Tag: 200-300

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases was written by Apsel, Beth;Blair, Jimmy A.;Gonzalez, Beatriz;Nazif, Tamim M.;Feldman, Morri E.;Aizenstein, Brian;Hoffman, Randy;Williams, Roger L.;Shokat, Kevan M.;Knight, Zachary A.. And the article was included in Nature Chemical Biology in 2008.SDS of cas: 754214-56-7 This article mentions the following:

The clin. success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of targets that are structurally divergent. Here we report the systematic discovery of mols. that potently inhibit both tyrosine kinases and phosphatidylinositol-3-OH kinases, two protein families that are among the most intensely pursued cancer drug targets. Through iterative chem. synthesis, X-ray crystallog. and kinome-level biochem. profiling, we identified compounds that inhibit a spectrum of new target combinations in these two families. Crystal structures revealed that the dual selectivity of these mols. is controlled by a hydrophobic pocket conserved in both enzyme classes and accessible through a rotatable bond in the drug skeleton. We show that compound I blocks the proliferation of tumor cells by direct inhibition of oncogenic tyrosine kinases and phosphatidylinositol-3-OH kinases. These mols. demonstrate the feasibility of accessing a chem. space that intersects two families of oncogenes. In the experiment, the researchers used many compounds, for example, 7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7SDS of cas: 754214-56-7).

7-Azaindole-5-boronic Acid Pinacol Ester (cas: 754214-56-7) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.SDS of cas: 754214-56-7

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Manufacture of foods. I. Influence of growth regulators on germination of barley and rye. 1. Amylase activity was written by Obara, Tetsujiro;Ogasawara, Yasokichi;Kimura, Tsugie. And the article was included in Nippon Shokuhin Kogyo Gakkaishi in 1963.Recommanded Product: 1912-45-4 This article mentions the following:

Influences of 婵?naphthaleneacetic acid and gibberellin were tested on amylase activities and growth of germinating barley and rye. Both barley and rye germinated best on a medium containing 0.1-1.0 ppm. gibberellin. Gibberellin increased the formation of amylase 60-100% at 1 ppm., while 婵?naphthaleneacetic acid had no effect. The highest amylase activity was produced after 80 hrs. of incubation in the presence of 1 ppm. gibberellin. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Recommanded Product: 1912-45-4).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1912-45-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Green Oxidation of Indoles Using Molecular Oxygen over a Copper Nitride Nanocube Catalyst was written by Xu, Hang;Yamaguchi, Sho;Mitsudome, Takato;Mizugaki, Tomoo. And the article was included in European Journal of Organic Chemistry in 2022.Application of 4583-55-5 This article mentions the following:

Oxidative transformation of indoles is a promising approach for synthesizing valuable nitrogen-containing compounds; however, conventional methods use toxic oxidants and additives. Herein, authors report for the first time the catalytic oxidative trimerization and the oxygenative cleavage (Witkop oxidation) of indoles using mol. oxygen under additive-free conditions accomplished by a copper nitride nanocube (Cu₃N NC) catalyst. The Cu₃N NC catalyst exhibits excellent activity to produce various indolin-3-ones and 2-ketoanilides with high functional group tolerance. Owing to this excellent catalytic performance, the Cu₃N NC catalyst is distinguished from the conventional copper catalysts, demonstrating the high catalytic potential of metal nitride in organic synthesis. In the experiment, the researchers used many compounds, for example, 5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5Application of 4583-55-5).

5-Bromo-2,3-dimethyl-1H-indole (cas: 4583-55-5) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application of 4583-55-5

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Organocatalytic Friedel-Crafts Alkylation/Lactonization Reaction of Naphthols with 3-Trifluoroethylidene Oxindoles: The Asymmetric Synthesis of Dihydrocoumarins was written by Zhao, Yun-Long;Lou, Qin-Xin;Wang, Long-Sheng;Hu, Wen-Hui;Zhao, Jun-Ling. And the article was included in Angewandte Chemie, International Edition in 2017.Computed Properties of C8H6BrNO This article mentions the following:

Naphthols and 3-trifluoroethylidene oxindoles were found to undergo an asym. Friedel-Crafts alkylation/lactonization reaction, catalyzed by only 2.5 mol % of a quinine-derived squaramide catalyst, to afford the corresponding 婵?aryl-闁?trifluoromethyl dihydrocoumarin derivatives I (R¹ = H, 5-Me, 5-Cl, 5-Br, 7-F, 7-Br; R² = H, 6-MeO, 6-OBn, 6-Ph, etc.) in high yields (up to 99 %) with excellent enantio- and diastereoselectivities (up to 98 % ee, >20:1 d.r.). Importantly, the lactonization proceeded by nucleophilic attack of the naphthol hydroxy group at the amide motif of the oxindoles under mild reaction conditions. This protocol represents a new strategy for the formation of dihydrocoumarins by an efficient intramol. amide C-N bond-cleavage and esterification process. In the experiment, the researchers used many compounds, for example, 7-Bromooxindole (cas: 320734-35-8Computed Properties of C8H6BrNO).

7-Bromooxindole (cas: 320734-35-8) belongs to indole derivatives. Indole could be stereoselectively alkylated with chiral cyclopentyl sulfone reagent. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Computed Properties of C8H6BrNO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isoindoles from phthalimidines. N-Arylisoindoles was written by Kovtunenko, V. A.;Kucherenko, T. T.;Kornilov, M. Yu.;Tyltin, A. K.;Turov, A. V.;Babichev, F. S.. And the article was included in Khimiya Geterotsiklicheskikh Soedinenii in 1987.Electric Literature of C14H11NO This article mentions the following:

N-Arylisoindoles I (R = Ph, 4-MeC₆H₄, 4-BrC₆H₄) were prepared by reduction of the resp. phthalimidines II (same R) with Li[(MeOCH₂CH₂O)₂AlH₂]. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Electric Literature of C14H11NO).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Electric Literature of C14H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Identification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro was written by Katane, Masumi;Osaka, Naoko;Matsuda, Satsuki;Maeda, Kazuhiro;Kawata, Tomonori;Saitoh, Yasuaki;Sekine, Masae;Furuchi, Takemitsu;Doi, Issei;Hirono, Shuichi;Homma, Hiroshi. And the article was included in Journal of Medicinal Chemistry in 2013.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid This article mentions the following:

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO. In the experiment, the researchers used many compounds, for example, 4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid).

4-Bromo-1H-indole-2-carboxylic acid (cas: 16732-64-2) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Application In Synthesis of 4-Bromo-1H-indole-2-carboxylic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis of a near-IR cyanine and its application in determination of biomolecules was written by Zheng, Hong;Li, Donghui;Chen, Qiuying;Xy, Jingou. And the article was included in Yingyong Huaxue in 1999.Product Details of 146368-07-2 This article mentions the following:

A novel water soluble near-IR cyanine dye (HMC) was synthesized and its structure was characterized by NMR and MS. The absorption and fluorescence spectral characteristics of HMC in aqueous solutions were also studied. It was found that in acidic solution of HMC the presence of protein could cause a hypochromic effect at 776 nm, that was used as a probe for the determination of total protein in human serum. The low fluorescence of in situ HMC dimer caused by cationic surfactant CTAB has been tested as a probe for nucleic acid determination In the experiment, the researchers used many compounds, for example, 1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2Product Details of 146368-07-2).

1-Ethyl-2,3,3-trimethyl-3H-indol-1-ium-5-sulfonate (cas: 146368-07-2) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Product Details of 146368-07-2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Carbon-13 delta shifts and steric interactions in N-Aryl-1-isoindolinones and -isoindoline-1,3-diones was written by Khadim, Mohammad A.;Colebrook, L. D.. And the article was included in Magnetic Resonance in Chemistry in 1985.Quality Control of 2-Phenylisoindolin-1-one This article mentions the following:

Consistently deshielding ¹³C 闂?shifts resulting from the presence of aryl ortho substituents are determined for the 3-methylene C atoms of N-aryl-1-isoindolinones (0.12-3.25 ppm) and for the C:O group C atoms of these compounds and corresponding N-arylisoindoline-1,3-diones (0.04-1.47 ppm). Low-temperature (-75 and -150 闂? ¹H NMR studies indicate that steric barriers to internal rotation about the aryl C-N bonds in the N-aryl-1-isoindolinones are low. The compounds with the bulkiest aryl ortho substituents tend to show the largest 闂?shifts (particularly for the 3-methylene C atoms). No consistent correlation with the size of aryl ortho-substituents or their expected electronic properties is evident. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Quality Control of 2-Phenylisoindolin-1-one).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Quality Control of 2-Phenylisoindolin-1-one

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Metabolomics-assisted discovery of a new anticancer GLS-1 inhibitor chemotype from a nortopsentin-inspired library: From phenotype screening to target identification was written by Carbone, Daniela;Vestuto, Vincenzo;Ferraro, Maria Rosalia;Ciaglia, Tania;Pecoraro, Camilla;Sommella, Eduardo;Cascioferro, Stella;Salviati, Emanuela;Novi, Sara;Tecce, Mario Felice;Amodio, Giuseppina;Iraci, Nunzio;Cirrincione, Girolamo;Campiglia, Pietro;Diana, Patrizia;Bertamino, Alessia;Parrino, Barbara;Ostacolo, Carmine. And the article was included in European Journal of Medicinal Chemistry in 2022.Product Details of 90271-86-6 This article mentions the following:

The enzyme glutaminase-1 (GLS-1) has shown a clear and coherent implication in the progression and exacerbation of different aggressive tumors such as glioblastoma, hepatocarcinoma, pancreas, bone, and triple-neg. breast cancer. Few chemotypes are currently available as selective GLS-1 inhibitors, and still, fewer of them are at the clin. stage. In the present paper, starting from a naturally-inspired antitumor compound library, metabolomics has been used to putatively identify the mol. mechanism underlying biol. activity. GLS-1 was identified as a potential target. Biochem. anal. confirmed the hypothesis leading to the identification of a new hit compound acting as a GLS-1 selective inhibitor (IC₅₀ = 3.96 闂?1.05 濠电偞鎸鹃幏?, compared to the GLS-2 isoform (IC₅₀ = 12.90 闂?0.87 濠电偞鎸鹃幏?, with remarkable antitumor potency over different aggressive tumor cell lines. Mol. modeling studies revealed new insight into the drug-target interaction providing robust SAR clues for the rational hit-to-lead development. The approach undertaken underlines the wide potential of metabolomics applied to drug discovery, particularly in target identification and hit discovery following phenotype screening. In the experiment, the researchers used many compounds, for example, 5-Bromo-3-cyanoindole (cas: 90271-86-6Product Details of 90271-86-6).

5-Bromo-3-cyanoindole (cas: 90271-86-6) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Product Details of 90271-86-6

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Preparation of Functionalized Arylmagnesium Reagents Bearing an o-Chloromethyl Group was written by Delacroix, Thomas;Berillon, Laurent;Cahiez, Gerard;Knochel, Paul. And the article was included in Journal of Organic Chemistry in 2000.Formula: C14H11NO This article mentions the following:

The selective iodine-magnesium exchange of 2-chloromethyl-1-iodobenzenes such as 3,2-I(ClCH₂)C₆H₃R (R = H CO₂Me) are reported. The resulting organomagnesium reagents 3,2-(BrMg)(ClCH₂)C₆H₃R (R = same as above) are synthetic equivalent of a zwitterionic synthon and prove to be well suited for participation in cyclization reactions. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Formula: C14H11NO).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole is an important structural motif of various drugs, therapeutic leads besides its prevalence in numerous natural products, agrochemicals, perfumery, and dyes.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.Formula: C14H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles