Safety of 3,4-Dimethoxybenzaldehyde. Salgin-Goksen, U; Telli, G; Erikci, A; Dedecengiz, E; Tel, BC; Kaynak, FB; Yelekci, K; Ucar, G; Gokhan-Kelekci, N in [Salgin-Goksen, Umut; Gokhan-Kelekci, Nesrin] Hacettepe Univ, Fac Pharm, Dept Pharmaceut Chem, TR-06100 Ankara, Turkey; [Salgin-Goksen, Umut] Turkish Med & Med Devices Agcy, Anal & Control Labs, TR-06100 Ankara, Turkey; [Telli, Gokcen; Tel, Banu Cahide] Hacettepe Univ, Fac Pharm, Dept Pharmacol, TR-06100 Ankara, Turkey; [Erikci, Acelya] Lokman Hekim Univ, Fac Pharm, Dept Biochem, TR-06510 Ankara, Turkey; [Dedecengiz, Ezgi; Kaynak, F. Betul] Hacettepe Univ, Dept Phys Engn, Fac Engn, TR-06800 Ankara, Turkey; [Yelekci, Kemal] Kadir Has Univ, Fac Engn & Nat Sci, Dept Bioinformat & Genet, TR-34083 Istanbul, Turkey; [Ucar, Gulberk] Hacettepe Univ, Fac Pharm, Dept Biochem, TR-06100 Ankara, Turkey published New 2-Pyrazoline and Hydrazone Derivatives as Potent and Selective Monoamine Oxidase A Inhibitors in 2021.0, Cited 82.0. The Name is 3,4-Dimethoxybenzaldehyde. Through research, I have a further understanding and discovery of 120-14-9.
Thirty compounds having 1-[2-(5-substituted-2-benzoxazolinone-3-yl) acetyl]-3,5-disubstitutedphenyl-2-pyrazoline structure and nine compounds having N’-(1,3-disubstitutedphenylallylidene)-2-(5-substituted- 2-benzoxazolinone-3-yl)-acetohydrazide skeleton were synthesized and evaluated as monoamine oxidase (MAO) inhibitors. All of the compounds exhibited selective MAO-A inhibitor activity in the nanomolar or low micromolar range. The results of the molecular docking for hydrazone derivatives supported the in vitro results. Five compounds, 6 (0.008 mu M, Selectivity Index (SI): 9.70 x 10(-4)), 7 (0.009 mu M, SI: 4.55 x 10(-5)), 14 (0.001 mu M, SI: 8.00 x 10(-4)), 21 (0.009 mu M, SI: 1.37 x 10(-5)), and 42 (0.010 mu M, SI: 5.40 x 10(-6)), exhibiting the highest inhibition and selectivity toward hMAO-A and nontoxic to hepatocytes were assessed for antidepressant activity as acute and subchronic in mice. All of these five compounds showed significant antidepressant activity with subchronic administration consistent with the increase in the brain serotonin levels and the compounds crossed the blood-brain barrier according to parallel artificial membrane permeation assay. Compounds 14, 21, and 42 exhibited an ex vivo MAO-A profile, which is highly consistent with the in vitro data.
Safety of 3,4-Dimethoxybenzaldehyde. Welcome to talk about 120-14-9, If you have any questions, you can contact Salgin-Goksen, U; Telli, G; Erikci, A; Dedecengiz, E; Tel, BC; Kaynak, FB; Yelekci, K; Ucar, G; Gokhan-Kelekci, N or send Email.
Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles