120-72-9, 1H-Indole is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
Preparation 6 Methyl indolyl-3-glyoxylate A solution of indole (2.0 g, 1.70 mmol) in Et2O (20 mL) was cooled to 0-5C under N2and oxalyl chloride (1.5 mL 1.70 mmol) was added dropwise at <5C. The resultant yellow slurry was stirred 30 min. in the ice bath and was then cooled to -65C and a 25% wt. solution of sodium methoxide (7.8 mL, 3.4 mmol) was slowly added at <-58C. The reaction was then allowed to warm to room temperature, water was added (10 mL), and the resultant mixture filtered. The solid was dried at room temperature to give 3.21 g (93%) of the titled compound. NMR. MS (FD) m/z= 203 (M+, 100%). Analytical calculated for C11H9NO3C, 65.02; H, 4.46; N, 6.89. Found C, 64.93; H, 4.25; N, 7.03. 120-72-9, 120-72-9 1H-Indole 798, aindole-building-block compound, is more and more widely used in various fields.
Reference£º
Patent; ELI LILLY AND COMPANY; EP825190; (1998); A1;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles