Tag: M.W=100-150

An article Synthesis of N-Protected 1-Aminoalkylphosphonium Salts from Amides, Carbamates, Lactams, or Imides WOS:000641292800037 published article about ALPHA-AMINO-ACIDS; ELECTROCHEMICAL SYNTHESIS; ELECTROORGANIC CHEMISTRY; AMIDOALKYLATING AGENTS; ANODIC-OXIDATION; PRECURSORS; REACTIVITY; CHIRALITY; SULFONES; MEMORY in [Adamek, Jakub; Zielezny, Paulina] Silesian Tech Univ, Dept Organ Chem Bioorgan Chem & Biotechnol, PL-44100 Gliwice, Poland; [Erfurt, Karol] Silesian Tech Univ, Dept Chem Organ Technol & Petrochem, PL-44100 Gliwice, Poland; [Adamek, Jakub] Silesian Tech Univ, Biotechnol Ctr, PL-44100 Gliwice, Poland in 2021.0, Cited 39.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. HPLC of Formula: C8H8O2

This report describes the development and optimization of the one-pot method for the synthesis of N-protected 1-aminoalkylphosphonium salts based on the three-component coupling of aldehydes and either amides, carbamates, lactams, imides, or urea in the presence of triarylphosphonium salts. The proposed strategy is very efficient and easy to carry out even on a larger scale (20 g) in any typical laboratory. Most reactions occur at temperatures between 50 and 100 degrees C in a short time (1-2 h) without requiring any catalyst, and simple workup procedures afford good to excellent yields. The exceptions are condensations with imides, which require much higher temperatures (150-170 degrees C) and longer reaction times (even 30 h). The possibility of carrying out the synthesis under solvent-free conditions (neat reactions) is also demonstrated. It is especially important for less reactive substrates (imides), and reactions required high temperature (or generally harsher conditions). Finally, we prove the developed one-pot methodology can be successfully applied for the synthesis of structurally diverse N-protected 1-aminoalkylphosphonium salts. Mechanistic studies showed the intermediate products of described couplings are 1-hydroxyalkylphosphonium salts, not N-hydroxyalkylamides, -imides, etc., as initially expected.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Adamek, J; Zielezny, P; Erfurt, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nasseri, MA; Rezazadeh, Z; Kazemnejadi, M; Allahresani, A in [Nasseri, Mohammad Ali; Rezazadeh, Zinat; Kazemnejadi, Milad; Allahresani, Ali] Univ Birjand, Dept Chem, Fac Sci, Birjand 97175615, Iran published Cu-Mn Bimetallic Complex Immobilized on Magnetic NPs as an Efficient Catalyst for Domino One-Pot Preparation of Benzimidazole and Biginelli Reactions from Alcohols in 2021, Cited 73. Category: indole-building-block. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

An efficient magnetically recyclable bimetallic catalyst by anchoring copper and manganese complexes on the Fe(3)O(4)NPs was prepared and named as Fe3O4@Cu-Mn. It was founded as a powerful catalyst for the domino one-pot oxidative benzimidazole and Biginelli reactions from benzyl alcohols as a green protocol in the presence of air, under solvent-free and mild conditions. Fe3O4@Cu-Mn NPs were well characterized by FT-IR, XRD, FE-SEM, TEM, VSM, TGA, EDX, DLS, and ICP analyses. The optimum range of parameters such as time, temperature, amount of catalyst, and solvent were investigated for the domino one-pot benzimidazole and Biginelli reactions to find the optimum reaction conditions. The catalyst was compatible with a variety of benzyl alcohols, which provides favorable products with good to high yields for all of derivatives. Hot filtration and Hg poisoning tests from the nanocatalyst revealed the stability, low metal leaching and heterogeneous nature of the catalyst. To prove the synergistic and cooperative effect of the catalytic system, the various homologues of the catalyst were prepared and then applied to a model reaction separately. Finally, the catalyst could be filtered from the reaction mixture simply, and reused for five consecutive cycles with a minimum loss in catalytic activity and performance. Graphic A new magnetically recyclable Cu/Mn bimetallic catalyst has been developed for domino one-pot oxidation-condensation of benzimidazole and Biginelli reactions from alcohols.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nasseri, MA; Rezazadeh, Z; Kazemnejadi, M; Allahresani, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-51-6. Authors Guan, RQ; Jing, LY; Zhang, XM; Chen, S; Xue, N; Yang, HQ in PERGAMON-ELSEVIER SCIENCE LTD published article about in [Guan, Ruqun; Jing, Lingyan; Zhang, Xiaoming; Xue, Nan; Yang, Hengquan] Shanxi Univ, Sch Chem & Chem Engn, Taiyuan 030006, Shanxi, Peoples R China; [Chen, Shuai] Chinese Acad Sci, Analyt Instrumentat Ctr, Inst Coal Chem, Taiyuan 030001, Shanxi, Peoples R China in 2019.0, Cited 60.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Carbon nanotube assemblies with controlled morphology and tailored architecture offer great potentials for myriad applications, but strategies for their production have remained a significant challenge. Here, we proposed a novel and simple microconfined-annealing strategy, in which a Pickering microdroplet patterned method and unique pyrolysis-stimulated-transformation processes were coupled unprecedentedly, for the fabrication of spherical nitrogen-doped carbon nanotube assemblies (NCNTA). Based on this strategy, the as-prepared superstructures not only retained the micrometer-size and well-defined morphology of the initial Pickering droplets, but also derived a hierarchical pomegranate-like structure where numerous interconnected NCNT particles were encapsulated by a carbon crust. More importantly, the interior architectures were shown to be manipulated through controlling synthesized parameters. Owing to the unique structure and composition of these assemblies, the yielded superstructures exhibited excellent performance and good recyclability in heterogeneous catalysis applications. This synthetic strategy provides new routes to access other micro- or macroscopic materials with novel structures and paves the way to expand their potential applications. (C) 2019 Elsevier Ltd. All rights reserved.

SDS of cas: 100-51-6. About Benzyl Alcohol, If you have any questions, you can contact Guan, RQ; Jing, LY; Zhang, XM; Chen, S; Xue, N; Yang, HQ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C5H8O2. Recently I am researching about OXIDATIVE CYCLIZATION; DIRECTING GROUP; ALLYLATION; ACTIVATION; ANNULATION; ISOINDOLINONES; C(SP(3))-H; ARYLATION; ALKENES; OLEFINS, Saw an article supported by the Natural Science Foundation of Zhejiang ProvinceNatural Science Foundation of Zhejiang Province [LQ20B020007]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Zhong, R; Xu, Y; Sun, MM; Wang, YR. The CAS is 80-59-1. Through research, I have a further understanding and discovery of (E)-2-Methylbut-2-enoic acid

A regioselective C-H functionalization/annulation reaction of N-sulfonyl amides and allylbenzenes through a palladium-catalyzed C(sp(2))-H allylation/aminopalladation/beta-H elimination/isomerization sequence has been reported. Various aryl and alkenyl carboxamides are found to be efficient substrates to construct isoquinolinones and pyridinones in up to 96% yield. Using ambient air as the terminal oxidant is another advantage regarding environmental friendliness and operational simplicity.

HPLC of Formula: C5H8O2. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Zhong, R; Xu, Y; Sun, MM; Wang, YR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

El-Malah, A; Mahmoud, Z; Salem, HH; Abdou, AM; Soliman, MMH; Hassan, RA in [El-Malah, Afaf; Mahmoud, Zeinab; Hassan, Rasha A.] Cairo Univ, Fac Pharm, Pharmaceut Organ Chem Dept, 33 Kasr El Aini St, Cairo 11562, Egypt; [El-Malah, Afaf] King Abdulaziz Univ, Fac Pharm, Pharmaceut Organ Chem Dept, Jeddah, Saudi Arabia; [Hamed Salem, Heba] King Khalid Univ, Fac Pharm, Abha, Saudi Arabia; [Hamed Salem, Heba] Cairo Univ, Biochem Dept, Fac Pharm, Cairo, Egypt; [Abdou, Amr M.; Soliman, Mona M. H.] Natl Res Ctr, Microbiol & Immunol Dept, Giza, Dokki, Egypt published Design, ecofriendly synthesis, anticancer and antimicrobial screening of innovative Biginelli dihydropyrimidines using beta-aroylpyruvates as synthons in 2021, Cited 50. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

New ecofriendly Biginelli reaction procedures have been adapted to prepare new dihydropyrimidines (DHPMs) using a multicomponent one-pot reaction. All the synthesized compounds were evaluated for their anticancer activity against 59 human cancer cell lines and evaluated for their antimicrobial activities against representatives of both Gram-positive and Gram-negative bacteria. Compound 4 showed marked wide spectrum anticancer activity towards most of the tested cancer cell lines with a percentage of growth inhibition of 29.04-71.68% against leukemia cell line (K-562 and SR), lung cancer cell line (NCI-H522), five colon cancer cell lines (HCT-116, HCT-15, HT29, KM12 and SW-620), CNS cancer cell line (SF-295 and SNB-75), melanoma cell lines (MALME-3M and M14), renal cancer cell line (CAKI-1) and breast cancer cell lines (MCF7 and MDA-MB-468). The highest observed anticancer activity was against leukemia cell lines K-562 and SR with inhibition percentages of 64.97 and 71.68%, respectively. The renal cancer cell line (UO-31) was particularly sensitive towards all the evaluated compounds. Compounds including 2b and 5c exhibited antibacterial activity against S. aureus while 2a and 5b exhibited antifungal activity against C. albicans. The results also showed that compounds 2c and 5e exhibited both antibacterial and antifungal activity against S. aureus and C. albicans respectively.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact El-Malah, A; Mahmoud, Z; Salem, HH; Abdou, AM; Soliman, MMH; Hassan, RA or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Catalytic oxidation of alcohols using Fe-bTAML and NaClO: Comparing the reactivity of Fe(V)O and Fe(IV)O intermediates WOS:000454151300059 published article about H BOND OXIDATION; C-H; AEROBIC OXIDATION; SECONDARY ALCOHOLS; HYDROGEN-PEROXIDE; IRON COMPLEXES; MECHANISM; FE-V(O); NANOPARTICLES; ACTIVATION in [Jana, Sandipan; Thomas, Jithin; Sen Gupta, Sayam] IISER, Dept Chem Sci, Kolkata 741246, Mohanpur, India in 2019.0, Cited 64.0. Computed Properties of C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

We demonstrate the selective oxidation of secondary alcohols and activated primary alcohols to their corresponding aldehydes or ketones using Fe-bTAML as the catalyst and sodium hypochlorite (NaClO) as the oxidant. Good to excellent yields of 80%-99% for the carbonyl compounds and turnover numbers up to similar to 500 was obtained with this catalytic system. The reactions are clean, performed under mild conditions (air, room temperature) and yielded sodium chloride as the only by-product. The yield and turnover number were dependent on the pH of the reaction and this difference was attributed to the different reactive intermediates that was formed at pH 7 and pH 12 (Fe-V(O) and Fe-IV(O) respectively). Reactions involving the Fe-V(O) intermediate oxidize secondary alcohols more efficiently than its Fe-IV(O) analog. This trend was reversed for the oxidation of activated primary alcohols where reactions involving Fe-IV(O) afforded much higher TON’s. This reactivity trend can be explained from the differences in bond dissociation energy (BDE) of their corresponding one electron reduced species ([Fe-IV-OH], similar to 99 kcal/mol; [Fe-III-OH], similar to 83 kcal/mol) as well as their relative stabilities in the solvent during reaction. This catalytic system was found to be unsuitable for nonconjugated primary alcohol due to the formation of the inactive Fe-IV(OMe) intermediate after one catalytic cycle.

Computed Properties of C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Jana, S; Thomas, J; Sen Gupta, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: (E)-2-Methylbut-2-enoic acid. In 2020 CHEMISTRYSELECT published article about CHIRAL LEWIS-ACID; MICHAEL ADDITION; ASYMMETRIC REACTION; DIELS-ALDER; CYCLOADDITIONS; NITROMETHANE; PROPIOLOYLPYRAZOLES; BENZYLHYDROXYLAMINE; MALONONITRILE; ACTIVATION in [Curran, Simon P.; Fallon, Brendan J.; Connon, Stephen J.] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Chem, 152-160 Pearse St, Dublin 2, Ireland in 2020, Cited 57. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

A single C-2-symmetric squaramide catalyst system allows the facile addition of either malononitrile or benzyl nitroacetate to simple pyrazole-based Michael acceptors with excellent enantiocontrol and at lower catalyst loadings than previously possible. The latter reactions are not diastereoselective, however facile hydrogenolysis leads to decarboxylation and formation of the formal adduct from the addition of nitromethane (a very recalcitrant nucleophile in this chemistry) with excellent yield and enantiocontrol.

Recommanded Product: (E)-2-Methylbut-2-enoic acid. About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Curran, SP; Fallon, BJ; Connon, SJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Yang, L; Zhuang, QL; Wu, M; Long, H; Lin, C; Lin, M; Ke, F in [Yang, Li; Ke, Fang] Yibin Univ, Fac Mat & Chem Engn, Yibin 644000, Peoples R China; [Zhuang, Qinglong] Fujian Med Univ, Sch Stomatol, Fuzhou 350122, Peoples R China; [Wu, Mei; Long, Hua; Lin, Chen; Lin, Mei; Ke, Fang] Fujian Med Univ, Sch Pharm, Fujian Prov Key Lab Nat Med Pharmacol, Inst Mat Med, Fuzhou 350122, Peoples R China published Electrochemical-induced hydroxylation of aryl halides in the presence of Et3N in water in 2021.0, Cited 68.0. COA of Formula: C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

A thorough study of mild and environmentally friendly electrochemical-induced hydroxylation of aryl halides without a catalyst is presented. The best protocol consists of hydroxylation of different aryl iodides and aryl bromides by water solution in the presence of Et3N under air, affording the target phenols in good isolated yields. Moreover, aryl chlorides were successfully employed as substrates. This methodology also provides a direct pathway for the formation of deoxyphomalone, which displayed a significant anti-proliferation effect.

COA of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Yang, L; Zhuang, QL; Wu, M; Long, H; Lin, C; Lin, M; Ke, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Nasario, FD; Moran, PJS; Rodrigues, JAR in [Nasario, Fabio D.; Moran, Paulo J. S.; Rodrigues, Jose Augusto R.] Univ Estadual Campinas, Inst Quim, Dept Quim Organ, BR-13084971 Campinas, SP, Brazil published Deracemization of sec-Alcohols through Sequential Application of C. albicans and Ketoreductases in 2019.0, Cited 51.0. Computed Properties of C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

A biocatalytic cascade process was developed using immobilized cells of the wild type yeast Candida albicans CCT 0776 in calcium alginate beads and a commercially available ketoreductase. The aim was to promote deracemization by stereoinversion of (+/-)-1-arylethanols in high substrate concentration (above 100 mmol L-1) to prepare the (R)-enantiomers of the alcohols (90-99%). with a high enantiomeric excess (83-99%) after 2 to 19 h. The (R)-1-(3-methoxyphenyl)ethanol, with 70% yield and 91% ee, obtained after 5 h was used to prepare (S)-1-(3-methoxyphenyl)-ethylamine with 60% yield and 91% ee after two steps. a key intermediate in the synthesis of (S)-rivastigmine.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Nasario, FD; Moran, PJS; Rodrigues, JAR or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 PHOTOCH PHOTOBIO SCI published article about SOLVENT POLARITY; RECENT PROGRESS; DESIGN; DYES; FLUORESCENCE; MOLECULES; DERIVATIVES; EMISSION; EMITTERS; RED in [Vinayakumara, D. R.; Kesavan, Rajalakshmi; Adhikari, Airody Vasudeva] Natl Inst Technol Karnataka, Dept Chem, Organ Mat Lab, Mangalore 575025, India; [Kumar, Sandeep] Raman Res Inst, SCM Grp, CV Raman Ave, Bangalore 560080, Karnataka, India in 2019.0, Cited 42.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. SDS of cas: 99-93-4

Herein, we describe the design, synthesis and optoelectronic characterization of a new series of highly fluorescent dyes configured with a D-A-D ‘ architecture, viz. CP1 to CP7. In the new molecular design, various electron-donating scaffolds were integrated with an efficient electron-accepting trialkoxyphenyl-substituted cyanopyridone moiety to study the effect of donor strength on their thermal and opto-physical properties. A detailed investigation of their thermal properties reveals that they are thermally robust with high melting and decomposition temperatures. Furthermore, in-depth photophysical studies expose their remarkable fluorescence ability in both solution and aggregated state within a wide spectral range from blue to orange. Evidently, among all the fluorophores, dyads bearing amino donors were found to be highly intense emitters due to their superior donating strength. Furthermore, solvatochromic studies showcase their ICT-dominated optoelectronic properties and it was confirmed by different correlation studies. Finally, the experimental results were correlated with their quantum chemical simulation data.

SDS of cas: 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Vinayakumara, DR; Kesavan, R; Kumar, S; Adhikari, AV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles