Tag: 200-300

Twisted intramolecular charge-transfer fluorescence of aromatic amides: conformation of the amide bonds in excited states was written by Azumaya, Isao;Kagechika, Hiroyuki;Fujiwara, Yoshihisa;Itoh, Michiya;Yamaguchi, Kentaro;Shudo, Koichi. And the article was included in Journal of the American Chemical Society in 1991.Electric Literature of C14H11NO This article mentions the following:

The mechanism of the dual fluorescence of benzanilide (I) and N-methylbenzanilide (II) in methylcyclohexane was investigated. The emission at longer wavelength is composed of one component for I (婵?sub>max 477 nm) and of one major component (96%, 婵?sub>max 518 nm) for II. Various substitutions on the aromatic rings permit the study of the F₂ fluorescence wavelength and intensity on twisting about the Ar-CO, the Ar-N, and the amide bond (N-CO) itself. Though the ground-state structures of I and II are very different from each other, the structures of the emitting species of both compounds are considered to be similar. Studies on conformationally restricted derivatives showed that the amide bond must be rotated for the emission of longer wavelength. Quant. data indicate that the F₂ emissions are generated from excited twisted intramol. charge-transfer (TICT) species with twisted amide bonds. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Electric Literature of C14H11NO).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. The indole subunit is an almost ubiquitous component of biologically active natural products, and its study has been the focus of research for decades. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Electric Literature of C14H11NO

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Defining the selectivity of processes along the auxin response chain: a study using auxin analogues was written by Simon, Sibu;Kubes, Martin;Baster, Pawel;Robert, Stephanie;Dobrev, Petre Ivanov;Friml, Jiri;Petrasek, Jan;Zazimalova, Eva. And the article was included in New Phytologist in 2013.Quality Control of 2-(5-Chloro-1H-indol-3-yl)acetic acid This article mentions the following:

The mode of action of auxin is based on its non-uniform distribution within tissues and organs. Despite the wide use of several auxin analogs in research and agriculture, little is known about the specificity of different auxin-related transport and signalling processes towards these compounds Using seedlings of Arabidopsis thaliana and suspension-cultured cells of Nicotiana tabacum (BY-2), the physiol. activity of several auxin analogs was investigated, together with their capacity to induce auxin-dependent gene expression, to inhibit endocytosis and to be transported across the plasma membrane. This study shows that the specificity criteria for different auxin-related processes vary widely. Notably, the special behavior of some synthetic auxin analogs suggests that they might be useful tools in investigations of the mol. mechanism of auxin action. Thus, due to their differential stimulatory effects on DR5 expression, indole-3-propionic (IPA) and 2,4,5-trichlorophenoxy acetic (2,4,5-T) acids can serve in studies of TRANSPORT INHIBITOR RESPONSE 1/AUXIN SIGNALLING F-BOX (TIR1/AFB)-mediated auxin signalling, and 5-fluoroindole-3-acetic acid (5-F-IAA) can help to discriminate between transcriptional and non-transcriptional pathways of auxin signalling. The results demonstrate that the major determinants for the auxin-like physiol. potential of a particular compound are very complex and involve its chem. and metabolic stability, its ability to distribute in tissues in a polar manner and its activity towards auxin signalling machinery. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Quality Control of 2-(5-Chloro-1H-indol-3-yl)acetic acid).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Due to this activity, the indole ring system has become an important component or intermediate in the synthesis of heterocycles.Quality Control of 2-(5-Chloro-1H-indol-3-yl)acetic acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Copper-Catalyzed Electrophilic Thiolation of Organozinc Halides by Using N-Thiophthalimides Leading to Polyfunctional Thioethers was written by Grassl, Simon;Hamze, Clemence;Koller, Thaddaeus J.;Knochel, Paul. And the article was included in Chemistry – A European Journal in 2019.Reference of 14204-27-4 This article mentions the following:

(Hetero)aryl, benzylic, and alkyl zinc halides were thiolated with N-thiophthalimides at 25 闂佺娅ｉ悡?within 1 h in the presence of 5-10 % Cu(OAc)₂闁荤姾娅ｉ弸?sub>2O to furnish the corresponding polyfunctionalized thioethers in good yields. This electrophilic thiolation was extended to the introduction of trifluoromethylthio (SCF₃), thiocyanate (SCN), and selenophenyl (SePh) groups. The utility of this method was shown in a seven-step synthesis of a potent cathepsin D inhibitor in 34% overall yield. In the experiment, the researchers used many compounds, for example, 2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4Reference of 14204-27-4).

2-(Phenylthio)isoindoline-1,3-dione (cas: 14204-27-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.Reference of 14204-27-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Structure-Guided Discovery of the Novel Covalent Allosteric Site and Covalent Inhibitors of Fructose-1,6-Bisphosphate Aldolase to Overcome the Azole Resistance of Candidiasis was written by Wen, Wuqiang;Cao, Hongxuan;Huang, Yunyuan;Tu, Jie;Wan, Chen;Wan, Jian;Han, Xinya;Chen, Han;Liu, Jiaqi;Rao, Li;Su, Chen;Peng, Chao;Sheng, Chunquan;Ren, Yanliang. And the article was included in Journal of Medicinal Chemistry in 2022.Related Products of 5388-42-1 This article mentions the following:

Fructose-1,6-bisphosphate aldolase (FBA) represents an attractive new antifungal target. Here, we employed a structure-based optimization strategy to discover a novel covalent binding site (C292 site) and the first-in-class covalent allosteric inhibitors of FBA from Candida albicans (CaFBA). Site-directed mutagenesis, liquid chromatog.-mass spectrometry, and the crystallog. structures of APO-CaFBA, CaFBA-G3P, and C157S-I revealed that S268 is an essential pharmacophore for the catalytic activity of CaFBA, and L288 is an allosteric regulation switch for CaFBA. Furthermore, most of the CaFBA covalent inhibitors exhibited good inhibitory activity against azole-resistant C. albicans, and compound II can inhibit the growth of azole-resistant strains 103 with the MIC₈₀ of 1濠电偞鎸鹃幐?mL. Collectively, this work identifies a new covalent allosteric site of CaFBA and discovers the first generation of covalent inhibitors for fungal FBA with potent inhibitory activity against resistant fungi, establishing a structural foundation and providing a promising strategy for the design of potent antifungal drugs. In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1Related Products of 5388-42-1).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. In addition to indole, the strain-release chemistry worked for numerous substrates including amines, alcohols, thiols, carboxylic acids, imidazoles, and pyrazoles.Related Products of 5388-42-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Crystal structure of 4-N-phenylisoindolinone, C₁₄H₁₁NO was written by Polamo, M.;Talja, M.. And the article was included in Zeitschrift fuer Kristallographie – New Crystal Structures in 2003.SDS of cas: 5388-42-1 This article mentions the following:

The title compound is monoclinic, space group P2₁/n, a 5.925(4), b 7.556(2), c 23.11(1) 闂? 闁?94.67(5)闂? Z = 4, Rgt(F) = 0.055, wRref(F²) = 0.140, T = 193 K. At. coordinates are given. The title compound, 4-N-phenylisoindolinone, has a slightly distorted sp2-hybridized nitrogen, the sum of angles at N1 is 359.1闂? Since the Ph ring is almost coplanar to the isoindolinone plane, 9.4(1)闂? a reasonable 闂?interaction could be expected. The bond length of N1-C1 is slightly shorter, 1.421(3) 闂? than in 2-[2,6-bis(1-methylethyl)phenyl]-2,3-dihydro-1H-isoindol-1-one, 1.428(2) 闂? in which 闂?interaction can not exist because the aryl ring adopts perpendicular orientation to the isoindolinone part of the mol. The 闂?interaction of the nitrogen to the Ph ring might also explain the weaker interaction of the nitrogen to the carbonyl group; N1-C2 bond is 1.376(3) 闂? whereas in 2-[2,6-bis(1-methylethyl)phenyl]-2,3-dihydro-1H-isoindol-1-one bond length is 1.358(2) 闂? In the experiment, the researchers used many compounds, for example, 2-Phenylisoindolin-1-one (cas: 5388-42-1SDS of cas: 5388-42-1).

2-Phenylisoindolin-1-one (cas: 5388-42-1) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles.Indole was synthesized in moderate yield via an o-naphthoquinone catalyzed tandem cross-coupling of substituted aniline and benzylamine under aerobic oxidation conditions.SDS of cas: 5388-42-1

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

The effect of chloro-derivatives of indoleacetic acid on plasma membrane electron transport and proton excretion was written by Barr, Rita;Boettger, Michael;Crane, Frederick L.. And the article was included in Proceedings of the Indiana Academy of Science in 1991.Synthetic Route of C10H8ClNO2 This article mentions the following:

As shown by M. Boettger and H. Hilgendorf (1988), the natural auxin indoleacetic acid in high concentrations (10 濠电偞鎸鹃幏? inhibited both e^– and proton efflux by corn roots of undamaged plants measured with a pH-stat combined with a redoxstat. In this study, it is shown that of various chloro-substituted indoleacetic acid derivatives, only 4-chloro-IAA inhibited NADH oxidation and several derivatives stimulated trans-membrane hexacyanoferrate reduction in concentrations from 0.1 nM to 10 濠电偞鎸鹃幏?in cultured carrot cells. Proton excretion by these cells was also stimulated by 5-, 6- and 5,7-chloro substituted indoleacetic acid, but the 4-chloro derivative inhibited H⁺ excretion by the plasma membrane H⁺-ATPase, while H⁺ excretion in presence of hexacyanoferrate was stimulated. These divergent effects of chloro-substituted indoleacetic acid derivatives show that the trans-membrane redox system is not directly related to proton movement through the membrane in a 1:1 relationship. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Synthetic Route of C10H8ClNO2).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole exists overwhelmingly in the 1H-indole form as do other simple indoles. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings.Synthetic Route of C10H8ClNO2

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Classical QSAR modelling of Indole-3-acetic acids for cancer therapy was written by Soni, Love Kumar. And the article was included in International Journal of ChemTech Research in 2012.Recommanded Product: 1912-45-4 This article mentions the following:

A set of 26 compound of the series halogenated Indole-3-acetic acids as oxidatively activate prodrugs with potential for targeted cancer therapy were subjected to quant. structure activity relationship (QSAR) anal. using combination of various electronic, thermodn. and spatial descriptors. Several statistical regression equations were obtained using multiple regression anal. QSAR anal. showed that the cytotoxin produced from oxidation of IAA with horseradish peroxidase (HRP) have significant correlation with electronic (Energy of Highest MO), and thermodn. (Non-1, 4-VDW energy, Henry law constant) properties of the mol. QSAR anal. suggests that substitution with electron withdrawing and bulkier group is more favorable for inhibitory activity. In the experiment, the researchers used many compounds, for example, 2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4Recommanded Product: 1912-45-4).

2-(5-Chloro-1H-indol-3-yl)acetic acid (cas: 1912-45-4) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. They are capable of binding to a variety of receptors with high affinity and thus have applications in a wide range of therapeutic areas.Recommanded Product: 1912-45-4

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization was written by Niemeyer, Zachary L.;Pindi, Suresh;Khrakovsky, Dimitri A.;Kuzniewski, Christian N.;Hong, Cynthia M.;Joyce, Leo A.;Sigman, Matthew S.;Toste, F. Dean. And the article was included in Journal of the American Chemical Society in 2017.Safety of 4-Bromoindole-3-acetic Acid This article mentions the following:

Computed descriptors for acyclic diaminocarbene ligands are developed in the context of a gold catalyzed enantioselective tandem [3,3]-sigmatropic rearrangement-[2+2]-cyclization. Surrogate structures enable the rapid identification of parameters that reveal mechanistic characteristics. The observed selectivity trends are validated in a robust multivariate anal. facilitating the development of a highly enantioselective process. In the experiment, the researchers used many compounds, for example, 4-Bromoindole-3-acetic Acid (cas: 89245-41-0Safety of 4-Bromoindole-3-acetic Acid).

4-Bromoindole-3-acetic Acid (cas: 89245-41-0) belongs to indole derivatives. Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Safety of 4-Bromoindole-3-acetic Acid

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Novel cyclopropapyrroloindole (CPI) bisalkylators bearing methoxycarbonyl and trifluoromethyl groups was written by Fukuda, Yasumichi;Furuta, Hirosuke;Kusama, Yoshie;Ebisu, Hiroyuki;Oomori, Yasuo;Terashima, Shiro. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1998.Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate This article mentions the following:

Novel 3-(methoxycarbonyl)-2-(trifluoromethyl)cyclopropapyrroloindole (MCTFCPI) bisalkylators were synthesized, and their antitumor activity was evaluated. Among these derivatives, I was found to exhibit more prominent cytotoxicity and antitumor activity than U-77,779 (bizelesin). In the experiment, the researchers used many compounds, for example, Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate).

Methyl 5-bromo-1H-indole-2-carboxylate (cas: 210345-56-5) belongs to indole derivatives. In addition to tryptophan, indigo, and indoleacetic acid, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. Moreover, it is known that it controls biofilm formation. However, the role of indole in the cell has not been fully elucidated.Recommanded Product: Methyl 5-bromo-1H-indole-2-carboxylate

Referemce:
Indole alkaloid derivatives as building blocks of natural products from闂佽壈浜崹淇沜illus thuringiensis闂佽壈浜粋鍧闂佽壈浜崹淇沜illus velezensis闂佽壈浜粋鍧 their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles