M.W=100-150 | - Page 2 of 348 - Indole Building Blocks

Zhou, Yiming team published research on Organic Letters in 2021 | 19005-93-7

19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., COA of Formula: C9H7NO

Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). COA of Formula: C9H7NO.

Zhou, Yiming;Li, Ning;Cai, Wei;Huang, You research published 《 Asymmetric Sequential Corey-Chaykovsky Cyclopropanation/Cloke-Wilson Rearrangement for the Synthesis of 2,3-Dihydrofurans》, the research content is summarized as follows. The first sequential Corey-Chaykovsky cyclopropanation/Cloke-Wilson rearrangement between propargyl sulfonium salts and acrylonitrile derivatives was developed, affording the tetra-substituted 2,3-dihydrofurans in generally excellent yields (57-98%) with good diastereoselectivities (7:1-18:1). In addition, chiral propargyl sulfonium salt is also suitable for this strategy, giving the optically active 2,3-dihydrofurans with good enantioselectivities. This reaction sequence was designed upon in situ generated 10π-conjugated structures from the dearomatization of indole fragments and subsequent intramol. 1,6-addition

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xu, Liangxuan team published research on Organic Chemistry Frontiers in 2022 | 19005-93-7

Electric Literature of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

In addition to indoleacetic acid, indigo, and tryptophan, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families. Electric Literature of 19005-93-7.

Xu, Liangxuan;Hu, Yue;Zhu, Xiang;He, Lin;Wu, Qing;Li, Chen;Xia, Chungu;Liu, Chao research published 《 Momentary click nitrile synthesis enabled by an aminoazanium reagent》, the research content is summarized as follows. Momentary and selective Schmidt-type nitrile synthesis was reported. The success of this achievement was ascribed to the employment of the stable and robust aminoazanium reagent H₂N-DABCO. A broad range of functionalized aldehydes were efficiently converted to nitriles within 5 min at room temperature in air. The robustness and speed of the protocol allow the CHO group to be regarded as a CN equivalent in organic synthesis. Moreover, the synthetic advantage of this developed protocol is further highlighted via the direct cyanation of a diversity of aldehyde precursors (carboxylic acids, aromatics, aryl halides, alkenes and alkynes) in a cyanide-free process. Addnl., this protocol can not only be used for rapid access to a wide range of ligands and material precursors, but it can also be used in the late-stage modification of complex bioactive mols.

Xu, Shi-Ming team published research on Nature Communications in 2019 | 19005-93-7

HPLC of Formula: 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Xu, Shi-Ming;Wei, Liang;Shen, Chong;Xiao, Lu;Tao, Hai-Yan;Wang, Chun-Jiang research published 《 Stereodivergent assembly of tetrahydro-γ-carbolines via synergistic catalytic asymmetric cascade reaction》, the research content is summarized as follows. An expedient and stereodivergent assembly of tetrahydro-γ-carbolines I [R = Ph, 4-ClC₆H₄, 2-furanyl, etc.; R¹ = H, Me, Bn, etc.; R² = H, 4-Me, 5-Cl, etc.] with remarkably high levels of stereoselective control in an efficient cascade process from aldimine esters and indolyl allylic carbonates via a synergistic Cu/Ir catalyst system was reported. Control experiments-guided optimization of synergistic catalysts and mechanistic investigations reveal that a stereodivergent allylation reaction and a subsequent highly stereoselective iso-Pictet-Spengler cyclization were the key elements to success.

Yang, Han team published research on ACS Omega in 2021 | 19005-93-7

Recommanded Product: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Yang, Han;Poznik, Michal;Tang, Shaojian;Xue, Peng;Du, Lidong;Liu, Chenlu;Chen, Xiaochuan;Chruma, Jason J. research published 《 Synthesis of Conformationally Liberated Yohimbine Analogues and Evaluation of Cytotoxic Activity》, the research content is summarized as follows. A modular synthetic approach to strategically unique structural analogs of the alkaloid yohimbine is reported. The overall synthetic strategy couples the transition-metal-catalyzed decarboxylative allylation of 2,2-diphenylglycinate imino esters with a scandium triflate-mediated highly endo-selective intramol. Diels-Alder (IMDA) cycloaddition to generate a small collection of de-rigidified yohimbine analogs lacking the ethylene linkage between the indole and decahydroisoquinoline units. One compound generated in this study contains an unprecedented pentacyclic urea core and appears to demonstrate increased cytotoxicity against the gastric cancer cell line SGC-7901 in comparison to a pancreatic cancer cell line (PATU-8988) and a normal human gastric mucosal cell line (GES-1).

Yang, Lei team published research on Tetrahedron Letters in 2020 | 19005-93-7

Yang, Lei;Chen, Xuan;Ni, Kaidong;Li, Yuansheng;Wu, Jianhong;Chen, Weilin;Ji, Yin;Feng, Lili;Li, Fei;Chen, Dongyin research published 《 Proton-exchanged montmorillonite-mediated reactions of hetero-benzyl acetates: Application to the synthesis of Zafirlukast》, the research content is summarized as follows. Proton-exchanged montmorillonite (H-mont) with outstanding surface characteristics can provide abundant acidic sites in the mesoporous, and serve as an efficient heterogeneous catalyst for the synthesis of heterocycle-containing diarylmethanes via Friedel-Crafts-like alkylation of (hetero)arenes by heterobenzyl acetates under mild reaction conditions without requiring any additives or an inert atm. Using this strategy, the gram-scale synthesis of indole-containing diarylmethane I has been accomplished in good yield for the preparation of Zafirlukast. In addition, H-mont can be applied to the nucleophilic substitution reactions of heterobenzyl acetate II with a variety of alcs. and 1,3-dicarbonyl compounds

You, Min team published research on Chemical Physics in 2019 | 19005-93-7

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. HPLC of Formula: 19005-93-7.

You, Min;Fan, Haoran;Wang, Yang;Zhang, Wenkai research published 《 Aldehyde-derivatized indoles as fluorescent probes for hydration environments》, the research content is summarized as follows. Tryptophan derivatives have long been used as site-specific fluorescent probes. 4-cyanotryptophan emits in the visible region and is the smallest blue fluorescent amino acid probe. We performed UV-Vis, steady-state and time-resolved fluorescence spectroscopy on six aldehyde-derivatized indoles dissolved in water and found that indole-4-carboxaldehyde (I4A) has the largest red shifts among all reported indole derivatives and can emit in the green region of the visible spectrum, which suggests that substitution of the indole ring of Trp using I4A may make a green fluorescent amino acid probe. It differs from tryptophan by only 3 atoms and will be the smallest green fluorescent amino acid probe that has great potential to be used in spectroscopic and microscopic measurements of proteins. We also found that I4A could be used as a fluorescent probe to detect trace water in organic solvents since its maximum emission wavelength is extremely sensitive to local hydrogen-bonding status.

Yu, Bangkui team published research on Journal of the American Chemical Society in 2020 | 19005-93-7

Product Details of C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Yu, Bangkui;Zou, Suchen;Liu, Hongchi;Huang, Hanmin research published 《 Palladium-Catalyzed Ring-Closing Reaction via C-N Bond Metathesis for Rapid Construction of Saturated N-Heterocycles》, the research content is summarized as follows. The ring-closing reactions based on chem. bond metathesis enable the efficient construction of a wide variety of cyclic systems which receive broad interest from medicinal and organic communities. However, the analogous reaction with C-N bond metathesis as a strategic fundamental step remains an unanswered challenge. Herein, we report the design of a new fundamental metallic C-N bond metathesis reaction that enables the palladium-catalyzed ring-closing reaction of aminodienes with aminals. The reactions proceed efficiently under mild conditions and exhibit broad substrate generality and functional group compatibility, leading to a wide variety of 5- to 16-membered N-heterocycles bearing diverse frameworks and functional groups.

Wang, Chao team published research on Advanced Synthesis & Catalysis in 2021 | 19005-93-7

Application In Synthesis of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Wang, Chao;Rui, Xiyan;Si, Dongjuan;Dai, Rupeng;Zhu, Yueyue;Wen, Hongmei;Li, Wei;Liu, Jian research published 《 Copper-Catalyzed Three-Component Cascade Reaction of Benzaldehyde with Benzylamine and Hydroxylamine or Aniline: Synthesis of 1,2,4-Oxadiazoles and Quinazolines》, the research content is summarized as follows. The analogous three-component synthesis strategy for substituted 1,2,4-oxadiazoles and quinazolines derivatives from readily available benzaldehydes, benzylamines and hydroxylamine or anilines was developed. Both the cascade reaction sequences involved nucleophilic addition of C-N bond, introduction a halogen donor, nucleophilic substitution and Cu(II)-catalyzed aerobic oxidation This synthesis methodol. demonstrated good yields, broad substrate scope and oxygen as a green oxidant. Thus, this synthesis protocol provided strategies for the construction of substituted 1,2,4-oxadiazole and quinazolines from readily and simple starting materials.

Wang, Chengyuan team published research on Organic Chemistry Frontiers in 2020 | 19005-93-7

Name: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Wang, Chengyuan;Li, Zhuopeng;Zhang, Jiong;Hui, Xin-Ping research published 《 Asymmetric N-alkylation of indoles with isatins catalyzed by N-heterocyclic carbene: efficient synthesis of functionalized cyclic N,O-aminal indole derivatives》, the research content is summarized as follows. An N-heterocyclic carbene-catalyzed enantioselective N-alkylation of indole-2-formaldehydes with isatins has been achieved. Functionalized cyclic N,O-aminal indole derivatives, e.g., I, were obtained in good yields with excellent enantioselectivities.

Wang, Lin-Xuan team published research on Green Chemistry in 2021 | 19005-93-7

Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. HPLC of Formula: 19005-93-7.

Wang, Lin-Xuan;Qiu, Bin;An, Xiao-De;Dong, Pei-Zhen;Liu, Rui-Bin;Xiao, Jian research published 《 Organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization: sustainable access to indole-2,3-fused diazocanes》, the research content is summarized as follows. An unprecedented organocatalytic cascade aldimine condensation/[1,6]-hydride transfer/Mannich-type cyclization of indole-2-carbaldehydes with o-aminoanilines was developed to assemble polycyclic indole-2,3-fused diazocanes in one step. This novel methodol. featured high step- and atom-economy, was redox-neutral and metal-free, and occurred at room temperature It opened a new window for the application of hydride transfer chem. in constructing medium-sized ring structures.