Discovery and characterization of novel indole and 7-azaindole derivatives as inhibitors of β-amyloid-42 aggregation for the treatment of Alzheimer’s disease was written by Sreenivasachary, Nampally;Kroth, Heiko;Benderitter, Pascal;Hamel, Anne;Varisco, Yvan;Hickman, David T.;Froestl, Wolfgang;Pfeifer, Andrea;Muhs, Andreas. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Name: 6-Nitro-1H-indole This article mentions the following:
The aggregation of amyloid-β peptides into cytotoxic oligomeric and fibrillary aggregates is believed to be one of the major pathol. events in Alzheimer disease. Here we report the design and synthesis of a novel series of indole and 7-azaindole derivatives containing, nitrile, piperidine and N-methyl-piperidine substituents at the 3-position to prevent the pathol. self-assembly of amyloid-β. We have further demonstrated that substitution of the azaindole and indole derivatives I (R = F, OMe) at the 3 positions is required to obtain compounds with improved physicochem. properties to allow brain penetration. In the experiment, the researchers used many compounds, for example, 6-Nitro-1H-indole (cas: 4769-96-4Name: 6-Nitro-1H-indole).
6-Nitro-1H-indole (cas: 4769-96-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Name: 6-Nitro-1H-indole
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Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles