Tag: 100-200

In 2019,ACS Catalysis included an article by Zhang, Lin-Bao; Zhu, Ming-Hui; Ni, Shao-Fei; Wen, Li-Rong; Li, Ming. Product Details of 399-52-0. The article was titled 《Silver-Mediated Indole (4 + 2) Dearomative Annulation with N-Radicals: A Strategy To Construct Heterocycle-Fused Indolines》. The information in the text is summarized as follows:

A regioselective AgI-mediated dearomative (4 + 2) annulation reaction of substituted indoles has been developed. The transformation provides rapid access to functionalized heterocycle fused indoline skeletons, e.g., I, with broad functional groups, high atom economy, and an easy-to-handle nature in one step. Moreover, the recovery experiment of silver catalysts could reduce the cost. D. functional theory studies support a “”radical cation”” pathway in which C-N bond formation determines the rate-limiting step. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Product Details of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Product Details of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 1H-IndoleIn 2019 ,《Tea aroma formation from six model manufacturing processes》 was published in Food Chemistry. The article was written by Feng, Zhihui; Li, Yifan; Li, Ming; Wang, Yijun; Zhang, Liang; Wan, Xiaochun; Yang, Xiaogen. The article contains the following contents:

Tea aroma is determined by the nature of the plant, the production processes, and many other factors influencing its formation and release. The objective of this study was to investigate the impact of manufacturing processes on the aroma composition of tea. Fresh tea leaves from the same cultivar and growing area were selected for producing the six types of tea: green, white, yellow, oolong, black, and dark teas. Comprehensive anal. by gas chromatog. mass spectrometry (GC/MS) was performed for the volatiles of tea infusion, prepared by solid-phase microextraction (SPME), solid-phase extraction (SPE), and solvent assisted flavor evaporation (SAFE). A total of 168 volatile compounds were identified. Black tea has the highest volatile concentration of 710 μg/g, while green tea has the lowest concentration of 20 μg/g. Significantly affected by these processes, tea aroma mols. are formed mainly from four precursor groups: carotenoids, fatty acids, glycosides, and amino acids/sugars. In the experiment, the researchers used 1H-Indole(cas: 120-72-9Safety of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reference of 1H-IndoleIn 2020 ,《The aryl hydrocarbon receptor as a mediator of host-microbiota interplay》 appeared in Gut Microbes. The author of the article were Dong, Fangcong; Perdew, Gary H.. The article conveys some information:

A review. Increasing evidence suggests a significant role for microbiota dependent metabolites and co-metabolites, acting as aryl hydrocarbon receptor (AHR) ligands, to facilitate bidirectional communication between the host and the microbiota and thus modulate physiol. Such communication is particularly evident within the gastrointestinal tract. Through binding to or activating the AHR, these metabolites play fundamental roles in various physiol. processes and likely contribute to the maintenance of intestinal homeostasis. In recent years, tryptophan metabolites were screened to identify physiol. relevant AHR ligands or activators. The discovery of specific microbiota-derived indole-based metabolites as AHR ligands may provide insight concerning how these metabolites affect interactions between gut microbiota and host intestinal homeostasis and how this relates to chronic GI disease and overall health. A greater understanding of the mechanisms that modulate the production of such metabolites and associated AHR activity may be utilized to effectively treat inflammatory diseases and promote human health. Here, we review microbiota-derived AHR ligands generated from tryptophan that modulate host-gut microbiota interactions and discuss possible intervention strategies for potential therapies in the future. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Reference of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 5-Fluoro-1H-indoleIn 2021 ,《Palladium-Catalyzed Direct and Specific C-7 Acylation of Indolines with 1,2-Diketones》 appeared in Organic Letters. The author of the article were Xie, Guilin; Zhao, Yuhan; Cai, Changqun; Deng, Guo-Jun; Gong, Hang. The article conveys some information:

Herein, a palladium-catalyzed direct and specific C-7 acylation of indolines in the presence of an easily removed directing group was developed. This strategy usually considered as a practical strategy for the preparation of acylated indoles because indoline can be easily converted to indole under oxidation conditions. In particular, these strategy greatly improved the alkacylation yield of indolines for which only an unsatisfactory yield could be achieved in the previous studies. Furthermore, the reaction can be scaled up to gram level in the standard reaction conditions with a much lower palladium loading (1 mol %). The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Application In Synthesis of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application In Synthesis of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《C2-H Arylation of Indoles Catalyzed by Palladium-Containing Metal-Organic-Framework in γ-Valerolactone》 was written by Anastasiou, Ioannis; Van Velthoven, Niels; Tomarelli, Elena; Lombi, Aurora; Lanari, Daniela; Liu, Pei; Bals, Sara; De Vos, Dirk E.; Vaccaro, Luigi. Quality Control of 5-Fluoro-1H-indole And the article was included in ChemSusChem in 2020. The article conveys some information:

An efficient and selective procedure was developed for the direct C2-H arylation of indoles using a Pd-loaded metal-organic framework (MOF) as a heterogeneous catalyst and the nontoxic biomass-derived solvent γ-valerolactone (GVL) as a reaction medium. The developed method allows for excellent yields and C-2 selectivity to be achieved and tolerates various substituents on the indole scaffold. The established conditions ensure the stability of the catalyst as well as recoverability, reusability, and low metal leaching into the solution In the experiment, the researchers used many compounds, for example, 5-Fluoro-1H-indole(cas: 399-52-0Quality Control of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Quality Control of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Weak Coordination-Guided Regioselective Direct Redox-Neutral C4 Allylation of Indoles with Morita-Baylis-Hillman Adducts》 were Pradhan, Sourav; De, Pinaki Bhusan; Punniyamurthy, Tharmalingam. And the article was published in Organic Letters in 2019. Synthetic Route of C8H6FN The author mentioned the following in the article:

A weak carbonyl coordination-guided regioselective C4 allylation of indoles is demonstrated using the versatile Morita-Baylis-Hillman adduct in the presence of Rh catalysts in a redox-neutral fashion. The substrate scope, functional group diversity, oxidant free character, mechanistic aspects, and synthetic utilities are important practical features. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Synthetic Route of C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Synthetic Route of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 120-72-9In 2019 ,《Zinc ferrite @ polyindole nanocomposites: synthesis, characterization and gas sensing applications》 appeared in Polymer Composites. The author of the article were Anjitha, T.; Anilkumar, T.; Mathew, G.; Ramesan, M. T.. The article conveys some information:

This research work deals with the synthesis and characterization of polyindole (PIN)/zinc ferrite (ZnFe2O4) nanocomposite. In situ polymerization of indole with different contents of ZnFe2O4 nanoparticles has been employed in the work. Structural, morphol., thermal, gas sensing and elec. properties of the prepared composites have been evaluated. The shifting of peaks in the fourier transform IR and UV-visible spectrum has been found to reveal the interaction of ZnFe2O4 nanoparticles with the PIN matrix. Crystalline nature of the nanocomposites resulting from the presence of crystalline (ZnFe2O4) has been revealed by X-ray diffraction studies (XRD). Scanning electron microscope and high-resolution transmission electron microscopy images revealed the uniform dispersion of nanoparticles at lower loading while at 15 % there are particle agglomerations. Improved thermal stability with the addition of (ZnFe2O4) nanoparticles in PIN has been confirmed by thermogravimetry while the enhancement in glass transition temperature of the nanocomposite with respect to pure polymer has been confirmed by differential scanning calorimetry. The addition of nanoparticles greatly enhanced the a.c. and d.c. conductivity, the dielec. constant and dielec. loss of PIN. The composite with 7 % shows the maximum properties. The fabricated composites showed excellent sensitivity and fast response to ammonia gas at room temperature Thus the study reveals that the PIN/ZnFe2O4 nanocomposites can be considered as a potential candidate for the applications in sensors and nanoelectronic devices. The experimental part of the paper was very detailed, including the reaction process of 1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Jiang, Zhidong; Zhou, Jianhui; Zhu, Haoran; Liu, Hong; Zhou, Yu published their research in Organic Letters in 2021. The article was titled 《Rh(III)-Catalyzed [5+1] Annulation of Indole-enaminones with Diazo Compounds To Form Highly Functionalized Carbazoles》.Category: indole-building-block The article contains the following contents:

A novel Rh(III)-catalyzed C-H activation/annulation cascade of indole-enaminones with diazo compounds was reported to construct diversely functionalized carbazole frameworks. The most notable characteristic was that, this transformation smoothly furnished a novel [5+1] cyclization product with good to excellent yields (up to 95%), accompanied by the thorough removal of acetyl and N,N-di-Me groups of two substrates from the target products, rather than the normally expected [4+2] cyclization products. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0Category: indole-building-block)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wu, Cheng-Juan; Cao, Wen-Xiao; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published their research in Organic Letters in 2021. The article was titled 《Tandem [2 + 2] Cycloaddition/Rearrangement toward Carbazoles by Visible-Light Photocatalysis》.Product Details of 399-52-0 The article contains the following contents:

Reported herein is the first example of the synthesis of carbazoles via oxidative cyclization of 3-alkenylindoles with styrenes under visible light. The irradiation of a catalytic amount of [Ir(dtbbpy)(ppy)2][PF6] as the photocatalyst enables various 3-alkenylindoles and styrenes to undergo tandem [2 + 2] cycloaddition/rearrangement, thereby leading to carbazole derivatives in good to excellent yields under aerobic conditions. Mechanistic studies reveal that photoinduced energy transfer followed by electron transfer is responsible for the tandem reaction. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0Product Details of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Product Details of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Frontiers in Immunology included an article by Kim, Woo H.; Lillehoj, Hyun S.; Min, Wongi. Application In Synthesis of 1H-Indole. The article was titled 《Indole treatment alleviates intestinal tissue damage induced by chicken coccidiosis through activation of the aryl hydrocarbon receptor》. The information in the text is summarized as follows:

In the present study, we examined the effects of dietary indoles, 3,3′-diindolylmethane (DIM) and indole-3-carbinol (I3C), on CD4+T cell population and functions in chickens. Furthermore, the effects of dietary DIM treatment on chicken coccidiosis caused by an apicomplexan parasite were investigated. Dietary treatment of healthy chickens with DIM and I3C induced increased CD4+CD25+ (Treg) cells and the mRNA expression of IL-10, while decreasing number of CD4+IL-17A+ (Th17) cells and Th17-related cytokines transcripts expression in the intestine. In addition, we explored the role of AhR in indole-treated splenic lymphocytes by using AhR antagonist and our results suggested that DIM is a ligand for chicken AhR. In chicken coccidiosis, treatment of DIM increased the ratio of Treg/Th17 cells and significantly reduced intestinal lesion although no significant changes in body weight and fecal oocyst production were noted compared to non-treated control group. These results indicate that DIM is likely to affect the ratios of Treg/Th17 reducing the level of local inflammatory response induced by Eimeria or facilitate repairing process of inflamed gut following Eimeria infection. The results described herein are thus consistent with the concept that AhR ligand modulates the T cell immunity through the alteration of Treg/Th17 cells with Treg dominance. To our knowledge, present study is the first scientific report showing the effects of dietary indole on T cell immunity in poultry species. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles