Tag: M.W=100-150

SDS of cas: 123-11-5. Authors Reddy, GM; Garcia, JR; Subbaiah, MV; Wen, JC in WILEY published article about in [Reddy, Guda Mallikarjuna] Ural Fed Univ, Chem Engn Inst, Ekaterinburg 620002, Russia; [Garcia, Jarem Raul] Univ Ponta Grossa, Dept Chem, Av Carlos Cavalcanti,4748 Campus Uvaranas,Bloco L, BR-84030900 Ponta Grossa, Parana, Brazil; [Subbaiah, Munagapati Venkata; Wen, Jet-Chau] Natl Yunlin Univ Sci & Technol, Res Ctr Soil & Water Resources & Nat Disaster Pre, 123,Sect 3,Univ Rd, Touliu 640, Yunlin, Taiwan; [Wen, Jet-Chau] Natl Yunlin Univ Sci & Technol, Dept Safety Hlth & Environm Engn, Touliu, Taiwan in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Benzothiazole-tethered pyranopyrazoles derivatives were prepared via environmentally favorable conditions, which included eco-friendly catalyst, ethanol-water solvent, one-pot reaction, and atom- and step-economy procedures. Excellent yield of the products was observed. Besides, all products were screened for their antimicrobial behavior. From the biological results, it was seen that most of the compounds possessed high to moderate antimicrobial properties. Compound 6a gave prominent antimicrobial property followed by 6d, 6l, and 6n. In addition, computer-aided studies of the active compounds were also conducted. In this, selected compounds were docked into the intercalation site of DNA of the DNA-gyrase complex. From these results, the highest binding energy of -10.1 kcal/mol was for 6a against DNA-gyrase. This is the first eco-friendly synthetic method for the preparation of benzothiazole-pyranopyrazoles and the synthetic effort in this study may serve as a model for additional environmentally benign reactions. The biological results may prompt further studies related to antibiotic drugs.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Reddy, GM; Garcia, JR; Subbaiah, MV; Wen, JC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis and in vitro antimycobacterial potential of novel hydrazones of eugenol WOS:000514837800079 published article about ANTIBACTERIAL ACTIVITY; SCHIFF-BASES; DERIVATIVES in [Rohane, Sachin H.] Kadi Sarva Vishwavidyalaya, Dept Pharmaceut Chem, Gandhinagar 382015, India; [Chauhan, Ashlesha J.] KB Inst Pharmaceut Educ & Res, Dept Chem, Gandhinagar 382023, Gujarat, India; [Fuloria, Neeraj Kumar; Fuloria, Shivkanya] AIMST Univ, Fac Pharm, Bedong 08100, Kedah, Malaysia in 2020.0, Cited 17.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Fifty one hydrazone derivatives of eugenol were designed and docked with 2NSD and 2X22 (enzymes of H37Rv strain) using Schrodinger v7.4. The selective ten hydrazone derivatives (4, 5, 11, 18, 30, 34, 35, 37, 42, and 45) of eugenol were synthesized via esterification, hydrazination and treatment with different aldehydes. Synthesized compounds were characterized by IR, H-1 NMR, and LCMS data. The compounds were evaluated for their antitubercular potential against H37Rv using microplate alamar blue assay (MABA). The study revealed that all synthesized compounds were significantly active at concentration 50 and 100 mu g/ml, whereas compound 11 exhibited activity at 25 mu g/ml. Present study showed that antitubercular activity of novel hydrazone derivatives of eugenol is strongly connected with the position of the substituent on aromatic aldehyde or ketones. (C) 2019 Production and hosting by Elsevier B.V. on behalf of King Saud University.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Rohane, SH; Chauhan, AJ; Fuloria, NK; Fuloria, S or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about STEREOSELECTIVE-SYNTHESIS; STEREOCONTROLLED SYNTHESIS; ARYL GLYCOSIDES; O-GLYCOSIDE; DERIVATIVES; REARRANGEMENT; GLYCALS; STRATEGIES; CATALYST; DESIGN, Saw an article supported by the National Key Research and Development Program of China [2018YFA0507602]; National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772006]; National Science and Technology Major Project of China [2019ZX09301106]. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Liu, M; Li, BH; Li, T; Wu, X; Liu, M; Xiong, DC; Ye, XS. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol. Application In Synthesis of m-Methoxyphenol

The C-glycosylation of C-nucleophiles including allyltrimethylsilane, silyl enol ethers and phenols with N-(glycosyloxy)acetamides as glycosyl donors has been realized. This protocol provides a convenient and practical route for the synthesis of alkyl C-glycosides and aryl 2-deoxy-beta-C-glycosides under mild reaction conditions.

Application In Synthesis of m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Liu, M; Li, BH; Li, T; Wu, X; Liu, M; Xiong, DC; Ye, XS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Single-step benzene hydroxylation by cobalt(ii) catalysts via a cobalt(iii)-hydroperoxo intermediate WOS:000530288800020 published article about LIQUID-PHASE HYDROXYLATION; HYDROGEN-PEROXIDE; HYDROPEROXO COMPLEX; DONOR LIGANDS; PHENOL; OXIDATION; REACTIVITY; OXYGENATION; ACTIVATION; MECHANISM in [Anandababu, Karunanithi; Muthuramalingam, Sethuraman; Mayilmurugan, Ramasamy] Madurai Kamaraj Univ, Sch Chem, Bioinorgan Chem Lab Phys Chem, Madurai 625021, Tamil Nadu, India; [Velusamy, Marappan] North Eastern Hill Univ, Dept Chem, Shillong 793022, Meghalaya, India in 2020.0, Cited 46.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. SDS of cas: 150-19-6

The cobalt(ii) complexes of 4N tetradentate ligands have been synthesized and characterized as the catalysts for phenol synthesis in a single step. The molecular structure of the complexes showed a geometry in between square pyramidal and trigonal bipyramidal (tau, 0.49-0.88) with Co-N-amine and Co-N-Py bond distances of 2.104-2.254 angstrom and 2.043-2.099 angstrom, respectively. The complexes exhibited a Co2+/Co3+ redox potential around 0.489-0.500 V vs. Ag/Ag+ in acetonitrile. The complexes catalyzed hydroxylation of benzene using H2O2 (30%) and afforded phenol selectively as the major product. A maximum yield of phenol up to 29% and turnover number (TON) of 286 at 60 degrees C, and a yield of 19% and TON of 191 at 25 degrees C are achieved. This is the highest catalytic performance reported using cobalt(ii) complexes as catalysts to date. This aromatic hydroxylation presumably proceeded via a cobalt(iii)-hydroperoxo species, which was characterized by ESI-MS, and vibrational and electronic spectral methods. The formation of key intermediate [(L)Co-III(OOH)](2+) was accompanied by the appearance of the characteristic O -> Co(iii) ligand to metal charge transfer (LMCT) transition around 488-686 nm and vibration modes at 832 cm(-1) (O-OH) and 564 cm(-1) (Co-O). The geometry of one of the catalytically active intermediates was optimized by DFT and its spectral properties were calculated by TD-DFT calculations. These data are comparable to the experimental observations. The kinetic isotope effect (KIE) values (0.98-1.07) support the involvement of cobalt-bound oxygen species as a key intermediate. Isotope-labeling experiments using (H2O2)-O-18 showed an 89% incorporation of O-18, revealing that H2O2 is the main oxygen supplier for phenol formation from benzene. The catalytic efficiencies of cobalt complexes are tuned by ligand architectures via their geometrical configurations and steric properties.

SDS of cas: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Anandababu, K; Muthuramalingam, S; Velusamy, M; Mayilmurugan, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Benzyl Alcohol. In 2019.0 ACS CATAL published article about ALLYLIC ALCOHOLS; ENANTIOSELECTIVE SYNTHESIS; ALPHA-IODOKETONES; ISOMERIZATION; SHIFT/CHLORINATION; CASCADE; KETONES; CORE; ACID; ARYL in [Molleti, Nagaraju; Martinez-Erro, Samuel; Carretero Cerdan, Alba; Sanz-Marco, Amparo; Martin-Matute, Belen] Stockholm Univ, Dept Organ Chem, SE-10691 Stockholm, Sweden; [Carretero Cerdan, Alba; Gomez-Bengoa, Enrique] Univ Basque Country, Dept Organ Chem 1, UPV EHU, San Sebastin 20080, Spain in 2019.0, Cited 56.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

The isomerization of dienyl alcohols and polyenyl alkyl ethers catalyzed by TBD (1,5,7-triazabicyclo[4.4.0]dec-5-ene) under metal-free conditions is presented. Two reaction pathways have been observed. For dienyl alcohols, the reaction proceeds by a [1,3]-proton shift to give gamma,delta-unsaturated ketones exclusively. On the other hand, the reaction with polyenyl alkyl ethers gives the corresponding conjugated vinyl ethers in good yields (up to 85%), with regioselectivities up to >20:1. Experimental and computational investigations suggest that the mechanism proceeds through consecutive chain-walking proton shifts (base walk) mediated by TBD.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Molleti, N; Martinez-Erro, S; Cerdan, AC; Sanz-Marco, A; Gomez-Bengoa, E; Martin-Matute, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of 4-Methoxybenzaldehyde. I found the field of Chemistry very interesting. Saw the article Choline chloride/pentaerythritol: a deep eutectic solvent for the synthesis of pyran and chromene derivatives published in 2021, Reprint Addresses Yavari, I (corresponding author), Tarbiat Modares Univ, Dept Chem, Tehran, Iran.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde.

A novel deep eutectic solvent system was prepared by mixing choline chloride as a hydrogen-bond acceptor with 2,2-bis(hydroxymethyl)propane-1,3-diol (pentaerythritol) as a hydrogen-bond donor. This green solvent was used for the one-pot synthesis of pyran and chromene derivatives from aromatic aldehydes, 1,3-dicarbonyl compounds, and malononitrile. The solvent was readily recycled and can be reused three times without significant loss of activity or mass. This procedure offers advantages such as environmental friendliness, shorter reaction times, and higher yields.

Application In Synthesis of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Azimzadeh-Sadeghi, S; Yavari, I or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Study of synergetic effect and comparison of novel sulfonated and carboxylated bulky diamine-diol and piperazine in preparation of negative charge NF membrane WOS:000468714100031 published article about COMPOSITE NANOFILTRATION MEMBRANES; IMPROVED WATER FLUX; INTERFACIAL POLYMERIZATION; ANTIFOULING PROPERTY; DESALINATION; PERFORMANCE; REJECTION; MELAMINE; REMOVAL; MONOMER in [Rezania, Hamidreza (Jafar); Shockravi, Abbas] Kharazmi Univ, Dept Organ Chem, Fac Chem, POB 15719-14911, Tehran, Iran; [Vatanpour, Vahid] Kharazmi Univ, Dept Appl Chem, Fac Chem, POB 15719-14911, Tehran, Iran; [Ehsani, Mortez] Iran Polymer & Petrochem Inst, POB 14965-115, Tehran, Iran in 2019.0, Cited 58.0. Application In Synthesis of 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

Two new sulfonated (SDA) and carboxylated (CDA) aromatic diamine-diol monomers were synthesized and applied to prepare thin-film composite (TFC) nanofiltration (NF) membranes with improved antifouling and performance properties. The interfacial polymerization method was used to make sulfonated and carboxylated TFC-NF membranes with reaction of trimesoyl chloride (TMC) in the organic phase with amine and hydroxyl agents in the aqueous phase. Herein, for the first time, a comparison between carboxylated and sulfonated TFC was carried out. Moreover, the probability of synergetic effect between these two synthetic monomers (CDA and SDA) and piperazine monomer was studied (the sulfonated monomer and piperazine showed a synergetic effect). The outcomes of flux recovery ratio (FRR), flux and contact angle showed that in the presence of newly synthesized monomers, membrane hydrophilicity considerably improved. The salt retention sequence for all membranes was Na2SO4 NaCl > CaCl2, which means all membranes had a negative charge. Among the five prepared TFC membranes (SDA, CDA, PIP, SDA/PIP, and CDA/PIP), the SDA/PIP showed the best salt rejection (97% Na2SO4) with flux (50 Lm(-2)h(-1)) and 91% FRR, at operating pressure of 10 bars. Although the SDA showed the highest permeability (62 Lm(-2) h(-1)) and FRR of 92%, it presented the lowest Na2SO4 rejection. The results indicated that mixing carboxylated monomers with PIP caused deterioration in properties, while mixing sulfonated monomer with PIP enhanced the performances of the related TFC. Better permeability of the membrane made by newly synthesized monomers is ascribed to the existence of strong hydrophilic sulfonic acid, carboxylic acid and terminal hydroxyls, and amine groups at polyamide top layer producing enhanced membrane antifouling properties.

Application In Synthesis of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Rezania, H; Vatanpour, V; Shockravi, A; Ehsani, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry very interesting. Saw the article Synthesis, anticancer activity and molecular docking studies on 1,2-diarylbenzimidazole analogues as anti-tubulin agents published in 2019.0. Formula: C7H6O2, Reprint Addresses Wang, ZC; Zhu, HL (corresponding author), Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China.; Jiang, AQ (corresponding author), Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, YL; Yang, R; Xia, LY; Man, RJ; Chu, YC; Jiang, AQ; Wang, ZC; Zhu, HL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 CATAL TODAY published article about METAL-ORGANIC FRAMEWORK; GOLD NANOPARTICLES; NANOPOROUS CARBON; ROOM-TEMPERATURE; EFFICIENT; CO; NITROGEN; SURFACE; SIZE; NANOCLUSTERS in [Chen, Fengfeng; Lu, Qingwen; Fan, Ting; Fang, Ruiqi; Li, Yingwei] South China Univ Technol, Sch Chem & Chem Engn, State Key Lab Pulp & Paper Engn, Guangzhou 510640, Peoples R China in 2020.0, Cited 50.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Application In Synthesis of Benzyl Alcohol

Here we report a novel approach to synthesize Au NPs immobilized on N-doped carbon materials. In this strategy, an ionic liquid (IL) [Bmim][AuCl4] was selected as the precursor for Au NPs and porous framework of ZIF-8 as the host for the IL. Raman spectroscopy, transmission electron microscopy, N-2 physical absorption and Fourier infrared spectra confirmed that the IL was successfully incorporated in the ZIF-8 pores. Followed by a thermal treatment under inert atmosphere, highly dispersed Au NPs were obtained and stabilized by nitrogen species from the carbonization of organic ligand in the metal-organic frameworks (MOFs). The [Bmim][AuCl4]@ ZIF-8-6.25%-T materials exhibited high catalytic activity for the selective aerobic oxidation of alcohols, affording excellent yields (up to > 99%) under atmospheric air and base-free conditions. Catalytic reaction along with catalyst characterization results revealed a strong interaction between Au NPs and N species. TEM, XRD and XPS characterization results further suggested that the N species could not only prevent the Au NPs from aggregation, but also further enhance the reaction activity.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Chen, FF; Lu, QW; Fan, T; Fang, RQ; Li, YW or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gong, YX; Zhu, ZD; Qian, Q; Tong, WQ; Gong, HG in AMER CHEMICAL SOC published article about in [Gong, Yuxin; Zhu, Zhaodong; Qian, Qun; Tong, Weiqi; Gong, Hegui] Shanghai Univ, Ctr Supramol Chem & Catalysis, Dept Chem, Shanghai 200444, Peoples R China in 2021.0, Cited 36.0. Name: Mequinol. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

We describe here the facile construction of sterically hindered tertiary alkyl ethers and thioethers via the Zn(OTf)(2)-catalyzed coupling of alcohols/phenols with unactivated tertiary alkyl bromides and the Cu(OTf)(2)-catalyzed thiolation of unactivated tertiary alkyl oxalates with thiols. The present protocol represents one of the most effective unactivated tertiary C(sp(3))-heteroatom bond-forming conditions via readily accessible Lewis acid catalysis that is surprisingly less developed.

Name: Mequinol. About Mequinol, If you have any questions, you can contact Gong, YX; Zhu, ZD; Qian, Q; Tong, WQ; Gong, HG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles