Maharshi Dayanand Univ, Fac Pharmaceut Sci, Rohtak 124001, Haryana, India; [Singh, Jasdir] Postgrad Inst Med Sci, Coll Pharm, Rohtak 124001, Haryana, India in 2019.0, Cited 45.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4
Background: In continuation of our work, new diazenyl chalcones scaffolds (C-18 to C-27) were efficiently synthesized from substituted acetophenone azo dyes (A-E) by base catalyzed Claisen-Schmidt condensation with different substituted aromatic/heteroaromatic aldehydes. Methodology: The synthesized chalcones were assessed for their in vitro antimicrobial potential towards several pathogenic microbial strains by tube dilution method and further evaluated for antioxidant potential by DPPH assay. These derivatives were also assessed for the cytotoxicity towards the human lung cancer cell line (A549) and normal cell line (HEK) by MTT assay. The most active antimicrobial compounds were docked using Schrodinger v18.1 software with the various potential bacterial receptors to explore the mechanism of interaction. Results: The derivative C-22 exhibited high antibacterial activity with very low MIC (1.95-3.90 mu g ml(-1)) and MBC (3.90-7.81 mu g ml(-1)) values. The derivatives C-23, C-24 and C-27 have demonstrated good antioxidant potential (IC50 = 7-18 mu g ml(-1)) correlated to the ascorbic acid (IC50 = 4.45 mu g ml(-1)). The derivative C-25 had shown comparable cytotoxicity to camptothecin against A549 cell line. The docking studies predicted the bacterial dihydrofolate reductase (PDB ID: 3SRW) and bacterial DNA gyrase (PDB ID: 4ZVI) as the possible targets for most of the active antimicrobial compounds. These derivatives affirmed their safety by presenting less cytotoxicity towards HEK cells. Further the ADME prediction by qikprop module of the Schrodinger proved that these compounds exhibited drug-like attributes. Conclusion: Hence, these compounds have shown their potential as lead for future expansion of novel antimicrobial and cytotoxic drugs.
HPLC of Formula: C8H8O2. Welcome to talk about 99-93-4, If you have any questions, you can contact Kaur, H; Singh, J; Narasimhan, B or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles