Tag: 169.13

Highly Enantioselective Synthesis of Spiro[cyclohexanone-oxindoles] and Spiro[cyclohexanone-pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions was written by Wu, Bin;Chen, Jian;Li, Mei-Qiu;Zhang, Jin-Xin;Xu, Xiao-Ping;Ji, Shun-Jun;Wang, Xing-Wang. And the article was included in European Journal of Organic Chemistry in 2012.Computed Properties of C8H5F2NO This article mentions the following:

The construction of spiro compounds through cascade [5+1] double Michael reactions between divinyl ketones and N-unprotected oxindoles or N-phenyl-protected pyrazolones catalyzed by a combination of the easily available 9-amino-9-deoxy-epi-quinine with N-Boc-D-phenylglycine. The desired multistereogenic spiro[cyclohexanone-oxindoles] and spiro[cyclohexanone-pyrazolones] were obtained with high yields (up to 98 %) and stereoselectivities (up to >20:1 dr, 99 % ee). In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Computed Properties of C8H5F2NO).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Computed Properties of C8H5F2NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Design, synthesis and antitumor activity of novel indolin-2-one derivatives containing 4-thiazolidinone moiety was written by Liu, Zijian;Hou, Yunlei;Zhang, Guogang;Xu, Ning;Mi, Bin;Gong, Ping;Zhao, Yanfang. And the article was included in Chemical Research in Chinese Universities in 2015.Quality Control of 5,6-Difluoroindolin-2-one This article mentions the following:

A series of novel indolin-2-one derivatives containing 4-thiazolidinone moiety(7a-7r) were synthesized and evaluated for their in vitro antitumor activities against MDA-MB-231(human breast cancer), H460(human lung cancer) and HT-29(human colon cancer) cell lines by standard 3-(4,5-dimethylthiazae-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Representative compounds(7d, 7k, 7m, 7p) with higher cytotoxicity were further examined against one normal cell line(WI-38, human fetal lung fibroblasts). The preliminary investigation shows that most of the compounds display moderate to excellent potency and high selectivity against different human cancer cell lines. In particular, the most potent compound 7m shows promising cytotoxicity against MDA-MB-231, H460 and HT-29 cell lines with IC₅₀ values of 0.78, 0.056 and 0.018 渭mol/L, resp. The potency is much higher than that of Sunitinib(IC₅₀=3.46 渭mol/L against MDA-MB-231, IC₅₀=2.59 渭mol/L against H460, IC₅₀=1.50 渭mol/L against HT-29) by 4.4, 46.3 and 83.3 fold. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Quality Control of 5,6-Difluoroindolin-2-one).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5,6-Difluoroindolin-2-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Highly Enantioselective Synthesis of Spiro[cyclohexanone-oxindoles] and Spiro[cyclohexanone-pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions was written by Wu, Bin;Chen, Jian;Li, Mei-Qiu;Zhang, Jin-Xin;Xu, Xiao-Ping;Ji, Shun-Jun;Wang, Xing-Wang. And the article was included in European Journal of Organic Chemistry in 2012.Computed Properties of C8H5F2NO This article mentions the following:

The construction of spiro compounds through cascade [5+1] double Michael reactions between divinyl ketones and N-unprotected oxindoles or N-phenyl-protected pyrazolones catalyzed by a combination of the easily available 9-amino-9-deoxy-epi-quinine with N-Boc-D-phenylglycine. The desired multistereogenic spiro[cyclohexanone-oxindoles] and spiro[cyclohexanone-pyrazolones] were obtained with high yields (up to 98 %) and stereoselectivities (up to >20:1 dr, 99 % ee). In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Computed Properties of C8H5F2NO).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Computed Properties of C8H5F2NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Design, synthesis and antitumor activity of novel indolin-2-one derivatives containing 4-thiazolidinone moiety was written by Liu, Zijian;Hou, Yunlei;Zhang, Guogang;Xu, Ning;Mi, Bin;Gong, Ping;Zhao, Yanfang. And the article was included in Chemical Research in Chinese Universities in 2015.Quality Control of 5,6-Difluoroindolin-2-one This article mentions the following:

A series of novel indolin-2-one derivatives containing 4-thiazolidinone moiety(7a-7r) were synthesized and evaluated for their in vitro antitumor activities against MDA-MB-231(human breast cancer), H460(human lung cancer) and HT-29(human colon cancer) cell lines by standard 3-(4,5-dimethylthiazae-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Representative compounds(7d, 7k, 7m, 7p) with higher cytotoxicity were further examined against one normal cell line(WI-38, human fetal lung fibroblasts). The preliminary investigation shows that most of the compounds display moderate to excellent potency and high selectivity against different human cancer cell lines. In particular, the most potent compound 7m shows promising cytotoxicity against MDA-MB-231, H460 and HT-29 cell lines with IC₅₀ values of 0.78, 0.056 and 0.018 μmol/L, resp. The potency is much higher than that of Sunitinib(IC₅₀=3.46 μmol/L against MDA-MB-231, IC₅₀=2.59 μmol/L against H460, IC₅₀=1.50 μmol/L against HT-29) by 4.4, 46.3 and 83.3 fold. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Quality Control of 5,6-Difluoroindolin-2-one).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5,6-Difluoroindolin-2-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Highly Enantioselective Synthesis of Spiro[cyclohexanone-oxindoles] and Spiro[cyclohexanone-pyrazolones] by Asymmetric Cascade [5+1] Double Michael Reactions was written by Wu, Bin;Chen, Jian;Li, Mei-Qiu;Zhang, Jin-Xin;Xu, Xiao-Ping;Ji, Shun-Jun;Wang, Xing-Wang. And the article was included in European Journal of Organic Chemistry in 2012.Computed Properties of C8H5F2NO This article mentions the following:

The construction of spiro compounds through cascade [5+1] double Michael reactions between divinyl ketones and N-unprotected oxindoles or N-phenyl-protected pyrazolones catalyzed by a combination of the easily available 9-amino-9-deoxy-epi-quinine with N-Boc-D-phenylglycine. The desired multistereogenic spiro[cyclohexanone-oxindoles] and spiro[cyclohexanone-pyrazolones] were obtained with high yields (up to 98 %) and stereoselectivities (up to >20:1 dr, 99 % ee). In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Computed Properties of C8H5F2NO).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Computed Properties of C8H5F2NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Design, synthesis and antitumor activity of novel indolin-2-one derivatives containing 4-thiazolidinone moiety was written by Liu, Zijian;Hou, Yunlei;Zhang, Guogang;Xu, Ning;Mi, Bin;Gong, Ping;Zhao, Yanfang. And the article was included in Chemical Research in Chinese Universities in 2015.Quality Control of 5,6-Difluoroindolin-2-one This article mentions the following:

A series of novel indolin-2-one derivatives containing 4-thiazolidinone moiety(7a-7r) were synthesized and evaluated for their in vitro antitumor activities against MDA-MB-231(human breast cancer), H460(human lung cancer) and HT-29(human colon cancer) cell lines by standard 3-(4,5-dimethylthiazae-2-yl)-2,5-diphenyltetrazolium bromide(MTT) assay. Representative compounds(7d, 7k, 7m, 7p) with higher cytotoxicity were further examined against one normal cell line(WI-38, human fetal lung fibroblasts). The preliminary investigation shows that most of the compounds display moderate to excellent potency and high selectivity against different human cancer cell lines. In particular, the most potent compound 7m shows promising cytotoxicity against MDA-MB-231, H460 and HT-29 cell lines with IC₅₀ values of 0.78, 0.056 and 0.018 μmol/L, resp. The potency is much higher than that of Sunitinib(IC₅₀=3.46 μmol/L against MDA-MB-231, IC₅₀=2.59 μmol/L against H460, IC₅₀=1.50 μmol/L against HT-29) by 4.4, 46.3 and 83.3 fold. In the experiment, the researchers used many compounds, for example, 5,6-Difluoroindolin-2-one (cas: 71294-07-0Quality Control of 5,6-Difluoroindolin-2-one).

5,6-Difluoroindolin-2-one (cas: 71294-07-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 5,6-Difluoroindolin-2-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles