Tag: M.W=100-150

COA of Formula: C8H8O2. In 2021 CHEM HETEROCYCL COM+ published article about KNOEVENAGEL-MICHAEL REACTION; C-H ACIDS; MULTICOMPONENT REACTIONS; HETEROCYCLIC CHEMISTRY; CARBONYL-COMPOUNDS; 1ST EXAMPLE; EFFICIENT; CONVENIENT; FACILE; MALONONITRILE in [Elinson, Michail N.; Vereshchagin, Anatoly N.; Ryzhkova, Yuliya E.; Karpenko, Kirill A.; Ryzhkov, Fedor V.; Egorov, Mikhail P.] Russian Acad Sci, ND Zelinsky Inst Organ Chem, 47 Leninsky Ave, Moscow 119991, Russia in 2021, Cited 64. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Electrocatalytic transformation of aldehydes with two equivalents of 1,3-diethyl-2-thiobarbituric acid has been carried out in alcohols in an undivided cell in the presence of sodium halides with the selective formation of the substituted 5,5′-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) in 87-98% yields and with 870-980% current efficiency. This new one-pot electrochemically induced tandem Knoevenagel-Michael process is a simple and efficient approach to substituted 5,5′-(arylmethylene)bis(1,3-diethyl-2-thiobarbituric acids) containing two 1,3-diethyl-2-thiobarbituric acid fragments separated by C-aryl-substituted spacer, which are promising compounds for different biomedical applications, including anticonvulsant, antiAIDS agents and anti-inflammatory remedies. Theoretical studies were carried out to investigate the interaction of the synthesized compounds with beef and human catalases.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Elinson, MN; Vereshchagin, AN; Ryzhkova, YE; Karpenko, KA; Ryzhkov, FV; Egorov, MP or concate me.. COA of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Homoselective synthesis of 5-substituted 1H-tetrazoles and one-pot synthesis of 2,4,5-trisubstuted imidazole compounds using BNPs@SiO2-TPPTSA as a stable and new reusable nanocatalyst WOS:000617742200001 published article about SOLVENT-FREE SYNTHESIS; CATALYZED SYNTHESIS; 3+2 CYCLOADDITION; HETEROGENEOUS EPOXIDATION; CHEMOSELECTIVE OXIDATION; EFFICIENT CATALYST; CLICK CHEMISTRY; RAPID SYNTHESIS; SILICA-GEL; GREEN in [Khodamorady, Minoo; Bahrami, Kiumars] Razi Univ, Fac Chem, Dept Organ Chem, Kermanshah 6714414971, Iran; [Ghobadi, Nazanin] Alzahra Univ, Sch Sci, Dept Chem, Tehran, Iran; [Ghobadi, Nazanin] Ohio Univ, Dept Chem & Biochem, Athens, OH USA; [Bahrami, Kiumars] Razi Univ, Nanosci & Nanotechnol Res Ctr NNRC, Kermanshah, Iran in 2021, Cited 86. Name: 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Considering the importance of tetrazole and imidazole derivatives in pharmacy, industry, and explosives, BNPs@SiO2-TPPTSA was easily prepared and used as an effective, stable, and renewable nanocatalyst for the homoselective synthesis of different 5-substituted 1H-tetrazoles and atom economic synthesis of 2,4,5-trisubstituted-1H-imidazoles in solventless conditions. BNPs@SiO2-TPPTSA was characterized by transmission electron microscopy (TEM), scanning electron microscopy (SEM), X-ray diffraction (XRD), energy dispersive X-ray analysis (EDX), thermal gravimetric-differential thermal analysis (TGA-DTA), mapping, pH analysis, and Fourier transform infrared (FT-IR) techniques. Furthermore, the catalyst recycled for at least sequential five loads without a remarkable drop-in catalytic activity.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Khodamorady, M; Ghobadi, N; Bahrami, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MELANIN; STABILITY, Saw an article supported by the Wellcome TrustWellcome TrustEuropean Commission [102705, 097377]; Medical Research Council Centre for Medical MycologyUK Research & Innovation (UKRI)Medical Research Council UK (MRC); University of Aberdeen [MR/N006364/1]. Quality Control of Benzyl Alcohol. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Piras, M; Patruno, I; Nikolakopoulou, C; Willment, JA; Sloan, NL; Zanato, C; Brown, GD; Zanda, M. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

We describe the chemical synthesis of the fungal naphthopyrones YWA1 and fonsecin B, as well as their functionalization with an amine-spacer arm and the conjugation of the resulting molecules to three different functional tags (i.e., biotin, Oregon green, 1-[3-(succinimidyloxycarbonyObenzyl]-4-[5-(4-methoxyphenyl)-2-oxazolyl]pyridinium bromide (PyMPO)). The naphthopyrone-biotin and -PyMPO constructs maintained the ability to bind the C-type lectin receptor MelLec, whose interaction with immunologically active fungal metabolites (i.e., 1,8-dihydroxynaphthalene-(DHN)-melanin and YWA1) is a key step in host recognition and induction of protective immune responses against Aspergillus fumigatus. The fluorescent Fonsecin B-PyMPO construct 21 was used to selectively visualize MelLec-expressing cells, thus validating the potential of this strategy for studying the role and functions of MelLec in immunity.

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Piras, M; Patruno, I; Nikolakopoulou, C; Willment, JA; Sloan, NL; Zanato, C; Brown, GD; Zanda, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Dehghani, A; Bahlakeh, G; Ramezanzadeh, B; Ramezanzadeh, M in [Dehghani, Ali; Bahlakeh, Ghasem] Golestan Univ, Fac Engn, Dept Chem Engn, Aliabad Katoul, Iran; [Ramezanzadeh, Bahram; Ramezanzadeh, Mohammad] Inst Color Sci & Technol, Dept Surface Coatings & Corros, POB 16765-654, Tehran, Iran published Aloysia citrodora leaves extract corrosion retardation effect on mild-steel in acidic solution: Molecular/atomic scales and electrochemical explorations in 2020.0, Cited 63.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

In the present research, the aqueous-extract of Aloysia citrodora leaves (Ac.L) was chosen as mild steel (MS) inhibitor against 1 M HCl medium. Electrochemical impedance spectroscopy (EIS) outcomes demonstrated that in the presence of 800 ppm Ac.L extract, and at immersion time of 2.5 h the MS corrosion was noticeably retarded by 94% inhibition degree. The kinetics of corrosion retardation were inspected by polarization studies, and the respective achievements declared that the Aloysia citrodora leaves extract constituents could retard corrosion reactions via cathodic/anodic (mixed) inhibition mechanism. The surface investigation results proved the effectiveness of Aloysia citrodora leaves extracts in MS surface damage retardation. Alongside the electrochemical/surface studies, comprehensive theoretical explorations utilizing Monte Carlo (MC)/molecular dynamics (MD) and quantum chemical computations of density functional theory (DFT) ensured the phytochemicals binding on target metallic substrate. (C) 2020 Elsevier B.V. All rights reserved.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Dehghani, A; Bahlakeh, G; Ramezanzadeh, B; Ramezanzadeh, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Chemistry; Pharmacology & Pharmacy very interesting. Saw the article Flexible multidentate benzyldiamine derivatives with high affinity for beta-amyloid in cerebral amyloid angiopathy published in 2021.0. Computed Properties of C7H8O2, Reprint Addresses Peng, ZP; Jia, JH (corresponding author), Chongqing Med Univ, Coll Basic Med, Dept Radiol Med & Oncol, Chongqing 400016, Peoples R China.; Xue, WW (corresponding author), Chongqing Univ, Sch Pharmaceut Sci, Chongqing 401331, Peoples R China.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

Cerebral amyloid angiopathy (CAA) commonly found in the aged is pathologically characterized by beta-amyloid (A beta) deposition in the walls of arteries and capillaries of brain. In this study, four flexible multidentate benzyldiamine derivatives as potential probes for cerebrovascular A beta deposition were designed and synthesized. In in vitro inhibition assays, the ligands 18-21 displayed high affinities for A beta aggregates with K-i values of 1.45 +/- 0.53 nM, 1.68 +/- 0.35 nM, 1.16 +/- 0.23 nM and 1.72 +/- 0.19 nM, respectively. A significant improvement in the binding affinity over the monomer, compounds 9-12 or benzyldiamine derivatives, demonstrated the applicability of the multidentate approach. The underlying mechanism of these novel A beta agents was explored by molecular docking technique, which theoretically verified the high affinities of the multidentate benzyldiamine derivatives for A beta aggregates. Moreover, the molecular masses of the ligands 18-21 are more than 700 Dalton, which are believed to be hardly capable of penetrating blood brain barrier. In this regard, these ligands could be used to distinguish CAA from Alzheimer’s disease which is another A beta-related disorder disease. To convert these ligands to positron emission tomography imaging agents, we attempted to radiosynthesize [F-18]18. Though the radiolabeling was not very successful, the preliminary results suggested that these newly proposed multidentate benzyldiamine derivatives may be used as potential A beta imaging agents in cerebral amyloid angiopathy. [GRAPHICS] .

Computed Properties of C7H8O2. About Mequinol, If you have any questions, you can contact He, YJ; Fu, TT; Li, YY; Xue, WW; Cui, MC; Wang, L; Niu, MD; Peng, ZP; Jia, JH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 100-51-6. In 2019.0 MOLECULES published article about ENANTIOSELECTIVE PROTONATION; WITTIG OLEFINATION; TETRAMIC ACIDS; BRONSTED ACID; VINYL ETHERS; HYDROLYSIS; CHEMISTRY; REAGENTS; LACTONES; SCAFFOLD in [Schutznerova, Eva; Krchnak, Viktor] Palacky Univ, Dept Organ Chem, Fac Sci, 17 Listopadu 12, Olomouc 77146, Czech Republic; [Krchnakova, Anna; Krchnak, Viktor] Univ Notre Dame, Dept Chem & Biochem, 251 Nieuwland Sci Ctr, Notre Dame, IN 46556 USA in 2019.0, Cited 46.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

In solid-phase organic synthesis, Wang resin is traditionally used for the immobilization of acids, alcohols, phenols, and amines. We report the use of Wang resin for the traceless synthesis of ketones via acid-labile enol ethers. We demonstrate the practicality of this synthetic strategy on the solid-phase synthesis of pyrrolidine-2,4-diones, which represent the core structure of several natural products, including tetramic acid. Base-triggered condensation of pyrrolidine-2,4-diones yielded 4-hydroxy-1,1 ‘,2 ‘,5-tetrahydro-2H,5 ‘ H-[3,3 ‘-bipyrrole]-2,5 ‘-diones.

About Benzyl Alcohol, If you have any questions, you can contact Schutznerova, E; Krchnakova, A; Krchnak, V or concate me.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Yang, Y; Zhu, WJ; Cui, DH; Lu, CL in [Yang, Yu] Hebei Normal Univ, Element Educ Dept, Shijiazhuang 050024, Hebei, Peoples R China; [Yang, Yu; Zhu, Wenjing; Cui, Donghui; Lu, Changli] Northeast Normal Univ, Coll Chem, Changchun 130024, Peoples R China published Mussel-inspired preparation of temperature-responsive polymer brushes modified layered double hydroxides@Pd/carbon dots hybrid for catalytic applications in 2021.0, Cited 52.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A novel type of multicomponent nanocomposite of LDH@PDA@PNIPAM@Pd/carbon dots (CDs) was successfully constructed for highly efficient heterogeneous catalytic reduction from two-dimensional layer double hydroxide (LDH) nanosheet functionalized with thermo-responsive PNIPAM polymer brushes based on the mussel-inspired chemistry. CDs were used as a reductant and stabilizer by in situ loading metal Pd onto LDH@PDA@PNIPAM. Compared with LDH@PDA@PNIPAM@Pd catalyst without CDs modification, the designed LDH@PDA@PNIPAM@Pd/CDs nanohybrid catalyst had better catalytic reduction ability for various dyes and nitrophenol thanks to the synergistic catalytic effect between metal active center and CDs, LDH and their high dispersion stability. Especially, a good catalytic reduction activity was demonstrated for methylene blue (MB) with a high TOF (545.2 min(-1)). Furthermore, the nanohybrid presented interesting thermo-responsive catalytic property due to the existence of PNIPAM polymer chains. In addition, the prepared catalyst also exhibited outstanding catalytic property for the Knoevenagel condensation reaction. Our study provides a new way for the composite preparation of organic-inorganic hybrid materials by polymer and inorganic materials, and shows great potential in the field of catalytic applications.

SDS of cas: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yang, Y; Zhu, WJ; Cui, DH; Lu, CL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Mittal, RK; Purohit, P in BENTHAM SCIENCE PUBL LTD published article about MOLECULAR-PROPERTIES PREDICTION; CYTOTOXIC EVALUATION; APOPTOSIS PATHWAYS; HIGHLY EFFICIENT; QUINOLINES; ANALOGS; LAVENDAMYCIN; INHIBITORS; ADDUCTS; BENIGN in [Mittal, Ravi K.] Natl Inst Pharmaceut Educ & Res NIPER, Dept Nat Prod, Sect 67, Sas Nagar 160062, Punjab, India; [Purohit, Priyank] HIMT, Dept Pharm, Greater Noida 201308, Uttar Pradesh, India in 2020.0, Cited 42.0. Quality Control of 3-Hydroxybenzaldehyde. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4

Background: The quinoline scaffold has been an attraction due to its pharmacological activities such as anti-HIV, anti-neoplastic, anti-asthmatic, anti-tuberculotic, anti-fungal, and anti-bacterial. Objective: The designed quinoline-3-carboxylate derivatives were synthesized through a two-step reaction and evaluated for antiproliferative activity against MCF-7 and K562 cell lines. Methods: Synthesized compounds were characterized by modern analytical techniques like NMR, 2DNMR, mass. and IR. Moreover, the purity of compounds was analyzed through the HPLC. In the progress of biological results, all synthesized compounds were evaluated for antiproliferative activity against MCF-7 and 1562 cell lines. Results: The synthesized compounds exhibited micromolar inhibition in all over the ranges, however, some of the compounds showed better activity than the standard anticancer drug such, as 4m and 4n with the IC50 value of 0.33 mu M against the MCF-7 cell line, and the compounds 4k and 4m showed potential activity against the K562 cell line with the IC50 value of 0.28 mu M. The anti-cancer activities of compounds were found to be thmugh the up-regulation of intrinsic apoptosis pathways. Conclusion: The biological data of all compounds in both cell lines were utilized for the structural activity relationship of the quinoline-3-carboxylate pharmacophore. The active lead was further validated through rigorous in silico studies for the drug-likeness (QED) and Absorption, Distribution, Metabolism, Excretion, and Toxicity (ADMET) properties. Here in the present research is utilized for the demonstration of an important pharmacophore, which could be utilized for further development to become a lead as an anticancer agent with minimal toxicity.

Quality Control of 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Mittal, RK; Purohit, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Beckmann rearrangement: Thiamine hydrochloride as a remarkable catalyst for one-pot synthesis of amides from ketones WOS:000530096600002 published article about ONE-STEP SYNTHESIS; CYCLOHEXANONE-OXIME; SOLVENT-FREE; ORGANIC-SYNTHESIS; NONCATALYTIC BECKMANN; SUPERCRITICAL WATER; EPSILON-CAPROLACTAM; EFFICIENT PROMOTER; REUSABLE CATALYST; IONIC LIQUIDS in [Mahajan, Sheena; Slathia, Nancy; Kapoor, Kamal K.] Univ Jammu, Dept Chem, Jammu 180006, India in 2020.0, Cited 74.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Computed Properties of C8H8O2

Thiamine hydrochloride catalyzed synthesis of amides from ketones including 3-acetyl coumarin via Beckmann rearrangement has been reported. The reaction is believed to involve oxime formation, cleavage of C-C bond followed by C-N bond formation in one-pot. Thiamine hydrochloride is stable, cheap, easy to handle and environmentally friendly. (C) 2020 Elsevier Ltd. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Mahajan, S; Slathia, N; Kapoor, KK or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Norouzi, M; Elhamifar, D in [Norouzi, Meysam; Elhamifar, Dawood] Univ Yasuj, Dept Chem, Yasuj 7591874831, Iran published Ionic liquid-modified magnetic mesoporous silica supported tungstate: A powerful and magnetically recoverable nanocatalyst in 2019.0, Cited 71.0. Safety of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

In this study, a novel ionic liquid-modified magnetic mesoporous silica supported tungstate (Fe3O4@MCM@IL-WO4=) with core-shell structure is prepared, characterized and applied as recoverable catalyst in the green oxidation of alcohols. The magnetic mesoporous Fe3O4@MCM material was prepared through surfactant directed modification of magnetic iron oxides with tetramethoxysilane. The Fe3O4@MCM@EL-W-4(=) nanocatalyst was then prepared via chemical attachment of alkyl imidazolium chloride on Fe3O4@MCM followed by treatment with sodium tungstate. This catalyst was characterized using FT-IR spectroscopy, TG, EDX, low-angle and wide-angle PXRD, SEM, VSM and nitrogen adsorption-desorption analyses. The Fe3O4@MCM@IL-WO4= was applied as powerful catalyst in the green oxidation of alcohols using hydrogen peroxide oxidant under ultrasonic conditions. The corresponding carbonyl products were obtained in high yield and selectivity. The reusability, recoverability and durability of this catalyst have also been studied under applied conditions.

About Benzyl Alcohol, If you have any questions, you can contact Norouzi, M; Elhamifar, D or concate me.. Safety of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles