Classical QSAR modelling of Indole-3-acetic acids for cancer therapy was written by Soni, Love Kumar. And the article was included in International Journal of ChemTech Research in 2012.Recommanded Product: 1912-45-4 This article mentions the following:
A set of 26 compound of the series halogenated Indole-3-acetic acids as oxidatively activate prodrugs with potential for targeted cancer therapy were subjected to quant. structure activity relationship (QSAR) anal. using combination of various electronic, thermodn. and spatial descriptors. Several statistical regression equations were obtained using multiple regression anal. QSAR anal. showed that the cytotoxin produced from oxidation of IAA with horseradish peroxidase (HRP) have significant correlation with electronic (Energy of Highest MO), and thermodn. (Non-1, 4-VDW energy, Henry law constant) properties of the mol. QSAR anal. suggests that substitution with electron withdrawing and bulkier group is more favorable for inhibitory activity. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Recommanded Product: 1912-45-4).
2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1912-45-4
Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles