32996-16-0, Ethyl 1H-indole-5-carboxylate is a indole-building-block compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated
General procedure: A solution of the appropriate ethyl or methyl esters 21a-d (1.0 mmol) in methanol (5 mL) was prepared in a 10 mL CEM microwave vessel. Hydrazine hydrate 50% (5.0 mmol) was added, the vessel was capped and placed in a microwave reactor and the reaction carried out with the following method in dynamic mode: 140 C, 60 min, 100 W, with high stirring. After completion the reaction mixture was transferred to a round bottom flask and the solvent evaporated under reduced pressure. The crude product was transferred to an Erlenmeyer flask and suspended in dichloromethane, heated at 50 C for 5 min, rapidly vacuum filtered and washed with the same solvent, to obtain the pure product (yield 80-90%). When the product was found to be still not pure, the purification procedure was repeated.
32996-16-0 Ethyl 1H-indole-5-carboxylate 10987040, aindole-building-block compound, is more and more widely used in various.
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Article; Rupiani, Sebastiano; Buonfiglio, Rosa; Manerba, Marcella; Di Ianni, Lorenza; Vettraino, Marina; Giacomini, Elisa; Masetti, Matteo; Falchi, Federico; Di Stefano, Giuseppina; Roberti, Marinella; Recanatini, Maurizio; European Journal of Medicinal Chemistry; vol. 101; (2015); p. 63 – 70;,
Indole alkaloid derivatives as building blocks of natural products from?Bacillus thuringiensis?and?Bacillus velezensis?and their antibacterial and antifungal activity study
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles