M.W=100-150 | - Page 3 of 348 - Indole Building Blocks

Xian, Liang team published research on Applied Organometallic Chemistry in 2020 | 19005-93-7

19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., Recommanded Product: 1H-Indole-2-carbaldehyde

Indole, first isolated in 1866, has the molecular formula C8H7N, and it is commonly synthesized from phenylhydrazine and pyruvic acid, 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. although several other procedures have been discovered.Indole is a colourless solid having a pleasant fragrance in highly dilute solutions. It melts at 52.5° C (126.5° F). Recommanded Product: 1H-Indole-2-carbaldehyde.

Xian, Liang;Ma, Cui-Ting;Ouyang, Ying-Gen;Di, Jia-Qi;Zhang, Zhan-Hui research published 《 Synthesis of pyrimidine derivatives via multicomponent reaction catalyzed by ferric chloride》, the research content is summarized as follows. An eco-friendly and practical approach was developed for the synthesis of pyrimidine derivatives via a one-pot, three-component coupling reaction of com. available aldehydes, alkynes, and indazole/triazole catalyzed by ferric chloride with good to excellent yields. The advantages of this method include environmentally friendly catalyst, easily available materials, and ease of product isolation.

Referemce:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Xing, Siyang team published research on Journal of Organic Chemistry in 2022 | 19005-93-7

Previous studies have identified that indole-oxidases are present in P. putida, whose major ligands are heterocyclic substrates and have an interesting affinity when the substrate is indole. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. These enzymes oxidize the ring so the substrate turns into Indigo. Synthetic Route of 19005-93-7.

Xing, Siyang;Wang, Yuhan;Jin, Changkun;Shi, Shaochen;Zhang, Yihui;Liao, Ziya;Wang, Kui;Zhu, Bolin research published 《 Construction of Bridged Aza- and Oxa-[n.2.1] Skeletons via an Intramolecular Formal [3 + 2] Cycloaddition of Aziridines and Epoxides with Electron-deficient Alkenes》, the research content is summarized as follows. An intramol. formal [3+2] cycloaddition of activated aziridines and epoxides with electron-deficient alkene I (X = N,O; R¹ = Me, Et, n-Pr, i-Pr, n-bu, Bn; R³ = H, F, Cl; R⁴ = H, OMe, CF₃; R⁵ = H, Me; R² = 4-Br₆H₄, 4-NO₂C₆H₄, C₆H₅) has been developed for the general and efficient construction of bridged aza- and oxa-[n.2.1] (n = 3,4) II skeletons. The strategy can be promoted by lithium iodide efficiently. In order to demonstrate its potential, the intramol. formal [3 + 2] cycloaddition was used to access the important intermediate of homoepiboxidine.

Sun, Xianwei team published research on ChemMedChem in 2022 | 19005-93-7

Name: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Indole, also called Benzopyrrole, a heterocyclic organic compound occurring in some flower oils, such as jasmine and orange blossom, in coal tar, and in fecal matter. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. It is used in perfumery and in making tryptophan, an essential amino acid, and indoleacetic acid (heteroauxin), a hormone that promotes the development of roots in plant cuttings. Name: 1H-Indole-2-carbaldehyde.

Sun, Xianwei;Admane, Prasad;Starosolski, Zbigniew A.;Eriksen, Jason L.;Annapragada, Ananth V.;Tanifum, Eric A. research published 《 1-Indanone and 1,3-indandione Derivatives as Ligands for Misfolded α-Synuclein Aggregates》, the research content is summarized as follows. The development of imaging agents for in vivo detection of alpha-synuclein (α-syn) pathologies faces several challenges. A major gap in the field is the lack of diverse mol. scaffolds with high affinity and selectivity to α-syn fibrils for in vitro screening assays. Better in vitro scaffolds can instruct the discovery of better in vivo agents. We report the rational design, synthesis, and in vitro evaluation of a series of novel 1-indanone and 1,3-indandione derivatives from a Structure-Activity Relationship (SAR) study centered on some existing α-syn fibril binding ligands. Our results from fibril saturation binding experiments show that two of the lead candidates compounds 8 and 32 bind α-syn fibrils with binding constants (Kd) of 9.0 and 18.8 nM, resp., and selectivity of greater than 10x for α-syn fibrils compared with amyloid-β (Aβ) and tau fibrils. Our results demonstrate that the lead ligands avidly label all forms of α-syn on PD brain tissue sections, but only the dense core of senile plaques in AD brain tissue, resp. These results are corroborated by ligand-antibody colocalization data from Syn211, which shows immunoreactivity toward all forms of α-syn aggregates, and Syn303, which displays preferential reactivity toward mature Lewy pathol. Our results reveal that 1-indanone derivatives have desirable properties for the biol. evaluation of α-synucleinopathies.

Suzuki, Takumi team published research on Advanced Synthesis & Catalysis in 2020 | 19005-93-7

In addition to indoleacetic acid, indigo, and tryptophan, numerous compounds obtainable from plant or animal sources contain the indole molecular structure. 19005-93-7, formula is C9H7NO, Name is 1H-Indole-2-carbaldehyde. The best-known group of these compounds is the indole alkaloids, members of which have been isolated from plants representing more than 30 families. Synthetic Route of 19005-93-7.

Suzuki, Takumi;Kuwano, Satoru;Arai, Takayoshi research published 《 Non-Bonding Electron Pair versus π-Electrons in Solution Phase Halogen Bond Catalysis: Povarov Reaction of 2-Vinylindoles and Imines》, the research content is summarized as follows. The non-bonding electron pair (n-pair) of heteroatoms and π-electrons are both efficient halogen bond (XB) acceptors. In solid and gas phase studies, n-pairs generally prevail over π-bonding orbitals as XB acceptors, whereas few studies have been conducted regarding the preference in solution phase. Herein, the Povarov reaction via the C-I···N XB interaction and [4+2] cycloaddition via the C-I···π XB interaction were evaluated, revealing that the n-pair was more dominant in the XB catalysis system in solution The XB donor-catalyzed Povarov reaction gave diverse indolyl-tetrahydroquinoline derivatives in good yields. Synthesis of indolyl-quinolines was also developed.

Tan, Yu Jia team published research on ACS Medicinal Chemistry Letters in 2021 | 19005-93-7

Synthetic Route of 19005-93-7, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Tan, Yu Jia;Li, Ming;Gunawan, Gregory Adrian;Nyantakyi, Samuel Agyei;Dick, Thomas;Go, Mei-Lin;Lam, Yulin research published 《 Amide-Amine Replacement in Indole-2-carboxamides Yields Potent Mycobactericidal Agents with Improved Water Solubility》, the research content is summarized as follows. Indolecarboxamides are potent but poorly soluble mycobactericidal agents. Here, it was found that modifying the incipient scaffold by amide-amine substitution and replacing the indole ring with benzothiophene or benzoselenophene led to striking (10-20-fold) improvements in solubility Potent activity could be achieved without the carboxamide linker but not in the absence of the indole ring. The indolylmethylamine, N-cyclooctyl-6-trifluoromethylindol-2-ylmethylamine (MIC_90Mtb 0.13μM, MBC_99.9Mtb 0.63μM), exemplifies a promising member that is more soluble and equipotent to its carboxamide equivalent It is also an inhibitor of the mycolate transporter MmpL3, a property shared by the methylamines of benzothiophene and benzoselenophene.

Taneda, Masatsugu team published research on Acta Crystallographica, Section E: Crystallographic Communications in 2022 | 19005-93-7

Taneda, Masatsugu;Nishi, Masato;Kubono, Koji;Kashiwagi, Yukiyasu;Matsumoto, Taisuke research published 《 Crystal structure of N-(1H-indol-2-ylmethylidene)-4-methoxyaniline》, the research content is summarized as follows. The mol. of the title compound, C₁₆H₁₄N₂O, contains an essentially planar indole ring system and a Ph ring. In the crystal, the mols. are linked by a weak intermol. C-H···O hydrogen bond and C-H···π interactions, forming a one-dimensional column structure along the b-axis direction. These columns are linked by other C-H···πinteractions, forming a two-dimensional network structure.

Tansky, Maxym team published research on Journal of Organic Chemistry in 2021 | 19005-93-7

Tansky, Maxym;Gu, Zipeng;Comito, Robert J. research published 《 Metal-free, Mild, and Selective Synthesis of Bis(pyrazolyl)alkanes by Nucleophile-Catalyzed Condensation》, the research content is summarized as follows. Bis(pyrazolyl)alkanes are a prolific class of ligands for catalysis, accessible by the condensation between bis(pyrazolyl)methanones and carbonyls. In this report, we describe a nucleophile-catalyzed innovation on this condensation that avoids the transition metals, high temperatures, reagent excess, and air-sensitive reagents common among the existing protocols. Significantly, this method accommodates sterically hindered and electronically diverse pyrazoles and aldehydes, applicable for systematic ligand optimization. Furthermore, our scope includes azoles and bridging functional groups previously unreported for this reaction, promising for new heteroscorpionate catalysts. We provide the first direct evidence for an elusive reaction intermediate and characterize the most complete mechanism for this condensation.

Thadem, Nagender team published research on Organic & Biomolecular Chemistry in | 19005-93-7

Application of C9H7NO, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Thadem, Nagender;Rajesh, Manda;Balaboina, Harikrishna;Das, Saibal research published 《 Synthesis of bridgehead-azacycles via dual C-N/C-C annulation of α-amino acids, aminals and maleimides》, the research content is summarized as follows. A method for easy access to succinamide-bridged azacyclic derivatives through the metal-free polarization-controlled dual C-N/C-C annulation of readily available α-amino acids, 2-amino benzaldehydes or pyrrole/indole-2-aldehyde and maleimide substrates was reported. This cascade features a rare dipolarophile-induced diastereo-selective amidative annulation, followed by 3 + 2 cycloaddition as key steps.

Tian, Fei team published research on Science China: Chemistry in 2021 | 19005-93-7

Recommanded Product: 1H-Indole-2-carbaldehyde, 1H-Indole-2-carbaldehyde is a useful research compound. Its molecular formula is C9H7NO and its molecular weight is 145.16 g/mol. The purity is usually 95%.
1H-Indole-2-carbaldehyde is a useful research chemical used as a reactant in the synthesis of substituted 2-amino-4H-chromenes and benzochromenes using K2CO3 as catalyst.
1H-Indole-2-carbaldehyde is a solvent that has been used in the protein data and molecular modeling study. The 1H NMR spectrum of this compound showed an intense signal at δ 4.8 ppm, corresponding to the hydroxyl proton. This solvent also has fluorescence properties, as shown by its photophysical and structural analysis. The 1H-indole-2-carbaldehyde molecule has an active methylene group and an oxindole ring with amine substituents., 19005-93-7.

Tian, Fei;Yang, Wu-Lin;Ni, Tao;Zhang, Jian;Deng, Wei-Ping research published 《 Catalytic asymmetric dipolar cycloadditions of indolyl delocalized metal-allyl species for the enantioselective synthesis of cyclopenta [b]indoles and pyrrolo[1,2-a]indoles》, the research content is summarized as follows. Herein, a novel indolyl substituted metal-allyl zwitterionic intermediates through the decarboxylation of conveniently available vinyl indoloxazolidones, which could be regarded as two types of dipolar species through the anionic delocalization was disclosed. The palladium-π-allyl species tended to served as an all-carbon 1,3-dipole in the asym. [3+2] cycloaddition with electron-deficient alkenes, which furnished polysubstituted cyclopenta[b]indoles I [R¹ = H, 7-F, 7-Cl, etc.; R² = Ph, 1-naphthyl, 2-furanyl, etc.; R³ = CN, CO₂Me] with high regio- and stereoselectivities. Meanwhile, the iridium-π-allyl species was recognized as an aza-1,3-dipole in asym. [3+2] cycloaddition with in situ generated C1 ammonium enolates, afforded pyrrolo[1,2-a]indoles II [R¹ = H, 7-F, 7-Cl, etc.; R⁴ = CH:CHCH₃, Ph, 3-thienyl, etc.] with high diastereo- and enantioselectivities. In addition, the dipolar cycloadditions could be easily scaled-up and several synthetic transformations of the cycloadducts were demonstrated for the rapid synthesis of diverse chiral polycyclic indoles.

van der Westhuyzen, Alet E. team published research on ARKIVOC (Gainesville, FL, United States) in 2020 | 19005-93-7

van der Westhuyzen, Alet E.;Hadjegeorgiou, Kathy;Green, Ivan R.;Pelly, Stephen C.;van Otterlo, Willem A. L. research published 《 Synthesis of pyrrolocarbazoles with N-substituted alkynyl-, alkylcyano- and alkylhydroxyl-groups》, the research content is summarized as follows. Due to their involvement in almost all stages of cellular life, kinase biomol. catalysts have been linked to cancer development and, thus, remain attractive drug targets for cancer therapeutics. 6-(3′-Hydroxypropyl)-, 6-(2′-hydroxyethyl)-, 6-(2′-propynyl)- and 6-(3′-propanenitrile)-pyrrolo[3,4-c]carbazole-1,3(2H,6H)-diones were synthesized as potential small mol. EGFR kinase inhibitors. The pyrrolocarbazole compounds were synthesized by way of a Diels-Alder approach involving N-alkylated 2-vinyl-1H-indole and maleimide as starting materials followed by aromatization with MnO2.