M.W=100-150 | - Page 10 of 348 - Indole Building Blocks

Faltracco, Matteo team published research on Advanced Synthesis & Catalysis in 2022 | 19005-93-7

COA of Formula: C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. COA of Formula: C9H7NO.

Faltracco, Matteo;Strahler, Sebastian;Snabilie, Demi;Ruijter, Eelco research published 《 Synthesis of Diverse Heterocyclic Scaffolds by (3+3) and (3+4) Cycloannulations of Donor-Acceptor Vinylcyclopropanes》, the research content is summarized as follows. Palladium-catalyzed (3+3) and (3+4) cycloannulations between vinylcyclopropanes and various (hetero)aromatic aldehydes are reported. The use of phosphonate-substituted vinylcyclopropanes provides access to a variety of bi- or tricyclic heteroaromatic scaffolds via an allylation/olefination cascade. The nature of the mechanism was investigated by various control experiments

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Chen, Qinfang team published research on RSC Advances in 2020 | 19005-93-7

Electric Literature of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Chen, Qinfang;Pan, Yihao;Zhao, Dongxin;Yang, Weiran;Zheng, Jing research published 《 Construct indeno[1,2-b]oxepine or cis-cyclopropylacrylate by sulfur ylides》, the research content is summarized as follows. For the first time, the [4 + 3] or [2 + 1] annulation of crotonate-derived sulfur ylides with arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione was reported using Na₂CO₃ as the base. This protocol was advantageous as it does not require prior preparation of arylidenemalononitrile or arylidene-1H-indene-1,3(2H)-dione substrates, due to the independent participation of the base in the two reactions. This mild, operationally multicomponent process could be employed for the transformation of a wide variety of com. available aldehydes into the corresponding indeno[1,2-b]oxepines I [R = H, 4-CNC₆H₄, 2-OMeC₆H₄, etc.; R¹ = Me, Et] or cyclopropyl acrylate core II in moderate to excellent yields under mild conditions.

Chen, Zhen team published research on Bioorganic & Medicinal Chemistry Letters in 2020 | 19005-93-7

Reference of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. Reference of 19005-93-7.

Chen, Zhen;Hou, Lu;Gan, Jiefeng;Cai, Qijun;Ye, Weijian;Chen, Jiahui;Tan, Zhiqiang;Zheng, Chao;Li, Guocong;Xu, Hao;Fowler, Christopher J.;Liang, Steven H.;Wang, Lu research published 《 Synthesis and preliminary evaluation of a novel positron emission tomography (PET) ligand for imaging fatty acid amide hydrolase (FAAH)》, the research content is summarized as follows. Fatty acid amide hydrolase (FAAH) exerts its main function in the catabolism of the endogenous chem. messenger anandamide (AEA), thus modulating the endocannabinoid (eCB) pathway. Inhibition of FAAH may serve as an effective strategy to relieve anxiety and possibly other central nervous system (CNS)-related disorders. Positron emission tomog. (PET) would facilitate us to better understand the relationship between FAAH in certain disease conditions, and accelerate clin. translation of FAAH inhibitors by providing in vivo quant. information. So far, most PET tracers show irreversible binding patterns with FAAH, which would result in complicated quant. processes. Herein, we have identified a new FAAH inhibitor (1-((1-methyl-1H-indol-2-yl)methyl)piperidin-4-yl)(oxazol-2-yl)methanone (8) which inhibits the hydrolysis of AEA in the brain with high potency (IC₅₀ value 11 nM at a substrate concentration of 0.5μM), and without showing time-dependency. The PET tracer [¹¹C]8 (also called [¹¹C]FAAH-1906) was successfully radiolabeled with [¹¹C]MeI in 17 ± 6% decay-corrected radiochem. yield (n = 7) with >74.0 GBq/μmol (2 Ci/μmol) molar activity and >99% radiochem. purity. Ex vivo biodistribution and blocking studies of [¹¹C]8 in normal mice were also conducted, indicating good brain penetration, high brain target selectivity, and modest to excellent target selectivity in peripheral tissues. Thus, [¹¹C]8 is a potentially useful PET ligand with enzyme inhibitory and target binding properties consistent with a reversible mode of action.

Cho, Hye Jin team published research on ACS Applied Materials & Interfaces in 2021 | 19005-93-7

19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Synthetic Route of 19005-93-7

In addition to indoleacetic acid, indigo, and tryptophan, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families. Synthetic Route of 19005-93-7.

Cho, Hye Jin;Kim, Kyung-su;Kim, Hyunwoo;Kim, Taewoo;Malyutin, Andrey G.;Rees, Douglas C.;Yoo, Byung-Kuk;Song, Changsik research published 《 Microcrystal Electron Diffraction Elucidates Water-Specific Polymorphism-Induced Emission Enhancement of Bis-arylacylhydrazone》, the research content is summarized as follows. Aggregation-induced emission (AIE) phenomena have gained intense interest over the last decades because of its importance in solid-state emission. However, the elucidation of a working mechanism is difficult owing to the limited characterization methods on solid-state mols., further complicated if dynamic structural changes occur. Here, a series of bis-arylacylhydrazones (BAHs) were synthesized, for which their AIE properties are only turned on by the reversible adsorption of water mols. We used microcrystal electron diffraction (MicroED) to determine the mol. structures of two BAHs directly from bulk powders (without attempting to grow crystals) prepared in the absence or presence of water adsorption. This study reveals the unambiguous characterization of the dependence of crystal packing on the specific cocrystn. with hydrates. The structural anal. demonstrates that water mols. form strong hydrogen bonds with three neighboring BAH-1, resulting in the almost complete planarization and restriction of the intramol. rotation of the mol. MicroED plays an important role in providing a decisive clue for the reversible polymorphism changes induced by the adsorption of water mols., regulating emissive properties.

Cui, Peipei team published research on Scientific Reports in 2022 | 19005-93-7

Cui, Peipei;Cai, Mingjiang;Meng, Yanan;Yang, Yan;Song, Hongjian;Liu, Yuxiu;Wang, Qingmin research published 《 Design, synthesis and biological activities of echinopsine derivatives containing acylhydrazone moiety》, the research content is summarized as follows. Based on the broad-spectrum biol. activities of echinopsine and acylhydrazones, a series of echinopsine derivatives containing acylhydrazone moieties I (R = C₆H₅, 4-MeSC₆H₄, 4-BrC₆H₄, etc.) have been designed, synthesized and their biol. activities were evaluated for the first time. The bioassay results indicated that most of the compounds showed moderate to good antiviral activities against tobacco mosaic virus (TMV), among which echinopsine (I) (inactivation activity, 49.5 +/- 4.4%; curative activity, 46.1 +/- 1.5%; protection activity, 42.6 +/- 2.3%) and its derivatives I (R = C₆H₅) (inactivation activity, 44.9 +/- 4.6%; curative activity, 39.8 +/- 2.6%; protection activity, 47.3 ± 4.3%), I (R = 4-t-BuC₆H₄) (inactivation activity, 47.9 +/- 0.9%; curative activity, 43.7 +/- 3.1%; protection activity, 44.6 +/- 3.3%), I (R = 4-PhC₆H₅) (inactivation activity, 46.2 +/- 1.6%; curative activity, 45.0 +/- 3.7%; protection activity, 41.7 +/- 0.9%) showed higher anti-TMV activity in vivo at 500 mg/L than com. ribavirin (inactivation activity, 38.9 +/- 1.4%; curative activity, 39.2 +/- 1.8%; protection activity, 36.4 +/- 3.4%). Some compounds exhibited insecticidal activities against Plutella xylostella, Mythimna sep. and Spodoptera frugiperda. Especially, compounds I (R = 4-PhC₆H₅, anthracen-9-yl) displayed excellent insecticidal activities against Plutella xylostell even at 0.1 mg/L. Addnl., most echinopsine derivatives exhibited high fungicidal activities against Physalospora piricola and Sclerotinia sclerotiorum.

Dawidowski, Maciej team published research on Journal of Medicinal Chemistry in 2020 | 19005-93-7

Dawidowski, Maciej;Kalel, Vishal C.;Napolitano, Valeria;Fino, Roberto;Schorpp, Kenji;Emmanouilidis, Leonidas;Lenhart, Dominik;Ostertag, Michael;Kaiser, Marcel;Kolonko, Marta;Tippler, Bettina;Schliebs, Wolfgang;Dubin, Grzegorz;Maeser, Pascal;Tetko, Igor V.;Hadian, Kamyar;Plettenburg, Oliver;Erdmann, Ralf;Sattler, Michael;Popowicz, Grzegorz M. research published 《 Structure-Activity Relationship in Pyrazolo[4,3-c]pyridines, First Inhibitors of PEX14-PEX5 Protein-Protein Interaction with Trypanocidal Activity》, the research content is summarized as follows. Trypanosoma protists are pathogens leading to a spectrum of devastating infectious diseases. The range of available chemotherapeutics against Trypanosoma is limited, and the existing therapies are partially ineffective and cause serious adverse effects. Formation of the PEX14-PEX5 complex is essential for protein import into the parasites’ glycosomes. This transport is critical for parasite metabolism and failure leads to mislocalization of glycosomal enzymes, with fatal consequences for the parasite. Hence, inhibiting the PEX14-PEX5 protein-protein interaction (PPI) is an attractive way to affect multiple metabolic pathways. Herein, we have used structure-guided computational screening and optimization to develop the first line of compounds that inhibit PEX14-PEX5 PPI. The optimization was driven by several X-ray structures, NMR binding data, and mol. dynamics simulations. Importantly, the developed compounds show significant cellular activity against Trypanosoma, including the human pathogen Trypanosoma brucei gambiense and Trypanosoma cruzi parasites.

Duan, Xiao-Yong team published research on Organic Letters in 2021 | 19005-93-7

Duan, Xiao-Yong;Tian, Zhaohui;Liu, Binghao;He, Tao;Zhao, Liang-Liang;Dong, Mengdie;Zhang, Pengna;Qi, Jing research published 《 Highly Enantioselective Synthesis of Pyrroloindolones and Pyrroloquinolinones via an N-Heterocyclic Carbene-Catalyzed Cascade Reaction》, the research content is summarized as follows. In this work, the NHC-catalyzed Michael/Mannich/lactamization cascade reaction of enals with either indole-2-carboxaldehyde-derived aldimines or indole-7-carboxaldehyde-derived aldimines is described. This protocol enables the rapid assembly of optically active pyrroloindolones, e.g., I, and pyrroloquinolinones derivatives, e.g., II, under mild conditions with high yields, excellent enantioselectivities, and a broad substrate scope.

Chen, Cong team published research on Organic & Biomolecular Chemistry in 2022 | 19005-93-7

SDS of cas: 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Chen, Cong;Jiao, Hongjian;Chen, Di;Tang, Tao;Xu, Ze-Feng;Duan, Shengguo;Li, Chuan-Ying research published 《 Access to tetrahydrocarbazoles and pyrrolo[3,4-b]carbazoles through sequential reactions of triazoles and indoles》, the research content is summarized as follows. Tetrahydrocarbazoles I (R = H, Me; R¹ = H, OMe, F, Cl, etc.; R² = H, Me; R³ = H, Me; R⁴ = Me, allyl; R⁵ = Et, t-Bu; R⁶ = Me, Ts, benzenesulfonyl, etc.; R⁷ = Ac, Boc, Bz, etc.) and pyrrolo[3,4-b]carbazoles II could be synthesized conveniently through sequential reactions of ester-tethered 1-sulfonyl-1,2,3-triazoles III and indoles IV. The reaction conditions were mild and the procedures were quite simple. Moreover, the key intermediate α,β-unsaturated imine acted as a [2C] synthon in the [4 + 2] cycloaddition reaction, and the imino group could be used as a nucleophile to construct the fourth ring.

Datta, Riya team published research on Indian Journal of Chemistry in 2021 | 19005-93-7

Application of C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). Application of C9H7NO.

Jacob, Biju;Datta, Riya research published 《 Synthesis, characterization and antimicrobial studies of novel Schiff bases and their complexes》, the research content is summarized as follows. Novel Schiff bases, Furan-2-carboxylic acid pyridin-4-ylmethyleneamide, and Thiophene-2-carboxylic acid 1H-indol-2-ylmethyleneamide and their mononuclear Ni(II) and Cu(II) complexes have been synthesized and characterized by elemental anal., molar conductance, UV-visible, FT-IR, ¹H NMR and EPR spectroscopy. The complexes are nonelectrolytes as evidenced from the molar conductance vaules. The ligands and their complexes have been tested for their antimicrobial activity against one gram pos. bacteria, Bacillus subtilis, gram neg. bacteria, Escherichia coli and fungi Candida albicans. It is found that metal complexes exhibited more activity than the free ligand.

Abdelkafi, Hajer team published research on Journal of Medicinal Chemistry in 2020 | 19005-93-7

Abdelkafi, Hajer;Michau, Aurelien;Pons, Valerie;Ngadjeua, Flora;Clerget, Alexandra;Ait Ouarab, Lilia;Buisson, David-Alexandre;Montoir, David;Caramelle, Lucie;Gillet, Daniel;Barbier, Julien;Cintrat, Jean-Christophe research published 《 Structure-Activity Relationship Studies of Retro-1 Analogues against Shiga Toxin》, the research content is summarized as follows. High-throughput screening has shown that Retro-1 inhibits ricin and Shiga toxins by diminishing their intracellular trafficking via the retrograde route, from early endosomes to the Golgi apparatus To improve the activity of Retro-1, a structure-activity relationship (SAR) study was undertaken and yielded an analog with a roughly 70-fold better half-maximal effective concentration (EC₅₀) against Shiga toxin cytotoxicity measured in a cell protein synthesis assay.