Tag: 200-300

Tois, Jan; Franzen, Robert; Aitio, Olli; Laakso, Into; Kylaenlahti, Irene published their research in Journal of Combinatorial Chemistry on December 31 ,2001. The article was titled 《Vilsmeier formylation of 2-carboxyindoles and preparation of O-benzylhydroxyureas on solid phase》.Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid The article contains the following contents:

The Vilsmeier formylation has been introduced for the solid-phase functionalization of five different 2-carboxyindoles, e.g. 2-carboxyindole. The aldehyde functionality has been utilized in the preparation of O-benzylhydroxyureas, e.g. I. In the experimental materials used by the author, we found 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid)

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Application In Synthesis of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoateOn November 30, 2004 ,《Peroxidases during adventitious rooting in cuttings of Arbutus unedo and Taxus baccata as affected by plant genotype and growth regulator treatment》 appeared in Plant Growth Regulation. The author of the article were Metaxas, Demetrios J.; Syros, Thomas D.; Yupsanis, Traianos; Economou, Athanasios S.. The article conveys some information:

Cuttings of Arbutus unedo (strawberry tree) and Taxus baccata (yew) were treated with 8.0 and 10.0 g l-1, resp., of KIBA, IBA, IAA, NAA and Paclobutrazol. No rooting occurred without growth regulator treatment. The effect of growth regulators on percentage of rooting followed the order KIBA > IBA > IAA = NAA = Paclobutrazol = 0% (for A. unedo) and KIBA > IBA > IAA > NAA > Paclobutrazol = 0% (for T. baccata). Genotypes of the above plant species had significant effects on the number and length of roots, percentage of rooting and peroxidase specific activity (PA) on KIBA-treated cuttings. High PA seems to be related with low percentage of rooting in the case of A. unedo cuttings while no similar results were noticed in the case of T. baccata. Electrophoretic anal. revealed the appearance of two to three anionic and one cationic peroxidase isoforms in A. unedo cuttings, while six to nine anionic and no cationic peroxidases isoforms appeared in the case of T. baccata genotypes. During adventitious rooting, the PA showed the three interdependent phases (induction, initiation, expression) in both K-IBA treated cuttings of A. unedo and T. baccata, but in a different time course. In addition to this study using Potassium 4-(1H-indol-3-yl)butanoate, there are many other studies that have used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate) was used in this study.

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Identification of β carbolines isolated from fluorescent human lens proteins》 was published in Nature (London, United Kingdom) in 1976. These research results belong to Dillon, James; Spector, Abraham; Nakanishi, Koji. Application of 59132-30-8 The article mentions the following:

The fluorescent 43,000 mol. weight protein (C1) obtained on alk. degradation of the insoluble or high mol. weight protein fraction of human lens gave 2 fully aromatic β-carbolines (I and II) on decomposition or oxidation These β-carbolines were also obtained on decomposition or oxidation of 3,4-dihydro-β-carboline 3-carboxylic acids (III and IV) showing that C1 is a mit. of III and IV. Protein hydrolysates from 45- and 77-year-old but not young human lens contained I and II, suggesting that there is an age-dependent formation of the β-carboline skeleton in human lens. Preliminary experiments suggested 1,2,3,4-tetrahydro-β-carboline 1,3-dicarboxylic acid (V) and its 1-Me derivative (VI) are the in vivo precursors of IV and III, resp. The experimental part of the paper was very detailed, including the reaction process of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Application of 59132-30-8)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Application of 59132-30-8They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Gatta, Franco; Misiti, Domenico published an article in Journal of Heterocyclic Chemistry. The title of the article was 《Sodium periodate oxidation of tetrahydro-β-carboline derivatives》.Computed Properties of C13H12N2O4 The author mentioned the following in the article:

The oxidation of some 3-(methoxy- and ethoxycarbonyl)tetrahydro-β-carboline derivatives with sodium periodate led to the formation of 1,4-benzodiazonine derivatives e.g. I, or fully aromatic β-carbolines depending on both nature and number of substituents at 1-position. After reading the article, we found that the author used 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Computed Properties of C13H12N2O4)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Computed Properties of C13H12N2O4They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Das, Banibrata; Vedachalam, Seenuvasan; Luo, Dan; Antonio, Tamara; Reith, Maarten E. A.; Dutta, Aloke K. published their research in Journal of Medicinal Chemistry on December 10 ,2015. The article was titled 《Development of a Highly Potent D2/D3 Agonist and a Partial Agonist from Structure-Activity Relationship Study of N6-(2-(4-(1H-Indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine Analogues: Implication in the Treatment of Parkinson’s Disease》.Name: 5-Bromo-7-fluoro-1H-indole The article contains the following contents:

The structure-activity relationship studies with N6-(2-(4-(1H-indol-5-yl)piperazin-1-yl)ethyl)-N6-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine derivatives led to development of a lead compound I which exhibited very high affinity (Ki, D2 = 16.4 nM, D3 = 1.15 nM) and full agonist activity (EC50 (GTPγS); D2 = 3.23 and D3 = 1.41 nM) at both D2 and D3 receptors. A partial agonist mol. II (EC50 (GTPγS); D2 = 21.6 (Emax = 27%) and D3 = 10.9 nM) was also identified. In a Parkinson’s disease (PD) animal model, I was highly efficacious in reversing hypolocomotion in reserpinized rats with a long duration of action, indicating its potential as an anti-PD drug. Compound II was also able to elevate locomotor activity in the above PD animal model significantly, implying its potential application in PD therapy. Furthermore, I was shown to be neuroprotective in protecting neuronal PC12 from toxicity of 6-OHDA. This report, therefore, underpins the notion that a multifunctional drug like I might have the potential not only to ameliorate motor dysfunction in PD patients but also to modify disease progression by protecting DA neurons from progressive degeneration. In the experiment, the researchers used many compounds, for example, 5-Bromo-7-fluoro-1H-indole(cas: 883500-73-0Name: 5-Bromo-7-fluoro-1H-indole)

5-Bromo-7-fluoro-1H-indole(cas: 883500-73-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Name: 5-Bromo-7-fluoro-1H-indole

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 59132-30-8On May 9, 1980 ,《Electrochemistry of natural products. 7. Oxidative decarboxylation of some tetrahydro-β-carbolinecarboxylic acids》 appeared in Journal of Organic Chemistry. The author of the article were Bobbitt, James M.; Willis, John P.. The article conveys some information:

A series of 1,2,3,4-tetrahydro-β-carboline-1- and -3-carboxylic acids containing various substituents in positions 1, 2, and 3 were oxidized electrochem. In general, the acids were decarboxylated, and unsaturation was introduced into the C ring. The oxidation appears to take place through the indole ring, N, and possible mechanisms of the reactions are given. Parallels between the observed reactions and early steps in indole alkaloid biosynthesis are discussed. The oxidative dimerization of tetrahydrocarbazole is reported. The experimental process involved the reaction of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8SDS of cas: 59132-30-8)

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.SDS of cas: 59132-30-8They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Boville, Christina E.; Romney, David K.; Almhjell, Patrick J.; Sieben, Michaela; Arnold, Frances H. published an article in Journal of Organic Chemistry. The title of the article was 《Improved Synthesis of 4-Cyanotryptophan and Other Tryptophan Analogues in Aqueous Solvent Using Variants of TrpB from Thermotoga maritima》.Category: indole-building-block The author mentioned the following in the article:

The use of enzymes has become increasingly widespread in synthesis as chemists strive to reduce their reliance on organic solvents in favor of more environmentally benign aqueous media. With this in mind, we previously endeavored to engineer the tryptophan synthase β-subunit (TrpB) for production of noncanonical amino acids that had previously been synthesized through multi-step routes involving water-sensitive reagents. This enzymic platform proved effective for the synthesis of analogs of the amino acid tryptophan (Trp), which are frequently used in pharmaceutical synthesis as well as chem. biol. However, certain valuable compounds, such as the blue fluorescent amino acid 4-cyanotryptophan (4-CN-Trp), could only be made in low yield, even at elevated temperature (75 °C). Here, we describe the engineering of TrpB from Thermotoga maritima that improved synthesis of 4-CN-Trp from 24% to 78% yield. Remarkably, although the final enzyme maintains high thermostability (T50 = 93 °C), its temperature profile is shifted, such that high reactivity is observed at ∼37 °C (76% yield), creating the possibility for in vivo 4-CN-Trp production The improvements are not specific to 4-CN-Trp; a boost in activity at lower temperature is also demonstrated for other Trp analogs. In addition to this study using 5-Bromo-7-fluoro-1H-indole, there are many other studies that have used 5-Bromo-7-fluoro-1H-indole(cas: 883500-73-0Category: indole-building-block) was used in this study.

5-Bromo-7-fluoro-1H-indole(cas: 883500-73-0) is a member of aromaticfluorinated building blocks. Depending on which substituents are present, fluoroaromatic intermediates can be converted into fluorinated or fluorine-free commercial end products.Fluorine-containing aromatics have been incorporated into drugs (hypnotics, tranquilizers, antiinflammatory agents, analgesics, antibacterials).Category: indole-building-block

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

《Effect of N6-isopentenyladenine concentration on growth initiation in vitro and rooting of bilberry and lingonberry microshoots》 was published in Plant Cell, Tissue and Organ Culture in 2001. These research results belong to Jaakola, Laura; Tolvanen, Anne; Laine, Kari; Hohtola, Anja. Related Products of 60096-23-3 The article mentions the following:

Buds and shoot tips of wild bilberry (Vaccinium myrtillus L.) and lingonberry (V. vitis-idaea L.) plants were cultured on a modified MS medium containing N6-isopentenyladenine (2iP), 9.8-78.4 μM, to study the effect of the 2iP-concentration on the initiation of growth. The experiment was first performed in the autumn and repeated in the spring to determine the influence of season on growth initiation. To optimize rooting, three different rooting treatments were tested for the bilberry and lingonberry microshoots. Shoots were rooted either in vitro with 0.49 μM IBA or ex vitro, incubating microshoots in 2.07 mM KIBA-solution (potassium salt of IBA) before planting, or microshoots were planted directly on peat without exogenous auxin. The best 2iP concentration for the initiation of the growth for bilberry was 49.2 μM and for lingonberry 24.6 μM. Increasing the 2iP concentration at the growth initiation stage increased the number of brownish explants both in bilberry and in lingonberry microcultures. Spring was a considerably better time than autumn for the initiation of new growth, for both species. The results of the rooting test showed that the KIBA-treatment before planting on peat increases rooting efficiency in both bilberry and lingonberry. The experimental part of the paper was very detailed, including the reaction process of Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Related Products of 60096-23-3)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Related Products of 60096-23-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yoshikawa, Kenji; Yokomizo, Aki; Naito, Hiroyuki; Haginoya, Noriyasu; Kobayashi, Shozo; Yoshino, Toshiharu; Nagata, Tsutomu; Mochizuki, Akiyoshi; Osanai, Ken; Watanabe, Kengo; Kanno, Hideyuki; Ohta, Toshiharu published their research in Bioorganic & Medicinal Chemistry on December 15 ,2009. The article was titled 《Design, synthesis, and SAR of cis-1,2-diaminocyclohexane derivatives as potent factor Xa inhibitors. Part I: Exploration of 5-6 fused rings as alternative S1 moieties》.Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid The article contains the following contents:

A series of cis-1,2-diaminocyclohexane derivatives were synthesized with the aim of optimizing previously disclosed factor Xa (fXa) inhibitors. The exploration of 5-6 fused rings as alternative S1 moieties resulted in two compounds which demonstrated improved solubility and reduced food effect compared to the clin. candidate, compound A. Herein, we describe the synthesis and structure-activity relationship (SAR), together with the physicochem. properties and pharmacokinetic (PK) profiles of some prospective compounds In the experiment, the researchers used 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid)

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Name: 5-Chloro-3-formyl-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Raup, Annie; Taylor, Matthew D. published their research in Journal of Environmental Horticulture on December 31 ,2012. The article was titled 《Cutting type and auxin treatment affect rooting of Cupressus cashmeriana》.HPLC of Formula: 60096-23-3 The article contains the following contents:

Cupressus cashmeriana is an ornamental evergreen conifer with little published information on vegetative propagation. Two experiments were conducted to determine the effects of cutting type and auxin concentration and form on adventitious rooting. Experiment 1 evaluated three cutting treatments (softwood, hardwood, and mallet) and four auxin treatments consisting of 0, 2500, 5000, and 10000 ppm potassium salt of indole-3-butyric acid (K-IBA). Experiment 2 evaluated the same cutting types as experiment 1 and auxin treatments consisted of 5000 ppm K-IBA, 5000 ppm naphthalene acetic acid (NAA), 2500 ppm K-IBA in combination with 2500 ppm NAA and zero auxin applied. In both experiments, rooting of softwood and hardwood cuttings was significantly higher than mallet cuttings. Treatment of cuttings with different rates and types of auxin lead to inconclusive results, which indicate auxin may not be beneficial for rooting of C. cashmeriana. This research suggests that the age of plant material is one of the most significant factors for successful rooting C. cashmeriana. The results came from multiple reactions, including the reaction of Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3HPLC of Formula: 60096-23-3)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.HPLC of Formula: 60096-23-3

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles