Tag: 159.1846

Direct Difluoromethylenation of Carbonyl Compounds Using TMSCF₃: The Right Conditions was written by Prakash, Surya G.;Krishnamoorthy, Sankarganesh;Kothandaraman, Jotheeswari;Saldana, Jacqueline. And the article was included in European Journal of Organic Chemistry in 2016.Recommanded Product: 27421-51-8 This article mentions the following:

Using readily available, inexpensive trifluoromethyltrimethylsilane (TMSCF₃), LiI and PPh₃, deoxygenative difluoromethylenation of carbonyl compounds is reported. The Li+ is proposed to prevent the unproductive exhaustion of TMSCF₃ by keeping the soluble free fluoride concentration in the reaction medium under control. Also, solvent combination strategy to increase the reactivity and thereby reducing the reaction temperature and time is disclosed. In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8Recommanded Product: 27421-51-8).

1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: 27421-51-8

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Palladium-Catalyzed Benzannulations of 1-(Indol-2-yl)but-3-yn-1-ols: Easy Access to Functionalized Carbazoles was written by Pramanik, Subhendu;Chatterjee, Sarat;Banerjee, Rumjhum;Chowdhury, Chinmay. And the article was included in Organic Letters in 2022.Quality Control of 1-Methyl-1H-indole-2-carbaldehyde This article mentions the following:

An atom economic direct synthesis of carbazoles having aryl and keto-aryl groups has been achieved through Pd(II)-catalyzed cascade reactions between 1-(indol-2-yl)-3-butyn-1-ols and aldehydes. The reaction proceeds through alkyne-carbonyl metathesis, an uncommon pathway using palladium catalyst, and constitutes a fast intermol. assembly through four carbon-carbon bond formations in one-pot. Absence of the aldehyde substrate resulted in the formation of C1-aryl substituted carbazoles. The reaction is amenable to the synthesis of bis-carbazole derivatives In the experiment, the researchers used many compounds, for example, 1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8Quality Control of 1-Methyl-1H-indole-2-carbaldehyde).

1-Methyl-1H-indole-2-carbaldehyde (cas: 27421-51-8) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 1-Methyl-1H-indole-2-carbaldehyde

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles