200-300 | - Page 42 of 43 - Indole Building Blocks

Diem, Stefanie’s team published research in Journal of Agricultural and Food Chemistry in 2001 | CAS: 59132-30-8

2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8) belongs to indole.The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades.Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acidThey are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.

Diem, Stefanie; Gutsche, Birgit; Herderich, Markus published their research in Journal of Agricultural and Food Chemistry on December 31 ,2001. The article was titled 《Degradation of Tetrahydro-β-carbolines in the Presence of Nitrite: HPLC-MS Analysis of the Reaction Products》.Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid The article contains the following contents:

Motivated by the identification of numerous novel tetrahydro-β-carboline-carboxylic acids in food samples, the authors studied the reactions of tetrahydro-β-carbolines in the presence of nitrosating agents. The anticipated formation of nitroso derivatives from unsubstituted tetrahydro-β-carbolines, and from tetrahydro-β-carboline-3-carboxylic acids was indicated by HPLC-MS/MS anal. and validated by the characteristic product ion spectra of the resp. nitroso compounds In addition, oxidative decarboxylation resulted in formation of the corresponding dihydro-β-carbolines, and in the generation of the β-carbolines harman or norharman. Subsequently, the authors studied the reactivity of tetrahydro-β-carboline-1-carboxylic acids derived from the Pictet-Spengler condensation of indole amines with α-oxo acids. Again, in the presence of nitrosating agents the rapid disappearance of the starting material was obvious, but no nitroso derivatives could be observed Instead, further HPLC-MS/MS studies demonstrated that dihydro-β-carbolines were the major products of tetrahydro-β-carboline-1-carboxylic acids. Finally, the authors demonstrated that freshly isolated nitroso-precursors spontaneously decomposed to yield harman alkaloids. Thus, nitroso-tetrahydro-β-carbolines can represent intermediates involved in the generation of β-carbolines; the authors established a novel pathway for the formation of harman alkaloids from nutritional tetrahydro-β-carbolines. The experimental part of the paper was very detailed, including the reaction process of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid(cas: 59132-30-8Reference of 2,3,4,9-Tetrahydro-1H-pyrido[3,4-b]indole-1,3-dicarboxylic acid)

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Velezheva, Valeriya’s team published research in Bioorganic & Medicinal Chemistry Letters in 2016 | CAS: 380448-07-7

5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7) is a member of organic chlorides. Organic chlorides are compounds containing a carbon-chlorine bond, which are widely used in the oil field as a wax dissolver. They are generally not present in crude oils and are typically the result of additives, cleaning solutions or chemicals used for oil recovery.Synthetic Route of C10H6ClNO3

Velezheva, Valeriya; Brennan, Patrick; Ivanov, Pavel; Kornienko, Albert; Lyubimov, Sergey; Kazarian, Konstantin; Nikonenko, Boris; Majorov, Konstantin; Apt, Alexander published an article on February 1 ,2016. The article was titled 《Synthesis and antituberculosis activity of indole-pyridine derived hydrazides, hydrazide-hydrazones, and thiosemicarbazones》, and you may find the article in Bioorganic & Medicinal Chemistry Letters.Synthetic Route of C10H6ClNO3 The information in the text is summarized as follows:

We describe the design, synthesis, and in vitro antimycobacterial activity of a series of novel simple hybrid hydrazides and hydrazide-hydrazones combining indole and pyridine nuclei. The compounds are derivatives of 1-acetylindoxyl or substituted indole-3-carboxaldehydes tethered via a hydrazine group by simple C-N or double C:N bonds with 3- and 4-pyridines, 1-oxide 3- and 4-pyridine carbohydrazides. The most active of the 15 compounds showed MICs values against an INH-sensitive strain of Mycobacterium tuberculosis H37Rv equal to that of INH (0.05-2 μg/mL). Five compounds demonstrated appreciable activity against the INH-resistant M. tuberculosis CN-40 clin. isolate (MICs: 2-5 μg/mL), providing justification for further in vivo studies. The results came from multiple reactions, including the reaction of 5-Chloro-3-formyl-1H-indole-2-carboxylic acid(cas: 380448-07-7Synthetic Route of C10H6ClNO3)

Struve, Daniel K.’s team published research in Journal of the American Society for Horticultural Science in 1984 | CAS: 60096-23-3

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Quality Control of Potassium 4-(1H-indol-3-yl)butanoate

Struve, Daniel K.; Moser, Bruno C. published an article on January 31 ,1984. The article was titled 《Auxin effects on root regeneration of scarlet oak seedlings》, and you may find the article in Journal of the American Society for Horticultural Science.Quality Control of Potassium 4-(1H-indol-3-yl)butanoate The information in the text is summarized as follows:

Dipping root systems of scarlet oak seedlings (Quercus coccinea) in indol-3-butyric acid K salt (K-IBA) [60096-23-3], 2,4-D [94-75-7], 2,4,5-T [93-76-5], 2,4,5-trichloropropanoic acid [93-72-1], β-naphthoxyacetic acid [120-23-0], and NAA [86-87-3], induced a 6-fold increase in adventitious root regeneration, as compared to control seedlings. Time to first root initiation was increased and root elongation rate was decreased for auxin-treated seedlings relative to untreated controls. Under field conditions, 1-yr-old seedlings treated with NAA, at 3000 mg/L, or K-IBA, at 1000 or 3000 mg/L, regenerated more roots and developed greater root length than did control plants. Toothpicks impregnated with a 1000 mg/L K-IBA solution and inserted into tap roots stimulated an 18-fold increase in root length, as compared to control seedlings. In the part of experimental materials, we found many familiar compounds, such as Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Quality Control of Potassium 4-(1H-indol-3-yl)butanoate)

Krezdorn, A. H.’s team published research in Proceedings of the Florida State Horticultural Society in 1977 | CAS: 60096-23-3

Category: indole-building-blockOn May 1, 1977 ,《Advances in rooting avocados》 appeared in Proceedings of the Florida State Horticultural Society. The author of the article were Krezdorn, A. H.; Marte, D.; Marte, R. J.. The article conveys some information:

Avocado (Persea americana) cuttings were rooted by applying bottom heat, combined with K indolebutyrate [60096-23-3] treatment. Other treatments were ineffective. Cuttings placed under intermittnet mist showed foliar Na, K, and K leaching. In the experiment, the researchers used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Category: indole-building-block)

Cobo, Maria Mercedes’s team published research in In Vitro Cellular & Developmental Biology: Plant in 2018 | CAS: 60096-23-3

Cobo, Maria Mercedes; Gutierrez, Bernardo; Torres, Maria de Lourdes published an article on February 28 ,2018. The article was titled 《Regeneration of mortinõ (Vaccinium floribundum Kunth) plants through axillary bud culture》, and you may find the article in In Vitro Cellular & Developmental Biology: Plant.Recommanded Product: 60096-23-3 The information in the text is summarized as follows:

The use of conventional propagation strategies for Vaccinium floribundum Kunth has proven difficult, which has resulted in this species’ escape from formal cultivation, despite its importance as a gastronomic and nutraceutical fruit. The current report presents an efficient propagation methodol. for V. floribundum using axillary bud growth. Axillary buds were cultured on modified Woody Plant medium (mWPM) supplemented with 3.0 mg L-1 N6-isopentenyladenine (2iP) or with 5.0 mg L-1 2iP plus 0.1 mg L-1 1-naphthaleneacetic acid (NAA). The best results for plant propagation were obtained on mWPM with 2iP and NAA, where significantly higher numbers of shoots per bud were observed In vitro-rooted plants were successfully acclimatized to a peat and vermiculite substrate, while unrooted plants could be efficiently grown after an ex vitro rooting treatment by submersion in an 0.5 g L-1 indole-3-butyric acid (IBA) or potassium IBA (KIBA) solution This is the first report of an efficient propagation methodol. for V. floribundum using plant tissue culture protocols, and provides a tool for the implementation of conservation strategies for this species. In the experiment, the researchers used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Recommanded Product: 60096-23-3)

Lee, C. I.’s team published research in Journal of the American Society for Horticultural Science in 1976 | CAS: 60096-23-3

In 1976,Journal of the American Society for Horticultural Science included an article by Lee, C. I.; Hackett, W. P.. Category: indole-building-block. The article was titled 《Root regeneration of transplanted Pistacia chinensis Bunge seedlings at different growth stages》. The information in the text is summarized as follows:

The root-regenerating potential (RRP) of 1-year-old P. chinensis seedlings at different growth states, was determined by recording the number of newly initiated roots during 4 weeks after bareroot transplanting into a bottom misting chamber. RRP of intact pistacias was greatest when leaves were fully expanded and the terminal bud was forming (stage III), and lowest when seedlings were dormant (stages V and VI). However, seedlings disbudded before transplanting and root cuttings showed 2 peaks in RRP; 1 at spring bud break (stage I) and the other at stage III. Removal of buds resulted in decreased RRP at stage I, but had little effect when plants were dormant. Thiourea [62-56-6] sprays of growing seedlings and chilling of dormant seedlings enhanced bud break and RRP. K indolebutyrate [60096-23-3] applied to the root system promoted RRP but did not eliminate the seasonal variation of RRP. K indolebutyrate could replace the influence of buds only when seedlings were not dormant. Sucrose [57-50-1] feeding via the stem increased RRP at spring bud break. Dormant condition of buds and the availability of carbohydrates are the factors controlling the RRP of bareroot transplanted pistacias. In the experiment, the researchers used many compounds, for example, Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Category: indole-building-block)

Deng, Shubo’s team published research in Chemical Engineering Journal (Amsterdam, Netherlands) in 2016 | CAS: 60096-23-3

Deng, Shubo; Chen, Tao; Zhao, Tianning; Yao, Xiaolong; Wang, Bin; Huang, Jun; Wang, Yujue; Yu, Gang published an article on February 15 ,2016. The article was titled 《Role of micropores and nitrogen-containing groups in CO2 adsorption on indole-3-butyric acid potassium derived carbons》, and you may find the article in Chemical Engineering Journal (Amsterdam, Netherlands).Name: Potassium 4-(1H-indol-3-yl)butanoate The information in the text is summarized as follows:

Nitrogen-rich carbons for CO2 capture have received much attention in recent years, but the role of N-containing groups in CO2 adsorption has not been clearly elucidated. In this study, indole-3-butyric acid potassium (IBAP) as a new precursor was used to prepare the nitrogen-rich carbons via one-step carbonization. The IBAP-derived carbon prepared at 700 °C exhibited high CO2 adsorption of 1.48 mmol/g at 0.15 bar and 4.53 mmol/g at 1 bar and 25 °C, among the highly efficient activated carbons for CO2 adsorption. The high CO2 adsorption was attributed to not only the high volume of effective micropores, but also the effective N-containing groups on the IBAP-derived carbons. When carbonization temperatures increased from 500 °C to 900 °C, the nitrogen contents in the IBAP-derived carbons decreased from 6.35% to 0.70%. XPS anal. confirmed that the pyrrolic-N in IBAP was converted into pyridinic-N, quaternary nitrogen and pyridinic-N-oxide in the carbonization process, and their contents first increased and then decreased with increasing carbonization temperatures Only the pyrrolic-N was proved to be effective for CO2 adsorption on the IBAP-derived carbons, and its contribution to CO2 adsorption was pronounced for the carbons prepared at low temperatures For the well-developed porous carbons, the effective micropores were mainly responsible for CO2 adsorption via micropore filling. In the experimental materials used by the author, we found Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Name: Potassium 4-(1H-indol-3-yl)butanoate)

Johnson, Emily P.’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2020 | CAS: 60096-23-3

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate

Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoateOn March 15, 2020, Johnson, Emily P.; Preece, John E.; Aradhya, Malli; Gradziel, Thomas published an article in Scientia Horticulturae (Amsterdam, Netherlands). The article was 《Rooting response of Prunus wild relative semi-hardwood cuttings to indole-3-butyric acid potassium salt (KIBA)》. The article mentions the following:

Wild Prunus germplasm is an important resource for pest and disease resistance traits for the continued improvement of almond and other Prunus rootstocks. Evaluation of resistance in these wild species requires clonal replicates that are traditionally produced by rooting cuttings. Over two consecutive years, leafy cuttings of 20 genotypes of the following wild Prunus species were collected in mid-late May and treated with a 15 s dip in 0, 500, 1000, 2000 or 4000 mg/L of the potassium salt of indole-3-butyric acid (KIBA): almonds (P. argentea (one genotype), P. bucharica (two genotypes), P. dulcis (two genotypes), P. tangutica (three genotypes)), peaches (P. davidiana (two genotypes), P. kansuensis, P. mira (two genotypes), P. persica (three genotypes including a com. peach rootstock, ‘Lovell’)), and plums (P. cerasifera (two genotypes), P. salicina (two genotypes)).. The cuttings were planted in a perlite-vermiculite medium under intermittent mist and periodically checked for roots. The plum species rooted at a higher percentage, and produced more roots than the peach species; and the almond species generally failed to root. The plums produced the most roots at 2000-4000 mg/L KIBA, although rooting in both P. cerasifera and P. salicina was genotype dependent. The plum cuttings that rooted generally produced from 2 to 14 roots that averaged 0.74-1.73 cm long when the cuttings were harvested; one accession produced 60 roots/cutting when treated with 4000 mg/L KIBA. The wild peach species produced the most roots at 1000-4000 mg/L KIBA, with cuttings of P. kansuensis and P. mira having significantly higher rooting percentages than P. davidiana and P. persica cuttings. All of the wild almond species tested did not root or rooted a very low percentage. After reading the article, we found that the author used Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate)

Potassium 4-(1H-indol-3-yl)butanoate(cas: 60096-23-3) is auxin-family plant hormone, and is thought to be a precursor of indole-3-acetic acid (IAA) the most abundant and the basic auxin natively occurring and functioning in plants. IAA generates the majority of auxin effects in intact plants, and is the most potent native auxin.Application In Synthesis of Potassium 4-(1H-indol-3-yl)butanoate

Organic Chemistry Frontiers | Cas: 165669-07-8 was involved in experiment

Application of 165669-07-8In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Application of 165669-07-8In 2020, Yuan, Yumeng;Pan, Guoshuai;Zhang, Xiaofeng;Huang, Qiufeng published 《One pot synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles via tandem C-H olefination/aza-Michael addition》. 《Organic Chemistry Frontiers》published the findings. The article contains the following contents:

The one-pot C-H olefination/aza-Michael addition tandem process was developed for the synthesis of pyrrolo[3,2,1-de]phenanthridines from 7-phenylindoles and alkenes using a [Cp*RhCl₂]₂/AgOAc/Me₄NOAc catalytic system. A relatively wide range of functional groups were tolerated, and a variety of pyrrolo[3,2,1-de]phenanthridines were obtained in good to excellent yields. And 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) was used in the research process.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Bioorganic & Medicinal Chemistry Letters | Cas: 165669-07-8 was involved in experiment

Synthetic Route of C9H8BrNIn addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families.

Owa, Takashi;Okauchi, Tatsuo;Yoshimatsu, Kentaro;Sugi, Naoko Hata;Ozawa, Yoichi;Nagasu, Takeshi;Koyanagi, Nozomu;Okabe, Tadashi;Kitoh, Kyosuke;Yoshino, Hiroshi published 《A focused compound library of novel N-(7-indolyl)benzenesulfonamides for the discovery of potent cell cycle inhibitors》 in 2000. The article was appeared in 《Bioorganic & Medicinal Chemistry Letters》. They have made some progress in their research.Synthetic Route of C9H8BrN The article mentions the following:

A series of compounds containing an N-(7-indolyl)benzenesulfonamide pharmacophore, e.g. I, was synthesized and evaluated as a potential antitumor agent. Cell cycle anal. with P388 murine leukemia cells revealed that there were two different classes of potent cell cycle inhibitors; one disrupted mitosis and the other caused G1 accumulation. The structure-activity relationships of the substituent patterns on this pharmacophore template are described. And 7-Bromo-4-methyl-1H-indole (cas: 165669-07-8) was used in the research process.