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Kost, A. N. et al. published their research in Zhurnal Organicheskoi Khimii in 1970 | CAS: 16732-64-2

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid

Transfer of substituent effects across the indole ring was written by Kost, A. N.;Minkin, V. I.;Sagitullin, R. S.;Gorbunov, V. I.;Sadekov, I. D.. And the article was included in Zhurnal Organicheskoi Khimii in 1970.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid This article mentions the following:

The pK values and σ constants (Taft, Hammett, Webster, and Dewar constants) were determined for substituted indole-2-carboxylic acids (I). The transfer of the elec. charges in this ring system is weaker than in carbocyclic systems. The electron-donating groups have very little effect. The relation of structure with the pK of I is best expressed in terms of the Dewar theory. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid).

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Tan, Qingfa et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Synthetic Route of C14H9NO2S

Asymmetric organocatalytic sulfenylation for the construction of a diheteroatom-bearing tetrasubstituted carbon centre was written by Tan, Qingfa;Chen, Qianping;Zhu, Zitong;Liu, Xiaohua. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2022.Synthetic Route of C14H9NO2S This article mentions the following:

Catalytic enantioselective sulfenylation to construct diheteroatom-bearing carbon centers was achieved by employing chiral guanidine organocatalysts. This protocol provided a facile route toward the synthesis of α-fluoro-α-sulfenyl-β-ketoamides, azlactone adducts and α-sulfur-substituted amino acid derivatives in high yields with good to excellent enantioselectivities. A possible working mode was proposed to elucidate the chiral control of the process. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Synthetic Route of C14H9NO2S).

Banu, Saira et al. published their research in Green Chemistry in 2021 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Computed Properties of C10H10BrN

Auto-tandem PET and EnT photocatalysis by crude chlorophyll under visible light towards the oxidative functionalization of indoles was written by Banu, Saira;Choudhari, Shubham;Patel, Girija;Yadav, Prem P.. And the article was included in Green Chemistry in 2021.Computed Properties of C10H10BrN This article mentions the following:

A tandem photocatalytic approach utilizing the natural pigment chlorophyll in crude form to achieve photoinduced electron transfer (PET) and energy transfer (EnT) towards the oxidative functionalization of indoles I [R = H, 4-OMe, 4,6-difluoro, 5-Br, etc.; R¹ = H, Me, Et; R² = H, Me, Ph; R¹R² = -(CH₂)₄-, -(CH₂)₅-] was reported. Redox potentials, ESR, fluorescence quenching and UV experiments have evidenced the dual catalytic activity of chlorophyll. The highlight of the study is the auto-tandem photocatalytic role of chlorophyll to enable the green oxidation of indoles I using mol. oxygen as the oxidant, water as the reaction medium, and photochem. energy from the visible region of the spectrum. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Computed Properties of C10H10BrN).

Zhang, Zhi-Guang et al. published their research in Synthesis in 2011 | CAS: 4583-55-5

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Synthetic Route of C10H10BrN

Efficient preparation of polyfunctional indoles via a zinc organometallic variation of the Fischer indole synthesis was written by Zhang, Zhi-Guang;Haag, Benjamin A.;Li, Jin-Shan;Knochel, Paul. And the article was included in Synthesis in 2011.Synthetic Route of C10H10BrN This article mentions the following:

Functionalized organozinc reagents readily react with various aryldiazonium salts furnishing regioselectively polyfunctional indoles after heating with microwave irradiation This new organometallic variation of the Fischer indole synthesis tolerates a wide range of functional groups and can be readily scaled up. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Synthetic Route of C10H10BrN).

Geng, Pengxin et al. published their research in Green Chemistry in 2019 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Safety of 2-Phenylisoindolin-1-one

A g-C₃N₄-based heterogeneous photocatalyst for visible light mediated aerobic benzylic C-H oxygenations was written by Geng, Pengxin;Tang, Yurong;Pan, Guanglong;Wang, Wentao;Hu, Jinchuan;Cai, Yunfei. And the article was included in Green Chemistry in 2019.Safety of 2-Phenylisoindolin-1-one This article mentions the following:

A metal-free heterogeneous photocatalytic system has been developed for highly efficient benzylic C-H oxygenations using oxygen as an oxidant. This visible light mediated oxidation reaction utilizes graphitic carbon nitride (g-C₃N₄) as a recyclable, nontoxic and low cost photocatalyst. Mild reaction conditions allow for the generation of synthetically and biol. valued isochromannones, phthalides, isoquinolinones, isoindolinones and xanthones from readily accessible alkyl aromatic precursors in good yields. The heterogeneous nature of the g-C₃N₄ catalytic system enables easy recovery and recycling as well as the use in multiple runs without loss of activity. The synthetic utility of this “green” methodol. was further demonstrated by applying in bioactive and drug valued target syntheses. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Safety of 2-Phenylisoindolin-1-one).

Chaudhari, Chandan et al. published their research in Green Chemistry in 2020 | CAS: 5388-42-1

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 2-Phenylisoindolin-1-one

One-pot synthesis of pyrrolidones from levulinic acid and amines/nitroarenes/nitriles over the Ir-PVP catalyst was written by Chaudhari, Chandan;Shiraishi, Masaya;Nishida, Yoshihide;Sato, Katsutoshi;Nagaoka, Katsutoshi. And the article was included in Green Chemistry in 2020.Application In Synthesis of 2-Phenylisoindolin-1-one This article mentions the following:

The synthesis of pyrrolidones I (R = C₆H₅, CH₂C₆H₅, 4-FC₆H₄, etc.) via reductive amination of levulinic acid with aniline was examined over polypyrrolidone-stabilized metal nanoparticle catalysts. Among them, Ir metal was the most effective and applicable for the reductive amination of levulinic acid with nitroarenes R¹NO₂ (R¹ = C₆H₅, 4-CH₃OC₆H₄, 4-CH₃C₆H₄, 4-ClC₆H₄, 4-FC₆H₄)/nitriles R²CN (R² = C₆H₅, 4-CH₃OC₆H₄, 4-CH₃C₆H₄, 4-ClC₆H₄, 4-CF₃C₆H₄). Importantly, this catalyst was used for the one-pot synthesis of the anti-inflammatory drug indoprofen from 2-formylbenzoic acid and 2-(4-nitrophenyl)propanoic acid. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Application In Synthesis of 2-Phenylisoindolin-1-one).

Rogness, Donald C. et al. published their research in Tetrahedron Letters in 2009 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of Methyl 5-bromo-1H-indole-2-carboxylate

Rapid synthesis of the indole-indolone scaffold via [3+2] annulation of arynes by methyl indole-2-carboxylates was written by Rogness, Donald C.;Larock, Richard C.. And the article was included in Tetrahedron Letters in 2009.Quality Control of Methyl 5-bromo-1H-indole-2-carboxylate This article mentions the following:

The reaction of Me indole-2-carboxylates, e.g., I, and arynes afforded a very efficient, high yielding synthesis of a novel indole-indolone ring system, e.g., II, which tolerated considerable functionality, was broad in scope, and proceeded under mild reaction conditions. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Quality Control of Methyl 5-bromo-1H-indole-2-carboxylate).

Dhawan, Sanjeev et al. published their research in Journal of Chemical and Pharmaceutical Research in 2016 | CAS: 14204-27-4

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione

Strategies for chemical synthesis of pyrazolone derivatives and their bio-significance was written by Dhawan, Sanjeev;Narang, Rakesh;Khatik, Gopal L.;Chopra, Harish Kumar;Nayak, Surendra Kumar. And the article was included in Journal of Chemical and Pharmaceutical Research in 2016.Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione This article mentions the following:

Over the last few decades, pyrazolone derivatives have been used for various biochem. applications. Some of these derivatives such as metamizole, phenazone, aminopyrine and propyphenazone, are widely used as antiinflammatory and analgesics. Moreover, pyrazolones have been exhibited antioxidant, antibacterial, anticancer and several other biol. activities. Thus, keeping in view of their importance, synthetic strategies for existing as well as novel pyrazolone derivatives have been developed and explored their biochem. utility. As versatile features of pyrozaolones have emerged, so the aim of the present paper is to put chem. synthetic schemes and biol. advancements of pyrazolone derivatives together. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione).

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). Recommanded Product: 2-(Phenylthio)isoindoline-1,3-dione

Fukuda, Yasumichi et al. published their research in Journal of Medicinal Chemistry in 1999 | CAS: 210345-56-5

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.HPLC of Formula: 210345-56-5

Novel cyclopropapyrroloindole derivative (AT-3510) bearing methoxycarbonyl and trifluoromethyl groups was written by Fukuda, Yasumichi;Furuta, Hirosuke;Kusama, Yoshie;Ebisu, Hiroyuki;Oomori, Yasuo;Terashima, Shiro. And the article was included in Journal of Medicinal Chemistry in 1999.HPLC of Formula: 210345-56-5 This article mentions the following:

The seco-Cl 3-methoxycarbonyl-2-trifluoromethylcyclopropapyrroloindole (MCTFCPI) derivatives dl- and/or (S)-I [Ar = Q, Q₁, Q₂, Q₃, R = 4,5,6-(MeO)₃, 5,6,7-(MeO)₃, 5-MeO, etc., X = NH, O, CH, Y = CH, N] carrying various acyl moieties at the N6-position were synthesized along with their prodrugs (S)-II, and their antitumor activity was evaluated. Among these derivatives, AT-3510 [(S)-II (Ar = Q¹, R = 7-MeO, X = O)], the novel prodrug MCTFCPI derivative carrying a 5-(7-methoxybenzofuran-2-ylcarbonyl)aminoindole-2-carbonyl group at the N6-position, was found to exhibit more excellent antitumor activity against human tumor xenografts than the clin. trial candidates carzelesin and KW-2189 (III) and cisplatin. In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5HPLC of Formula: 210345-56-5).

Markova, Larysa I. et al. published their research in Dyes and Pigments in 2013 | CAS: 146368-07-2

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Category: indole-building-block

Comparison of a series of hydrophilic squaraine and cyanine dyes for use as biological labels was written by Markova, Larysa I.;Terpetschnig, Ewald A.;Patsenker, Leonid D.. And the article was included in Dyes and Pigments in 2013.Category: indole-building-block This article mentions the following:

Unlike cyanine dyes, which are widely used as fluorescent probes and labels for biomedical applications squaraine dyes are less investigated. A series of monoreactive, water-soluble, squaraine dyes with two aromatic sulfo groups and up to 3 sulfobutyl groups was synthesized and the spectral properties of these dyes were compared to dicarbocyanines of identical structure. Compared to the cyanines in aqueous solutions the squaraine dyes absorb and emit at shorter wavelengths (630-636 nm/639-645 nm vs. 647-653 nm/665-672 nm), have higher molar absorptivities (284,000-333,000 M^-1 cm^-1vs. 242,000-260,000 M^-1 cm^-1), lower fluorescence quantum yields (4.3-9.4% vs. 27-32%) and lower fluorescence lifetimes (0.2-0.3 ns vs. 1.0-1.2 ns) but the quantum yields and lifetimes substantially increase when bound to proteins (Bovine Serum Albumin (BSA) or antibodies, IgG (IgG)). Squaraines with two aromatic sulfo groups show no aggregation tendency up to concentrations of 2 × 10^-4 M while the corresponding cyanine dye is free of aggregation up to 5 × 10^-4 M. The increase in the number of sulfobutyl groups bears a strong influence on the aggregation tendency of both dye classes upon covalent labeling to BSA and IgG resulting in increased quantum yields and lifetimes of the protein conjugates. Compared to cyanines, squaraine dyes exhibit higher photostabilities and much higher sensitivity of the quantum yields and fluorescence lifetimes toward the microenvironment and are therefore better suited as fluorescence sensors. In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Category: indole-building-block).