I found the field of Chemistry very interesting. Saw the article Nucleophile-assisted cyclization of beta-propargylamino acrylic compounds catalyzed by gold(I): a rapid construction of multisubstituted tetrahydropyridines and their fused derivatives published in 2020.0. Name: m-Methoxyphenol, Reprint Addresses Pour, M (corresponding author), Charles Univ Prague, Fac Pharm Hradec Kralove, Dept Organ & Bioorgan Chem, Heyrovskeho 1203, Hradec Kralove 50005, Czech Republic.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol
Au(I)-catalyzed cyclization of beta-propargylamino acrylic derivatives 1, carried out in the presence of methanol, afforded tetrahydropyridines 3 in high isolated yields. An intramolecular version, using substrates with pending OH, NHBoc and 3-MeOC6H4 groups as internal O-, N-, and C-nucleophiles, yielded the orthofused cyclic derivatives, namely furo[2,3-b]pyridine derivative 14, pyrrolo[2,3-b]pyridine 18, and an unusual chromeno[3,4-c]pyridine 22 with a new quaternary carbon center. Synthetic utilization of the tetrahydropyridines 3 has been demonstrated by their conversion into substances with privileged pharmacophore scaffold. Thus, four 4-aryl piperidine derivatives 23a,b,f,g were obtained on catalytic hydrogenation of the representative 4-aryl tetrahydropyridines 3a,b,f,g; furthermore, the Diels-Alder cycloaddition of dimethyl acetylene dicarboxylate (DMAD) to dienes 3r-3u, possessing a masked dendralene framework, afforded tetrahydroisoquinolines 25r-25u that can be aromatized to produce polysubstituted isoquinolines, as demonstrated by the conversion of 25r into 27r. These domino transformations thus offer numerous variations of this methodology and reveal its potential for synthetic applications.
Name: m-Methoxyphenol. Welcome to talk about 150-19-6, If you have any questions, you can contact Matous, P; Kadanik, M; Timoracky, M; Kunes, J; Marikova, J; Ruzicka, A; Kocovsky, P; Pour, M or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles