Tag: 205.1669

Isatincarboxylic acid was written by Waldmann, Hans. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1937.HPLC of Formula: 103030-10-0 This article mentions the following:

o-H₂NC₆H₄CO₂Me (31.5 g.), 35 g. Cl₃CCHO.H₂O, 54 g. NH₂OH.H₂SO₄ and 25 g. H₂SO₄ in 1400 g. H₂O, heated 8 min., give Me isonitrosoacetoanthranilate (I), m. 180掳. Isonitrosoaceto-p-aminobenzoic acid does not m. 310掳 (Me ester (II), m. 231掳); m-isomer (III), m. 228掳. Addition of I in small portions to concentrated H₂SO₄ at 70掳 and then warming for 10 min. at 80掳 gives the Me ester, yellow, m. 192掳, of isatin-7- carboxylic acid, orange, m. 276-7掳 (Sandmeyer, C. A. 13, 1840, gives 235掳); cold alkali gives a blood-red color, disappearing in a short time; with PhAc in EtOH-33% KOH (heating 6 hrs. at 100掳) there results 2-phenylquinoline-4,8-dicarboxylic acid, pale yellow, does not melt 310掳. Isatin-5-carboxylic acid, orange-yellow, m. 292-3掳 (decomposition), results from II and concentrated H₂SO₄, purification of which is complicated by the presence of the oxime, yellow, decomposes 282掳 (Me ester, yellow, m. 264掳; oxime, decomposes 280掳); 2-phenylquinoline-4,6- dicarboxylic acid does not m. at 310掳. III gives isatin-6- carboxylic acid, orange, m. 292掳 (decomposition)(Me ester, orange-yellow, m. 209掳). In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0HPLC of Formula: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.SDS of cas: 103030-10-0 This article mentions the following:

A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH₃, 5-Cl, 5-Br, 5-NO₂, 7-NO₂, 7-CH₃] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC₅₀ values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC₅₀ values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0SDS of cas: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from聽Bacillus thuringiensis聽and聽Bacillus velezensis聽and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isatincarboxylic acid was written by Waldmann, Hans. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1937.HPLC of Formula: 103030-10-0 This article mentions the following:

o-H₂NC₆H₄CO₂Me (31.5 g.), 35 g. Cl₃CCHO.H₂O, 54 g. NH₂OH.H₂SO₄ and 25 g. H₂SO₄ in 1400 g. H₂O, heated 8 min., give Me isonitrosoacetoanthranilate (I), m. 180°. Isonitrosoaceto-p-aminobenzoic acid does not m. 310° (Me ester (II), m. 231°); m-isomer (III), m. 228°. Addition of I in small portions to concentrated H₂SO₄ at 70° and then warming for 10 min. at 80° gives the Me ester, yellow, m. 192°, of isatin-7- carboxylic acid, orange, m. 276-7° (Sandmeyer, C. A. 13, 1840, gives 235°); cold alkali gives a blood-red color, disappearing in a short time; with PhAc in EtOH-33% KOH (heating 6 hrs. at 100°) there results 2-phenylquinoline-4,8-dicarboxylic acid, pale yellow, does not melt 310°. Isatin-5-carboxylic acid, orange-yellow, m. 292-3° (decomposition), results from II and concentrated H₂SO₄, purification of which is complicated by the presence of the oxime, yellow, decomposes 282° (Me ester, yellow, m. 264°; oxime, decomposes 280°); 2-phenylquinoline-4,6- dicarboxylic acid does not m. at 310°. III gives isatin-6- carboxylic acid, orange, m. 292° (decomposition)(Me ester, orange-yellow, m. 209°). In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0HPLC of Formula: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.SDS of cas: 103030-10-0 This article mentions the following:

A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH₃, 5-Cl, 5-Br, 5-NO₂, 7-NO₂, 7-CH₃] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC₅₀ values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC₅₀ values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0SDS of cas: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Isatincarboxylic acid was written by Waldmann, Hans. And the article was included in Journal fuer Praktische Chemie (Leipzig) in 1937.HPLC of Formula: 103030-10-0 This article mentions the following:

o-H₂NC₆H₄CO₂Me (31.5 g.), 35 g. Cl₃CCHO.H₂O, 54 g. NH₂OH.H₂SO₄ and 25 g. H₂SO₄ in 1400 g. H₂O, heated 8 min., give Me isonitrosoacetoanthranilate (I), m. 180°. Isonitrosoaceto-p-aminobenzoic acid does not m. 310° (Me ester (II), m. 231°); m-isomer (III), m. 228°. Addition of I in small portions to concentrated H₂SO₄ at 70° and then warming for 10 min. at 80° gives the Me ester, yellow, m. 192°, of isatin-7- carboxylic acid, orange, m. 276-7° (Sandmeyer, C. A. 13, 1840, gives 235°); cold alkali gives a blood-red color, disappearing in a short time; with PhAc in EtOH-33% KOH (heating 6 hrs. at 100°) there results 2-phenylquinoline-4,8-dicarboxylic acid, pale yellow, does not melt 310°. Isatin-5-carboxylic acid, orange-yellow, m. 292-3° (decomposition), results from II and concentrated H₂SO₄, purification of which is complicated by the presence of the oxime, yellow, decomposes 282° (Me ester, yellow, m. 264°; oxime, decomposes 280°); 2-phenylquinoline-4,6- dicarboxylic acid does not m. at 310°. III gives isatin-6- carboxylic acid, orange, m. 292° (decomposition)(Me ester, orange-yellow, m. 209°). In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0HPLC of Formula: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole produced by Proteus, Pseudomonas, Escherichia and other species was shown to be a growth promoting factor in Arabidopsis thaliana. Indole plays a fundamental role for QS in E. coli, being one of the signal molecules responsible for the transcription of a variety of genes (gabT, and tnaB ASTD). HPLC of Formula: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Synthesis and characterization of cytotoxic activity of certain n-(6-benzoyl-1H-benzo [d] imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides was written by Rani, B. Shoba;Priyanka, K. Blessi;Sammaiah, G.. And the article was included in International Journal of Pharmacy and Biological Sciences in 2014.SDS of cas: 103030-10-0 This article mentions the following:

A series of N-(6-benzoyl-1H-benzo[d]imidazol-2-yl)-2-(2-oxoindolin-3-ylidene) hydrazine carboxamides I [R = H, 5-CH₃, 5-Cl, 5-Br, 5-NO₂, 7-NO₂, 7-CH₃] were synthesized by treating (5-benzoyl-1H-benzo[d]imidazol-2-yl) carbamates II with different substituted isatins. All the synthesized derivatives I were screened for anticancer activity against Hela using MTT assay and produced a dose dependent inhibition of growth of the cells. The IC₅₀ values of all the synthetic test compounds were found between 16.03 to 41.75. The potency of (IC₅₀ values) of cytotoxicity of compounds was compared with that of known cytotoxic agent, Cisplatin. Among all the synthesized novel compound I (R = 5-Cl) showed the most potent activity against MCF-7 cell lines. In the experiment, the researchers used many compounds, for example, Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0SDS of cas: 103030-10-0).

Methyl 2,3-dioxoindoline-7-carboxylate (cas: 103030-10-0) belongs to indole derivatives. Indole, first isolated in 1866, and it is commonly synthesized from phenylhydrazine and pyruvic acid, although several other procedures have been discovered. More than 200 indole derivatives have already been marketed as drugs or are under advanced stages of clinical trials.SDS of cas: 103030-10-0

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles