Tag: M.W=100-150

In 2019.0 METABOLITES published article about TORULASPORA-DELBRUECKII; SHERRY WINES; RED WINES; AROMA; SACCHAROMYCES; COMPONENTS; IMPACT in [Fracassetti, Daniela; Bottelli, Paolo; Foschino, Roberto; Vigentini, Ileana] Univ Milan, Dept Food Environm & Nutr Sci, Via G Celoria 2, I-20133 Milan, Italy; [Corona, Onofrio] Univ Palermo, Dept Agr Food & Forest Sci, Viale Sci, I-90128 Palermo, Italy in 2019.0, Cited 32.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Safety of Benzyl Alcohol

In this study, Cabernet Sauvignon and Chardonnay musts, and fruit juices from cherry, kiwi, peach, and strawberry were co-fermented with Saccharomyces cerevisiae EC1118 and Torulaspora delbrueckii UMY196 at two different proportions (80:20 (v/v) and 60:40 (v/v)). The most pleasant fruit-based drink was obtained with Cabernet Sauvignon must and kiwi juice in a proportion of 60:40 and fermented with T. delbrueckii. This beverage was produced in higher volume to simulate a scale-up, and the aromatic profile, sensory description, and consumer acceptability were determined. The most powerful odorants of the kiwi-based drink were ethyl octanoate, phenylethanal, ethyl hexanoate, vinyl-guaiacol, benzaldehyde, and nonanal, for which the odor activity values were 21.1, 3.3, 2.6, 2.2, 1.9, and 1.6, respectively. These findings were in accordance with the sensory analysis, since the emerged descriptors were fruity (ethyl octanoate), honey and floral (phenylethanal), apple and peach (ethyl hexanoate), and citrus (nonanal). The consumers judged the kiwi-based drink acceptable (67%) and 39% of them would buy it. The reliable fermentation of a grape must/fruit juice was demonstrated. The kiwi-based drink represents an innovative and pleasant beverage with a positive impact on sustainability as its production can limit the loss of fresh fruits, as well as contribute to the enological field.

Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Fracassetti, D; Bottelli, P; Corona, O; Foschino, R; Vigentini, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H6O2. Zhou, L; Zhu, C; Bi, PJ; Feng, C in [Zhou, Lu; Zhu, Chuan; Bi, Peijia; Feng, Chao] Nanjing Tech Univ, Inst Adv Synth, Sch Chem & Mol Engn, Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing 211816, Jiangsu, Peoples R China published Ni-catalyzed migratory fluoro-alkenylation of unactivated alkyl bromides with gem-difluoroalkenes in 2019.0, Cited 65.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

We describe a nickel-catalyzed highly regio- and stereoselective migratory fluoro-alkenylation of unactivated alkyl bromides. A unique catalytic cycle merging alkyl nickel chain-walking and defluorinative coupling enables the introduction of a broad array of fluoroalkenyl moieties into carbon chains. Control experiments with other halogenated alkenes demonstrated the essential role of fluorine atoms in this reaction. Notably, the reaction proceeds under mild conditions and allows for the synthesis of a variety of valuable monofluoroalkenes.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhou, L; Zhu, C; Bi, PJ; Feng, C or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Methoxybenzaldehyde. Authors Zhang, L; Hu, YY; Wang, Y; Kong, BH; Chen, Q in ELSEVIER published article about in [Zhang, Lang; Hu, Yingying; Kong, Baohua; Chen, Qian] Northeast Agr Univ, Coll Food Sci, Harbin 150030, Peoples R China; [Wang, Yan] Shimadzu CO LTD China, Shenyang 110016, Peoples R China in 2021.0, Cited 40.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

This study evaluated the effect of different sugar smoking times on the flavour profiles of chicken drumsticks using an electronic nose (E-nose), electronic tongue (E-tongue), and headspace solid-phase microextraction gas chromatography-mass spectrometry (HS-SPME/GC-MS). The moisture content, water activity, pH, and L*-value decreased from 71.26% to 65.23%, 0.987 to 0.979, 6.66 to 5.36, and 61.84 to 52.34, respectively (P < 0.05). The a*-value and b*-value increased from 4.96 to 9.65 and 16.61 to 26.45, respectively (P < 0.05) with the increase in smoking times. Seventy-five volatile compounds were identified, and 18 volatile compounds were identified as key odour compounds and among them seven key volatile compounds with variable importance in projection (VIP) > 1 were detected. Principal component analysis of E-nose, E-tongue, and HS-SPME/GC-MS indicated that 3-, 4-, and 5-min smoking samples had similar odour and taste profiles. Sensory analysis indicated that the 4-min sample had increased overall acceptability. The correlation analysis of E-nose and key volatile compounds with odour activity value > 1 and VIP >1 confirmed that W1C, W3C, and W5C sensors were sensitive to aromatic compounds, and W2S sensor was sensitive to ketones. These results may provide guidance for smoked chicken producers to reasonably control flavour formation.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, L; Hu, YY; Wang, Y; Kong, BH; Chen, Q or concate me.. Quality Control of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Mequinol. In 2021.0 SYNTHETIC COMMUN published article about ONE-POT SYNTHESIS; MEDIATED HYDROARYLATION; ASYMMETRIC-SYNTHESIS; DIHYDROCOUMARINS; COUMARINS; DERIVATIVES; EFFICIENT; 4-ARYL-3,4-DIHYDROBENZOPYRAN-2-ONES; 3,4-DIHYDROCOUMARINS; FLAVONOIDS in [Huu-Phuoc Le; Cong-Thang Duong; Xuan-Triet Nguyen; Thi Xuan Thi Luu] Univ Sci, Dept Organ Chem, Ho Chi Minh City, Vietnam; [Thi Xuan Thi Luu] Vietnam Natl Univ, Dept Chem, Ho Chi Minh City, Vietnam in 2021.0, Cited 55.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

Amberlyst 15 resin supported the tandem reaction of cinnamic acids with phenols under solvent-free reaction condition has been introduced to afford 4-aryl-3,4-dihydrocoumarin (neoflavanone) derivatives. The efficiency of solid acidic sulfonic resin (A-15) has been illustrated in two reaction activation methods such as microwave irradiation and conventional heating. The important roles of Amberlyst 15 have been emphasized strongly through the high yields of 4-aryl-3,4-dihydrocoumarin in the shorter time under the assistance of microwave irradiation than of conventional heating, and its high recovery and reusability for six catalyst runs. The original catalyst as well as the recycled catalyst were characterized by XRD and FE-SEM to study the correlation of the surface of reused catalyst and its recyclability.

Application In Synthesis of Mequinol. About Mequinol, If you have any questions, you can contact Le, HP; Duong, CT; Nguyen, XT; Luu, TXT or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PICTET-SPENGLER REACTION; CRYSTAL-STRUCTURE; EFFICACY, Saw an article supported by the Shandong Natural Science FoundationNatural Science Foundation of Shandong Province [ZR2017MH093]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [81973200]; China-Australia Centre for Health Sciences Research. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Yang, EL; Sun, B; Huang, ZY; Lin, JG; Jiao, B; Xiang, L. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Quality Control of 3-Hydroxybenzaldehyde

A green, biomimetic, phosphate-mediated Pictet-Spengler reaction was used in the synthesis of three catecholic tetrahydroisoquinolines, 1, 2, and 12, present in the medicinal plant Portulaca oleracea, as well as their analogues 3-11, 13, and 14, with dopamine hydrochloride and aldehydes as the substrates. AB-8 macroporous resin column chromatography was applied for purification of the products from the one-step high efficacy synthesis. It eliminated the difficulties in the isolation of catecholic tetrahydroisoquinolines from the aqueous reaction system and unreacted dopamine hydrochloride. Activity screening in CHO-K1/G alpha 15 cell models consistently expressing alpha(1B)-, beta(1)-, or beta(2)-adrenergic receptors indicated that 12 and 2, compounds that are present in P. oleracea, possessed the most potent beta(2)-adrenergic receptor agonist activity and 2 was a selective beta(2)-adrenergic receptor agonist at the concentration of 100 mu M. Both 12 and 2 exhibited dose-dependent bronchodilator effects on the histamine-induced contraction of isolated guinea-pig tracheal smooth muscle, with EC50 values of 0.8 and 2.8 mu M, respectively. These findings explain the scientific rationale of P. oleracea use as an antiasthmatic herb in folk medicine and provide the basis for the discovery of novel antiasthma drugs.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Yang, EL; Sun, B; Huang, ZY; Lin, JG; Jiao, B; Xiang, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Vonlanthen, M; Rojas-Montoya, SM; Cuetara-Guadarrama, F; Martiez-Serrano, RD; Burillo, G; Rivera, E in WILEY-V C H VERLAG GMBH published article about RECENT PROGRESS; RADIATION; SENSOR; FILM; IMMOBILIZATION; POLYMERS; PYRENE; UNITS in [Vonlanthen, Mireille; Rojas-Montoya, Sandra M.; Cuetara-Guadarrama, Fabian; Martinez-Serrano, Ricardo D.; Rivera, Ernesto] Univ Nacl Autonoma Mexico, Inst Invest Mat, Circuito Exterior Ciudad Univ, Mexico City 04510, DF, Mexico; [Burillo, Guillermina] Univ Nacl Autonoma Mexico, Inst Ciencias Nucl, Circuito Exterior Ciudad Univ, Mexico City 04510, DF, Mexico in 2020.0, Cited 39.0. Quality Control of m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

A coumarin-based chemosensor is synthesized and grafted onto a polyethylene (PE) surface by means of gamma radiation. The obtained polymeric film results to work as test-paper-like colorimetric sensor for the detection of Cu(2+)ions. After immersion of the grafted PE film into a solution of Cu(2+)in chloroform/methanol (8/2), a color change from colorless to green is observed by naked eye together with a quenching of the fluorescence emission. Control experiment with methoxy-grafted PE films shows no response after the immersion in the same Cu(2+)solution. The polymeric sensor can be washed and reused over several cycles for the detection of Cu2+. Moreover, the obtained polymeric sensor is used to detect Zn(2+)by means of photoinduced electron transfer (PET) quenching disrupting mechanism. The fluorescence emission increases about three times after immersion in a solution containing Zn2+. A similar behavior is observed in the presence of acidic protons.

Quality Control of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Vonlanthen, M; Rojas-Montoya, SM; Cuetara-Guadarrama, F; Martiez-Serrano, RD; Burillo, G; Rivera, E or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H8O. In 2019.0 J APPL SPECTROSC+ published article about SOLUBILITY; POLYSORBATE-80; DISSOLUTION; FORMULATION; BEHAVIOR in [Leontiev, V. N.; Lazovskaya, O. I.] Belarusian State Technol Univ, 13a Sverdlov Str, Minsk 220006, BELARUS in 2019.0, Cited 15.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

The stability of micellar solutions of amiodarone hydrochloride in the presence of polysorbate-80 and benzyl alcohol was studied using fluorescence spectrometry with lambda(ex) = 420 m and lambda(em) = 506 nm. A formation scheme for mixed micelles consisting of nonionizable surfactant polysorbate-80 and cationic amiodarone with chloride counterion was proposed. Benzyl alcohol was found to lower the stability of the mixed micelles and lead to crystallization o f amiodarone hydrochloride. The counterion was replaced in the presence of acetate so that crystals of amiodarone acetate with a characteristic band for acetate carbonyl stretching vibrations v(C=O) at 1734 cm(-1) were formed. The solubilities of amiodarone hydrochloride and acetate in H2O at 20 degrees C were determined to be 0.33 and 0.058 mg/mL. A change of the amiodarone hydrochloride to polysorbate-80 mole ratio and avoidance of benzyl alcohol and acetate-containing solutions are recommended to improve the stability of the parenteral dosage form.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Leontiev, VN; Lazovskaya, OI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BIOLOGICAL EVALUATION; MICROTUBULE DYNAMICS; TUMOR-GROWTH; CELL-DEATH; CANCER; DERIVATIVES; COLCHICINE; RESISTANT; DISCOVERY; INSIGHT, Saw an article supported by the Public Science, Technology research Funds Project of Ocean [201505023]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21602103]; National Undergraduate Innovation Program; [J1210026]. Application In Synthesis of 4′-Hydroxyacetophenone. Published in ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER in ISSY-LES-MOULINEAUX ,Authors: Zhang, YL; Li, BY; Yang, R; Xia, LY; Fan, AL; Chu, YC; Wang, LJ; Wang, ZC; Jiang, AQ; Zhu, HL. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

In current work, a class of novel 4,5-dihydro-1H-pyrazole-1-carboxylate derivatives (E01-E28) were designed, synthesized and evaluated. Among them, the most potent compound E24 exhibited comparable activity against a panel of cancer cells (GI(50) ranging 0.05-0.98 mu M) and tubulin polymerization inhibition (IC50 = 1.49 mu M) with reference drug CA-4(P) (GI(50) ranging 0.019-0.32 mu M, IC50 = 2.18 mu M). The following assays indicated that compound E24 disturbed the dynamics of tubulin catastrophe and rescue, which triggered G2/M arrest, leading to ROS accumulation, cleavage of PARP and apoptosis. Molecular dynamics simulation validated that compound E24 could tightly bind into tubulin heterodimers with beta Lys 254 and beta Cys 241 of tubulin in the docking pose. Metabolic stability and pharmacokinetics parameters were also determined. The half time (t(1/2)) displayed species differences in three microsomes. The plasma elimination half-life (t(1/2)), peak plasma concentration (C-max), mean retention time (MRT), the area under the curve (AUC(0-infinity),) and distribution volume (V-z) of E24 after intravenous administration were 0.90 +/- 0.22 h, 594.50 +/- 97.23 ng/mL, 1.09 +/- 0.22 h, 413.67 +/- 105.64 ng/mL*h and 5.03 +/- 1.82 L/kg, respectively. In HeLa-xenografts, compound E24 exhibited obvious antitumor efficacy via the suppression of tumor growth without weight loss of body or organ. In brief, compound E24 might be a hopeful candidate with excellent properties for oncotherapy as tubulin polymerization inhibitor. (C) 2018 Elsevier Masson SAS. All rights reserved.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhang, YL; Li, BY; Yang, R; Xia, LY; Fan, AL; Chu, YC; Wang, LJ; Wang, ZC; Jiang, AQ; Zhu, HL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Stable and color tunable MEH-PPV/PMMA polymer blends for light-emitting applications WOS:000645125200002 published article about POLY(METHYL METHACRYLATE); CONJUGATED POLYMERS; PPV; MORPHOLOGY; CHAIN; PHOTOLUMINESCENCE; LUMINESCENCE; AGGREGATION; DEGRADATION; EXCITATIONS in [Kumar, Sangeetha Ashok; Shankar, Jaya Seeli; Periyasamy, Bhuvana K.; Nayak, Sanjay K.] Cent Inst Petrochem Engn & Technol CIPET, Sch Adv Polymer Res SARP ARSTPS, Chennai, Tamil Nadu, India; [Gouthaman, Siddan] CSIR Cent Leather Res Inst CLRI, Ind Chem Polymer Div, Chennai, Tamil Nadu, India in 2021.0, Cited 30.0. Category: indole-building-block. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Light Emitting Polymers (LEPs) have gained attention in optoelectronics. However, stability and regulation of emission color remain a challenge. This study aims to overcome the challenge by formulating a Polymer Blend (PB) which consists of a LEP ? poly [2-methoxy,5-(2-ethylhexyloxy)1,4-phynylenevinylene (MEH-PPV) and a non-conjugated polymer ? poly(methyl methacrylate) (PMMA). A simple approach of in situ polymerization of the non-conjugated polymer in the MEH-PPV solution leads to alteration of size of the MEH-PPV polymer chain and modified the emission color from red-orange to bluish-green. The barrier properties of PMMA improve the stability of PB in an ambient environment with unnoticeable luminescence loss. This type of PB shall find application in Organic Light-Emitting Devices.

About Mequinol, If you have any questions, you can contact Kumar, SA; Gouthaman, S; Shankar, JS; Periyasamy, BK; Nayak, SK or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Science & Technology – Other Topics very interesting. Saw the article Bioinspired Radical-Mediated Transition-Metal-Free Synthesis of N-Heterocycles under Visible Light published in 2021. Formula: C8H8O2, Reprint Addresses Adhikari, D (corresponding author), Indian Inst Sci Educ & Res IISER Mohali, Dept Chem Sci, Sas Nagar 140306, Punjab, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A redox-active iminoquinone motif connected with pi-delocalized pyrene core has been reported that can perform efficient two-electron oxidation of a class of substrates. The design of the molecule was inspired by the organic redox cofactor topaquinone (TPQ), which executes amine oxidation in the enzyme, copper amine oxidase. Easy oxidation of both primary and secondary alcohols happened in the presence of catalytic KOtBu, which could reduce the ligand backbone to its iminosemiquinonate form under photoinduced conditions. Moreover, this easy oxidation of alcohols under aerobic condition could be elegantly extended to multi-component, one-pot coupling for the synthesis of quinoline and pyrimidine. This organocatalytic approach is very mild (70 degrees C, 8 h) compared to a multitude of transition-metal catalysts that have been used to prepare these heterocycles. A detailed mechanistic study proves the intermediacy of the iminosemiquinonate-type radical and a critical hydrogen atom transfer step to be involved in the dehydrogenation reaction.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Bains, AK; Ankit, Y; Adhikari, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles