Tag: 100-200

On January 31, 1982, Kaneko, Chikara; Fujii, Harue; Kawai, Shinji; Hashiba, Kazuhiko; Karasawa, Yoshio; Wakai, Masue; Hayashi, Reiko; Somei, Masanori published an article.Reference of Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Studies on the N-oxides of 蟺-deficient N-heteroaromatics. XXXVI. Studies on oxazepine derivatives. XII. Photochemical and thermal Michael reactions of alcohols with methyl 2-phenyl-3,1-benzoxazepine-5-carboxylate and its derivatives. And the article contained the following:

Irradiation (鈮?00 nm) of Me 2-phenyl-3,1-benzoxazepine-5-carboxylate in an alc. afforded Z-2-BzNHC6H4C(:COR)CO2Me (I, R = Me, Et, CHMe2, CMe3, allyl) as the major addition product. In contrast, thermal reaction of the oxazepine with a primary alc. in the presence of NEt3 led to the exclusive formation of E-I. Similar addition products were also obtained stereoselectively from 3,1-benzoxazepines having an acetyl group at the 5-position. E-I and Z-I were equilibrated photochem. and the stereochem. of the two isomers was determined by 1H-NMR. An explanation is proposed for the stereoselectivities observed in the photochem. and thermal reactions. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Reference of Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to phenylbenzoxazepine carboxylate alcoholysis photochem thermal, benzoxazepinecarboxylate alcoholysis thermal photochem, benzamidophenylacrylate alkoxy isomer, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Esters, Acyl Peroxides, Acyl Halides and other aspects.Reference of Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 15, 2015, Ferencz, Zs.; Adok-Sipiczki, M.; Hannus, I.; Sipos, P.; Palinko, I. published an article.Name: H-Idc-OH The title of the article was Structural features of intercalated CaFe-layered double hydroxides studied by X-ray diffractometry, infrared spectroscopy and computations. And the article contained the following:

The intercalation of various N-containing carboxylic acid anions into CaFe-layered double hydroxides was performed by the dehydration-rehydration method. Particular attention was paid to the effect of solvent mixture used during preparation It was found that various solvent mixtures resulted in different interlayer distances and, thus, different arrangements of the anions between the layers. The dimensions of the intercalated anions and detailed anal. of the IR spectra gave clues for the reasonable prediction of the spatial arrangements of the anions in the interlamellar space. The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH

The Article related to calcium iron layered double hydroxide intercalation, Inorganic Chemicals and Reactions: Metal-Containing Salts and Related Metal-Containing Compounds and other aspects.Name: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 7, 1998, Bromidge, Steven M.; Dabbs, Steven; Davies, David T.; Duckworth, D. Malcolm; Forbes, Ian T.; Ham, Peter; Jones, Graham E.; King, Frank D.; Saunders, Damian V.; Starr, Susannah; Thewlis, Kevin M.; Wyman, Paul A.; Blaney, Frank E.; Naylor, Christopher B.; Bailey, Fiona; Blackburn, Thomas P.; Holland, Vicky; Kennett, Guy A.; Riley, Graham J.; Wood, Martyn D. published an article.Related Products of 52537-00-5 The title of the article was Novel and Selective 5-HT2C/2B Receptor Antagonists as Potential Anxiolytic Agents: Synthesis, Quantitative Structure-Activity Relationships, and Molecular Modeling of Substituted 1-(3-Pyridylcarbamoyl)indolines. And the article contained the following:

The synthesis, biol. activity, and mol. modeling of a novel series of substituted 1-(3-pyridylcarbamoyl)indolines are reported. These compounds are isosteres of the previously published indole urea SB-206553 and illustrate the use of aromatic disubstitution as a replacement for fused five-membered rings in the context of 5-HT2C/2B receptor antagonists. By targeting a region of space previously identified as sterically allowed at the 5-HT2C receptor but disallowed at the 5-HT2A receptor, a number of compounds which are the most potent and selective 5-HT2C/2B receptor antagonists yet reported, were identified. 1-(3-Pyridylcarbamoyl)-5-methylthio-6-trifluoromethylindoline was selected on the basis of its overall biol. profile for further evaluation as a novel, potential nonsedating anxiolytic agent. A CoMFA anal. of these compounds produced a model with good predictive value and in addition good qual. agreement with both a 5-HT2C receptor model and a proposed binding mode for this class of ligands within that model. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Related Products of 52537-00-5

The Article related to pyridylcarbamoylindoline preparation 5ht receptor antagonist anxiolytic, Pharmacology: Effects Of Nervous System- and Behavior-Affecting Drugs and Neuromuscular Agents and other aspects.Related Products of 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On June 13, 2013, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.Recommanded Product: 52537-00-5 The title of the patent was Preparation of substituted piperidinyl-pyridazinyl derivatives as SCD1 inhibitors. And the patent contained the following:

The title compounds I [R1 = P1, P2, P3, etc.; wherein m = 0-3; R2 = halo, C1-4 alkyl, C1-4 alkoxy, etc.; R3 = Q1, Q2, Q3, etc.; wherein R4 = H, halo, C1-4 alkyl, etc.] or pharmaceutically acceptable salts thereof were prepared Compounds I are useful as Stearoyl-CoA desaturase 1 (SCD1) inhibitors for treatment of obesity, type 2 diabetes and other related metabolic disorders. For example, compound II was prepared in a multi-step synthesis and displayed IC50 of 0.12 μM against SCD1 in A431 cells. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Recommanded Product: 52537-00-5

The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 52537-00-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On August 11, 2015, Yang, Shyh-Ming; Kuo, Gee-Hong; Gaul, Micheal D.; Rano, Thomas A. published a patent.COA of Formula: C8H8ClN The title of the patent was Substituted piperidinyl-pyridazinyl derivatives useful as scd 1 inhibitors. And the patent contained the following:

The present invention is directed to novel piperidinyl-pyridazinyl derivatives, pharmaceutical compositions containing them and their use as inhibitors of SCD1, useful in the treatment of obesity, type-II diabetes and other related metabolic disorders. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).COA of Formula: C8H8ClN

The Article related to piperidinyl pyridazinyl derivative preparation scd1 inhibitor, obesity type 2 diabetes treatment piperidinyl pyridazinyl derivative preparation, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.COA of Formula: C8H8ClN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 30, 1993, Guven, Alaattin; Jones, R. Alan published an article.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate The title of the article was Potentially tautomeric 1,2-dihydro-1-oxo-5H-pyridazino[4,5-b]indole and 3,4-dihydro-4-oxo-5H-pyridazino[4,5-b]indole. And the article contained the following:

The potentially tautomeric title compounds I and II were synthesized from Et 2-formylindole-3-carboxylate and hydrazine and from Et 3-formylindole-2-carboxylate and hydrazine, resp., and their tautomeric equilibrium confirmed by their electronic spectra and their acidity functions. Many related compounds were examined for their tautomeric equilibrium between hydroxyl and oxo groups. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

The Article related to tautomerism dihydrooxopyridazinoindole, pyridazinoidole dihydrooxo tautomerism, electronic spectra dihydrooxopyridazinoindole, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: Methyl 2-methyl-1H-indole-3-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Xiaohong; Zheng, Guangfan; Song, Guoyong; Li, Xingwei published an article in 2018, the title of the article was Rhodium(III)-Catalyzed Synthesis of Cinnolinium Salts from Azobenzenes and Diazo Compounds.Recommanded Product: 65417-22-3 And the article contains the following content:

A Rh(III)-catalyzed C-H activation of azobenzenes in the coupling with diazo compounds has been realized, providing a straightforward strategy to access functionalized cinnolinium triflates, e.g., I in high yields. This protocol features silver free mild reaction conditions and compatibility with diverse functional groups. The coupling proceeds via initial Rh(III)-catalyzed C-H alkylation, followed by zinc triflate-mediated cyclization, where zinc triflate acts as a Lewis acid as well as a triflate source. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Recommanded Product: 65417-22-3

The Article related to cinnolinium salt preparation, azobenzene diazo compound carbon hydrogen activation coupling rhodium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Recommanded Product: 65417-22-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On May 27, 2021, Jing, Peng; Guo, Qiang; Dou, Fei; Wan, Zehong; Hu, Zhijing published a patent.Name: 6-Chloro-2,3-dihydro-1H-indole The title of the patent was Fused heterocyclic derivative and application. And the patent contained the following:

The invention disclosed a kind of fused heterocyclic derivative, its preparation method and application for treating neuropsychiatric diseases. The claimed compound is shown in structure I (Z = O or S C2-8 chain or halo substituted C2-8 chain; A = II; R = heteroaryl; Q = N or CH; Y = O or S; R1,R2,R3 = H, halo, C1-6 alkyl, etc.; n1 = 1-3 integers). The claimed compound is prepared via multiple steps (procedure given). The prepared compound can be used for treating neuropsychiatric diseases such as schizophrenia, depression, anxiety, sleep disorders, neurodegenerative diseases, bipolar disorder, post-traumatic stress syndrome, addiction disorders, abstinence syndrome, or attention deficit. The experimental process involved the reaction of 6-Chloro-2,3-dihydro-1H-indole(cas: 52537-00-5).Name: 6-Chloro-2,3-dihydro-1H-indole

The Article related to fused heterocyclic derivative preparation neuropsychiatric disease treatment, Heterocyclic Compounds (More Than One Hetero Atom): Pyridazines, Cinnolines, and Phthalazines and other aspects.Name: 6-Chloro-2,3-dihydro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Shi, Yao; Ke, Zhihai; Yeung, Ying-Yeung published an article in 2018, the title of the article was Environmentally benign indole-catalyzed position-selective halogenation of thioarenes and other aromatics.Category: indole-building-block And the article contains the following content:

An environmentally benign protocol for the synthesis of aryl bromides RBr [R = 3,4-di-MeOC6H3, 4-MeSC6H4, 2-Me-thienyl, etc.] was developed via regioselective electrophilic bromination of aromatic compounds Indole-catalyst was suitable for a wide range of substrates including thioarenes. The experimental process involved the reaction of Methyl 2-methyl-1H-indole-3-carboxylate(cas: 65417-22-3).Category: indole-building-block

The Article related to bromoarene green preparation regioselective, thioether bromination indole organocatalyst, arene bromination indole organocatalyst, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Halides and Halonium Compounds and other aspects.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

On September 12, 2013, Liu, Jin-Qiang; Cao, Xin-Xiang; Ji, Baoming; Zhao, Bangtun published an article.Name: H-Idc-OH The title of the article was Determination and Correlation of Solubilities of (S)-Indoline-2-carboxylic Acid in Six Different Solvents from (283.15 to 358.15) K. And the article contained the following:

The solubilities of (S)-indoline-2-carboxylilc acid (SIn2CA) in six pure solvents including water, methanol, ethanol, 1-propanol, 2-propanol, and 1-butanol were determined from (283.15 to 358.15) K at atm. pressure using the synthetic method. The solubility was determined by a laser monitoring observation technique and found to increase with the rise of temperature The exptl. solubilities were correlated by the modified Apelblat and λh (Buchowski) equations with the relative deviation less than 3.65% with the modified Apelblat equation and less than 0.023% with the λh equation. Thermodn. functions of the solution of SIn2CA in different solvents including apparent dissolution enthalpy and entropy were obtained by van’t Hoff equation, and the apparent dissolution Gibbs free energy change was also calculated The experimental process involved the reaction of H-Idc-OH(cas: 79815-20-6).Name: H-Idc-OH

The Article related to correlation solubility indolinecarboxylate water methanol ethanol propanol butanol, Phase Equilibriums, Chemical Equilibriums, and Solutions: Phase Equilibriums, Solubility and other aspects.Name: H-Idc-OH

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles