Tag: 100-200

In 2022,Nasr, Mohamed A.; Timmins, Logan R.; Martin, Vincent J. J.; Kwan, David H. published an article in ACS Synthetic Biology. The title of the article was 《A Versatile Transcription Factor Biosensor System Responsive to Multiple Aromatic and Indole Inducers》.Recommanded Product: 1H-Indole The author mentioned the following in the article:

Allosteric transcription factor (aTF) biosensors are valuable tools for engineering microbes toward a multitude of applications in metabolic engineering, biotechnol., and synthetic biol. One of the challenges toward constructing functional and diverse biosensors in engineered microbes is the limited toolbox of identified and characterized aTFs. To overcome this, extensive bioprospecting of aTFs from sequencing databases, as well as aTF ligand-specificity engineering are essential in order to realize their full potential as biosensors for novel applications. In this work, using the TetR-family repressor CmeR from Campylobacter jejuni, we construct aTF genetic circuits that function as salicylate biosensors in the model organisms Escherichia coli and Saccharomyces cerevisiae. In addition to salicylate, we demonstrate the responsiveness of CmeR-regulated promoters to multiple aromatic and indole inducers. This relaxed ligand specificity of CmeR makes it a useful tool for detecting mols. in many metabolic engineering applications, as well as a good target for directed evolution to engineer proteins that are able to detect new and diverse chemistries. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Recommanded Product: 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Qin, Hong; Zhang, Jie; Qiao, Kai; Zhang, Dong; He, Wei; Liu, Chengkou; Fang, Zheng; Guo, Kai published an article in 2021. The article was titled 《Palladium-Catalyzed C2-Regioselective Perfluoroalkylation of the Free (NH)-Heteroarenes》, and you may find the article in Journal of Organic Chemistry.Related Products of 399-52-0 The information in the text is summarized as follows:

A highly regioselective and atom-efficient strategy for the construction of fused free (NH) heteroarenes I (R = 3-Me, 4-Cl, 7-F, etc.) and II (R1 = 2-C(O)2Me, 3-C(O)2Me, 3-C(O)2Et-4-Me) through a palladium-catalyzed perfluoroalkyl insertion reaction has been accomplished. This protocol employed multiple iodofluoroalkanes R2I [R2 = 1,2,2,3,3,4,4,5,5,6,6-undecafluorocyclohexyl, 1,1,2,2,3,3,3-heptafluoropropyl, (benzenesulfonyl)difluoromethyl, etc.] as practical and available perfluoroalkyl sources to provide an operationally simple and versatile route for the synthesis of perfluoroalkylated indoles III. Moreover, indoles I without the assistance of guide groups were utilized as substrates, achieving C(sp2)-H site-selective functionalization of indoles I in yields up to 95%. Furthermore, this protocol was also used for late-stage C2 perfluoroalkylation of bioactive compounds such as auxin, tryptophan, and melatonin analogs. The experimental part of the paper was very detailed, including the reaction process of 5-Fluoro-1H-indole(cas: 399-52-0Related Products of 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Related Products of 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Agostini, Federica; Sinn, Ludwig; Petras, Daniel; Schipp, Christian J.; Kubyshkin, Vladimir; Berger, Allison Ann; Dorrestein, Pieter C.; Rappsilber, Juri; Budisa, Nediljko; Koksch, Beate published an article in 2021. The article was titled 《Multiomics Analysis Provides Insight into the Laboratory Evolution of Escherichia coli toward the Metabolic Usage of Fluorinated Indoles》, and you may find the article in ACS Central Science.Formula: C8H6FN The information in the text is summarized as follows:

Organofluorine compounds are known to be toxic to a broad variety of living beings in different habitats, and chem. fluorination has been historically exploited by mankind for the development of therapeutic drugs or agricultural pesticides. However, several studies so far demonstrated that, under appropriate conditions, living systems (in particular bacteria) can tolerate the presence of fluorinated mols. (e.g., amino acids analogs) within their metabolism and even repurpose them as alternative building blocks for the synthesis of cellular macromols. such as proteins. Understanding the mol. mechanism behind these phenomena would greatly advance approaches to the biotechnol. synthesis of recombinant proteins and peptide drugs. However, information about the metabolic effects of long-term exposure of living cells to fluorinated amino acids remains scarce. Hereby, the authors report the long-term propagation of Escherichia coli (E. coli) in an artificially fluorinated habitat that yielded two strains naturally adapted to live on fluorinated amino acids. In particular, the authors applied selective pressure to force a tryptophan (Trp)-auxotrophic strain to use either 4- or 5-fluoroindole as essential precursors for the in situ synthesis of Trp analogs, followed by their incorporation in the cellular proteome. Full adaptation to both fluorinated Trp analogs requires a low number of genetic mutations but is accompanied by large rearrangements in regulatory networks, membrane integrity, and quality control of protein folding. These findings highlight the cellular mechanisms behind the adaptation to unnatural amino acids and provide the mol. foundation for bioengineering of novel microbial strains for synthetic biol. and biotechnol. The authors eliminated the metabolic ability of E. coli to produce the canonical amino acid tryptophan and introduced synthesis of two fluorinated analogs in vivo using 4- and 5-fluoroindole as precursors. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Formula: C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nguyen, Ngoc-Khanh; Nam, Duong Ha; Phuc, Ban Van; Nguyen, Van Ha; Trinh, Quang Thang; Hung, Tran Quang; Dang, Tuan Thanh published their research in Molecular Catalysis in 2021. The article was titled 《Efficient copper-catalyzed synthesis of C3-alkylated indoles from indoles and alcohols》.Computed Properties of C8H6FN The article contains the following contents:

A highly efficient copper(II) catalyst system for alkylation of indoles with alcs. via hydrogen borrowing method has been developed to afford C3-alkylated indoles I (R1 = H, 5-OMe, 7-Me, etc.; R2 = n-pentyl, Ph, 3-FC6H4, etc.) in good to excellent yields. Cu(OAc)2 in the combination with dppm ligand has been found to be the most suitable catalyst system for this alkylation reaction. After reading the article, we found that the author used 5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Cp*Co(III)-Catalyzed Regioselective C2-Amidation of Indoles Using Acyl Azides》 were Shah, Tariq A.; De, Pinaki Bhusan; Pradhan, Sourav; Banerjee, Sonbidya; Punniyamurthy, Tharmalingam. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 399-52-0 The author mentioned the following in the article:

A cobalt-catalyzed C2-selective amidation of indoles using acyl azides has been accomplished. Isotope experiments suggest that C-H activation is reversible. The use of sustainable Co-catalysis, functional group diversity, substrate scope and regioselective are the important practical features. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0HPLC of Formula: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.HPLC of Formula: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Chemistry – A European Journal included an article by Pang, Yadong; Ishiyama, Tatsuo; Kubota, Koji; Ito, Hajime. Reference of 5-Fluoro-1H-indole. The article was titled 《Iridium(I)-Catalyzed C-H Borylation in Air by Using Mechanochemistry》. The information in the text is summarized as follows:

Mechanochem. has been applied for the first time to an iridium(I)-catalyzed C-H borylation reaction. By using either none or just a catalytic amount of a liquid, the mechanochem. C-H borylation of a series of heteroaromatic compounds proceeded in air to afford the corresponding arylboronates in good-to-excellent yields. A one-pot mechanochem. C-H borylation/Suzuki-Miyaura cross-coupling sequence for the direct synthesis of 2-aryl indole derivatives is also described. The present study constitutes an important milestone towards the development of industrially attractive solvent-free C-H bond functionalization processes in air. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Reference of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Reference of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019,Nature (London, United Kingdom) included an article by Lv, Jiahang; Chen, Xiangyang; Xue, Xiao-Song; Zhao, Binlin; Liang, Yong; Wang, Minyan; Jin, Liqun; Yuan, Yu; Han, Ying; Zhao, Yue; Lu, Yi; Zhao, Jing; Sun, Wei-Yin; Houk, Kendall. N.; Shi, Zhuangzhi. Related Products of 120-72-9. The article was titled 《Metal-free directed sp2-C-H borylation》. The information in the text is summarized as follows:

Direct borylation of 1- or 3-pivaloyl-1H-indoles was achieved by reaction with BBr3 with subsequent esterification with pinacol, yielding 7- or 4-indoleboronates, resp., without use of metal catalyst. N-acylated aromatic amines were successfully borylated into o-position with the same protocol, giving 2-pivaloylaminophenylboronic acids. Organoboron reagents are important synthetic intermediates that have a key role in the construction of natural products, pharmaceuticals and organic materials. The discovery of simpler, milder and more efficient approaches to organoborons can open addnl. routes to diverse substances. Here we show a general method for the directed C-H borylation of arenes and heteroarenes without the use of metal catalysts. C7- and C4-borylated indoles are produced by a mild approach that is compatible with a broad range of functional groups. The mechanism, which is established by d. functional theory calculations, involves BBr3 acting as both a reagent and a catalyst. The potential utility of this strategy is highlighted by the downstream transformation of the formed boron species into natural products and drug scaffolds. In addition to this study using 1H-Indole, there are many other studies that have used 1H-Indole(cas: 120-72-9Related Products of 120-72-9) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Related Products of 120-72-9

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Synthesis of Chiral Bis(3-indolyl)methanes Bearing a Trifluoromethylated All-Carbon Quaternary Stereocenter via Nickel-Catalyzed Asymmetric Friedel-Crafts Alkylation Reaction》 was written by Zhu, Wen-Jing; Gong, Jun-Fang; Song, Mao-Ping. Safety of 5-Fluoro-1H-indoleThis research focused ontrifluoromethyl bis indolyl methane nitromethyl enantioselective preparation; nitroalkene indolyl trifluoromethyl enantioselective Friedel Crafts alkylation indole nickel. The article conveys some information:

Here, an efficient method for the synthesis of chiral trifluoromethylated bis(3-indolyl)methanes I (R1 = H, 5-F, 6-Me, 7-MeO, etc.; R2 = H, 4-F, 5-CO2Me, etc.; R3 = Boc, Ts) via a catalytic asym. Friedel-Crafts (F-C) alkylation reaction of R1-substituted indoles with (nitrovinyl)indoles II has been developed. Both enantiomers of the products could be obtained by tuning chiral substituents on a catalyst. With 5 mol% of Ni(II)/(imidazoline-oxazoline) complex as catalyst, F-C reaction of indoles with β-CF3-β-(3-indolyl)nitroalkenes proceeded well to afford a series of chiral bis(3-indolyl)methanes bearing a trifluoromethylated all-carbon quaternary stereocenter I in generally good yields with excellent enantioselectivities (up to 98% yield and 94% ee). Furthermore, by interchanging indole moieties of two reactants, indole vs. β-CF3-β-(3-indolyl)nitroalkene in F-C reaction, both enantiomers of a given trifluoromethylated bis(3-indolyl)methane were obtained with high enantioselectivities (89-94% ee) upon removal of indole N-protecting group in F-C products. The current work represents the first general catalytic enantioselective approach to important class of trifluoromethylated bis(3-indolyl)methanes. In the part of experimental materials, we found many familiar compounds, such as 5-Fluoro-1H-indole(cas: 399-52-0Safety of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Safety of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H6FNIn 2019 ,《Redox-Neutral Cascade Dearomatization of Indoles via Hydride Transfer: Divergent Synthesis of Tetrahydroquinoline-Fused Spiroindolenines》 was published in Journal of Organic Chemistry. The article was written by Shen, Yao-Bin; Li, Long-Fei; Xiao, Ming-Yan; Yang, Jian-Ming; Liu, Qing; Xiao, Jian. The article contains the following contents:

The redox-neutral cascade dearomatization of indoles with o-aminobenzaldehydes was realized via the hydride transfer strategy, achieving the condition- and substrate-controlled divergent synthesis of tetrahydroquinoline-fused spiroindolenines. The integration of hydride transfer-involved C(sp3)-H functionalization with dearomatization provides a promising platform for the construction of structurally diverse mols.5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Sun, Minghe; Liu, Min; Li, Changkun published an article in 2021. The article was titled 《Rhodium-Catalyzed Chemodivergent Regio- and Enantioselective Allylic Alkylation of Indoles》, and you may find the article in Chemistry – A European Journal.Computed Properties of C8H6FN The information in the text is summarized as follows:

The control of C3/N1 chemoselectivity in indole alkylation with the same electrophiles is still challenging. An Rh/bisoxazolinephosphane-catalyzed chemodivergent regio- and enantioselective allylic alkylation of indoles was developed. Chiral C3- and N1-allylindoles was selectively obtained with high branched/linear ratio and up to 99% ee by changing the counteranion of Rh, the allylic carbonate, the reaction temperature, and the ligand. In addition to this study using 5-Fluoro-1H-indole, there are many other studies that have used 5-Fluoro-1H-indole(cas: 399-52-0Computed Properties of C8H6FN) was used in this study.

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.Computed Properties of C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles