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Mondal, Manas et al. published their research in Tetrahedron Letters in 2019 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.SDS of cas: 14204-27-4

Benign synthesis of thiophosphates, thiophosphinates and selenophosphates in neat condition using N-chalcogenoimides as the source of electrophilic sulfur/selenium was written by Mondal, Manas;Saha, Amit. And the article was included in Tetrahedron Letters in 2019.SDS of cas: 14204-27-4 This article mentions the following:

A neat reaction protocol was developed for synthesis of thiophosphate, thiophosphinate and selenophosphate compounds N-chalcogenoimides were used for chalcogenylation of P(O)H moieties of various H-phosphonates under solvent, catalyst and base free condition at room temperature in aerial atm. Both S-aryl and S-alkyl phosphorothioate compounds were prepared by this method in good yields. Selenophosphates were also synthesized using N-(phenylseleno)phthalimide under solvent free condition. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4SDS of cas: 14204-27-4).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bansode, Ajay H. et al. published their research in Advanced Synthesis & Catalysis in 2021 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C14H11NO

Visible-Light-Induced Controlled Oxidation of N-Substituted 1,2,3,4-Tetrahydroisoquinolines for the Synthesis of 3,4-Dihydroisoquinolin-1(2H)-ones and Isoquinolin-1(2H)-ones was written by Bansode, Ajay H.;Suryavanshi, Gurunath. And the article was included in Advanced Synthesis & Catalysis in 2021.Synthetic Route of C14H11NO This article mentions the following:

A visible light-rose bengal-TBHP mediated, controlled oxidation of N-substituted 1,2,3,4-tetrahydroisoquinolines I (R = Me, 4-bromophenyl, thiophen-3-yl, etc.; R¹ = H, Br; R² = H, I) is developed for the synthesis of 3,4-dihydroisoquinolin-1(2H)-ones II and isoquinolin-1(2H)-ones III. The present method feature’s a broad substrate scope and good functional group tolerances, and the products II and III are prepared in good to excellent yields. The developed methodol. further demonstrated in the synthesis of isoindolo[2,1-b] isoquinolin-5(7H)-one (topoisomerase-I inhibitor). In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Synthetic Route of C14H11NO).

Winstead, Angela J. et al. published their research in Molecules in 2013 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate

Synthesis of quaternary heterocyclic salts was written by Winstead, Angela J.;Nyambura, Grace;Matthews, Rachael;Toney, Deveine;Oyaghire, Stanley. And the article was included in Molecules in 2013.Recommanded Product: 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate This article mentions the following:

The microwave synthesis of twenty quaternary ammonium salts, trimethylbenz[e]indolium derivatives I (R = CH₃, CH₂CH₃, (CH₂)₂CH₃, etc.; X = I, Br), quinolinium derivatives II, trimethyl-5-sulfo-3H-indolium derivatives III is described. The syntheses feature comparable yields to conventional synthetic methods reported in the current literature with reduced reaction times and the absence of solvent or minimal solvent. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Recommanded Product: 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate).

Raut, Amol B. et al. published their research in Journal of Catalysis in 2020 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.SDS of cas: 5388-42-1

Reductive amination of levulinic acid to N-substituted pyrrolidones over RuCl₃ metal ion anchored in ionic liquid immobilized on graphene oxide was written by Raut, Amol B.;Shende, Vaishali S.;Sasaki, Takehiko;Bhanage, Bhalchandra M.. And the article was included in Journal of Catalysis in 2020.SDS of cas: 5388-42-1 This article mentions the following:

Reductive amination of biomass derived Levulinic acid (LA) for the synthesis of N-substituted pyrrolidones is one of the highly attractive routes for biomass valorization. The supported homogeneous metal precursor into the solid surface is an important context in the field of catalysis because these types of catalysts provide the heterogeneous nature and meet the needs of recyclability. Herein, we have reported a synthesis of catalyst with ruthenium ion supported on ionic liquid immobilized into graphene oxide (Ru@GOIL) and its application for reductive amination reaction. Synthesized catalyst is characterized using different anal. techniques such as FT-IR, x-ray diffraction, XPS, TGA, FEG-SEM, TEM and EXAFS anal. The prepared Ru@GOIL found to be highly effective for reductive amination of LA and under these optimized conditions various N-substituted pyrrolidones derivatives were synthesized in excellent yield (78-93%). Ru@GOIL catalyst demonstrated great catalytic performance for reductive amination reaction of LA giving good turnover frequency (TOF = 62 h^-1) value in comparison with other catalysts. The Ru@GOIL catalyst was recycled for six reaction runs with slight drop-in activity after 4^th cycle. Practical applicability of the developed catalyst was successfully demonstrated by direct transformation of biomass waste (rice husk and wheat straw) derived LA to N-substituted pyrrolidones. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1SDS of cas: 5388-42-1).

Shirakawa, Seiji et al. published their research in Chemical Science in 2013 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione

Efficient approach for the design of effective chiral quaternary phosphonium salts in asymmetric conjugate additions was written by Shirakawa, Seiji;Kasai, Atsuyuki;Tokuda, Takashi;Maruoka, Keiji. And the article was included in Chemical Science in 2013.Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:

An efficient approach for the design of chiral quaternary phosphonium bromides as chiral phase-transfer catalysts was demonstrated. A catalyst library of phosphonium salts with various structures was readily constructed using com. available chiral phosphines as catalyst precursors, and an optimized catalyst was successfully applied to highly enantioselective conjugate additions under base-free phase-transfer conditions with low catalyst loading. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Application In Synthesis of 2-(Phenylthio)isoindoline-1,3-dione).

Kaila, Neelu et al. published their research in Journal of Medicinal Chemistry in 2007 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

2-(4-Chlorobenzyl)-3-hydroxy-7,8,9,10-tetrahydrobenzo[H]quinoline-4-carboxylic Acid (PSI-697): Identification of a Clinical Candidate from the Quinoline Salicylic Acid Series of P-Selectin Antagonists was written by Kaila, Neelu;Janz, Kristin;Huang, Adrian;Moretto, Alessandro;DeBernardo, Silvano;Bedard, Patricia W.;Tam, Steve;Clerin, Valerie;Keith, James C. Jr.;Tsao, Desiree H. H.;Sushkova, Natalia;Shaw, Gray D.;Camphausen, Raymond T.;Schaub, Robert G.;Wang, Qin. And the article was included in Journal of Medicinal Chemistry in 2007.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

P-selectin-PSGL-1 interaction causes rolling of leukocytes on the endothelial cell surface, which subsequently leads to firm adherence and leukocyte transmigration through the vessel wall into the surrounding tissues. P-selectin is upregulated on the surface of both platelets and endothelium in a variety of atherosclerosis-associated conditions. Consequently, inhibition of this interaction by means of a small mol. P-selectin antagonist is an attractive strategy for the treatment of atherosclerosis. High-throughput screening and subsequent analoging had led to the identification of compound 1 as the lead candidate. Herein, we report the continuation of this work and the discovery of a second-generation series, the tetrahydrobenzoquinoline salicylic acids. These compounds have improved pharmacokinetic properties, and a number of them have shown oral efficacy in mouse and rat models of atherogenesis and vascular injury. The lead 31 (PSI-697), is currently in clin. development for the treatment of atherothrombotic vascular events. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).

Matviitsuk, Anastassia et al. published their research in Angewandte Chemie, International Edition in 2019 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Category: indole-building-block

Enantio- and Diastereoselective, Lewis Base Catalyzed, Cascade Sulfenoacetalization of Alkenyl Aldehydes was written by Matviitsuk, Anastassia;Denmark, Scott E.. And the article was included in Angewandte Chemie, International Edition in 2019.Category: indole-building-block This article mentions the following:

In the presence of a nonracemic selenophosphoramide Lewis base, 5-hexenal and ortho-alkenylbenzaldehydes such as 2-allyl-4-methylbenzaldehyde underwent diastereoselective and enantioselective sulfenoacetalization reactions with N-(2,6-diisopropylphenylthio)phthalimide in hexafluoroisopropanol to yield nonracemic sulfenyl acetals such as I and isochroman acetals such as II. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Category: indole-building-block).

Kahnberg, Pia et al. published their research in Journal of Medicinal Chemistry in 2006 | CAS: 16732-64-2

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Related Products of 16732-64-2

Design, Synthesis, Potency, and Cytoselectivity of Anticancer Agents Derived by Parallel Synthesis from α-Aminosuberic Acid was written by Kahnberg, Pia;Lucke, Andrew J.;Glenn, Matthew P.;Boyle, Glen M.;Tyndall, Joel D. A.;Parsons, Peter G.;Fairlie, David P.. And the article was included in Journal of Medicinal Chemistry in 2006.Related Products of 16732-64-2 This article mentions the following:

Chemotherapy in the last century was characterized by cytotoxic drugs that did not discriminate between cancerous and normal cell types and were consequently accompanied by toxic side effects that were often dose limiting. The ability of differentiating agents to selectively kill cancer cells or transform them to a nonproliferating or normal phenotype could lead to cell- and tissue-specific drugs without the side effects of current cancer chemotherapeutics. This may be possible for a new generation of histone deacetylase inhibitors derived from amino acids. Structure-activity relationships are now reported for 43 compounds derived from 2-aminosuberic acid that kill a range of cancer cells, 26 being potent cytotoxins against MM96L melanoma cells (IC₅₀ 20 nM-1 μM), while 17 were between 5- and 60-fold more selective in killing MM96L melanoma cells vs. normal (neonatal foreskin fibroblasts, NFF) cells. This represents a 10- to 100-fold increase in potency and up to a 10-fold higher selectivity over previously reported compounds derived from cysteine (J. Med. Chem. 2004, 47, 2984). Selectivity is also an underestimate, because the normal cells, NFF, are rarely all killed by the drugs that also induce selective blockade of the cell cycle for normal but not cancer cells. Selected compounds were tested against a panel of human cancer cell lines (melanomas, prostate, breast, ovarian, cervical, lung, and colon) and found to be both selective and potent cytotoxins (IC₅₀ 20 nM-1 μM). Compounds in this class typically inhibit human histone deacetylases, as evidenced by hyperacetylation of histones in both normal and cancer cells, induce expression of p21, and differentiate surviving cancer cells to a nonproliferating phenotype. These compounds may be valuable leads for the development of new chemotherapeutic agents. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Related Products of 16732-64-2).

Hou, Shaohua et al. published their research in European Journal of Medicinal Chemistry in 2021 | CAS: 16732-64-2

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C9H6BrNO2

Structure-based discovery of 1H-indole-2-carboxamide derivatives as potent ASK1 inhibitors for potential treatment of ulcerative colitis was written by Hou, Shaohua;Yang, Xiping;Tong, Yu;Yang, Yuejing;Chen, Quanwei;Wan, Boheng;Wei, Ran;Wang, Yuchen;Zhang, Yanmin;Kong, Bo;Huang, Jianhang;Chen, Yadong;Lu, Tao;Hu, Qinghua;Du, Ding. And the article was included in European Journal of Medicinal Chemistry in 2021.Synthetic Route of C9H6BrNO2 This article mentions the following:

Apoptosis signal-regulating kinase 1 (ASK1), a member of the mitogen-activated protein kinase (MAPK) family, is implicated in many human diseases. Here, we describe the structural optimization of a hit compound and conduct further structure-activity relationship (SAR) studies that result in the development of the indole-2-carboxamide I. I displays potent anti-ASK1 kinase activity and stronger inhibitory effect on ASK1 in AP1-HEK293 cells than previously described ASK1 inhibitor GS-4997. Besides improved in vitro activity, I also exhibits an appropriate in vivo PK profile. In a dextran sulfate sodium (DSS)-induced mouse model of ulcerative colitis (UC), I shows significant anti-UC efficacy and markedly attenuates DSS-induced body weight loss, colonic shortening, elevation in disease activity index (DAI) and inflammatory cell infiltration in colon tissues. Mechanistically, I represses the phosphorylation of ASK1-p38/JNK signaling pathways and suppresses the overexpression of inflammatory cytokines. Together, these findings suggest that ASK1 inhibitors can potentially be used as a therapeutic strategy for UC. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Synthetic Route of C9H6BrNO2).

Jiang, Lin-Ling et al. published their research in Tetrahedron Letters in 2007 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate

An efficient approach to the synthesis of water-soluble cyanine dyes using poly(ethylene glycol) as a soluble support was written by Jiang, Lin-Ling;Dou, Li-Fang;Li, Bao-Lin. And the article was included in Tetrahedron Letters in 2007.Quality Control of 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate This article mentions the following:

An efficient synthesis approach to unsym. water-soluble amphoteric cyanine dyes has been established. Loading and activation of a sulfoindolenium inner salt on polyethylene glycol (PEG) as a first step have been achieved via a simple strategy. The cyanine dyes are released by the attack of a heterocyclic carbon nucleophile and the cleavage of the PEG-bound hemicyanine. The efficient approach delivers cyanine dyes in high purity without the nontrivial chromatog. separation often encountered in a solution process. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Quality Control of 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate).