With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1008-07-7,7-Chloro-1H-indole-3-carbaldehyde,as a common compound, the synthetic route is as follows.
To a stirring solution of 7-chloro-?H-indole-3-carbaldehyde SM1 (200 mg, 1.lmmol) in MeOH (10m1),was added TMSCN (168mg, 1.5mmol), NH3 (gas) was chargedinto the mixture at 0C. The reaction mixture stirred at 45C for 3 h. After consumption of the starting material (by TLC), the reaction mixture concentrated under reduced pressure to obtain crude product, which washed with ether to afford compound 1 (200mg, 88%). TLC:30% EA/PE (Rf: 0.3). LC-MS: m/z = 206[(M+1)], 1008-07-7
As the paragraph descriping shows that 1008-07-7 is playing an increasingly important role.
Reference：
Patent; ABBVIE INC.; KESICKI, Edward A.; WANG, Ce; PATANE, Michael A.; KLUGE, Arthur F.; VAN DRIE, JR., John H.; (121 pag.)WO2016/44777; (2016); A1;,
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