100-200 | - Page 74 of 93 - Indole Building Blocks

Yu, Zong-Yi’s team published research in RSC Advances in 2020 | CAS: 399-52-0

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Electric Literature of C8H6FN

《Rose bengal as photocatalyst: visible light-mediated Friedel-Crafts alkylation of indoles with nitroalkenes in water》 was written by Yu, Zong-Yi; Zhao, Jing-Nan; Yang, Fan; Tang, Xiao-Fei; Wu, Yu-Feng; Ma, Cun-Fei; Song, Bo; Yun, Lei; Meng, Qing-Wei. Electric Literature of C8H6FN And the article was included in RSC Advances in 2020. The article conveys some information:

A novel and facile visible-light-mediated alkylation of indoles and nitroalkenes has been developed. In this protocol, rose bengal acts as a photosensitizer, and environmentally benign water was used as the green and efficient reaction medium. Indoles reacted smoothly with nitroalkenes under the irradiation of visible-light and generated corresponding 3-(2-nitroalkyl)indoles I (R1 = H, 5-F, 6-Me, etc.; R2 = C6H5, 4-FC6H4, 2-thienyl, etc.) in moderate to good yields (up to 87%). In the experiment, the researchers used 5-Fluoro-1H-indole(cas: 399-52-0Electric Literature of C8H6FN)

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Somboonna, Naraporn’s team published research in mBio in 2019 | CAS: 120-72-9

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

In 2019,mBio included an article by Somboonna, Naraporn; Ziklo, Noa; Ferrin, Thomas E.; Suh, Jung Hyuk; Dean, Deborah. Application In Synthesis of 1H-Indole. The article was titled 《Clinical persistence of Chlamydia trachomatis sexually transmitted strains involves novel mutations in the functional αββα tetramer of the tryptophan synthase operon》. The information in the text is summarized as follows:

We examined serial urogenital samples from a woman who had recurrent Ct infections over 4 years despite antibiotic treatment. The Ct isolates from each infection episode were genome sequenced and analyzed for phenotypic, structural, and functional characteristics. Each isolate displayed an altered αββα structure, could not synthesize tryptophan from indole, and had significantly lower trpBA expression but higher intracellular tryptophan levels compared with those of reference Ct strain F/IC-Cal3. Our data indicate that emergent mutations in the tryptophan operon, which were previously thought to be restricted only to ocular Ct strains, likely resulted in in vivo persistence in the described patient and represents a novel host-pathogen adaptive strategy for survival. IMPORTANCE:Chlamydia trachomatis (Ct) is the most common sexually transmitted bacterium with more than 131 million cases occurring annually worldwide. Here, we discovered that the genomes of serial isolates from a woman with recurrent, treated Ct STIs over many years were identical with a novel synthase mutation. Our findings indicate an emerging adaptive host-pathogen evolutionary strategy for survival in the urogenital tract that will prompt the field to further explore chlamydial persistence, evaluate the genetics of mutant Ct strains and fitness within the host, and their implications for disease pathogenesis. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

Zou, Bin’s team published research in Tetrahedron in 2014 | CAS: 885518-25-2

6-Fluoro-1H-indol-4-amine(cas: 885518-25-2) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Electric Literature of C8H7FN2

Zou, Bin; Chen, Chun; Leong, Seh Yong; Ding, Mei; Smith, Paul W. published an article on January 21 ,2014. The article was titled 《An efficient synthesis of 4,6-dihydrospiro[azepino[4,3,2-cd]indole-3,3′-indoline]-2′,5(1H)-diones via multi-component reaction》, and you may find the article in Tetrahedron.Electric Literature of C8H7FN2 The information in the text is summarized as follows:

A facile and efficient one-pot three-component synthesis of spiroazepinoindolones has been developed. Using DMF as solvent without any addnl. acid or metal catalysts, the three-component reaction of readily available isatins, indolamines, and Meldrum’s acid affords a new class of spiroheterocycles in moderate yield. In the experimental materials used by the author, we found 6-Fluoro-1H-indol-4-amine(cas: 885518-25-2Electric Literature of C8H7FN2)

Zhao, Fei’s team published research in ACS Catalysis in 2021 | CAS: 399-52-0

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Recommanded Product: 5-Fluoro-1H-indole

Recommanded Product: 5-Fluoro-1H-indoleIn 2021 ,《Chemo-, Regio-, and Stereoselective Assembly of Polysubstituted Furan-2(5H)-ones Enabled by Rh(III)-Catalyzed Domino C-H Alkenylation/Directing Group Migration/Lactonization: A Combined Experimental and Computational Study》 appeared in ACS Catalysis. The author of the article were Zhao, Fei; Zhou, Zhi; Lu, Yangbin; Qiao, Jin; Zhang, Xiaoning; Gong, Xin; Liu, Siyu; Lin, Shuang; Wu, Xiaowei; Yi, Wei. The article conveys some information:

Exploring multistep cascade reactions triggered by C-H activation are recognized as appealing, yet challenging. Herein, author disclose a Rh(III)-catalyzed domino C-H coupling of N-carbamoyl indoles and 4-hydroxy-2-alkynoates for the streamlined assembly of highly functionalized furan-2(5H)-ones in which the carbamoyl-directing group (DG) is given a dual role of an auxiliary group and a migrating acylating reagent via the cleavage of stable C-N bonds at room temperature More importantly, the obtained furan-2(5H)-one skeleton could be further functionalized under air in situ via C5-H hydroxylation by simply switching the solvent or additive, providing fully substituted furan-2(5H)-ones with the installation of an alc.-based C5 quaternary carbon center. Detailed exptl. studies and d. functional theory calculations reveal that a Rh(III)-mediated tandem C-H activation/alkyne insertion/DG migration/lactonization accounts for the developed transformation to achieve high functionalities with the observed exclusive selectivity. The potential biol. application of the obtained furan-2(5H)-ones as a class of potent PPARγ ligands further highlights the synthetic utility of the developed methodol. This protocol is endowed with several salient features including efficient multistep cascade triggered by C-H activation, excellent chemo-, regio-, and stereoselectivity, high bond-forming efficiency (e.g., two C-C and two C-O bonds), solvent- or additive-controlled product selectivity. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Recommanded Product: 5-Fluoro-1H-indole)

Kumar, Alok’s team published research in ACS Sensors in 2020 | CAS: 120-72-9

《Ultrafast detection and discrimination of methanol gas using a polyindole-embedded substrate integrated waveguide microwave sensor》 was written by Kumar, Alok; Wang, Cong; Meng, Fan-Yi; Jiang, Cheng-Peng; Yan, Guo-Feng; Zhao, Meng; Jing, Chang-Qiang; Wang, Lei. COA of Formula: C8H7N And the article was included in ACS Sensors in 2020. The article conveys some information:

The fast and sensitive detection of methanol gas using cost-effective sensors in the industry is a significant issue to be addressed. Herein, a polyindole (PIn)-deposited substrate integrated waveguide (SIW) has been introduced to perform quant. and qual. methanol gas sensing with quick response and recovery time at room temperature First, PIn is synthesized and deposited in the microwell etched at the intensified elec. field region of the microwave-based cavity resonator, which gives a sensing response through variation of PIn’s high-frequency conductivity and dielec. property caused by the adsorption and desorption of methanol gas. Second, an enhanced filling factor and high Q factor have been attained using the proposed microwell etched SIW structure, which exhibits high sensitivity in terms of frequency shift (3.33 kHz/ppm), amplitude shift (0.005 dB/ppm), bandwidth broadening (3.66 kHz/ppm), and loaded Q factor (10.60 Q value/ppm). Third, the gas measurement results reveal excellent long-term stability with a relative standard deviation (RSD) of 0.02% for 7 days, excellent repeatability with an RSD of 0.004%, and desired response and recovery time of 95 and 120 s, resp. The results indicate that the proposed microwave sensor has great potential to achieve high sensitivity and fast response toward methanol gas mols. at room temperature In the experiment, the researchers used many compounds, for example, 1H-Indole(cas: 120-72-9COA of Formula: C8H7N)

Kim, Taegwan’s team published research in Molecules in 2022 | CAS: 120-72-9

Application of 120-72-9In 2022 ,《Recent Advances in Divergent Synthetic Strategies for Indole-Based Natural Product Libraries》 appeared in Molecules. The author of the article were Kim, Taegwan; Ha, Min Woo; Kim, Jonghoon. The article conveys some information:

A review. Considering the potential bioactivities of natural product and natural product-like compounds with highly complex and diverse structures, the screening of collections and small-mol. libraries for high-throughput screening (HTS) and high-content screening (HCS) has emerged as a powerful tool in the development of novel therapeutic agents. Herein, we review the recent advances in divergent synthetic approaches such as complexity-to-diversity (Ctd) and biomimetic strategies for the generation of structurally complex and diverse indole-based natural product and natural product-like small-mol. libraries. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Application of 120-72-9)

Zhang, Ming’s team published research in Catalysts in 2020 | CAS: 399-52-0

《TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles》 was written by Zhang, Ming; Lu, Sicong; Li, Guofeng; Hong, Liang. Safety of 5-Fluoro-1H-indoleThis research focused ontosylaminomethylidene ethoxydihydroisobenzofuran indole trimethylchlorosilane tandem aza Michael addition rearrangement; indolyl tosyl tetrahydroisoquinolinone preparation regioselective. The article conveys some information:

A TMSCl-catalyzed tandem reaction of dihydroisobenzofuran acetals with indoles was developed, which provided an efficient and straightforward access to various tetrahydroisoquinolones in moderate to excellent yields. This process involved the first addition of the indoles to acetals, followed by skeletal rearrangement. In the experiment, the researchers used many compounds, for example, 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)

Wen, Zhen-Kang’s team published research in Organic Letters in 2020 | CAS: 399-52-0

《Palladium-Catalyzed Regioselective Coupling Cyclohexenone into Indoles: Atom-Economic Synthesis of β-Indolyl Cyclohexenones and Derivatization Applications》 was written by Wen, Zhen-Kang; Wu, Xiao-Xue; Bao, Wen-Kai; Xiao, Jing-Jing; Chao, Jian-Bin. Recommanded Product: 399-52-0 And the article was included in Organic Letters in 2020. The article conveys some information:

Herein, we report a palladium-catalyzed dehydrogenative cross-coupling of indoles with cyclic enones to give β-indolyl cyclic enones under mild and neutral reaction conditions. The key to the success is to explore a mild condition, which ensures the indole C-H activation and subsequent syn β-hydride elimination through rapid enolization isomerization of Pd(II)-enolate while suppressing other undesired side reactions. Synthetic utility has also been demonstrated in the flexible transformation of the coupling products to meta-phenols and benzo[a]carbazoles. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Recommanded Product: 399-52-0)

Dong, Chun-Lin’s team published research in Organic Letters in 2020 | CAS: 399-52-0

《Merging Visible Light Photocatalysis and L-/D-Proline Catalysis: Direct Asymmetric Oxidative Dearomatization of 2-Arylindoles To Access C2-Quaternary Indolin-3-ones》 was written by Dong, Chun-Lin; Ding, Xuan; Huang, Lan-Qian; He, Yan-Hong; Guan, Zhi. Computed Properties of C8H6FN And the article was included in Organic Letters in 2020. The article conveys some information:

A mild and effective method for asym. synthesis of C2-quaternary indolin-3-ones directly from 2-arylindoles by combining visible light photocatalysis and organocatalysis is described. In this reaction, 2-substituted indoles undergo photocatalyzed oxidative dearomatization, followed by an organocatalyzed asym. Mannich reaction with ketones or aldehydes. Products with opposite configurations are easily obtained in satisfactory yields with excellent enantio- and diastereoselectivity by employing readily available L- and D-proline as chiral organocatalysts. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN)

Levitre, Guillaume’s team published research in ChemCatChem in 2019 | CAS: 399-52-0

In 2019,ChemCatChem included an article by Levitre, Guillaume; Audubert, Clement; Dumoulin, Audrey; Goual, Nawel; Retailleau, Pascal; Moreau, Xavier; Masson, Geraldine. Application of 399-52-0. The article was titled 《Combining Organocatalysis and Photoredox Catalysis: An Asymmetric Synthesis of Chiral β-Amino α-Substituted Tryptamines》. The information in the text is summarized as follows:

A stereoselective synthesis of functionalized β-amino α-substituted tryptamines I [R1 = Me, cyclopropyl, (CH2)3OTBDPS, etc.; R2 = H, 7-I, 5-MeO, etc.] was achieved by a sequential asym. organocatalytic three-component electrophilic amination and photocatalyzed Friedel-Crafts reaction of indoles with moderate to high diastereoselectivities (up to >99 : 1 dr) and excellent enantioselectivities (up to >99 % ee). It was also demonstrated that the β-amino α-substituted tryptamines could be successfully engaged in a further catalytic step, furnishing various α, β-substituted tryptamines II [R3 = allyl, 2-methoxythienyl, benzofuran-3-yl, etc.] without erosion of enantioselectivity and with complete diastereoselectivity. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0Application of 399-52-0)