Tag: M.W=100-150

Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L in [Krasowska, Dorota; Drabowicz, Jozef; Sancineto, Luca] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Organ Chem, Sienkiewicza 112, PL-90363 Lodz, Poland; [Iraci, Nunzio] Univ Salerno, Dept Pharm, Via G Paolo II 132, I-84084 Salerno, Italy; [Santi, Claudio; Palomba, Martina] Univ Perugia, Dept Pharmaceut Sci, Via Liceo 1, I-06123 Perugia, Italy; [Drabowicz, Jozef] Jan Dlugosz Univ Czestochowa, Inst Chem, Armii Krajowej 13-15, PL-42200 Czestochowa, Poland; [Cieslak, Marcin; Kazmierczak-Baranska, Julia; Krolewska-Golinska, Karolina; Magiera, Jakub] Polish Acad Sci, Ctr Mol & Macromol Studies, Div Bioorgan Chem, Sienkiewicza 112, PL-90363 Lodz, Poland published Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors in 2019.0, Cited 73.0. Recommanded Product: 100-51-6. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

A series of variously functionalized selenium-containing compounds were purposely synthesized and evaluated against a panel of cancer cell lines. Most of the compounds showed an interesting cytotoxicity profile with compound 5 showing a potent activity on MCF7 cells. The ethyl amino derivative 5 acts synergistically with cis-platin and inhibits the GST enzyme with a potency that well correlates with the cytotoxicity observed in MCF7 cells. A computational analysis suggests a possible binding mode on the GST enzyme. As the main outcome of the present study, the ethyl amino derivative 5 emerged as a valid lead compound for further, future developments.

Recommanded Product: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Krasowska, D; Iraci, N; Santi, C; Drabowicz, J; Cieslak, M; Kazmierczak-Baranska, J; Palomba, M; Krolewska-Golinska, K; Magiera, J; Sancineto, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Influence of vanillin acrylate and 4-acetylphenyl acrylate hydrophobic functional monomers on phase separation of N-isopropylacrylamide environmental terpolymer: fabrication and characterization WOS:000529690700006 published article about STIMULI-RESPONSIVE POLYMERS; THIN-FILMS; COPOLYMERS in [Abdelaty, Momen S. A.] Al Azhar Univ, Fac Sci Assiut, Chem Dept, Polymer Lap, Assiut 71524, Egypt in 2020.0, Cited 44.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

In the present study, we synthesized new functional hydrophobic acrylate monomers. The first monomer was based on 4-acetylacetophenone, and the other one was based on vanillin as a renewable resource. The starting material was reacted with acryloyl chloride for the formation of 4-acetylphenyl acrylate (APA) and 4-formyl-2-methoxyphenylacrylate (vanillin acrylate) or (VA), respectively. The chemical structures were deduced by H-1 NMR, 13C NMR, and FTIR. The effect of these monomers on the transition temperature or lower critical solution temperature of thermo-responsive N-isopropylacrylamide was achieved by the free radical polymerization of three different molar concentrations of both APA and VA with NIPAAm in solution and using 2,2 ‘ azobis(isobutyronitrile) (AIBN) as an initiator. The terpolymers were chemically evaluated. They have been also investigated by gel permission chromatography (GPC) for molecular weight and molecular weight distribution; the glass temperatures were determined by differential scanning calorimetry DSC; X-ray diffraction (XRD) was used for the extent of crystallinity; scanning electron microscopy was used (SEM) for surface morphology. The phase separation and lower critical solution temperature T-c were measured using two methods: UV-Vis spectroscopy for turbidity measurements and micro-DSC of the polymer solution. In the future, we will use these polymers in the bio-separation process and the formation of a responsive hydrogel. [GRAPHICS] .

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Abdelaty, MSA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of (E)-2-Methylbut-2-enoic acid. In 2021 ORG LETT published article about DIRECT ORTHO ARYLATION; CARBOXYLIC-ACIDS; BENZOIC-ACIDS; BOND; PALLADIUM; HYDROARYLATION; OLEFINATION; ARYL; ALKYNES; ACTIVATION in [Hu, Zhiyong; Belitz, Florian; Zhang, Guodong; Papp, Florian; Goossen, Lukas J.] Ruhr Univ Bochum, Evonik Chair Organ Chem, D-44801 Bochum, Germany in 2021, Cited 68. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

In the presence of [p-cymene)RuCl2](2), (E)-configured alkenyl bromides couple with aromatic carboxylates to form orthovinylbenzoic acids. This C-H vinylation proceeds in high yields without any activating phosphine ligands and has an excellent functional group tolerance. Starting from commonly available (E/Z)-mixtures of alkenyl bromides, (E)-configured vinyl arenes or dienes are formed exclusively. Mechanistic studies show that this selectivity is achieved because the (E)configured alkenyl bromides undergo a smooth coupling, whereas the (Z)-isomers are rapidly eliminated with the formation of alkynes.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Hu, ZY; Belitz, F; Zhang, GD; Papp, F; Goossen, LJ or concate me.. Application In Synthesis of (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Authors Moosavi-Zare, AR; Rezaei-Gohar, M; Tavasoli, M; Goudarziafshar, H in SPRINGER published article about in [Moosavi-Zare, Ahmad Reza; Goudarziafshar, Hamid] Hamedan Univ Technol, Dept Chem Engn, Hamadan 65155, Hamadan, Iran; [Rezaei-Gohar, Mohammad; Tavasoli, Mahsa] Sayyed Jamaleddin Asadabadi Univ, Asadabad 6541861841, Iran in 2021, Cited 33. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

4-Carboxy-1-sulfopyridin-1-ium monozinc(II) trichloride {[4CSPy]ZnCl3} as a new acidic catalyst was designed and tested on the synthesis of 5-amino-1H-pyrazole-4-carbonitriles by anomeric based oxidative aromatization. The structure of [4CSPy]ZnCl3 was studied by various analyses such as Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (H-1 NMR and C-13 NMR), energy-dispersive X-ray spectroscopy, thermal gravimetric analysis, differential thermal gravimetric analysis and mass spectroscopy (MS). [GRAPHICS] .

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Moosavi-Zare, AR; Rezaei-Gohar, M; Tavasoli, M; Goudarziafshar, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Fingerprinting the volatile profile of traditional tobacco and e-cigarettes: A comparative study WOS:000652611300007 published article about ORGANIC-COMPOUNDS; SMOKE CHEMISTRY; PART I; NICOTINE; CARBONYLS; EXPOSURE; INGREDIENTS; ADDITIVES; PRODUCTS; BENZENE in [Berenguer, Cristina; Pereira, Jorge A. M.; Camara, Jose S.] Univ Madeira, CQM Ctr Quim Madeira, Campus Penteada, P-9020105 Funchal, Portugal; [Camara, Jose S.] Univ Madeira, Fac Ciencias Exatas & Engn, Dept Quim, Campus Penteada, P-9020105 Funchal, Portugal in 2021.0, Cited 59.0. Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Electronic cigarettes (e-cigarettes) have become popular alternatives to traditional tobacco. Despite this, a comprehensive evaluation of their long-term effects and safety for the consumers and the environment is missing. To contribute to filling this gap, headspace solid-phase microextraction combined with gas chromatography-mass spectrometry (HS-SPME/GC-MS) was employed to establish and compare the volatile fingerprints of traditional tobacco and e-cigarettes. The analysis of traditional tobacco included two popular brands and different parts of the cigarette (solid tobacco, cigarette smoke, cigarette paper and filter). Regarding the e-cigarettes, two e-liquids, with and without nicotine, their main constituents (e-bases) and corresponding vapours, obtained under default vaping (power) conditions, were analysed. A total of 80 volatile organic compounds (VOCs) were identified in traditional tobacco, of which 14 carbonyl compounds, 9 benzene derivatives, 9 ethyl esters and 9 hydrocarbons. Slight differences in the volatile profile of cigarette paper and filter between the two brands were also detected, showing that exogenous components of tobacco influence the flavour and harmfulness perceived by the smokers. In turn, 92 VOCs were identified in e-cigarettes, including 31 ethyl esters, 18 alcohols and 10 hydrocarbons. No VOCs with potentially toxic or harmful effects were identified in the vapour of Do It Yourself (DIY) liquids and Premium samples. Therefore, taking into consideration the volatile compositions obtained for smoking and vaping procedures under normal conditions of operation and using certified e-liquid mixtures, the e-cigarettes analysed seemed to constitute a valid and less harmful alternative to traditional tobacco for smokers, secondhand smokers and the environment.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Berenguer, C; Pereira, JAM; Camara, JS or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C7H6O2. I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Food Science & Technology very interesting. Saw the article Qualitative Chemical Characterization and Multidirectional Biological Investigation of Leaves and Bark Extracts of Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) published in 2019.0, Reprint Addresses Ferrante, C (corresponding author), Univ G dAnnunzio, Dept Pharm, I-66100 Chieti, Italy.; Zengin, G (corresponding author), Selcuk Univ, Fac Sci, Dept Biol, TR-42130 Konya, Turkey.; Mahomoodally, MF (corresponding author), Univ Mauritius, Fac Sci, Dept Hlth Sci, Reduit 230, Mauritius.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde.

Anogeissus leiocarpus (DC.) Guill. & Perr. (Combretaceae) has a long history of use by folk populations for the management of multiple human ailments. Based on the published literature, there has been no attempt to conduct a comparative assessment of the biological activity and the phytochemical profiles of the leaves and stem bark of A. leiocarpus extracted using methanol, ethyl acetate, and water. By high-performance liquid chromatography with electrospray ionization mass spectrometric detection (HPLC-ESI-MSn) analysis, quinic, shikimic, gallic, and protocatechuic acids were tentatively identified from all the extracts, while chlorogenic, caffeic, ferulic, and dodecanedioic acids were only characterised from the leaves extracts. Additionally, a pharmacological study was carried out to evaluate potential protective effects that are induced by the extracts in rat colon and colon cancer HCT116 cell line. In general, the methanol and water extracts of A. leiocarpus leaves and stem bark showed potent radical scavenging and reducing properties. It was noted that the stem bark extracts were more potent antioxidants as compared to the leaves extracts. The methanol extract of A. leiocarpus leaves showed the highest acetyl (4.68 mg galantamine equivalent/g) and butyryl (4.0 mg galantamine equivalent/g) cholinesterase inhibition. Among ethyl acetate extracts, the pharmacological investigation suggested stem bark ethyl acetate extracts to be the most promising. This extract revealed ability to protect rat colon from lipopolysaccharide-induced oxidative stress, without exerting promoting effects on HCT116 cell line viability and migration. As a conclusion, A. leiocarpus represents a potential source of bioactive compounds in the development of novel therapeutic agents.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Orlando, G; Ferrante, C; Zengin, G; Sinan, KI; Bene, K; Diuzheva, A; Jeko, J; Cziaky, Z; Di Simone, S; Recinella, L; Chiavaroli, A; Leone, S; Brunetti, L; Picot-Allain, CMN; Mahomoodally, MF; Menghini, L or concate me.. Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Rahnamafa, R; Moradi, L; Khoobi, M in [Rahnamafa, Reyhaneh; Moradi, Leila] Univ Kashan, Dept Organ Chem, Fac Chem, POB 8731753153, Kashan, Iran; [Khoobi, Mehdi] Univ Tehran Med Sci, Dept Pharmaceut Biomat, Fac Pharm, Tehran, Iran published Rapid and green synthesis of 4H-benzo[b]pyrans using triethanolamine as an efficient homogeneous catalyst under ambient conditions in 2020.0, Cited 63.0. Recommanded Product: 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

4H-benzo[b]pyrans were obtained rapidly in high yields using triethanolamine as an efficient, eco-friendly and low-cost basic catalyst. One-pot three-component condensation reaction of a series of aldehydes, malononitrile and 1,3-diketones was performed at room temperature. All the products were obtained in high-to-excellent yields and characterized in detail. Green, rapid and mild process, very short reaction times (1-12 min) and simple workup are some of the advantages of this method.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Rahnamafa, R; Moradi, L; Khoobi, M or concate me.. Recommanded Product: 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. Authors Salem, SA; Khazaei, A; Seyf, JY; Sarmasti, N; Gilan, MM in TAYLOR & FRANCIS LTD published article about in [Salem, Shadan Andalibi; Khazaei, Ardeshir; Sarmasti, Negin; Gilan, Maryam Mahmoudiani] Bu Ali Sina Univ, Fac Chem, Hamadan 6517838683, Hamadan, Iran; [Seyf, Jaber Yousefi] Hamedan Univ Technol, Dept Chem Engn, Hamadan, Hamadan, Iran in 2021, Cited 47. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A nanomagnetic catalyst based on the nano-Fe3O4 core was synthesized and used in the synthesis of the hexahydroquinoline derivatives which acts as a solid heterogeneous catalyst. The as-prepared catalyst was characterized by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction, energy dispersive X-ray spectroscopy, field emission scanning electron microscopy, transmission electron microscopy, vibrational sample magnetometry, and thermal gravimetric analysis. Catalyst activity was tested in the synthesis of hexahydroquinoline derivatives. The FTIR shows that the catalyst can activate as the carbonyl group of the benzaldehyde, so that it can motivate the reaction. The proposed method has important features which include solvent free, mild, high yield, shorter reaction time, easy preparation and separation of the catalyst, and efficient workup procedure. On the other hand, the design of experiment was used as a systematic method for the programing of the reaction condition. Optimization showed that the optimal reaction temperature and amount of catalyst were 65 degrees C and 0.05 g, respectively.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Salem, SA; Khazaei, A; Seyf, JY; Sarmasti, N; Gilan, MM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Effect of Formulation Variables on the Nasal Permeability and Stability of Naloxone Intranasal Formulations WOS:000472825100004 published article about DRUG-DELIVERY; PHARMACOKINETICS; PERMEATION; ENHANCERS; CAPRATE; MUCOSA; SPRAY in [Hsu, Hao-Jui; Yang, Yang; Ashraf, Muhammad; Al-Ghabeish, Manar] US FDA, Div Prod Qual Res, Off Testing & Res, Off Pharmaceut Qual,Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA; [Pavuluri, Venkateswara; Abraham, Ciby] US FDA, Div New Drug Prod 2, Off New Drug Prod, Off Pharmaceut Qual,Ctr Drug Evaluat & Res, Silver Spring, MD 20993 USA; [Abraham, Ciby] AstraZeneca, One Medimmune Way, Gaithersburg, MD 20878 USA; [Naraharisetti, Suresh Babu] US FDA, Div Clin Pharmacol 2, Off Clin Pharmacol, Off Translat Sci,Ctr Drug Evaluat & Res, 10903 New Hampshire Ave, Silver Spring, MD 20993 USA in 2019.0, Cited 35.0. Application In Synthesis of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Naloxone is an opioid antagonist with high affinity for -opioid receptor, and for this reason it is used for the emergency treatment of opioid overdose. Originally, it was available only as an injectable product. However, for the ease of administration, intranasal (IN) formulations have also become available. These IN formulations contain preservatives and stabilizers such as benzalkonium chloride (BKC), benzyl alcohol (BA), and ethylenediaminetetraacetic acid (EDTA). Some of these ingredients are known to affect permeability of drugs. This study focuses on investigating the effect of formulation variables including choice of preservatives, stabilizer, and pH on the permeability and stability of naloxone IN formulations. The in vitro permeability of naloxone was evaluated employing EpiAirway tissue-mounted Ussing chambers. BKC was found to enhance the apparent permeability (P-app) of naloxone significantly (p<0.05) at very low concentration, while BA caused similar enhancement at a much higher concentration. EDTA was found to decrease P-app of naloxone by lowering the pH, and the P-app of naloxone was found to decrease approximately 51-fold with the decrease in formulation pH from 6.0 to 4.0. The product stability was, however, found optimal only below pH 5.0. Thus, selection of formulation ingredients, buffering agent, and pH of IN formulation is a balancing act for achieving desired permeability and optimal stability to achieve reasonable shelf life of naloxone IN formulation. About Benzyl Alcohol, If you have any questions, you can contact Hsu, HJ; Yang, Y; Pavuluri, V; Abraham, C; Naraharisetti, SB; Ashraf, M; Al-Ghabeish, M or concate me.. Application In Synthesis of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 3-Hydroxybenzaldehyde. In 2019.0 BIOORG CHEM published article about COLCHICINE BINDING-SITE; BIOLOGICAL EVALUATION; COMBRETASTATIN A-4; TUBULIN; INHIBITORS; CHEMOTHERAPY; DERIVATIVES; DESIGN; SERIES in [Zhang, Ya-Liang; Yang, Rong; Xia, Lin-Ying; Man, Ruo-Jun; Chu, Yi-Chun; Wang, Zhong-Chang; Zhu, Hai-Liang] Nanjing Univ, Sch Life Sci, State Key Lab Pharmaceut Biotechnol, Nanjing 210023, Jiangsu, Peoples R China; [Man, Ruo-Jun] Guangxi Univ Nationalities, Guangxi Biol Polysaccharide Separat Purificat & M, Nanning 530006, Peoples R China; [Jiang, Ai-Qin] Nanjing Univ, Med Sch, Nanjing 210093, Jiangsu, Peoples R China in 2019.0, Cited 29.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Twenty-four 1,2-diarylbenzimidazole derivatives were designed, synthesized and biologically evaluated. It turned out that most of them were potential anticancer drugs. Among them, compound c24 showed the highest anti-tumor activity (GI(50) = 0.71-2.41 mu M against HeLa, HepG2, A549 and MCF-7 cells), and low toxicity to normal cells (CC50 > 100 mu M against L02 cells). In the microtubule binding assay, c24 showed the most potent inhibition of microtubule polymerization (IC50 = 8.47 mu M). The binding ability of compound c24 to tubulin crystal was verified by molecular docking simulation experiment. Further studies on HepG2 and HeLa cells showed that compound c24 could cause mitotic arrest of tumor cells to G2/M phase then inducing apoptosis. To sum up, compound c24 is a promising microtubule assembly inhibitor.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Zhang, YL; Yang, R; Xia, LY; Man, RJ; Chu, YC; Jiang, AQ; Wang, ZC; Zhu, HL or concate me.. Safety of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles