Tag: M.W=100-150

Zhou, MX; He, ED; Zhang, L; Chen, JZ; Zhang, ZF; Liu, YG; Zhang, WB in [Zhou, Muxing; He, Ende; Zhang, Lu; Zhang, Zhenfeng; Liu, Yangang; Zhang, Wanbin] Shanghai Jiao Tong Univ, Shanghai Key Lab Mol Engn Chiral Drugs, Sch Pharm, 800 Dongchuan Rd, Shanghai 200240, Peoples R China; [Chen, Jianzhong; Zhang, Wanbin] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, 800 Dongchuan Rd, Shanghai 200240, Peoples R China published Development of a new bicyclic imidazole nucleophilic organocatalyst for direct enantioselective C-acylation in 2019, Cited 62. Quality Control of m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A novel chiral nucleophilic organocatalyst easily synthesized from simple starting materials bearing a 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine skeleton has been developed and successfully applied in the direct enantioselective C-acylation of 3-substituted benzofuranones. Its catalytic efficiency was shown to be comparable to that of the previously reported chiral 6,7-dihydro-5H-pyrrolo[1,2-a]imidazole catalyst. A wide range of 3,3-disubstituted benzofuranones, possessing a quaternary stereocenter, were synthesized with high yields and enantioselectivities.

About m-Methoxyphenol, If you have any questions, you can contact Zhou, MX; He, ED; Zhang, L; Chen, JZ; Zhang, ZF; Liu, YG; Zhang, WB or concate me.. Safety of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H8O2. In 2021.0 ORG BIOMOL CHEM published article about H BOND FUNCTIONALIZATION; FRIEDEL-CRAFTS REACTION; C-H; SYNTHETIC APPLICATIONS; ARYL; ALKYLATION; NAPHTHOLS; ACCESS; CHLORINATION; METHYLATION in [Tang, Zhiqiong; Li, Dongdong; Yue, Yidi; Peng, Dan; Liu, Lu] East China Normal Univ, Sch Chem & Mol Engn, 500 Dongchuan Rd, Shanghai 200241, Peoples R China; [Liu, Lu] East China Normal Univ, Shanghai Engn Res Ctr Mol Therapeut & New Drug De, Shanghai 200062, Peoples R China in 2021.0, Cited 69.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

We have developed a Bronsted acid catalysed highly ortho-selective functionalization of free phenols with readily available N,O-acetals under mild conditions, furnishing various corresponding aminomethylated phenol products in moderate to excellent yields. The salient features of this transformation include mild conditions, good substrate scope, excellent ortho-selectivity, high efficiency, and ease of further transformation.

HPLC of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Tang, ZQ; Li, DD; Yue, YD; Peng, D; Liu, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Authors Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD in ROYAL SOC CHEMISTRY published article about in [Paul, Avishek; Shipman, Michael A.; Onabule, Dolapo Y.; Sproules, Stephen; Symes, Mark D.] Univ Glasgow, Sch Chem, WestCHEM, Univ Ave, Glasgow G12 8QQ, Lanark, Scotland in 2021, Cited 30. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The enhancement of reactivity inside supramolecular coordination cages has many analogies to the mode of action of enzymes, and continues to inspire the design of new catalysts for a range of reactions. However, despite being a near-ubiquitous class of reactions in organic chemistry, enhancement of the reduction of carbonyls to their corresponding alcohols remains very much underexplored in supramolecular coordination cages. Herein, we show that encapsulation of small aromatic aldehydes inside a supramolecular coordination cage allows the reduction of these aldehydes with the mild reducing agent sodium cyanoborohydride to proceed with high selectivity (ketones and esters are not reduced) and in good yields. In the absence of the cage, low pH conditions are essential for any appreciable conversion of the aldehydes to the alcohols. In contrast, the specific microenvironment inside the cage allows this reaction to proceed in bulk solution that is pH-neutral, or even basic. We propose that the cage acts to stabilise the protonated oxocarbenium ion reaction intermediates (enhancing aldehyde reactivity) whilst simultaneously favouring the encapsulation and reduction of smaller aldehydes (which fit more easily inside the cage). Such dual action (enhancement of reactivity and size-selectivity) is reminiscent of the mode of operation of natural enzymes and highlights the tremendous promise of cage architectures as selective catalysts.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Paul, A; Shipman, MA; Onabule, DY; Sproules, S; Symes, MD or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Efficient methylation of anilines with methanol catalysed by cyclometalated ruthenium complexes WOS:000639998200015 published article about HYDROGEN-TRANSFER REDUCTION; MONO-N-METHYLATION; BORROWING HYDROGEN; PINCER RUTHENIUM; OS COMPLEXES; AMINES; KETONES; LIGANDS; RU; HETEROCYCLES in [Piehl, Patrick; Amuso, Roberta; Spannenberg, Anke; Neumann, Helfried; Beller, Matthias] Leibniz Inst Katalyse eV, Albert Einstein Str 29a, D-18059 Rostock, Germany; [Amuso, Roberta; Gabriele, Bartolo] Univ Calabria, Dept Chem & Chem Technol, Lab Ind & Synthet Organ Chem LISOC, Via Pietro Bucci 12-C, I-87036 Arcavacata Di Rende, CS, Italy in 2021.0, Cited 63.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Cyclometalated ruthenium complexes 4-10 allow the effective methylation of anilines with methanol to selectively give N-methylanilines. This hydrogen autotransfer procedure proceeds under mild conditions (60 degrees C) in a practical manner (NaOH as base). Mechanistic investigations suggest an active homogenous ruthenium complex and beta-hydride elimination of methanol as the rate determining step.

About Benzyl Alcohol, If you have any questions, you can contact Piehl, P; Amuso, R; Spannenberg, A; Gabriele, B; Neumann, H; Beller, M or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. Authors Zhang, F; Niu, YJ; Hong, DC; Ye, YL; Hua, YH; Ding, SH; Zhang, YD in ELSEVIER SCIENCE INC published article about in [Zhang, Yandong] Xiamen Univ, Dept Chem, iChEM, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, iChEM, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China in 2021, Cited 42. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Atkamine is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asymmetric Michael addition. The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, F; Niu, YJ; Hong, DC; Ye, YL; Hua, YH; Ding, SH; Zhang, YD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 BIOORG MED CHEM LETT published article about BIOLOGICAL EVALUATION; TUBULIN INHIBITORS; ANTICANCER AGENTS; COMBRETASTATIN ANALOGS; COLCHICINE SITE; BINDING; DERIVATIVES; PHOSPHATE; DESIGN; CYTOTOXICITY in [Dwivedi, Ashish Ranjan; Kumar, Vijay; Kaur, Harmeet; Kumar, Naveen; Poduri, Ramarao; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda 151001, Punjab, India; [Yadav, Ravi Prakash; Baranwal, Somesh] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Microbiol, Bathinda 151001, Punjab, India; [Kumar, Vinod] Cent Univ Punjab, Lab Organ & Med Chem, Dept Chem, Bathinda 151001, Punjab, India in 2020.0, Cited 47.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. COA of Formula: C8H8O2

A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 mu M, 4.78 mu M and 4.23 mu M, HK-10 showed IC50 values of 0.81 mu M, 5.89 mu M, 4.96 mu M and HK-13 showed IC50 values 3.24 mu M, 4.93 mu M and 4.73 mu M against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 mu M against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.

COA of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 99-93-4. Authors Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS in WILEY published article about in [Telu, Jhonsee Rani; Kuntala, Naveen; Anireddy, Jaya Shree] Jawaharlal Nehru Technol Univ Hyderabad, Ctr Chem Sci & Technol, Inst Sci & Technol, Hyderabad 500085, India; [Kankanala, Kavitha; Pal, Sarbani] MNR Degree & PG Coll, Dept Chem, Hyderabad, India; [Banothu, Venkanna] JNTUH, IST, Ctr Biotechnol, Hyderabad, India in 2021.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

We describe the synthesis, characterization, and in vitro antibacterial evaluation of a library of novel compounds based on 1,2,3-triazolo phosphonate framework along with the evaluation of DNA gyrase inhibitory potential of a promising molecule in silico. Preparation of these compounds was carried out via a multistep sequence comprising of the Abramov reaction followed by the Cu(I)-catalyzed azide-alkyne cycloaddition (CuAAC) as the key steps. Various alpha-hydroxyphosphonate derivatives containing either a secondary or tertiary alcohol at the alpha position were prepared. When screened for their antibacterial activities in vitro using a Gram-positive (Staphylococcus aureus) and three Gram-negative (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa) strains, majority of these derivatives exhibited reasonable to good effects with the analogue 5k being active against all the strains. The SAR analysis indicated that the activity was influenced by the position of the alpha-hydroxyphosphonate moiety as well as the substituent present on the benzene ring attached to the 1,2,3-triazole ring. Moreover, the compound 5k showed strong interactions with the DNA active site when docked into the DNA gyrase in silico. Thus, the 1,2,3-triazolo phosphonate derivative 5k appeared to be a novel and promising hit molecule that deserves further study as a potential antibacterial agent.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Telu, JR; Kuntala, N; Kankanala, K; Banothu, V; Pal, S; Anireddy, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: m-Methoxyphenol. I found the field of Chemistry very interesting. Saw the article Expanding the Family of Fluorescent Coumarin[4]arenes: Improved Synthesis, pi-Extension, and Characterization published in 2019.0, Reprint Addresses Venkatakrishnan, P (corresponding author), Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol.

A novel series of bicyclic fluorescent heterocalixarenes – C-alkyl coumarin[4]arenes – with built-in chirality has been synthesized successfully in excellent yields under well-optimized, improved reaction conditions. Further, structural elaboration (including pi-extension) of coumarin[4]arenes has been demonstrated by using Pd-catalyzed Suzuki and Sonogashira cross-coupling methods. All of these macrocycles are shown to possess averaged C-4-symmetric conformation in solution as opposed to the coumarin[4]arene tetratriflate derivative of C-2 symmetry in the solid state. Finally, the macrocyclic coumarin[4]arenes reveal UV/near-UV absorption and visible blue emission in solution. Such a visible blue luminescence of this macrocycle highlights its potential for sensing, bioimaging, and light-emissive applications.

Recommanded Product: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Kumar, P; Venkatakrishnan, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-51-6. Ben Hsouna, A; Dhibi, S; Dhifi, W; Ben Saad, R; Brini, F; Hfaidh, N; Mnif, W in [Ben Hsouna, Anis] Fac Sci Gafsa, Dept Life Sci, Zarroug 2112, Gafsa, Tunisia; [Ben Hsouna, Anis; Ben Saad, Rania] Ctr Biotechnol Sfax, Lab Biotechnol & Plant Improvement, Sfax, Tunisia; [Dhibi, Sabah; Brini, Faical; Hfaidh, Najla] Fac Sci Gafsa, Unit Macromol Biochem & Genet, Sidi Ahmed Zarrouk 2112, Gafsa, Tunisia; [Dhifi, Wissal] Biotechpole Sidi Thabet, Higher Inst Biotechnol Sidi Thabet, LR17 ES03 Physiopathol Food & Biomolecules, Ariana 2020, Tunisia; [Mnif, Wissem] Univ Bisha, Fac Sci & Arts Balgarn, Dept Chem, POB 199, Bisha 61922, Saudi Arabia; [Mnif, Wissem] Univ Manouba, ISBST, BVBGR, LR11ES31,Biotechpole Sidi Thabet, Ariana 2020, Tunisia published Essential oil from halophyte Lobularia maritima: protective effects against CCl4-induced hepatic oxidative damage in rats and inhibition of the production of proinflammatory gene expression by lipopolysaccharide-stimulated RAW 264.7 macrophages in 2019.0, Cited 56.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

The present study evaluates the chemical profiling of the essential oil of a halophyte, L. maritima (LmEO), and its protective potential against CCl4-induced oxidative stress in rats. Forty compounds have been identified in LmEO. The major components are alpha-pinene (3.51%), benzyl alcohol (8.65%), linalool (22.43%), pulegone (3.33%), 1-phenyl butanone (7.33%), globulol (4.32%), gamma-terpinene (6.15%), terpinen-4-ol (4.31%), alpha-terpineol (3.9%), ledol (3.59%), epi-alpha-cadinol (3.05%) and alpha-cadinol (4.91%). In comparison with the CCl4-intoxicated group, LmEO treatment resulted in decreased liver serum marker enzymes, decreased lipid peroxidation and increased antioxidant enzyme levels, with overall further amelioration of oxidative stress. The administration of LmEO to CCl4-treated rats at a dose of 250 mg kg(-1) body weight significantly reduced the toxic effects and the oxidative stress on the liver, thus validating the traditional medicinal claim of this plant. Moreover, the anti-inflammatory activity of LmEO was evaluated in lipopolysaccharide-stimulated murine RAW 264.7 cells. Our oil could modulate the inflammatory mode of the macrophages by causing reduction in iNOS and COX2 enzymes as well as in IL-1 beta, IL-6, and TNF-alpha cytokine levels. These findings suggest that LmEO exerts anti-inflammatory effects by regulating the expression of inflammatory cytokines.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Ben Hsouna, A; Dhibi, S; Dhifi, W; Ben Saad, R; Brini, F; Hfaidh, N; Mnif, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. Naveen; Tittal, RK; Ghule, VD; Kumar, N; Kumar, L; Lal, K; Kumar, A in [Naveen; Tittal, Ram Kumar; Ghule, Vikas D.; Kumar, Nikhil] Natl Inst Technol, Dept Chem, Kurukshetra 136119, Haryana, India; [Kumar, Lokesh; Lal, Kashmiri] GJUS&T, Dept Chem, Hisar 125001, Haryana, India; [Kumar, Ashwani] GJUS&T, Dept Pharmaceut Sci, Hisar 125001, Haryana, India published Design, synthesis, biological activity, molecular docking and computational studies on novel 1,4-disubstituted-1,2,3-Triazole-Thiosemicarbazone hybrid molecules in 2020.0, Cited 44.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A library of some novel 1,4-disubstituted-1,2,3-triazole-thiosemicarbazone hybrid molecules were designed and synthesized from (4-Prop-2-ynyloxy-benzylidene)-thiosemicarbazone and aryl azides under Cu(I)-catalyzed cycloaddition reaction. All newly synthesized [4-(1-Benzyl-1H-[1,2,3]triazol-4-ylmethoxy)-benzylidene] -thiosemicarbazone hybrid molecules were efficiently characterized by IR, H-1 NMR, C-13 NMR, HRMS and structure of alkynes 3 & 12 were finally supported by X-ray crystallographic data. Compounds 5c, 5d, 9c, 9d 13c and 13d demonstrated excellent potency results for B. Subtilis and P. Aeruginosa bacterial strains with MIC values 0.0141, 0.0152, 0.0562, 0.0608, 0.0141, 0.0608, 0.0141, 0.0304, 0.0281, 0.0304, 0.0281, 0.0304, respectively as compared to reference drug Ciprofloxacin. Antibacterial activity results were supported by molecular docking and DFT studies. (C) 2020 Elsevier B.V. All rights reserved.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Naveen; Tittal, RK; Ghule, VD; Kumar, N; Kumar, L; Lal, K; Kumar, A or concate me.. Quality Control of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles