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Thomson, A. et al. published their research in New Phytologist in 1988 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

The response of stomata to ring-substituted indolylacetic acids was written by Thomson, A.;Cox, R. C.;Mansfield, T. A.. And the article was included in New Phytologist in 1988.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

Indol-3-ylacetic acids with substituents in the aromatic ring (Cl, Cl₂, Me) have been synthesized and their effect on stomata on isolated Commelina communis epidermis tested. Unlike IAA which induces stomatal opening, all the substituted acids caused closure. The perception mechanism in the guard cells may therefore involve receptors with high specificity for IAA. The ability of guard cells to discriminate IAA from closely related mols. may be higher than in other cellular systems. There was no synergism between the IAA derivatives and ABA. Also, the percentage stomatal closure induced by CO₂ was more or less constant regardless of the concentration of substituted IAAs. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Wen, Kangmei et al. published their research in Journal of Organic Chemistry in 2022 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C10H8ClNO2

Copper-Mediated Cyclization of o-Hydroxyaryl Enaminones with 3-Indoleacetic Acids toward the Synthesis of 3-Indolmethyl-Chromones was written by Wen, Kangmei;Li, Yinyan;Gao, Qiwen;Chen, Jiewen;Yang, Jie;Tang, Xiaodong. And the article was included in Journal of Organic Chemistry in 2022.Synthetic Route of C10H8ClNO2 This article mentions the following:

A copper-mediated tandem decarboxylative coupling/annulation protocol of o-hydroxyaryl enaminones with 3-indoleacetic acids. A series of 3-indolmethyl-chromones were afforded in up to 97% yield. A one-pot method for 3-indolmethyl-chromones from o-hydroxy acetophenones, N, N-dimethylformamide di-Me acetal, and 3-indoleacetic acids was also developed. Derivatization of the products was conducted to provide various indolmethyl-substituted pyrimidines. Moreover, a biol. evaluation revealed that some compounds had anti-influenza viral activities. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Synthetic Route of C10H8ClNO2).

Aganda, Kim Christopher C. et al. published their research in Advanced Synthesis & Catalysis in 2019 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Computed Properties of C14H11NO

Aerobic α-Oxidation of N-Substituted Tetrahydroisoquinolines to Dihydroisoquinolones via Organo-photocatalysis was written by Aganda, Kim Christopher C.;Hong, Boseok;Lee, Anna. And the article was included in Advanced Synthesis & Catalysis in 2019.Computed Properties of C14H11NO This article mentions the following:

An efficient visible-light-induced α-oxidation of N-substituted tetrahydroisoquinolines to dihydroisoquinolones I (R¹ = H, OMe; R² = Me, Ph, 2-pyridyl, etc.) has been developed using eosin Y as an organo-photocatalyst and oxygen as a green oxidant. The reactions were carried out under mild reaction conditions; the desired dihydroisoquinolones were obtained in up to 96% yield at room temperature under oxygen atm. This transformation provides a convenient route to dihydroisoquinolones with a wide range of substrates. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Computed Properties of C14H11NO).

Li, Yuehui et al. published their research in Angewandte Chemie, International Edition in 2014 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Application of 4583-55-5

Catalytic methylation of C-H bonds using CO₂ and H₂ was written by Li, Yuehui;Yan, Tao;Junge, Kathrin;Beller, Matthias. And the article was included in Angewandte Chemie, International Edition in 2014.Application of 4583-55-5 This article mentions the following:

Formation of C-C bonds from CO₂ is a much sought after reaction in organic synthesis. To date, other than C-H carboxylations using stoichiometric amounts of metals, base, or organometallic reagents, little is known about C-C bond formation. In fact, to the best of the authors’ knowledge, no catalytic methylation of C-H bonds using CO₂ and H₂ was reported. Herein, the combination of CO₂ and H₂ is described for efficient methylation of C-nucleophiles such as indoles, pyrroles, and electron-rich arenes. Comparison experiments which employ paraformaldehyde show similar reactivity for the CO₂/H₂ system. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Application of 4583-55-5).

Duval, Eric et al. published their research in Tetrahedron Letters in 2004 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

Synthesis of substituted carbazoles and β-carbolines by cyclization of diketoindole derivatives was written by Duval, Eric;Cuny, Gregory D.. And the article was included in Tetrahedron Letters in 2004.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

A new route to substituted β-carbolines and carbazoles is described. Diketoindole intermediates, prepared by Friedel-Crafts acylations of 3-substituted indoles, were converted to 3-hydroxycarbazoles and β-carbolines in good yields, 51-96% and 82-97%, resp. This method also allows for the formation of 4-substituted β-carbolines. The application of this methodol. to the synthesis of the natural products hyellazole and 6-chlorohyellazole is also described. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

Ranasinghe, Nadeesha et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2013 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: indole-building-block

Extending the versatility of the Hemetsberger-Knittel indole synthesis through microwave and flow chemistry was written by Ranasinghe, Nadeesha;Jones, Graham B.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.Category: indole-building-block This article mentions the following:

Microwave, flow and combination methodologies were applied to the synthesis of a number of substituted indoles. Based on the Hemetsberger-Knittel (HK) process, modifications allow formation of products rapidly and in high yield. Adapting the methodol. allows formation of 2-unsubstituted indoles and derivatives, and a route to analogs of the antitumor agent PLX-4032 is demonstrated. The utility of the HK substrates is further demonstrated through bioconjugation and subsequent ring closure and via Huisgen type [3+2] cycloaddition chem., allowing formation of peptide adducts which can be subsequently labeled with fluorine tags. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Category: indole-building-block).

Wang, Yixuan et al. published their research in Molecules in 2019 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: 2-Phenylisoindolin-1-one

Synthesis and broad antiviral activity of novel 2-aryl-isoindolin-1-ones towards diverse enterovirus A71 clinical isolates was written by Wang, Yixuan;Wang, Huiqiang;Jiang, Xinbei;Jiang, Zhi;Guo, Tingting;Ji, Xingyue;Li, Yanping;Li, Yuhuan;Li, Zhuorong. And the article was included in Molecules in 2019.Recommanded Product: 2-Phenylisoindolin-1-one This article mentions the following:

Enterovirus 71 (EV-A71) is the main causative pathogen of childhood hand, foot and mouth disease. Effective medicine is currently unavailable for the treatment of this viral disease. Using the fragment-hopping strategy, a series of 2-aryl-isoindolin-1-one compounds were designed, synthesized and investigated for their in vitro antiviral activity towards multiple EV-A71 clin. isolates (H, BrCr, Shenzhen98, Jiangsu52) in Vero cell culture in this study. The structure-activity relationship (SAR) studies identified 2-phenyl-isoindolin-1-ones as a new potent chemotype with potent antiviral activity against EV-A71. Ten out of the 24 tested compounds showed significant antiviral activity (EC50 < 10 muM) towards four EV-A71 strains. Compounds A3 and A4 exhibited broad and potent antiviral activity with the 50% effective concentration (EC50) values in the range of 1.23-1.76 muM. Moreover, the selectivity indexes of A3 and A4 were significantly higher than those of the reference compound, pirodavir. The western blotting experiment indicated that the viral VP1 was significantly decreased at both the protein and RNA level in a dose-dependent manner following treatment with compound A3. Moreover, compound A3 inhibited the viral replication by acting on the virus entry stage. In summary, this study led to the discovery of 2-aryl-isoindolin-1-ones as a promising scaffold with potent anti-EV-A71 activities, which deserves further in-depth studies. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Recommanded Product: 2-Phenylisoindolin-1-one).

Pietka-Ottlik, Magdalena et al. published their research in Molecules in 2010 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Formula: C14H11NO

Crucial role of selenium in the virucidal activity of benzisoselenazol-3(2H)-ones and related diselenides was written by Pietka-Ottlik, Magdalena;Potaczek, Piotr;Piasecki, Egbert;Mlochowski, Jacek. And the article was included in Molecules in 2010.Formula: C14H11NO This article mentions the following:

Several substituted 1,2-benzisoselenazol-3(2H)-one derivatives and their non-selenium-containing analogs were designed. The synthesis of the target compounds was achieved using as reactants 2-(chloroseleno)benzoyl chloride and 2-(chlorothio)benzoyl chloride or 2-(chloromethyl)benzoyl chloride and the products thus obtained were evaluated against several viruses (HHV-1, human herpes, EMCV Encephalomyocarditis virus and VSV, Vesicular stomatitis virus) to determine the extent to which selenium plays a role in antiviral activity. The data presented here show that the presence of selenium is crucial for the antiviral properties of benzisoselenazol-3(2H)-ones since their isostructural analogs having different groups but lacking selenium either did not show any antiviral activity or their activity was substantially lower. The open-chain analogs of benzisoselenazol-3(2H)-ones (diselenides) also exhibited high antiviral activity while selenides and disulfides were completely inactive towards model viruses. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Formula: C14H11NO).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Formula: C14H11NO

Oderinde, Martins S. et al. published their research in Journal of the American Chemical Society in 2020 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Category: indole-building-block

Synthesis of Cyclobutane-Fused Tetracyclic Scaffolds via Visible-Light Photocatalysis for Building Molecular Complexity was written by Oderinde, Martins S.;Mao, Edna;Ramirez, Antonio;Pawluczyk, Joseph;Jorge, Christine;Cornelius, Lyndon A. M.;Kempson, James;Vetrichelvan, Muthalagu;Pitchai, Manivel;Gupta, Anuradha;Gupta, Arun Kumar;Meanwell, Nicholas A.;Mathur, Arvind;Dhar, T. G. Murali. And the article was included in Journal of the American Chemical Society in 2020.Category: indole-building-block This article mentions the following:

We describe the synthesis through visible-light photocatalysis of novel functionalized tetracyclic scaffolds that incorporate a fused azabicyclo[3.2.0]heptan-2-one motif, which are structurally interesting cores with potential in natural product synthesis and drug discovery. The synthetic approach involves an intramol. [2 + 2] cycloaddition with concomitant dearomatization of the heterocycle via an energy transfer process promoted by an iridium-based photosensitizer, to build a complex mol. architecture with at least three stereogenic centers from relatively simple, achiral precursors. These fused azabicyclo[3.2.0]heptan-2-one-based tetracycles were obtained in high yield (generally >99%) and with excellent diastereoselectivity (>99:1). The late-stage derivatization of a bromine-substituted, tetracyclic indoline derivative with alkyl groups, employing a mild Negishi C-C bond forming protocol as a means of increasing structural diversity, provides addnl. modularity that will enable the delivery of valuable building blocks for medicinal chem. D. functional theory calculations were used to compute the T₁-S₀ free energy gap of the olefin-tethered precursors and also to predict their reactivities based on triplet state energy transfer and transition state energy feasibility. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Category: indole-building-block).

Wang, Xin et al. published their research in Organic Letters in 2019 | CAS: 754214-56-7

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Application of 754214-56-7

A Monophosphine Ligand Derived from Anthracene Photodimer: Synthetic Applications for Palladium-Catalyzed Coupling Reactions was written by Wang, Xin;Liu, Wei-Gang;Tung, Chen-Ho;Wu, Li-Zhu;Cong, Huan. And the article was included in Organic Letters in 2019.Application of 754214-56-7 This article mentions the following:

Herein, we present an air-stable dianthracenyl monophosphine ligand (diAnthPhos) which can be prepared in two steps from com. available anthracene derivatives The ligand exhibits excellent efficiency for palladium-catalyzed coupling reactions. In particular, Miyaura borylation of heterocycle-containing electrophiles can be facilitated employing the diAnthPhos ligand with a broad substrate scope and low catalyst loading. The valuable synthetic utility of the new ligand is further demonstrated by a one-pot Miyaura borylation/Suzuki coupling protocol for heteroaryl-containing substrates. In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7Application of 754214-56-7).