Tag: M.W=100-150

Product Details of 123-11-5. Authors Becerra, D; Rojas, H; Castillo, JC in MDPI published article about in [Becerra, Diana; Rojas, Hugo; Castillo, Juan-Carlos] Univ Pedag & Tecnol Colombia, Escuela Ciencias Quim, Fac Ciencias, Ave Cent Norte 39-115, Tunja 150003, Colombia in 2021, Cited 27. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

We reported an efficient one-pot two-step synthesis of 3-(tert-butyl)-N-(4-methoxybenzyl)-1-methyl-1H-pyrazol-5-amine 3 in good yield by a solvent-free condensation/reduction reaction sequence starting from 3-(tert-butyl)-1-methyl-1H-pyrazol-5-amine 1 and p-methoxybenzaldehyde 2. The one-pot reductive amination proceeded by the formation in situ of the N-(5-pyrazolyl)imine 4 as key synthetic intermediate of other valuable pyrazole derivatives. This methodology is distinguished by its operational easiness, short reaction time, isolation and purification of the aldimine intermediate is not required. The structure of the synthesized N-heterocyclic amine 3 was fully characterized by FTIR-ATR, 1D and 2D NMR experiments, EIMS, and elemental analysis.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Becerra, D; Rojas, H; Castillo, JC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Zeimyte, S; Stoncius, S in [Zeimyte, Simona] Vilnius Univ, Dept Organ Chem, Naugarduko 24, LT-03225 Vilnius, Lithuania; [Stoncius, Sigitas] Ctr Phys Sci & Technol, Dept Organ Chem, Akademijos 7, LT-08412 Vilnius, Lithuania published Chiral bipyridine-annulated bicyclo[3.3.1]nonane N-oxide organocatalysts for stereoselective allylation and hydrosilylation reactions in 2021.0, Cited 61.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

The synthesis of chiral C-2-symmetric bis(bipyridine N,N’-dioxide) and bis(bipyridine N-monooxide) derivatives featuring bipyridine-annulated bicyclo[3.3.1 ]nonane framework is reported. The new Lewis basic bipyridine N,N’-dioxides exhibited good catalytic activity in the asymmetric allylation of aldehydes with allyltrichlorosilane, furnishing corresponding homoallylic alcohols in up to 75% ee. Reduction of ketimines and beta-enamino esters with trichlorosilane catalyzed by bipyridine N,N’-dioxides proceeded in high yields but modest enantioselectivity (38-54% ee); good levels of asymmetric induction (up to 73% ee) were attained in the reduction of alpha-imino esters at room temperature. (C) 2020 Elsevier Ltd. All rights reserved.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zeimyte, S; Stoncius, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Oxidative amidation by Cu(ii)-guanidine acetic acid immobilized on magnetized sawdust with eggshell as a natural base WOS:000548246700040 published article about DIRECT AMIDE SYNTHESIS; ONE-POT SYNTHESIS; BENZYL ALCOHOLS; HYDROTHERMAL CARBONIZATION; AMINES; ALDEHYDES; EFFICIENT; COPPER; CATALYST; WASTE in [Darvishi, Atefeh; Miraki, Maryam Kazemi; Arefi, Marzban; Heydari, Akbar] Tarbiat Modares Univ, Chem Dept, POB 14155-4838, Tehran, Iran in 2020.0, Cited 87.0. Name: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Copper(ii)-guanidine acetic acid complex was immobilized on the surface of magnetized raw waste sawdust (SD) as an abundant natural biopolymer and employed as an efficient and recoverable catalyst in oxidative amidation reaction, while waste eggshell (ES) powder was used as a low-cost solid base. The magnetic raw catalyst was fully characterized using FTIR, XRD, SEM, EDX, TGA, and VSM. A variety of amide derivatives were successfully synthesized in moderate to good yields using benzyl alcohol and amine salts. The application of sawdust and eggshell as two natural and abundant waste materials is the main advantage of this research. Moreover, these low-cost catalysts were recovered at least five times and utilized in reaction systems with a minimal decrease in activity.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Darvishi, A; Miraki, MK; Arefi, M; Heydari, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MULTITARGET-DIRECTED LIGANDS; ALZHEIMERS-DISEASE; BIOLOGICAL EVALUATION; CHOLINESTERASE-INHIBITORS; POTENTIAL TREATMENT; MULTIPOTENT MAO; DONEPEZIL; NEUROPROTECTION; HYBRIDS; DESIGN, Saw an article supported by the DST-SERB [EMR/2015/002339, ECR/2015/000240]; Central University of Punjab, Bathinda [RSM GP25]; CUP, Bathinda; CSIRCouncil of Scientific & Industrial Research (CSIR) – India; UGCUniversity Grants Commission, India. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. COA of Formula: C7H6O2

Alzheimer’s disease (AD) is a multifactorial neurological disorder involving complex pathogenesis. Single target directed drugs proved ineffective and since last few years’ different pharmacological strategies including multi-targeting agents are being explored for the effective drug development for AD. A total of 19 dipropargyl substituted diphenylpyrimidines have been synthesized and evaluated for the monoamine oxidase (MAO) and acetylcholinesterase (AChE) inhibition potential. All the compounds were found to be selective and reversible inhibitors of MAO-B isoform. These compounds also displayed good AChE inhibition potential with IC50 values in low micromolar range. AVB4 was found to be the most potent MAO-B inhibitor with IC50 value of 1.49 +/- 0.09 mu M and AVB1 was found to be the most potent AChE inhibitor with IC50 value of 135 +/- 0.03 mu M. In the ROS protection inhibition studies, AVB1 and AVB4 displayed weak but interesting activity in SH-SYSY cells. In the cytotoxicity studies involving SH-SY5Y cells, both AVB1 and AVB4 were found to be non-toxic to the tissue cells. In the molecular dynamic simulation studies of 30 ns, the potent compounds were found to be quite stable in the active site of MAO-B and AChE. The results suggested that AVB1 and AVB4 are promising dual inhibitors and have the potential to be developed as anti-Alzheimer’s drug. (C) 2019 Published by Elsevier Masson SAS.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumar, B; Kumar, V; Prashar, V; Saini, S; Dwivedi, AR; Bajaj, B; Mehta, D; Parkash, J; Kumar, V or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology very interesting. Saw the article Innovative Alcoholic Drinks Obtained by Co-Fermenting Grape Must and Fruit Juice published in 2019.0. SDS of cas: 100-51-6, Reprint Addresses Vigentini, I (corresponding author), Univ Milan, Dept Food Environm & Nutr Sci, Via G Celoria 2, I-20133 Milan, Italy.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

In this study, Cabernet Sauvignon and Chardonnay musts, and fruit juices from cherry, kiwi, peach, and strawberry were co-fermented with Saccharomyces cerevisiae EC1118 and Torulaspora delbrueckii UMY196 at two different proportions (80:20 (v/v) and 60:40 (v/v)). The most pleasant fruit-based drink was obtained with Cabernet Sauvignon must and kiwi juice in a proportion of 60:40 and fermented with T. delbrueckii. This beverage was produced in higher volume to simulate a scale-up, and the aromatic profile, sensory description, and consumer acceptability were determined. The most powerful odorants of the kiwi-based drink were ethyl octanoate, phenylethanal, ethyl hexanoate, vinyl-guaiacol, benzaldehyde, and nonanal, for which the odor activity values were 21.1, 3.3, 2.6, 2.2, 1.9, and 1.6, respectively. These findings were in accordance with the sensory analysis, since the emerged descriptors were fruity (ethyl octanoate), honey and floral (phenylethanal), apple and peach (ethyl hexanoate), and citrus (nonanal). The consumers judged the kiwi-based drink acceptable (67%) and 39% of them would buy it. The reliable fermentation of a grape must/fruit juice was demonstrated. The kiwi-based drink represents an innovative and pleasant beverage with a positive impact on sustainability as its production can limit the loss of fresh fruits, as well as contribute to the enological field.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Fracassetti, D; Bottelli, P; Corona, O; Foschino, R; Vigentini, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Visible light-induced mono-bromination of arenes with BrCCl3 published in 2021. Application In Synthesis of m-Methoxyphenol, Reprint Addresses Cheng, XM; Lu, YN; Loh, TP (corresponding author), Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat,Nanjing, Nanjing 211816, Peoples R China.; Loh, TP (corresponding author), Nanyang Technol Univ, Sch Phys & Math Sci, Div Chem & Biol Chem, Singapore 637371, Singapore.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

A highly efficient and regioselective bromination of electron-rich arenes and heteroarenes using commercially available BrCCl3 as a Br source has been developed. The reaction was performed in air under mild conditions with photocatalyst Ru(bpy)(3)Cl-2 center dot 6H(2)O, avoiding the usage of strong acids and strong oxidants. Mono-brominated products were obtained with medium to excellent yields (up to 94%). This strategy has shown good compatibility and high para-selectivity, which will facilitate the complicated synthesis.

Application In Synthesis of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Fan, JL; Wei, QC; Zhu, ES; Gao, J; Cheng, XM; Lu, YN; Loh, TP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Wu, RP; Gao, K in ROYAL SOC CHEMISTRY published article about in [Wu, Rongpei; Gao, Ke] Cent China Normal Univ, Coll Chem, 152 Luoyu Rd, Wuhan, Hubei, Peoples R China in 2021.0, Cited 44.0. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A highly efficient B(C6F5)(3)-catalyzed tandem protonation/deuteration and reduction of in situ-formed enamines in the presence of water and pinacolborane was developed. Regioselective beta-deuteration of tertiary amines was achieved with high chemo- and regioselectivity. D2O was used as a readily available and cheap source of deuterium. Mechanistic studies indicated that B(C6F5)(3) could activate water to promote the protonation and reduction of enamines.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wu, RP; Gao, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Authors Mitsui, A; Nagao, K; Ohmiya, H in WILEY-V C H VERLAG GMBH published article about in [Mitsui, Atsuhisa; Nagao, Kazunori; Ohmiya, Hirohisa] Kanazawa Univ, Grad Sch Med Sci, Div Pharmaceut Sci, Kakuma Machi, Kanazawa, Ishikawa 9201192, Japan; [Ohmiya, Hirohisa] PRESTO, JST, 4-1-8 Honcho, Kawaguchi, Saitama 3320012, Japan in 2021.0, Cited 59.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A reductive cross-coupling reaction between aromatic aldehydes and arylnitriles using a copper catalyst and a silylboronate as a reductant is reported. This protocol represents an unprecedented approach to the chemoselective synthesis of alpha-hydroxy ketones by electrophile-electrophile cross-coupling.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Mitsui, A; Nagao, K; Ohmiya, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020 CHEMISTRYSELECT published article about COPPER-CATALYZED HYDROXYLATION; ARYLBORONIC ACIDS; IPSO-HYDROXYLATION; BORONIC ACIDS; HETEROGENEOUS CATALYST; ORGANOCATALYTIC OXIDATION; ARYL HALIDES; NANOPARTICLES; MILD; ALDEHYDES in [Gujjarappa, Raghuram; Vodnala, Nagaraju; Malakar, Chandi C.] Natl Inst Technol Manipur, Dept Chem, Imphal 795004, Manipur, India; [Garg, Aakriti; Gupta, Sreya] NIPER, Dept Med Chem, 168 Maniktala Main Rd, Kolkata 700054, India; [Hazra, Chinmoy K.] Indian Inst Technol Delhi, Dept Chem, Hauz Khas, New Delhi 110016, India in 2020, Cited 80. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

An efficient amino-acid-mediated ipso-hydroxylation of arylboronic acids, aryl boronate esters and aryl trifluoroborates to aryl alcohols has been described. The current protocol was realized by using sub-stoichiometric amount of l-histidine in presence of triethylamine under aerobic conditions in DMF as solvent. This amino-acid-mediated process provides an alternative route for the hydroxylation of organoborons through in situ generation of hydrogen peroxide. The present protocol explores the synthetic utility of amino acids as organocatalysts for the preparation of aryl alcohols. It was observed that l-histidine plays an important role for the conversion of aerial oxygen in to hydrogen peroxide via thermal excitation process followed by thermal degradation of Et3N. The developed approach holds good for a wide range of compounds with excellent yields and competent functional group tolerance.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Gujjarappa, R; Vodnala, N; Garg, A; Hazra, CK; Gupta, S; Malakar, CC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Authors Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV in SPRINGER published article about in [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Thi, Phuong Hoang; Tuan, Anh Nguyen; Mai, Ha Hoang; Ha, Thanh Nguyen; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Inst Chem, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Thi, Tuyet Anh Dang; Le-Nhat-Thuy, Giang; Thi, Quynh Giang Nguyen; Mai, Ha Hoang; Van Nguyen, Tuyen] Vietnam Acad Sci & Technol, Grad Univ Sci & Technol, 18 Hoang Quoc Viet St, Hanoi 100000, Vietnam; [Le, Tuan Anh] Vietnam Natl Univ Hanoi, Univ Sci, Fac Chem, 334 Nguyen Trai, Hanoi 100000, Vietnam in 2021.0, Cited 37.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Synthesis of novel 3-arylated 2-hydroxy-1,4-naphthoquinone derivatives via microwave-assisted three-component reaction starting from 2-hydroxy-1,4-naphthoquinone, tetronic acid, and various aromatic aldehydes has been described. This multicomponent domino reaction proceeded through the Knoevenagel condensation, Michael addition, deprotonation, and 1,3-H shift steps. Five of the synthesized compounds displayed good cytotoxic activity against two human cancer cell lines, KB and HepG2, with half maximal inhibitory concentration values in a range of 4-20 mu M.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Thi, TAD; Le-Nhat-Thuy, G; Thi, QGN; Thi, PH; Tuan, AN; Mai, HH; Ha, TN; Le, TA; Nguyen, TV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles