Tag: M.W=100-150

Safety of 4-Methoxybenzaldehyde. Authors Zeid, SB; Hamade, A; Najjar, F; Carreaux, F; Eid, S in SPRINGER INTERNATIONAL PUBLISHING AG published article about in [Zeid, Samar Bou; Hamade, Aline; Najjar, Fadia; Eid, Samar] Lebanese Univ, Fac Sci 2, Dept Biol Chem & Biochem, Lab Innovat Therapeut, Fanar, Lebanon; [Zeid, Samar Bou; Carreaux, Francois] Univ Rennes 1, CNRS, ISCR, UMR 6226, 263 Ave Gen Leclerc,Campus Beaulieu, F-35000 Rennes, France in 2021, Cited 43. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Herein we describe the synthesis of five new 2-aryl and 2-alkylimidazolone derivatives via an effective one-pot synthetic strategy assisted by microwave irradiations which allowed us to access the desired product in a reduced time reaction compared to the thermal heating and a slightly better yield (48% compared to 45%). The new imidazolone derivatives were evaluated for their anticancer activity in vitro against MCF-7, MDA-MB-231 and HepG2 cell lines. The results showed good cytotoxic effects for some of these derivatives on both MCF-7 and HepG2 cell lines in the range of 5.7-11.3 mu M. Among the synthesized derivatives, 2ab and 2b showed the strongest activity with IC50 values of 7 and 5.7 mu M (MCF-7) and 6.2 and 8.6 mu M (HepG2), respectively. The cytotoxic activities of these derivatives were moderate compared to those of doxorubicin. However, this product showed higher toxicity in vivo on the development of zebrafish embryos than the synthesized imidazolones. These derivatives at high concentrations exhibited some morphological abnormalities on the embryos.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zeid, SB; Hamade, A; Najjar, F; Carreaux, F; Eid, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 XENOBIOTICA published article about HUMAN ARYLACETAMIDE DEACETYLASE; HUMAN CARBOXYLESTERASE; ESTER; IDENTIFICATION; PARAOXONASES; PURIFICATION; HYDROLYSIS; SUBSTRATE; CLONING; ENZYME in [Mizoi, Kenta; Takahashi, Masato; Sakai, Sachiko; Haba, Masami; Hosokawa, Masakiyo] Chiba Inst Sci, Fac Pharm, 15-8 Shi Cho, Choshi, Chiba 2880025, Japan; [Mizoi, Kenta; Ogihara, Takuo] Takasaki Univ Hlth & Welf, Fac Pharm, Takasaki, Gumma, Japan in 2020.0, Cited 28.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. SDS of cas: 100-51-6

1. We investigated the structure-activity relationship of 31 kinds of synthesized atorvastatin esters, thioesters, amides and lactone, selected as prodrug models, for metabolic activation by microsomes and hydrolases. 2. The susceptibility to human carboxylesterase 1 (hCES1) was influenced not only by the size of the acyl group and alkoxy group but also by the degree of steric crowding around the alkoxy group. 3. The susceptibility to human carboxylesterase 2 (hCES2) increased with a decrease in electron density around the alkoxy group of the substrate. 4. Lactone was specifically hydrolyzed by paraoxonase 3 (PON3). 5. These findings should be useful in prodrug design for controlling metabolic activation.

About Benzyl Alcohol, If you have any questions, you can contact Mizoi, K; Takahashi, M; Sakai, S; Ogihara, T; Haba, M; Hosokawa, M or concate me.. SDS of cas: 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. In 2019.0 EUR J MED CHEM published article about ALZHEIMERS-DISEASE; A-BETA; TC-99M/RE COMPLEXES; PROBES; PET; RADIOLIGAND; TECHNETIUM; CHALCONE; RE in [Molavipordanjani, Sajjad; Noaparast, Zohreh; Hosseinimehr, Seyed Jalal] Mazandaran Univ Med Sci, Dept Radiopharmacy, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Molavipordanjani, Sajjad] Mazandaran Univ Med Sci, Student Res Comm, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Dept Med Chem, Fac Pharm, Sari, Iran; [Emami, Saeed] Mazandaran Univ Med Sci, Pharmaceut Sci Res Ctr, Fac Pharm, Sari, Iran; [Mardanshahi, Alireza] Mazandaran Univ Med Sci, Dept Radiol, Fac Med, Sari, Iran; [Amiri, Fereshteh Talebpour] Mazandaran Univ Med Sci, Dept Anat, Fac Med, Sari, Iran in 2019.0, Cited 37.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Six novel 2-arylimidazo[2,1-b]benzothiazole (IBT) derivatives were synthesized as potential tridentate radiotracers for AD imaging purposes. Two of these ligands (6a,b) were successfully labeled with Tc-99m radionuclide at high radiochemical purity using fac-(Tc-99(m)(CO)(3)(H2O)(3)](+) synthon. [Tc-99m]7a and [Tc-99m]7b were evaluated as single photon emission computed tomography (SPECT) imaging agents for A beta plaque in AD. [Tc-99m]7a and (Tc-99m]7b exhibited suitable affinity toward A beta aggregates with IC50 values of 33.2 and 102.5 nM, respectively. The IC50 value of these radiotracers depends on the length of the spacer (alkyl chain). In biodistribution study, these complexes showed good initial brain uptakes (0.78 and 0.86% ID/g at 2 min post-injection) and fast blood clearance. Autoradiography results confirmed that these small Tc-99m complexes (Mw about 600 Da) can bind to A beta plaques in the brain sections of the rat AD model. Histopathological staining with Congo red approved the presence of A beta plaques in these brain sections. (C) 2019 Elsevier Masson SAS. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Molavipordanjani, S; Emami, S; Mardanshahi, A; Amiri, FT; Noaparast, Z; Hosseinimehr, SJ or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry; Food Science & Technology; Toxicology very interesting. Saw the article Pyrrolizidine alkaloid profiling of four Boraginaceae species from Northern Germany and implications for the analytical scope proposed for monitoring of maximum levels published in 2020. Quality Control of (E)-2-Methylbut-2-enoic acid, Reprint Addresses These, A (corresponding author), German Fed Inst Risk Assessment, Dept Safety Food Chain, Max Dohrn Str 8-10, D-10589 Berlin, Germany.. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid

Pyrrolizidine alkaloids (PAs) and their corresponding N-oxides (PANOs) have been determined in food and feed at levels relevant for consumer health. More than 660 different PAs have been detected, but few are available as reference substances for analytical demands. In the context of the European legislation on maximum levels of PAs in food products, a defined analytical scope of 21 PAs for determination has been suggested. An expansion of the scope from 21 to 35 PAs, including 14 structural isomers, is currently under discussion. In the present study, a target screening method was established for a comprehensive characterisation of PA profiles of the species Echium vulgare, Heliotropium europaeum, Cynoglossum officinale and Symphytum spp. to assess whether an expansion of the analytical scope is required to quantitatively cover the total PA contents of Boraginaceae species. The scope of the method comprised known and unknown PAs previously screened and confirmed in the respective plant extracts. A total of 176 PAs and PANOs were detected. The toxic 1,2-unsaturated PAs represent the predominant PA type with about 98% of the mean total content. This PA profiling demonstrates that an expansion of the scope from 21 to 35 PAs is required to adequately cover the mean total PA contents of Cynoglossum officinale and H. europaeum, whereas in the case of Symphytum spp. and Echium vulgare an expansion would not be necessary.

Quality Control of (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Madge, I; Gehling, M; Schone, C; Winterhalter, P; These, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Drennhaus, T; Ohler, L; Djalali, S; Hofmann, S; Muller, C; Pietruszka, J; Worgull, D in WILEY-V C H VERLAG GMBH published article about STEREOSELECTIVE-SYNTHESIS; ASYMMETRIC-SYNTHESIS; CINCHONA ALKALOIDS; DIASTEREOSELECTIVE SYNTHESIS; FACILE SYNTHESIS; 4+1 ANNULATION; EFFICIENT; DERIVATIVES; CYCLOPROPANATION; QUATERNARY in [Oehler, Laura; Djalali, Saveh; Hoefmann, Svenja; Mueller, Clemens; Pietruszka, Joerg; Worgull, Dennis] Heinrich Heine Univ Dusseldorf, Forschungszentrum Julich, Inst Bioorgan Chem, Stetternicher Forst, Bldg 15-8, D-52426 Julich, Germany; [Drennhaus, Till; Pietruszka, Joerg] Forschungszentrum Julich, Inst Bio & Geosci IBG 1, D-52426 Julich, Germany in 2020, Cited 82. Safety of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

An ammonium ylide mediated access towardstrans-beta,gamma-disubstituted,all-trans-alpha,beta,gamma-trisubstituted, and alpha,alpha,beta,gamma-tetrasubstituted gamma-butyrolactones bearing a broad variety of functionalities was developed. Starting from widely accessible benzylidene Meldrum’s acid derivatives and alpha-bromo carbonyl compounds,gamma-butyrolactones were obtained in yields between 32-99% with up to excellent diastereoselectivities (>95:5)viaa DABCO-mediated [2+1] annulation. Utilization of enantiomerically pure cinchona alkaloid derivatives enables the first asymmetric ammonium ylide mediated method to provide (3R, 4R)-beta,gamma-disubstituted and (2R, 3R, 4R)-alpha,beta,gamma-trisubstituted gamma-butyrolactones in moderate to good yields with up to very good enantiomeric ratios (97:3). The scalability of the transformation was proven while determining the absolute configuration.

Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Drennhaus, T; Ohler, L; Djalali, S; Hofmann, S; Muller, C; Pietruszka, J; Worgull, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA in [Kapoor, Garima; Pathak, Dharam Pal; Bhutani, Rubina] Delhi Inst Pharmaceut Sci & Res, Dept Pharmaceut Chem, New Delhi 110017, India; [Husain, Asif; Iqbal, Md. Azhar] Hamdard Univ, Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi, India; [Jain, Sandeep] Guru Jambeshwar Univ Sci & Technol, Dept Pharmaceut Chem, Hisar, Haryana, India published Synthesis, ADME, docking studies and in vivo anti-hyperglycaemic potential estimation of novel Schiff base derivatives from octadec-9-enoic acid in 2019.0, Cited 40.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-gamma (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores – 9.19, – 8.68 and – 8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from – 40.01 and – 80.54 kcal/mol, significant when compared with pioglitazone (- 51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Ultrasound promoted and Kit-6 mesoporous silica-supported Fe3O4 magnetic nanoparticles catalyzed cyclocondensation reaction of 4-hydroxycoumarin, 3,4-methylenedioxyphenol, and aromatic aldehydes WOS:000604548400001 published article about POT MULTICOMPONENT SYNTHESIS; ACIDIC IONIC LIQUID; GREEN SYNTHESIS; 3-COMPONENT SYNTHESIS; RECOVERABLE CATALYST; TIO2 NANOPARTICLES; EFFICIENT; DERIVATIVES; NANOCOMPOSITE; FE3O4-AT-SIO2-AT-KIT-6 in [Abdolmohammadi, Shahrzad] Islamic Azad Univ, East Tehran Branch, Dept Chem, POB 18735-138, Tehran, Iran; [Shariati, Shahab] Islamic Azad Univ, Rasht Branch, Dept Chem, Rasht, Iran; [Mirza, Behrooz] Islamic Azad Univ, Karaj Branch, Dept Chem, Karaj, Iran in 2021, Cited 80. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2

A new effective approach to synthesize a series of 7-aryl-6H,7H-[1]benzopyrano[4,3-b][1,3]dioxolo[4,5-g][1]benzopyran-6-ones was reported using Fe3O4@SiO2@Kit-6 as heterogeneous catalyst at room temperature under ultrasonic irradiation in aqueous media. This procedure is of great value due to its short reaction time, high yields, simple processing, and the use of easily available and magnetically recyclable heterogeneous catalyst.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Abdolmohammadi, S; Shariati, S; Mirza, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Synthesis of Nerol Derivatives Containing a 1,2,3-Triazole Moiety and Evaluation of Their Activities against Cancer Cell Lines published in 2019.0. Computed Properties of C7H8O, Reprint Addresses Teixeira, RR (corresponding author), Univ Fed Vicosa, Dept Quim, Av PH Rolfs S-N, BR-36570900 Vicosa, MG, Brazil.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

In the present investigation, a collection of twenty two nerol derivatives, containing 1,2,3-triazolic appendages, was synthesized and screened in vitro for their cytotoxic activity against HL60, Nalm6, and Jurkat human leukemia cells as well as against B16F10 (melanoma cell line). In most cases, derivatives were able to reduce cell viability. The most potent compound (Z)-4-(((3,7-dimethylocta-2,6-dien-1-yl)oxy)methyl)-1-(4-(trifluoromethoxy)benzyl)1H-1,2,3 triazole showed antiproliferative activity against Jurkat cells and reduced B16F10 cell migration. Physicochemical properties of the compounds were calculated in order to evaluate their potential for drug development. Most of the evaluated physicochemical parameters seemed to be favorable for drug development. In addition, for a better understanding of the biological activity results, 3D quantitative structure-activity relationship (QSAR) studies were carried out. 3D-QSAR studies indicate that the anticancer activities observed for the cell lines HL60 and Jurkat may occur by a similar mechanism of action and the same was found for the Nalm6 and B16F10 cell lines.

About Benzyl Alcohol, If you have any questions, you can contact Teixeira, RR; da Silva, AM; Siqueira, RP; Goncalves, VHS; Pereira, HS; Ferreira, RS; Costa, AV; de Melo, EB; Paula, FR; Ferreira, MMC; Bressan, GC or concate me.. Computed Properties of C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of Benzyl Alcohol. I found the field of Food Science & Technology very interesting. Saw the article Chemical characterization of four Brazilian brown propolis: An insight in tracking of its geographical location of production and quality control published in 2019.0, Reprint Addresses Narain, N (corresponding author), Univ Fed Sergipe, Lab Flavor & Chromatog Anal, Sao Cristovao, Sergipe, Brazil.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.

The aim of this work was to undertake a detailed analysis on chemical constituents of brown propolis, originating from four different states (Bahia, Minas Gerais, Parana and Sergipe) of Brazil. The volatile profile was determined by using HS-SPME-GC-MS along with the determination of total phenolic compounds content, flavonoids and antioxidant activity. A total of 315 volatile compounds were identified, however, several of them have not been reported so far in the Brazilian brown propolis. The terpenes represented the major class with 40.92-84.66% of the total area in the chromatograms. PCA analysis of the majority of compounds successfully indicated the volatile profile of each propolis sample according to their geographical origin. The analysis of volatile compounds and its characterization also varied significantly and confirmed that these depended on the geographical area of collection of propolis. The data generated in this work may help in establishing criteria for quality control and tracking the specific region of propolis production in different states of Brazil.

About Benzyl Alcohol, If you have any questions, you can contact Olegario, LS; Andrade, JKS; Andrade, GRS; Denadai, M; Cavalcanti, RL; da Silva, MAAP; Narain, N or concate me.. Safety of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis of Salicylate and Salicylamide Alcohols for the Preparation of Phosphorodiamidates and Ifosfamide Prodrugs WOS:000646298500005 published article about CYCLOPHOSPHAMIDE; ALDOPHOSPHAMIDE; METABOLITES; MUSTARD in [Pal, Ashutosh] Raja Peary Mohan Coll, Dept Chem, Uttarpara, W Bengal, India in 2021.0, Cited 26.0. Safety of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Prodrugs are derivatives of drugs which gives parent drug or release drug when it breaks inside the body by the presence of suitable enzyme, and then exert desired pharmacological effect. For many years, prodrug strategy has been developed enormously to solve many unwanted drug properties. In drug discovery and development, prodrugs have well-known pharmacokinetic effects of pharmacologically nimble products. Almost 10% of drugs permitted whole world are classified as prodrugs, where the application of a prodrug method during initial stages of development is an emergent fashion. Phosphorodiamidates prodrugs are well known anticancer agents particularly against leucomia. To improve the selectivity of the chemotherapeutic agents and reduce systemic toxicity, I herein report different types of salicylate and salicylamide alcohols for the preparation of phosphorodiamidates and ifosfamide prodrugs.

Safety of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Pal, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles