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Cai, Yunfei et al. published their research in Organic Letters in 2012 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). SDS of cas: 14204-27-4

Catalytic Asymmetric Sulfenylation of Unprotected 3-Substituted Oxindoles was written by Cai, Yunfei;Li, Jun;Chen, Weiliang;Xie, Mingsheng;Liu, Xiaohua;Lin, Lili;Feng, Xiaoming. And the article was included in Organic Letters in 2012.SDS of cas: 14204-27-4 This article mentions the following:

Catalytic asym. sulfenylation of unprotected 3-substituted oxindoles I (R¹ = Ph, R² = H, 5-Me, 6-Br, 7-F, etc.; R¹ = Me, Et, i-Bu, H₂C:CHCH₂, MeCO₂CH₂, 2-MeC₆H₄, 4-MeOC₆H₄CH₂, 2-naphthylmethyl, etc., R² = H) has been developed via cooperative catalysis of a chiral N,N’-dioxide-Sc(OTf)₃ complex and a Bronsted base. Utilizing readily available N-(phenylthio)phthalimide as the sulfur source, a wide range of optically active 3-phenylthiooxindoles II were obtained in excellent yields with excellent enantioselectivities under mild reaction conditions. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4SDS of cas: 14204-27-4).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Murugesan, Kathiravan et al. published their research in Green Chemistry in 2018 | CAS: 90271-86-6

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 5-Bromo-3-cyanoindole

Stable and reusable nanoscale Fe₂O₃-catalyzed aerobic oxidation process for the selective synthesis of nitriles and primary amides was written by Murugesan, Kathiravan;Senthamarai, Thirusangumurugan;Sohail, Manzar;Sharif, Muhammad;Kalevaru, Narayana V.;Jagadeesh, Rajenahally V.. And the article was included in Green Chemistry in 2018.Recommanded Product: 5-Bromo-3-cyanoindole This article mentions the following:

The sustainable introduction of nitrogen moieties in the form of nitrile or amide groups in functionalized mols. is of fundamental interest because nitrogen-containing motifs are found in a large number of life science mols., natural products and materials. Hence, the synthesis and functionalization of nitriles and amides from easily available starting materials using cost-effective catalysts and green reagents is highly desired. In this regard, herein the nanoscale iron oxide-catalyzed environmentally benign synthesis of nitriles and primary amides from aldehydes and aqueous ammonia in the presence of 1 bar O₂ or air was reported. Under mild reaction conditions, this iron-catalyzed aerobic oxidation process proceeds to synthesize functionalized and structurally diverse aromatic, aliphatic and heterocyclic nitriles. Addnl., applying this iron-based protocol, primary amides have also been prepared in a water medium. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6Recommanded Product: 5-Bromo-3-cyanoindole).

Ramachandran, Sreekanth A. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2017 | CAS: 754214-56-7

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Recommanded Product: 7-Azaindole-5-boronic Acid Pinacol Ester

Discovery of pyrazolopyrimidine derivatives as novel inhibitors of ataxia telangiectasia and rad3 related protein (ATR) was written by Ramachandran, Sreekanth A.;Jadhavar, Pradeep S.;Singh, Manvendra P.;Sharma, Ankesh;Bagle, Gaurav N.;Quinn, Kevin P.;Wong, Po-yin;Protter, Andrew A.;Rai, Roopa;Pham, Son M.;Lindquist, Jeffrey N.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2017.Recommanded Product: 7-Azaindole-5-boronic Acid Pinacol Ester This article mentions the following:

The ATR pathway is a critical mediator of the replication stress response in cells. In aberrantly proliferating cancer cells, this pathway can help maintain sufficient genomic integrity for cancer cell progression. Herein the authors describe the discovery of 1-(4-(methylsulfonyl)phenyl)-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine, a pyrazolopyrimidine-containing inhibitor of ATR via a strategic repurposing of compounds targeting PI3K. In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7Recommanded Product: 7-Azaindole-5-boronic Acid Pinacol Ester).

Kumar, Vishal et al. published their research in Advanced Synthesis & Catalysis in 2012 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Reference of 5388-42-1

Cobalt(II) Phthalocyanine-Catalyzed Highly Chemoselective Reductive Amination of Carbonyl Compounds in a Green Solvent was written by Kumar, Vishal;Sharma, Upendra;Verma, Praveen K.;Kumar, Neeraj;Singh, Bikram. And the article was included in Advanced Synthesis & Catalysis in 2012.Reference of 5388-42-1 This article mentions the following:

Cobalt phthalocyanine has been employed for the highly chemoselective reductive amination of aldehydes and ketones in ethanol as a green solvent. A large range of functional groups such as nitro, acid, amide, ester, nitrile, halogen, lactone, methoxy, hydroxy, alkene, N-benzyl, O-benzyl and heterocyclic rings were well tolerated under the present reaction conditions. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Reference of 5388-42-1).

Katekar, GerardF. et al. published their research in Phytochemistry (Elsevier) in 1983 | CAS: 1912-45-4

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid

Auxins. Part 3. Structure-activity differences between indoleacetic acid auxins on pea and wheat was written by Katekar, GerardF.;Geissler, Art E.. And the article was included in Phytochemistry (Elsevier) in 1983.Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

A series of halogenated indoleacetic acids were assessed for auxin activity on pea stem and wheat coleoptile sections. Activity differences between the 2 species were found. These are discussed in terms of differences in receptor models for pea and wheat, with the models differing in the areas covered by the 6- and 7-substituted compounds In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Name: 2-(5-Chloro-1H-indol-3-yl)acetic acid).

Bowman, W. Russell et al. published their research in Tetrahedron in 1994 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 14204-27-4

Generation of aminyl radicals using sulfenamides as synthetic precursors was written by Bowman, W. Russell;Clark, David N.;Marmon, Robert J.. And the article was included in Tetrahedron in 1994.Recommanded Product: 14204-27-4 This article mentions the following:

Sulfenamides R¹R²NSPh (R¹, R² = alkyl, cycloalkyl, bicycloalkyl, aryl et al.)are synthesized from reactions of R¹R²NH and N-(benzenesulfenyl)phthalimide or PhSCl. The sulfenamides undergo reaction with Bu₃SnH to yield aminyl radicals which can be cyclized onto suitable alkenes. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Recommanded Product: 14204-27-4).

Pan, Han-Peng et al. published their research in Journal of Organic Chemistry in 2021 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Quality Control of 5-Bromo-2,3-dimethyl-1H-indole

Dearomatization of 2,3-Disubstituted Indoles via 1,8-Addition of Propargylic (Aza)-para-Quinone Methides was written by Pan, Han-Peng;Zhu, Zhi-Qiang;Qiu, Zong-Wang;Liu, Hong-Fu;Ma, Jiong-Dong;Li, Bao Qiong;Feng, Na;Ma, Ai-Jun;Peng, Jin-Bao;Zhang, Xiang-Zhi. And the article was included in Journal of Organic Chemistry in 2021.Quality Control of 5-Bromo-2,3-dimethyl-1H-indole This article mentions the following:

An efficient method for dearomatization of 2,3-disubstituted indoles to generate diverse indolimines with tetrasubstituted allenes is described. This work accomplishes dearomatization of 2,3-disubstituted indoles I [R¹ = H, F, MeO, MeO₂C, etc.; R² = R³ = Me; R²R³ = (CH₂)₄] through 1,8-addition of (aza)-para-quinone methides, generated in situ from propargylic alcs. II (R⁴ = OH, AcNH, t-BuCONH, TsNH, etc.; R⁵ = Me, n-Pr, Ph, 4-FC₆H₄, 4-ClC₆H₄; R⁶ = n-Bu, cyclopropyl, 1-cyclohexenyl, Ph, etc.). A series of synthetically useful indolenines containing quaternary carbon centers and tetrasubstituted allenes III can be accessed in good yields (up to 99%). Addnl., the separability of product isomers, diversified product transformations, and easy scale-up of the reaction demonstrate the potential application of this method. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Quality Control of 5-Bromo-2,3-dimethyl-1H-indole).

Cox, Brian et al. published their research in ACS Medicinal Chemistry Letters in 2020 | CAS: 16732-64-2

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Computed Properties of C9H6BrNO2

Escaping from Flatland: Antimalarial Activity of sp³-Rich Bridged Pyrrolidine Derivatives was written by Cox, Brian;Duffy, James;Zdorichenko, Victor;Bellanger, Corentin;Hurcum, Jessica;Laleu, Benoit;Booker-Milburn, Kevin I.;Elliott, Luke D.;Robertson-Ralph, Michael;Swain, Christopher J.;Bishop, Stephen J.;Hallyburton, Irene;Anderson, Mark. And the article was included in ACS Medicinal Chemistry Letters in 2020.Computed Properties of C9H6BrNO2 This article mentions the following:

Synthetic photochem. to generate novel sp3-rich scaffolds and report the design, synthesis, and biol. testing of a diverse series of amides based on the 1-(amino-methyl)-2-benzyl-2-aza-bicyclo[2.1.1]hexane scaffold was utilized . Preliminary antimalarial screening of the library provided promising compounds with activity in the 1-5μM range with an enhanced hit rate. Further evaluation (solubility, drug metabolism and pharmacokinetics (DMPK), and toxicity) of a selected compound (9) suggested that this series represents an excellent opportunity for further optimization with the framework offering multiple opportunities for the addition of uniquely vectorally positioned extra functionality. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Computed Properties of C9H6BrNO2).

Hu, Zhang et al. published their research in International Journal of Chemistry (Toronto, ON, Canada) in 2010 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Electric Literature of C14H9NO2S

Quaternized chitosan as an efficient catalyst for synthesis of N-alkylthio-phthalimides was written by Hu, Zhang;Li, Sidong. And the article was included in International Journal of Chemistry (Toronto, ON, Canada) in 2010.Electric Literature of C14H9NO2S This article mentions the following:

A practical and efficient synthesis of N-alkylthio-phthalimides by the reaction of N-chlorophthalimide with thiols catalyzed by quaternized chitosan was described. The reactions were carried out in relatively mild conditions, and a variety of N-alkylthio-phthalimides were efficiently prepared with moderate to good yields. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Electric Literature of C14H9NO2S).

Morzyk-Ociepa, Barbara et al. published their research in Journal of Molecular Structure in 2018 | CAS: 1000340-39-5

3-Bromo-4-chloro-7-azaindole (cas: 1000340-39-5) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C7H4BrClN2

Crystal structures, vibrational spectra and DFT calculations of five halogeno-derivatives of 7-azaindole (3Br7AI, 4Br7AI, 4Cl7AI, 3Br4Cl7AI and 5Br3Cl7AI): a comparative study was written by Morzyk-Ociepa, Barbara;Dysz, Karolina;Turowska-Tyrk, Ilona;Michalska, Danuta. And the article was included in Journal of Molecular Structure in 2018.Formula: C7H4BrClN2 This article mentions the following:

Structures and vibrational spectra of 3-bromo-7-azaindole (3Br7AI), 4-bromo-7-azaindole (4Br7AI), 4-chloro-7-azaindole (4Cl7AI), 5-bromo-3-chloro-7-azaindole (5Br3Cl7AI) and 3-bromo-4-chloro-7-azaindole (3Br4Cl7AI) have been investigated. For the first time a single crystal anal. is reported for the three compounds: 3Br7AI (P2₁/n space group; a = 12.6586(3), b = 3.98664(12), c = 14.1189(4)Å, β = 100.901(2)°, Z = 4); 4Br7AI (P21/n space group; a = 5.38136 (13), b = 9.2262 (2), c = 13.9806 (4)Å, β = 90.052 (2)°, Z = 4); and 5Br3Cl7AI (C2/c space group; a = 22.9444(10), b = 3.91953(12), c = 17.8500(6)Å, β = 102.621(4)o, Z = 8). In the crystal structure, a pair of mols. forms a centrosym. dimer connected by dual nearly linear N-H···N hydrogen bonds between the pyrrole and pyridine rings. In addition, the structures of 4Br7AI and 5Br3Cl7AI are stabilized by C2-H2···Br hydrogen bonds. The IR and Raman spectra of all compounds and their N-deuterated derivatives were recorded in the solid state. The theor. mol. structures and vibrational spectra of the centrosym. dimers of five investigated compounds were calculated using the B3LYP method with the 6-311G++(d,p) basis set. The optimized structural parameters and the calculated vibrational spectra reproduce well the experiment Detailed vibrational assignments for all these compounds have been made on the basis of the calculated potential energy distributions (PEDs). The characteristic marker bands for the chloro- and bromo-derivativeds of 7-azaindoles are reported. In the experiment, the researchers used many compounds, for example, 3-Bromo-4-chloro-7-azaindole (cas: 1000340-39-5Formula: C7H4BrClN2).