In 2019.0 ARCH PHARM published article about COUMARIN DERIVATIVES; BIOLOGICAL EVALUATION; OXIDATIVE STRESS; TARGETING ACETYLCHOLINESTERASE; ANTICHOLINESTERASE ACTIVITY; DESIGN; DISEASE; PHTHALIMIDE in [Kara, Jiraporn; Suwanhom, Paptawan; Lomlim, Luelak] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, 15 Karnjanavanich Rd, Hat Yai 90112, Songkhla, Thailand; [Wattanapiromsakul, Chatchai; Puripattanavong, Jindaporn] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmacognosy & Pharmaceut Bot, Hat Yai, Thailand; [Nualnoi, Teerapat] Prince Songkla Univ, Fac Pharmaceut Sci, Dept Pharmaceut Technol, Hat Yai, Songkhla, Thailand; [Khongkow, Pasarat] Prince Songkla Univ, Inst Biomed Engn, Fac Med, Hat Yai, Thailand; [Lee, Vannajan Sanghiran] Univ Malaya, Dept Chem, Fac Sci, Kuala Lumpur, Malaysia; [Gaurav, Anand] UCSI Univ, Fac Pharmaceut Sci, Dept Pharmaceut Chem, Kuala Lumpur, Malaysia in 2019.0, Cited 38.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. SDS of cas: 150-19-6
Sixteen novel coumarin-based compounds are reported as potent acetylcholinesterase (AChE) inhibitors. The most active compound in this series, 5a (IC50 0.04 +/- 0.01 mu M), noncompetitively inhibited AChE with a higher potency than tacrine and galantamine. Compounds 5d, 5j, and 5m showed a moderate antilipid peroxidation activity. The compounds showed cytotoxicity in the same range as the standard drugs in HEK-293 cells. Molecular docking demonstrated that 5a acted as a dual binding site inhibitor. The coumarin moiety occupied the peripheral anionic site and showed p-p interaction with Trp278. The tertiary amino group displayed significant cation-p interaction with Phe329. The aromatic group showed p-p interaction with Trp83 at the catalytic anionic site. The long chain of methylene lay along the gorge interacting with Phe330 via hydrophobic interaction. Molecular docking was applied to postulate the selectivity toward AChE of 5a in comparison with donepezil and tacrine. Structural insights into the selectivity of the coumarin derivatives toward huAChE were explored by molecular docking and 3D QSAR and molecular dynamics simulation for 20 ns. ADMET analysis suggested that the 2-(2-oxo-2H-chromen-4-yl)acetamides showed a good pharmacokinetic profile and no hepatotoxicity. These coumarin derivatives showed high potential for further development as anti-Alzheimer agents.
About m-Methoxyphenol, If you have any questions, you can contact Kara, J; Suwanhom, P; Wattanapiromsakul, C; Nualnoi, T; Puripattanavong, J; Khongkow, P; Lee, VS; Gaurav, A; Lomlim, L or concate me.. SDS of cas: 150-19-6
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,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles