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Jiang, Hai-Xia et al. published their research in Organic & Biomolecular Chemistry in 2014 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 210345-56-5

Design, synthesis, and biological evaluation of novel trifluoromethyl indoles as potent HIV-1 NNRTIs with an improved drug resistance profile was written by Jiang, Hai-Xia;Zhuang, Dao-Min;Huang, Ying;Cao, Xing-Xin;Yao, Jian-Hua;Li, Jing-Yun;Wang, Jian-Yong;Zhang, Chen;Jiang, Biao. And the article was included in Organic & Biomolecular Chemistry in 2014.HPLC of Formula: 210345-56-5 This article mentions the following:

A novel series of trifluoromethyl indole derivatives have been designed, synthesized and evaluated for anti-HIV-1 activities in MT-2 cells. The hydrophobic constant, acute toxicity, carcinogenicity and mutagenicity were predicted. Trifluoromethyl indoles (I) and (II) showed extremely promising activities against WT HIV-1 with IC₅₀ values at the low nanomolar level, similar to efavirenz, better than nevirapine, and also possessed higher potency towards the drug-resistant mutant strain Y181C than nevirapine. Preliminary SAR and docking studies of detailed binding mode provided some insights for discovery of more potent NNRTIs. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5HPLC of Formula: 210345-56-5).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Luo, Xinling et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2022 | CAS: 754214-56-7

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Reference of 754214-56-7

Discovery of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors for the treatment of colorectal cancer was written by Luo, Xinling;Yang, Ruicheng;Li, Yueshan;Zhang, Liting;Yang, Shengyong;Li, Linli. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2022.Reference of 754214-56-7 This article mentions the following:

Colorectal cancer (CRC) is one of the most commonly diagnosed cancer types and Traf2- and Nck-interacting kinase (TNIK) has been thought as a potential target for CRC treatment. Herein we report the discovery and structure-activity relationship (SAR) of benzo[d]oxazol-2(3H)-one derivatives as a new class of TNIK inhibitors. The most potent compound 8g showed an IC₅₀ value of 0.050 渭M against TNIK. It effectively suppressed proliferation and migration of colorectal cancer cells. Western blot anal. indicated that 8g could inhibit aberrant transcription activation of Wnt signaling. Collectively, this study provides a potential lead compound for subsequent drug discovery targeting TNIK. In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7Reference of 754214-56-7).

Tatarets, Anatoliy L. et al. published their research in Analytica Chimica Acta in 2006 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 146368-07-2

Synthesis of water-soluble, ring-substituted squaraine dyes and their evaluation as fluorescent probes and labels was written by Tatarets, Anatoliy L.;Fedyunyayeva, Irina A.;Dyubko, Tatyana S.;Povrozin, Yevgeniy A.;Doroshenko, Andrey O.;Terpetschnig, Ewald A.;Patsenker, Leonid D.. And the article was included in Analytica Chimica Acta in 2006.Reference of 146368-07-2 This article mentions the following:

A series of ring-substituted squaraines absorbing and emitting in the red and NIR spectral region was synthesized and their spectral and photophys. properties (quantum yields, fluorescence lifetimes) and photostabilities were measured and compared to Cy5, a commonly used fluorescent label. The absorption maxima in aqueous media were between 628 and 667 nm and the emission maxima are between 642 and 685 nm. Squaraine dyes exhibit high extinction coefficients (163,000-265,000 M^-1 cm^-1) and lower quantum yields (2-7%) in aqueous buffer but high quantum yields (up to 45%) and long fluorescence lifetimes (up to 3.3 ns) in presence of BSA. Dicyanomethylene- and thio-substituted squaraines exhibit an addnl. absorption around 400 nm with extinction coefficients between 21,500 and 44,500 M^-1 cm^-1. These dyes are excitable not only with red but also with blue diode lasers or light emitting diodes. Due to the favorable spectral and photophys. properties these dyes can be used as fluorescent probes and labels for intensity- and fluorescence lifetime-based biomedical applications. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Reference of 146368-07-2).

Hucher, Nicolas et al. published their research in Journal of Organic Chemistry in 2001 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Quality Control of 2-(Phenylthio)isoindoline-1,3-dione

蟺-Aromatic and Sulfur Nucleophilic Partners in Cationic 蟺-Cyclizations: Intramolecular Amidoalkylation and Thioamidoalkylation Cyclization via 蠅-Carbinol Lactams was written by Hucher, Nicolas;Decroix, Bernard;Daiech, Adam. And the article was included in Journal of Organic Chemistry in 2001.Quality Control of 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:

NaBH₄ reduction of imides followed by a 蟺-cyclization of the resultant N-acyliminium ions, generated in trifluoroacetic acid conditions, afforded two positional isomers, isoindolobenzothiazolinones. These ring closures proceeded via an intramol. 伪-amidoalkylation with the classical 蟺-aromatic or the atypical sulfur atom as an internal nucleophile. A ready access to the related six-membered N,S-heterocyclic compounds such as isoindolobenzothiazinones is also described. During this reaction, we have shown that a 蠅-carbinol lactam precursor led to endocyclic and exocyclic N-acyliminium ions in equilibrium via the a cyclic aza-sulfonium ion. The latter furnished the expected products in good yields. Similarly, different 蠅-carbinol lactams substituted at C-angular position afforded the corresponding isoindolobenzothiazinones bearing an angular alkyl, aralkyl, or aryl group. In the case of Me and benzyl groups, an addnl. amount of the dehydration products was isolated. These results indicate that the isomerization-蟺-cyclization takes place via the cleavage of the thioether linkage in acidic medium. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Quality Control of 2-(Phenylthio)isoindoline-1,3-dione).

Park, Jin Woo et al. published their research in Bioconjugate Chemistry in 2012 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Formula: C13H17NO3S

Novel Cyanine Dyes with Vinylsulfone Group for Labeling Biomolecules was written by Park, Jin Woo;Kim, YoungSoo;Lee, Kee-Jung;Kim, Dong Jin. And the article was included in Bioconjugate Chemistry in 2012.Formula: C13H17NO3S This article mentions the following:

Novel vinylsulfone cyanine dyes (em. 550-850 nm) were designed and synthesized for fluorescent labeling of biomols. via 1,2-addition reaction in aqueous conditions. Due to the virtue of chem. structures of both fluorophore and reactive group, these dyes could be significantly stable and reactive in various aqueous/organic conditions. A wide variety of pH, temperature, buffer concentration, and protein were tested for the optimal labeling condition. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Formula: C13H17NO3S).

Ielo, Laura et al. published their research in Advanced Synthesis & Catalysis in 2020 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 14204-27-4

Consecutive C1-Homologation / Displacement Strategy for Converting Thiosulfonates into O,S-Oxothioacetals was written by Ielo, Laura;Pillari, Veronica;Miele, Margherita;Holzer, Wolfgang;Pace, Vittorio. And the article was included in Advanced Synthesis & Catalysis in 2020.HPLC of Formula: 14204-27-4 This article mentions the following:

A conceptually intuitive synthesis of oxothioacetals RSCH₂OR¹ [R = Me, Ph, 4-FC₆H₄, 2-F₃CC₆H₄, (4,6-dimethylpyrimidin-2-yl); R¹ = Me, 2-BrC₆H₄, 1-naphthyl, etc.] was reported starting from thiosulfonates as electrophilic sulfur donors. The installation of a reactive CH₂Cl motif with a homologating carbenoid reagent, followed by the immediate nucleophilic displacement with alc. groups [(hetero)-aromatic, aliphatic] offered a convenient access to the title compounds RSCH₂OR¹. Genuine chemoselectivity was uniformly observed in the case of multi-functionalized systems. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4HPLC of Formula: 14204-27-4).

Narayana, B. et al. published their research in Organic Chemistry: An Indian Journal in 2006 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate

Simple syntheses of 5-fluoro/ chloro/ bromoindole-2-methanols and 5-fluoro/ chloro/ bromoindole-2-aldehydes was written by Narayana, B.;Ashalatha, B. V.;Raj, K. K. Vijaya. And the article was included in Organic Chemistry: An Indian Journal in 2006.Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate This article mentions the following:

Efficient and simple methods for the syntheses of 5-haloindole-2-methanols and 5-haloindole-2-aldehydes have been described. 5-Haloindole-2-methanols were prepared by reduction of Me 5-haloindole-2-carboxylates with sodium borohydride in methanol/ THF media and 5-haloindole-2-aldehydes were prepared from the prepared 5-haloindole-2-methanols by oxidation with pyridinium chlorochromate or chromium trioxide-pyridine prepared in situ. The synthesized compounds were isolated in good yields and characterized by ¹H NMR, ¹³C NMR, FABMS and elemental anal. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate).

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate

Kona, Chandrababu Naidu et al. published their research in Organic Letters in 2021 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 14204-27-4

Sulfur-Directed C₇-Selective Alkenylation of Indoles under Rhodium Catalysis was written by Kona, Chandrababu Naidu;Nishii, Yuji;Miura, Masahiro. And the article was included in Organic Letters in 2021.SDS of cas: 14204-27-4 This article mentions the following:

In this report, a Rh-catalyzed C7-selective alkenylation of indole derivatives using a new sulfur directing group N-SCy is reported. A notable feature of this system is that the directing group is readily installed to the indoles and easily removed after the catalysis under mild conditions. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4SDS of cas: 14204-27-4).

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 14204-27-4

Kost, A. N. et al. published their research in Khimiya Geterotsiklicheskikh Soedinenii in 1965 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Product Details of 4583-55-5

Bromination of 2,3-dimethylindole was written by Kost, A. N.;Yudin, L. G.;Budylin, V. A.;Yaryshev, N. G.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1965.Product Details of 4583-55-5 This article mentions the following:

Bromination of 2,3-dimethylindole (I) in concentrated H₂SO₄ containing Ag₂SO₄ gave 75% 5-bromo-2,3-dimethyl-indole (II), m. 138掳. Bromination of 1-acetyl-2,3-dimethyl-indole followed by hydrolysis gave 70% 5-bromo-2,3-dimethyl-indole (III), b₁₀ 135-7掳, n²⁰_D 1.5923, d₂₀ 0.9982. Dehydration of III with chloranil gave 45% II. II was also prepared in 70% yield by acid treatment of 2-butanone p-bromophenylhydrazone. Bromination in acid of 2,3-dimethylindoline gave 50% 6-bromo-2,3-dimethylindoline (IV), b₄ 132-4掳. Dehydration of IV with chloranil gave 37% 6-bromo-2,3-dimethylindole (V), m. 164掳. II and V could also be distinguished by ir bands at 590 cm.^-1 in II and 1326 cm.^-1 in V. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Product Details of 4583-55-5).

Fang, Xinxin et al. published their research in Organic Chemistry Frontiers in 2017 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.COA of Formula: C10H10BrN

Pd(II)-Catalyzed oxidative dearomatization of indoles: substrate-controlled synthesis of indolines and indolones was written by Fang, Xinxin;Gao, Shang;Wu, Zijun;Yao, Hequan;Lin, Aijun. And the article was included in Organic Chemistry Frontiers in 2017.COA of Formula: C10H10BrN This article mentions the following:

A Pd(II)-catalyzed oxidative Wacker-type cyclization/dearomatization of 2,3-disubstituted indoles with mol. oxygen as the oxidant was developed. This strategy provided straightforward access to diverse fused indolines bearing C2-oxygenated quaternary stereocenters with good functional group tolerance and high atom economy. Meanwhile, a Pd(II)-catalyzed oxidation/dearomatization of 2-substituted indoles was presented, which enabled the facile synthesis of indolones. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5COA of Formula: C10H10BrN).