Tag: M.W=100-150

An article Synthesis, ADME, docking studies and in vivo anti-hyperglycaemic potential estimation of novel Schiff base derivatives from octadec-9-enoic acid WOS:000458112400050 published article about ACTIVATED RECEPTORS ALPHA; FREE FATTY-ACIDS; BIOLOGICAL EVALUATION; ANTIDIABETIC ACTIVITY; GENE-EXPRESSION; MANNICH BASES; PPAR; THIAZOLIDINEDIONE; DESIGN; SILICO in [Kapoor, Garima; Pathak, Dharam Pal; Bhutani, Rubina] Delhi Inst Pharmaceut Sci & Res, Dept Pharmaceut Chem, New Delhi 110017, India; [Husain, Asif; Iqbal, Md. Azhar] Hamdard Univ, Jamia Hamdard, Fac Pharm, Dept Pharmaceut Chem, New Delhi, India; [Jain, Sandeep] Guru Jambeshwar Univ Sci & Technol, Dept Pharmaceut Chem, Hisar, Haryana, India in 2019.0, Cited 40.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-gamma (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores – 9.19, – 8.68 and – 8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from – 40.01 and – 80.54 kcal/mol, significant when compared with pioglitazone (- 51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA or concate me.. COA of Formula: C7H6O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O. I found the field of Agriculture very interesting. Saw the article Phytochemical and biological activities of Silene viridiflora extractives. Development and validation of a HPTLC method for quantification of 20-hydroxyecdysone published in 2019.0, Reprint Addresses Mamadalieva, NZ (corresponding author), Acad Sci Uzbek, Inst Chem Plant Subst, Mirzo Ulugbek St 77, Tashkent 100170, Uzbekistan.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.

Silene viridifiora (Caryophyllaceae) has adaptogen, tonic, actoprotector and immunomodulator properties that are mainly attributed to ecdysteroids. The aim of the present study is to investigate the chemical constituents of essential oil as well as the 20-hydroxyecdysone content in the methanol extract S. viridiflora and its related biological activity. GC-MS analysis showed the essential oil of S. viridifiora to have a complex composition, which was dominated by methyl palmitate (8.05%), 3-hexen-1-ol (7.54%), 3-hexenyl benzoate (3.86%), beta-myrcene (3.80%), 1,1-diethoxy-2-phenylethane (3.65%), hexahydrofarnesyl acetone (3.20%) and 4-terpineol (2.47%). A high performance thin-layer chromatography (HPTLC) method was developed to analyze the methanolic extracts of S. viridifiora and to quantify the main ecdysteroid, 20-hydroxyecdysone. Validation showed that the method was accurate over the entire calibration range and resulted in errors of less than 10% in the 100-815 mu g/ml concentration range. Antioxidant and enzyme inhibitory potentials of methanol extract and individual compounds of S. viridiflora were evaluated. The results could provide a starting point for designing novel phyto-pharmaceuticals.

About Benzyl Alcohol, If you have any questions, you can contact Mamadalieva, NZ; Bohmdorfer, S; Zengin, G; Bacher, M; Potthast, A; Akramov, DK; Janibekov, A; Rosenau, T or concate me.. COA of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Identification of a potent heme oxygenase-2 (HO-2) inhibitor by targeting the secondary hydrophobic pocket of the HO-2 western region WOS:000592529800004 published article about ACID PHENETHYL ESTER; DRUG DISCOVERY; DERIVATIVES; IMIDAZOLE; INDUCERS; ANALOGS in [Floresta, Giuseppe; Fallica, Antonino N.; Romeo, Giuseppe; Sorrenti, Valeria; Salerno, Loredana; Rescifina, Antonio; Pittala, Valeria] Univ Catania, Dept Drug Sci, Vle Doria 6, I-95125 Catania, Italy; [Floresta, Giuseppe] Kings Coll London, Dept Analyt Environm & Forens, Stamford St, London SE1 9NH, England in 2020.0, Cited 54.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

The enzymatic family of heme oxygenase (HO) is accountable for heme breakdown. Among the two isoforms characterized to date, HO-2 is poorly investigated due to the lack of potent HO-2 chemical modulators and the greater attentiveness towards HO-1 isoform. In the present paper, we report the rational design and synthesis of HO-2 inhibitors achieved by modulating the volume of known HO-1 inhibitors. The inhibition preference has been moved from HO-1 to HO-2 by merely increasing the volume of the substituent in the western region of the inhibitors. Docking studies demonstrated that new derivatives soak differently in the two binding pockets, probably due to the presence of a Tyr187 residue in HO-2. These findings could be useful for the design of new selective HO-2 compounds.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Floresta, G; Fallica, AN; Romeo, G; Sorrenti, V; Salerno, L; Rescifina, A; Pittala, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Gemini Surfactant-Directed Facile Pillaring of Two-Dimensional Zeolites with Enhanced Catalytic Activity in Friedel-Crafts Alkylation WOS:000573372100020 published article about UNIT-CELL THICK; LAYER STRUCTURE PRESERVATION; BRONSTED ACID SITES; EXTERNAL SURFACE; MOLECULAR-SIEVE; MWW ZEOLITES; MFI; NANOSHEETS; MCM-36; SELECTIVITY in [Yuan, Mei-Ting; Zhao, Dong-Yang; Hao, Qing-Qing; Luo, Qun-Xing; Zhang, Jianbo; Chen, Huiyong; Sun, Ming; Xu, Long; Ma, Xiaoxun] Northwest Univ, Sch Chem Engn, Xian 710069, Shaanxi, Peoples R China; [Hao, Qing-Qing; Luo, Qun-Xing; Zhang, Jianbo; Chen, Huiyong; Sun, Ming; Xu, Long; Ma, Xiaoxun] Minist Educ Adv Use Technol Shanbei Energy, Chem Engn Res Ctr, Xian 710069, Shaanxi, Peoples R China; [Hao, Qing-Qing; Luo, Qun-Xing; Zhang, Jianbo; Chen, Huiyong; Sun, Ming; Xu, Long; Ma, Xiaoxun] Int Sci & Technol Cooperat Base Most Clean Utiliz, Collaborat Innovat Ctr Dev Energy & Chem Ind Nort, Xian 710069, Shaanxi, Peoples R China in 2020, Cited 42. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

We report an efficient procedure for the synthesis of pillared MWW zeolites (MCM-36) via integrating intercalation and hydrolysis of tetraethyl orthosilicate (TEOS) into one step. Specifically, two specially selected surfactants with more hydrophilicity instead of the conventional swelling agent cetyltrimethylammonium bromide (CTAB) were employed to increase the interlayer wetting ability and water content. The resultant intercalation and hydrolysis of TEOS occur concurrently in a confined interlayer microenvironment with enriched interlayer water and basic hexamethyleneimine (HMI). It is found that the wetting ability of swelling surfactants has a profound effect on pillarization efficiency, resulting in the different degrees of order of the layered structure, pore-size distribution, and accessibility of the acid sites of MCM-36. MCM-36 prepared using a gemini-type surfactant as a swelling agent shows a highly long-range ordered structure and enhanced catalytic activity for alkylation of benzene with benzyl alcohol compared to the one produced using conventional CTAB as a swelling agent.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Yuan, MT; Zhao, DY; Hao, QQ; Luo, QX; Zhang, JB; Chen, HY; Sun, M; Xu, L; Ma, XX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Mequinol. Authors Kumar, MSL; Ali, K; Chaturvedi, P; Meena, S; Datta, D; Panda, G in ELSEVIER published article about in [Kumar, Srinivas Lavanya M.; Ali, Kasim; Panda, Gautam] Cent Drug Res Inst, CSIR, Med & Proc Chem Div, Sitapur Rd, Lucknow 226031, UP, India; [Chaturvedi, Priyank; Meena, Sanjeev; Datta, Dipak] Cent Drug Res Inst, CSIR, Canc Biol Div, Sitapur Rd, Lucknow 226031, UP, India in 2021.0, Cited 33.0. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

In this study, we attempted the chemical simplification of Psammaplin (PsA), while retaining its activity in vitro . Inspired by the previous Structure Activity Relationship (SAR) studies on various PsA analogues and relying on the fact that oxime is metabolically unstable, we initially designed and synthesized a diverse library of PsA analogues and evaluated for cytotoxic activity. Among 32 compounds of Psammaplin analogues synthesized, the compound 10b was almost equally active as parent Psammaplin in vitro. (C) 2020 Elsevier B.V. All rights reserved.

Name: Mequinol. About Mequinol, If you have any questions, you can contact Kumar, MSL; Ali, K; Chaturvedi, P; Meena, S; Datta, D; Panda, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An expeditious one-pot synthesis of pyrido[2,3-d]pyrimidines using Fe3O4-ZnO-NH2-PW12O40 nanocatalyst WOS:000474875100013 published article about EFFICIENT; CATALYST in [Farokhian, Pegah] Univ Guilan, Dept Chem, Univ Campus 2, Rasht, Iran; [Mamaghani, Manouchehr; Mahmoodi, Nosrat Ollah; Tabatabaeian, Khalil; Shojaie, Abdollah Fallah] Univ Guilan, Fac Sci, Dept Chem, POB 41335-1914, Rasht, Iran in 2019.0, Cited 21.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Quality Control of 3-Hydroxybenzaldehyde

An efficient protocol for the facile synthesis of a series of pyrido[2,3-d]pyrimidine derivatives has been developed applying Fe3O4-ZnO-NH2-PW12O40 nanocatalyst in water. This novel method has the benefits of operational simplicity, green aspects by avoiding toxic solvents and high to excellent yields of products. Fe3O4-ZnO-NH2-PW12O40 was synthesized and characterized by Fourier transform infrared, X-ray diffraction, vibrating sample magnetometer, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and transmission electron microscopy analyses. The nanocatalyst is readily isolated and recovered from the reaction mixture by an external magnet.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Farokhian, P; Mamaghani, M; Mahmoodi, NO; Tabatabaeian, K; Shojaie, AF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Molloy, JJ; Schafer, M; Wienhold, M; Morack, T; Daniliuc, CG; Gilmour, R in [Molloy, John J.; Schaefer, Michael; Wienhold, Max; Morack, Tobias; Daniliuc, Constantin G.; Gilmour, Ryan] Westfalische Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 36, D-48149 Munster, Germany published Boron-enabled geometric isomerization of alkenes via selective energy-transfer catalysis in 2020, Cited 90. HPLC of Formula: C5H8O2. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Isomerization-based strategies to enable the stereodivergent construction of complex polyenes from geometrically defined alkene linchpins remain conspicuously underdeveloped. Mitigating the thermodynamic constraints inherent to isomerization is further frustrated by the considerations of atom efficiency in idealized low-molecular weight precursors. In this work, we report a general ambiphilic C-3 scaffold that can be isomerized and bidirectionally extended. Predicated on highly efficient triplet energy transfer, the selective isomerization of beta-borylacrylates is contingent on the participation of the boron p orbital in the substrate chromophore. Rotation of the C(sp(2))-B bond by 90 degrees in the product renders re-excitation inefficient and endows directionality. This subtle stereoelectronic gating mechanism enables the stereocontrolled syntheses of well-defined retinoic acid derivatives.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Molloy, JJ; Schafer, M; Wienhold, M; Morack, T; Daniliuc, CG; Gilmour, R or concate me.. HPLC of Formula: C5H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C8H8O2. Authors Shaibuna, M; Sreekumar, K in TAYLOR & FRANCIS INC published article about in [Shaibuna, M.; Sreekumar, K.] Cochin Univ Sci & Technol, Dept Appl Chem, Cochin, Kerala, India in 2021.0, Cited 44.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Deep eutectic solvents are a class of new generation green solvents formed from two or more components, which furnish a new homogeneous liquid phase with lower melting point than the individual components. Here, for the first time, dual role of DES as catalyst and reaction medium was studied for the synthesis of symmetric dihydropyridine derivatives from aldehyde, ethyl acetoacetate and ammonium acetate. The present article reports the suitability of six DESs for Hantzsch dihydropyridine synthesis at room temperature. Among this, DES 2 (ZrOCl2.8H(2)O and ethylene glycol at 1:2 ratio) was found to be the catalyst of choice with excellent recyclability. The role of DES in the present protocol was to activate the reactants through strong hydrogen bonding interaction and provide suitable medium for the reaction. The major advantages of DESs for the titled reaction are the easy preparation, low cost, non-volatility, biodegradability, simple catalytic process, excellent conversion and the reusability.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Shaibuna, M; Sreekumar, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of alpha 6 GABAA receptors: Formulation approach toward improved in vivo performance WOS:000555462800006 published article about CREMOPHOR-EL; ORAL BIOAVAILABILITY; DRUG; NANOSUSPENSIONS; STABILITY; PHARMACOKINETICS; STABILIZATION; DISSOLUTION; SOLUBILITY; STRATEGIES in [Mitrovic, Jelena R.; Dokovic, Jelena B.; Calija, Bojan R.; Savic, Snezana D.] Univ Belgrade, Fac Pharm, Dept Pharmaceut Technol & Cosmetol, Vojvode Stepe 450, Belgrade 11221, Serbia; [Divovic, Branka; Savic, Miroslav M.] Univ Belgrade, Fac Pharm, Dept Pharmacol, Vojvode Stepe 450, Belgrade 11221, Serbia; [Knutson, Daniel E.; Cook, James M.] Univ Wisconsin, Dept Chem & Biochem, Milwaukee Inst Drug Discovery, 3210N Cramer St, Milwaukee, WI 53211 USA; [Vulic, Predrag J.] Univ Belgrade, Fac Min & Geol, Crystallog Lab, Dusina 7, Belgrade 11000, Serbia; [Randjelovic, Danijela V.] Univ Belgrade, Inst Chem Technol & Met, Dept Microelect Technol, Njegoseva 12, Belgrade 11000, Serbia; [Dobricic, Vladimir D.] Univ Belgrade, Fac Pharm, Dept Pharmaceut Chem, Vojvode Stepe 450, Belgrade 11221, Serbia in 2020.0, Cited 58.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. SDS of cas: 100-51-6

DK-I-56-1 (7-methoxy-2-(4-methoxy-d(3)-phenyl)-2,5-dihydro-3H-pyrazolo[4,3-c]quinolin-3-one), a recently de-veloped deuterated pyrazoloquinolinone, has been recognized as a lead candidate for treatment of various neuropsychiatric disorders. During preclinical investigation of poorly water-soluble compounds such as DK-I-56-1, the application of nanotechnology could be advantageous due to improved safety and possibly increased bioavailability of nanosized formulation. DK-I-56-1 nanosuspensions stabilized by polysorbate 80, alone or in combination with poloxamers 188 i.e. 407 or D-alpha-tocopheryl polyethylene glycol 1000 succinate, were prepared using a small-scale media milling device. With particle size 208.7-250.6 nm and polydispersity index <0.250, selected nanodiseprsions were stable for three weeks. Pharmacokinetic and biodistribution studies following intraperitoneal administration of three types of formulation in mice indicated high plasma DK-I-56-1 levels after solution (10,228.6 +/- 1037.2 ngh/ml) and nanosuspension (6770.4 +/- 770.7 ngh/ml) but not suspension ad-ministration (966.0 +/- 58.1 ngh/ml). However, distribution of DK-I-56-1 after solution was heavily influenced by its composition, and brain availability of nanosuspension was superior to that of solution formulation. In spontaneous locomotor activity test, the expected hyperlocomotor effect was observed after nanosuspension administration, without compromising impact of the vehicle/excipients used. Therefore, nanonization of drug compound assembled with proper selection of stabilizers may seemingly contribute further thorough testing of DK-I-56-1 preclinical efficacy. SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Mitrovic, JR; Divovic, B; Knutson, DE; Dokovic, JB; Predrag, J; Randjelovic, DV; Dobricic, VD; Calija, BR; Cook, JM; Savic, MM; Snezana, D or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Biophysics very interesting. Saw the article Design, synthesis, biological evaluation and molecular dynamics studies of 4-thiazolinone derivatives as protein tyrosine phosphatase 1B (PTP1B) inhibitors published in 2020.0. Category: indole-building-block, Reprint Addresses Dong, WL; Wang, RL (corresponding author), Tianjin Med Univ, Sch Pharm, Tianjin Key Lab Technol Enabling Dev Clin Therape, Tianjin, Peoples R China.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

Protein tyrosine phosphatase 1B (PTP1B) is a key negative regulator of insulin signaling pathway, and more and more studies have shown that it is a potential target for the treatment of type 2 diabetes mellitus (T2DM). In this study, 17 new 4-thiazolinone derivatives were designed and synthesized as novel PTP1B inhibitors, and ADMET prediction confirmed that these compounds were to be drug-like. In vitro enzyme activity experiments were performed on these compounds, and it was found that a plurality of compounds had good inhibitory activity and high selectivity against PTP1B protein. Among them, compound 7p exhibited the best inhibitory activity with an IC50 of 0.92 mu M. The binding mode of compound 7p and PTP1B protein was explored, revealing the reason for its high efficiency. In addition, molecular dynamics simulations for the PTP1B(WT) and PTP1B(comp#7p) systems revealed the effects of compound 7p on PTP1B protein at the molecular level. In summary, the study reported for the first time that 4-thiazolinone derivatives as a novel PTP1B inhibitor had good inhibitory activity and selectivity for the treatment of T2DM, providing more options for the development of PTP1B inhibitors.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Liu, WS; Wang, RR; Yue, H; Zheng, ZH; Lu, XH; Wang, SQ; Dong, WL; Wang, RL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles