Tag: 100-200

Application In Synthesis of 5-Fluoro-1H-indoleIn 2019 ,《Re-Catalyzed Annulations of Weakly Coordinating N-Carbamoyl Indoles/Indolines with Alkynes via C-H/C-N Bond Cleavage》 appeared in Chemistry – A European Journal. The author of the article were Yang, Yunhui; Wang, Congyang. The article conveys some information:

A rhenium-catalyzed [3+2] annulations of N-carbamoyl indoles with alkynes via C-H/C-N bond cleavage, provided rapid access to fused-ring pyrroloindolone derivs I [R1 = H, 6-F, 7-Br, etc.; R2 = R3 = Ph, 4-MeC6H4, 1-naphthyl, etc.]. For the first time, the weakly coordinating O-directing group was successfully employed in rhenium-catalyzed C-H activation reactions, enabled by the unique catalytic ratio of Re2(CO)10, Me2Zn and ZnCl2. Mechanistic studies revealed that aminozinc species played an important role in the reaction. Based on the mechanistic understanding, a more powerful catalytic ratio of Re2(CO)10, [MeZnNPh2]2 and Zn(OTf)2 was devised and applied successfully in the [4+2] annulations of indolines and alkynes affording pyrroloquinolinone derivs II. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0Application In Synthesis of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Application In Synthesis of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Begum, Bushra; Bilal, Salma; Shah, Anwar ul Haq Ali; Rose, Philipp published an article in 2021. The article was titled 《Physical, Chemical, and Electrochemical Properties of Redox-Responsive Polybenzopyrrole as Electrode Material for Faradaic Energy Storage》, and you may find the article in Polymers (Basel, Switzerland).Recommanded Product: 1H-Indole The information in the text is summarized as follows:

Polybenzopyrrole (Pbp) is an emerging candidate for electrochem. energy conversion and storage. There is a need to develop synthesis strategies for this class of polymers that can help improve its overall properties and make it as suitable for energy storage applications as other well-studied polymers in this substance class, such as polyaniline and polypyrrole. In this study, by synthesizing Pbp in surfactant-supported acidic medium, we were able to show that the physicochem. and electrochem. properties of Pbp-based electrodes are strongly influenced by the resp. polymerization conditions. Through appropriate optimization of various reaction parameters, a significant enhancement of the thermal stability (up to 549.9°C) and the electrochem. properties could be achieved. A maximum specific capacitance of 166.0 ± 2.0 F g-1 with an excellent cycle stability of 87% after 5000 cycles at a c.d. of 1 A g-1 was achieved. In addition, a particularly high-power d. of 2.75 kW kg-1 was obtained for this polybenzopyrrole, having a gravimetric energy d. of 17 Wh kg-1. The results show that polybenzopyrroles are suitable candidates to compete with other conducting polymers as electrode materials for next-generation Faradaic supercapacitors. In addition, the results of the current study can also be easily applied to other systems and used for adaptations or new syntheses of advanced hybrid/composite Pbp-based electrode materials.1H-Indole(cas: 120-72-9Recommanded Product: 1H-Indole) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Recommanded Product: 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Rotational spectra of indole in the lowest vibrational states》 were Vavra, K.; Lukova, K.; Kania, P.; Koucky, J.; Urban, S.. And the article was published in Journal of Molecular Spectroscopy in 2019. Synthetic Route of C8H7N The author mentioned the following in the article:

The millimetre- and submillimetre-wave rotational spectra of indole (C8H7N) have been recorded in several frequency regions from 140 to 715 GHz. Nearly 6000 rotational transitions corresponding to the ground and two vibrationally excited states ν42 and ν41 were assigned and analyzed using the A-reduced Hamiltonian. All newly measured transitions were fitted together with the previously published data yielding significantly improved rotational and centrifugal distortion constants Such highly precise mol. parameters could support future searches of the spectral features of indole in the interstellar medium as this mol. is the simplest prototype of polycyclic N-substituted aromatic hydrocarbons (PANHs), the possible sources of unidentified IR emission in the interstellar medium. In the part of experimental materials, we found many familiar compounds, such as 1H-Indole(cas: 120-72-9Synthetic Route of C8H7N)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C8H7N

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Multiple-species hormetic phenomena induced by indole: A case study on the toxicity of indole to bacteria, algae and human cells》 were Sun, Haoyu; Zheng, Min; Song, Jinyuan; Huang, Shengyou; Pan, Yongzheng; Gong, Ruochong; Lin, Zhifen. And the article was published in Science of the Total Environment in 2019. Safety of 1H-Indole The author mentioned the following in the article:

Hormesis is a dose-response relationship phenomenon characterized by low-dose stimulation and high-dose inhibition. Although hormetic phenomena have been reported in broadly ranging biol. areas, there is still no unified mechanism of hormesis. Investigating multiple-species hormesis of one compound and then exploring the possible mechanism may be an effective approach to clarify the reason for the occurrence of hormetic phenomena in a broad range of organisms. In this study, indole was selected as the test chem. due to the broad biol. and hormetic effects of indole compounds The results show that indole induces multiple-species hormetic phenomena in bacteria (Aliivibrio fischeri (A. fischeri), Escherichia coli and Bacillus subtilis), algae (Microcystis aeruginosa and Selenastrum capricornutum), and human cells (human skin fibroblasts and human cervical cancer cells). Through in-depth investigation of the time-dependent hormetic effects of indole, indole derivatives and indole’s structural analogs on the bioluminescence of A. fischeri, indole ring has been identified as the potential key structure that causes indole to act on quorum sensing of A. fischeri to induce hormetic effects on the bioluminescence at lag, logarithmic, and stationary phases. Therefore, the occurrence of multiple-species hormetic phenomena is speculated to be derived from the action of indole on the cell-to-cell communication of organism cells. This paper can not only further confirm the generalizability of hormesis but also provide a reasonable explanation for hormesis, which will benefit the development of hormesis and the risk assessment of environmental pollutants.1H-Indole(cas: 120-72-9Safety of 1H-Indole) was used in this study.

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Safety of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Trisulfonamide calix[6]arene-catalysed Michael addition to nitroalkenes》 was written by Cera, Gianpiero; Balestri, Davide; Bazzoni, Margherita; Marchio, Luciano; Secchi, Andrea; Arduini, Arturo. Quality Control of 5-Fluoro-1H-indole And the article was included in Organic & Biomolecular Chemistry in 2020. The article conveys some information:

The application of a novel family of trisulfonamide (TSA) calix[6]arenes I in general acid catalysis was described. Hydrogen-bonding interactions between acidic TSA and methanol boosted the reactivity of the Michael addition of indoles II (R = H, Me; R1 = H, F, Br, OH, OMe) to nitroalkene derivatives 3-R2-4-R3-C6H3CH=CHNO2 (R2 = H, OMe; R3 = H, Me, Br, Cl, OMe). The transformation occurs at a low catalyst loading of 5 mol%, allowing for the synthesis of nitroalkanes III with good yields and functional group tolerance. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Quality Control of 5-Fluoro-1H-indole)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Quality Control of 5-Fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The author of 《Interspecies and intraspecies signals synergistically regulate Lysobacter enzymogenes twitching motility》 were Feng, Tao; Han, Yong; Li, Bingqing; Li, Zhiqiang; Yu, Yameng; Sun, Qingyang; Li, Xiaoyu; Du, Liangcheng; Zhang, Xiao-Hua; Wang, Yan. And the article was published in Applied and Environmental Microbiology in 2019. Reference of 1H-Indole The author mentioned the following in the article:

The twitching motility of bacteria is closely related to environmental adaptability and pathogenic behaviors. Lysobacter is a good genus in which to study twitching motility because of the complex social activities and distinct movement patterns of its members. Regardless, the mechanism that induces twitching motility is largely unknown. In this study, we found that the interspecies signal indole caused Lysobacter to have irregular, random twitching motility with significantly enhanced speed. Deletion of qseC or qseB from the two-component system for indole signaling perception resulted in the disappearance of rapid, random movements and significantly decreased twitching activity. Indole-induced, rapid, random twitching was achieved through upregulation of expression of gene cluster pilE1-pilY11-pilX1-pilW1-pilV1-fimT1. In addition, under conditions of extremely low bacterial d., individual Lysobacter cells grew and divided in a stable manner in situ without any movement. The intraspecies quorum-sensing signaling factor 13-methyltetradecanoic acid, designated L. enzymogenes diffusible signaling factor (LeDSF), was essential for Lysobacter to produce twitching motility through indirect regulation of gene clusters pilM-pilN-pilO-pilP-pilQ and pilS1-pilR-pilA-pilB-pilC. These results demonstrate that the motility of Lysobacter is induced and regulated by indole and LeDSF, which reveals a novel theory for future studies of the mechanisms of bacterial twitching activities. The results came from multiple reactions, including the reaction of 1H-Indole(cas: 120-72-9Reference of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Reference of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Electric Literature of C10H8FNO2On May 31, 1988, Fagan, Gay P.; Chapleo, Christopher B.; Lane, Anthony C.; Myers, Malcolm; Roach, Alan G.; Smith, Colin F. C.; Stillings, Michael R.; Welbourn, Anthony P. published an article in Journal of Medicinal Chemistry. The article was 《Indoline analogs of idazoxan: potent α2-antagonists and α1-agonists》. The article mentions the following:

The synthesis and α-adrenergic activity of a series of substituted 2-imidazolinylindolines are described. Substitution in the indoline ring generated compounds with a spectrum of adrenoreceptor antagonist/agonist profiles that proved sensitive to both the nature and position of the substituent. Many of the derivatives possess greater presynaptic antagonist potency than the corresponding benzodioxan, dihydrobenzofuran, and indan analogs; however, this α2-antagonism is often accompanied by α1-agonist activity. It was not possible to sep. α2-antagonist from α1-agonist properties in this series. Compounds of most interest proved to be the N-Et, 5-chloro-N-Me, and 5-chloro-N-Et derivatives, all being potent α2-antagonists and α1-agonists. Substitution at the 4- and 7-position of the indoline ring generally gave compounds with nonselective agonist properties. In the part of experimental materials, we found many familiar compounds, such as Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0Electric Literature of C10H8FNO2)

Methyl 4-fluoro-1H-indole-2-carboxylate(cas: 113162-36-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Electric Literature of C10H8FNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Oxidative trimerization of indoles via water-assisted visible-light photoredox catalysis and the study of their anti-cancer activities》 was written by Cheng, Li-Ting; Luo, Sheng-Qi; Hong, Bor-Cherng; Chen, Chia-Ling; Li, Wen-Shan; Lee, Gene-Hsiang. Formula: C8H6FNThis research focused ontrisindolone preparation antitumor crystal structure mol; indole oxidative trimerization photocatalyst water assisted. The article conveys some information:

A series of trisindolones I [R = H, 5-Me, 6-Br, etc.] was synthesized via water assisted visible-light photocatalyzed oxidative trimerization of indoles under mild and scalable reaction conditions. Compounds I were evaluated against three human cancer cell lines (MDA-MB-231, A549 and HeLa). Compound I [R = 5-I] represented a potent, micromolar to submicromolar range anticancer agent against MDA-MB-231, A549 and HeLa cells. The successful example of the catalyst-free CFL irradiation of 5-iodo-1H-indole provided a green, natural, and convenient synthetic process of compound I [R = 5-I]. The experimental process involved the reaction of 5-Fluoro-1H-indole(cas: 399-52-0Formula: C8H6FN)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Formula: C8H6FN

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 1H-IndoleIn 2020 ,《The importance of indole and azaindole scaffold in the development of antitumor agents》 appeared in European Journal of Medicinal Chemistry. The author of the article were Han, Yu; Dong, Wei; Guo, Qunqun; Li, Xiufen; Huang, Longjiang. The article conveys some information:

A review. With some indoles and azaindoles being successfully developed as anticancer drugs, the design and synthesis of indole and azaindole derivatives with remarkable antitumor activity has received increasing attention and significant progress has been made. This paper reviews the recent progress in the study of tumorigenesis, mechanism of actions and structure activity relationships about anticancer indole and azindole derivatives Combining structure activity relationships and mol. targets-related knowledge, this review will help researchers design more effective, safe and cost-effective anticancer indoles and azindoles agents. In the experimental materials used by the author, we found 1H-Indole(cas: 120-72-9Application In Synthesis of 1H-Indole)

1H-Indole(cas: 120-72-9) belongs to indole. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application In Synthesis of 1H-Indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2022,Zhang, Shang-Shi; Liu, Yan-Zhi; Zheng, Yi-Chuan; Xie, Hui; Chen, Shao-Yong; Song, Jia-Lin; Shu, Bing published an article in Advanced Synthesis & Catalysis. The title of the article was 《Rhodium(III)-Catalyzed Regioselective C-H Allylation and Prenylation of Indoles at C4-Position》.SDS of cas: 399-52-0 The author mentioned the following in the article:

Herein, Rh(III)-catalyzed C4-selective C-H allylation and prenylation of indoles, e.g., I (R = H), by using a weak carbonyl coordination directing group have been reported. By employing 5-methylene-1,3-dioxan-2-ones, 4-vinyl-1,3-dioxolan-2-ones and 2-methyl-2,3-butadiene as scalable cross-coupling partners, these divergent synthesis protocols proceed smoothly under redox-neutral reaction conditions, delivering various allylated and prenylated indoles, e.g., I [R = CH2C(=CH2)CH2OH, CH2CH=CHCH2OH], in moderate to satisfactory yields. This transformation exhibits high functional-groups compatibility and broad substrate scope. A scale-up experiment and mechanistic studies were also accomplished. In the experimental materials used by the author, we found 5-Fluoro-1H-indole(cas: 399-52-0SDS of cas: 399-52-0)

5-Fluoro-1H-indole(cas: 399-52-0) is a member of aromaticfluorinated building blocks. Fluorine-containing aromatics have been incorporated into crop-protection chemicals (herbicides, insecticides, fungicides). Liquid crystals, positron emission tomography, and imaging systems represent new areas where fluoroaromatics and fluoroheterocyclics have gained attention.SDS of cas: 399-52-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles