Tag: 100-200

Wan, Xiao; Sun, Meng; Wang, Jing-Yi; Yu, Lei; Wu, Qiong; Zhang, Yu-Chen; Shi, Feng published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Regio- and enantioselective ring-opening reaction of vinylcyclopropanes with indoles under cooperative catalysis》.SDS of cas: 399-52-0 The article contains the following contents:

The title reaction has been established under the cooperative bimetallic catalysis of iridium and copper catalysts, which afforded indole C3-allylation products I [R = CH(CN)2, CH(C(O)2Et)2; R1 = 2-Me, 5-Br, 7-F, etc.; R2 = H, Me] with branched selectivity in moderate yields (up to 78%) and good enantioselectivities (up to 97 : 3 er). This reaction not only represents the first catalytic asym. ring-opening reaction of vinylcyclopropanes like 1,1-dicyano-2-vinylcyclopropane and 1,1-di-Et 2-ethenyl-1,1-cyclopropanedicarboxylate with C3-unsubstituted indoles II, but also has provided an atom-economic and straightforward method for the synthesis of C3-allylic indoles I with high regio- and enantioselectivity. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Dynamics of transcription-translation coordination tune bacterial indole signaling》 was published in Nature Chemical Biology in 2020. These research results belong to Wang, Tianmin; Zheng, Xiang; Ji, Haonan; Wang, Ting-Liang; Xing, Xin-Hui; Zhang, Chong. Recommanded Product: 120-72-9 The article mentions the following:

Indole signaling is an important cross-species communication pathway in the mammalian gut. In bacteria, upon induction by tryptophan, the mol. sensor (tnaC) controls indole biosynthesis by precisely coordinating dynamics of the corresponding macromol. machineries during its transcription and translation. The authors’ understanding of this regulatory program is still limited owing to its rapid dynamic nature. To address this shortcoming, the authors adopted a massively parallel profiling method to quantify the responses of 1450 synthetic tnaC variants in the presence of three concentrations of tryptophan in living bacterial cells. The resultant dataset enabled the authors to comprehensively probe the key intermediate states of macromol. machineries during the transcription and translation of tnaC. The authors also used modeling to provide a systems-level understanding of how these critical states collectively shape the output of this regulatory program quant. A similar methodol. will likely apply to other poorly understood dynamics-dependent cis-regulatory elements. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Pantoea agglomerans YS19 poly(A) polymerase I gene possesses the indole-sensing sequence in the promoter region》 were Zheng, Jing; Liu, Qi; Xia, Yifan; Bai, Lijuan; Feng, Yongjun. And the article was published in FEMS Microbiology Letters in 2019. Product Details of 120-72-9 The author mentioned the following in the article:

Pantoea agglomerans YS19 is a predominant diazotrophic endophyte with multiple growth-promoting effects on its host plant that was isolated from rice. Indole is confirmed to induce many changes of physiol. and biochem. characteristics in bacteria. Although YS19 cannot produce indole, it can sense indole in the environment and be regulated by indole. Here, using gfp as a reporter gene, we constructed a series of recombinant plasmids containing the promoter region of the poly(A) polymerase I gene (pcnB) fused with gfp, and compared the green fluorescence intensity at different concentrations of exogenous indole by a flow cytometer. In this research, we confirmed that exogenous indole significantly inhibited the expression of pcnB by its promoter; the regulation sequence sensitive to indole in the promoter region of the pcnB gene (In-pcnB) was between -129 and -88 bp. In-pcnB is widely distributed and strictly conserved in the same genus. These results suggest novel roles of In-pcnB in P. agglomerans YS19, showing its special relation to the indole regulatory pathway. After reading the article, we found that the author used 1H-Indole(cas: 120-72-9Product Details of 120-72-9)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Product Details of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin》 were Wani, Tanveer A.; Bakheit, Ahmed H.; Zargar, Seema; Bhat, Mashooq A.; Al-Majed, Abdulrahman A.. And the article was published in Bioorganic Chemistry in 2019. Recommanded Product: 120-72-9 The author mentioned the following in the article:

The indole derivative 2-(5-methoxy-2-methyl-1H-indol-3-yl)-N’-[(E)-(3-nitrophenyl) methylidene]acetohydrazide (IND) was synthesized for its therapeutic potential to inhibit cyclooxygenase (COX)-II. Binding if IND to bovine serum albumin (BSA) was investigated was because most drugs bind to serum albumin in-vivo. Fluorescence, UV-vis spectrophotometry and mol. modeling methodologies were employed for studying the interaction mechanism. The intrinsic fluorescence of BSA was quenched by BSA and the quenching mechanism involved was static quenching. The binding constants between IND and BSA at the three studied temperatures (298, 301 and 306 K) were 1.09 × 105, 4.36 × 104 and 1.23 × 104 L mol-1 resp. The most likely site for binding IND to BSA was Site I (subdomain IIA). The anal. of thermodn. parameter revealed the involvement of hydrogen bonding and van der Waals forces in the IND-BSA interaction. Synchronous fluorescence spectroscopic (SFS) and UV-vis spectrophotometric studies suggested conformational change in BSA mol. post interaction to IND. Mol. docking and the exptl. results corroborated one another. The study can prove as an insight for future IND drug development.1H-Indole(cas: 120-72-9Recommanded Product: 120-72-9) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Rhodium-Catalyzed Diastereo- and Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines》 was written by Grugel, Christian P.; Breit, Bernhard. HPLC of Formula: 399-52-0This research focused onvinylic spiroindoline preparation enantioselective diastereoselective rhodium catalyst; allenylindole spirocyclization reduction. The article conveys some information:

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction’s synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0HPLC of Formula: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).HPLC of Formula: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 1H-IndoleIn 2019 ,《Medicinal chemistry of indole derivatives: Current to future therapeutic prospectives》 appeared in Bioorganic Chemistry. The author of the article were Kumari, Archana; Singh, Rajesh K.. The article conveys some information:

A review. Indole is a versatile pharmacophore, a privileged scaffold and an outstanding heterocyclic compound with wide ranges of pharmacol. activities due to different mechanisms of action. It is an superlative moiety in drug discovery with the sole property of resembling different structures of the protein. Plenty of research has been taking place in recent years to synthesize and explore the various therapeutic prospectives of this moiety. This review summarizes some of the recent effective chem. synthesis (2014-2018) for indole ring. This review also emphasized on the structure-activity relationship (SAR) to reveal the active pharmacophores of various indole analogs accountable for anticancer, anticonvulsant, antimicrobial, antitubercular, antimalarial, antiviral, antidiabetic and other miscellaneous activities which have been investigated in the last five years. The precise features with motives and framework of each research topic is introduced for helping the medicinal chemists to understand the perspective of the context in a better way. This review will definitely offer the platform for researchers to strategically design diverse novel indole derivatives having different promising pharmacol. activities with reduced toxicity and side effects. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Name: 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Name: 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2022,Mullins, Terry; Karamatskos, Evangelos T.; Wiese, Joss; Onvlee, Jolijn; Rouzee, Arnaud; Yachmenev, Andrey; Trippel, Sebastian; Kuepper, Jochen published an article in Nature Communications. The title of the article was 《Picosecond pulse-shaping for strong three-dimensional field-free alignment of generic asymmetric-top molecules》.Formula: C8H7N The author mentioned the following in the article:

Fixing mols. in space is a crucial step for the imaging of mol. structure and dynamics. Here, we demonstrate three-dimensional (3D) field-free alignment of the prototypical asym. top mol. indole using elliptically polarized, shaped, off-resonant laser pulses. A truncated laser pulse is produced using a combination of extreme linear chirping and controlled phase and amplitude shaping using a spatial-light-modulator (SLM) based pulse shaper of a broadband laser pulse. The angular confinement is detected through velocity-map imaging of H+ and C2+ fragments resulting from strong-field ionization and Coulomb explosion of the aligned mols. by intense femtosecond laser pulses. The achieved three-dimensional alignment is characterized by comparing the result of ion-velocity-map measurements for different alignment directions and for different times during and after the alignment laser pulse to accurate computational results. The achieved strong three-dimensional field-free alignment of cos2δ = 0.89 demonstrates the feasibility of both, strong three-dimensional alignment of generic complex mols. and its quant. characterization.1H-Indole(cas: 120-72-9Formula: C8H7N) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Formula: C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhou, Su; Liu, Qianqian; Bao, Ming; Huang, Jie; Wang, Junjian; Hu, Wenhao; Xu, Xinfang published an article in 2021. The article was titled 《Gold(I)-catalyzed redox transformation of o-nitroalkynes with indoles for the synthesis of 2,3′-biindole derivatives》, and you may find the article in Organic Chemistry Frontiers.SDS of cas: 399-52-0 The information in the text is summarized as follows:

An efficient and practical methods for the syntheses of 2-indolyl indolone N-oxides I [R = H, Me, CH2CH=CH2; R1 = 4-F, 5-Cl, 6-Me, etc.; R2 = H, 6-Me, 7-F, etc.; R3 = H, Me] and 1’H,3H-[2,3′-biindol]-3-ones II [R4 = H, Ph, Bn, 4-ClPhCH2; R5 = H, 6-Me, 5-F, 7-F ] via gold(I)-catalyzed cascade reaction of o-nitroalkynes with indoles were reported. The generated product could be readily converted into the 2-indolylbenzoxazinone, which emitted strong blue fluorescence. Also some of the compounds I and II evaluated for antitumor activity for small cell lung cancer and the results showed that compounds I [R = H; R1 = 6-Me; R2 = H; R3 = H] and II [R4 = H; R5 = 6-Me] exhibited high anticancer potency against SCLC cells. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Green Chemistry included an article by Vaidya, Gargi Nikhil; Fiske, Sneha; Verma, Hansa; Lokhande, Shyam Kumar; Kumar, Dinesh. SDS of cas: 399-52-0. The article was titled 《A micellar catalysis strategy applied to the Pd-catalyzed C-H arylation of indoles in water》. The information in the text is summarized as follows:

A modular and selective C-H arylation of indoles I (R = 5-CN, 5-OCH3, 6-Cl, etc.; R1 = H, Me) following the micellar catalysis approach using the third generation “”designer”” surfactant SPGS-550-M in the presence of 1 mol of [(cinnamyl)PdCl]2 under mild conditions has been described. Thus, access to high value C-3-arylated indoles II [R2 = H, F, MeO, CF3, C(O)Me] and C-2-arylated indoles III (Ar = Ph, 4-fluorophenyl, 2H-1,3-benzodioxol-5-yl) was achieved by fulfilling the “”triple bottom line philosophy”” of green chem. The nature of the phosphine ligand was found to be critical for achieving site-selectivity, DPPF and DPPP being the most effective in promoting the arylation at C3-H and C2-H, resp. The reaction is scalable and offers high chemo- (C vs. N) and regio-selectivity (C-3 vs. C-2) with a wide range of functional group tolerance. The surfactant aqueous solution can be recycled and reused without compromising on product yields. The results came from multiple reactions, including the reaction of 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Knepper, Kerstin; Brase, Stefan published their research in Organic Letters on August 7 ,2003. The article was titled 《Bartoli Indole Synthesis on Solid Supports》.Synthetic Route of C9H6ClNO2 The article contains the following contents:

Bartoli indole synthesis was performed on solid supports. Starting from Merrifield resin, immobilization of five nitrobenzoic acids was performed. Addition of four different alkenyl Grignard reagents and basic cleavage leads to substituted Me indolecarboxylates in excellent purities. Features of this reaction are the stability of halide groups, ester moieties, and tolerance of o,o’-unsubstituted nitro resins. Heck and Sonogashira reactions are also possible with immobilized indoles. In the part of experimental materials, we found many familiar compounds, such as 7-Chloro-1H-indole-4-carboxylic acid(cas: 588688-45-3Synthetic Route of C9H6ClNO2)

7-Chloro-1H-indole-4-carboxylic acid(cas: 588688-45-3) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C9H6ClNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles