Tag: M.W=100-150

Recommanded Product: 99-93-4. Recently I am researching about ENDOCRINE-DISRUPTING CHEMICALS; HIGH LACCASE ACTIVITY; DEGRADATION; REMOVAL; BIOREMEDIATION; FERREDOXIN; REDUCTION; TOXICITY; EXPOSURE; BACTERIA, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31540067, 21876201]; Basic Research Fund of the Chinese Academy of Agricultural Sciences [1610042017001, 1610042018005, 1610042018006]. Published in MDPI in BASEL ,Authors: Jia, Y; Eltoukhy, A; Wang, JH; Li, XJ; Hlaing, TS; Aung, MM; Nwe, MT; Lamraoui, I; Yan, YC. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30 degrees C and 6.5, respectively. The biodegradation pathway was proposed based on the identification of the metabolites. The addition of cytochrome P450 (CYP) inhibitor 1-aminobenzotriazole significantly decreased the degradation of BPA by Sphingobium sp. YC-JY1. Escherichia coli BL21 (DE3) cells harboring pET28a-bisdAB achieved the ability to degrade BPA. The bisdB gene knockout strain YC-JY1 Delta bisdB was unable to degrade BPA indicating that P450(bisdB) was an essential initiator of BPA metabolism in strain YC-JY1. For BPA polluted soil remediation, strain YC-JY1 considerably stimulated biodegradation of BPA associated with the soil microbial community. These results point out that strain YC-JY1 is a promising microbe for BPA removal and possesses great application potential.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jia, Y; Eltoukhy, A; Wang, JH; Li, XJ; Hlaing, TS; Aung, MM; Nwe, MT; Lamraoui, I; Yan, YC or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Anti-proliferative potential of triphenyl substituted pyrimidines against MDA-MB-231, HCT-116 and HT-29 cancer cell lines WOS:000576785800009 published article about BIOLOGICAL EVALUATION; TUBULIN INHIBITORS; ANTICANCER AGENTS; COMBRETASTATIN ANALOGS; COLCHICINE SITE; BINDING; DERIVATIVES; PHOSPHATE; DESIGN; CYTOTOXICITY in [Dwivedi, Ashish Ranjan; Kumar, Vijay; Kaur, Harmeet; Kumar, Naveen; Poduri, Ramarao; Kumar, Vinod] Cent Univ Punjab, Dept Pharmaceut Sci & Nat Prod, Bathinda 151001, Punjab, India; [Yadav, Ravi Prakash; Baranwal, Somesh] Cent Univ Punjab, Sch Basic & Appl Sci, Dept Microbiol, Bathinda 151001, Punjab, India; [Kumar, Vinod] Cent Univ Punjab, Lab Organ & Med Chem, Dept Chem, Bathinda 151001, Punjab, India in 2020.0, Cited 47.0. Recommanded Product: 99-93-4. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A series of triphenyl substituted pyrimidines as analogous of colchicine and combretastatin A-4 was synthesized and evaluated for the antiproliferative potential. The compounds were screened against MDA-MB-231, HCT-116 and HT-29 cell lines using MTT assay. Most of the compounds displayed antiproliferative activity in low to sub micro molar concentration. Amongst the synthesized derivatives, compounds HK-2, HK-10 and HK-13 were found to be effective against all the three cancer cell lines. HK-2 exhibited IC50 values of 3.39 mu M, 4.78 mu M and 4.23 mu M, HK-10 showed IC50 values of 0.81 mu M, 5.89 mu M, 4.96 mu M and HK-13 showed IC50 values 3.24 mu M, 4.93 mu M and 4.73 mu M against MDA-MB-231, HCT-116 and HT-29 cancer cell lines, respectively. HK-10 was found to be the most potent compound in the series with IC50 values of 0.81 mu M against MDA-MB-231. In the cell cycle analysis, HK-2 and HK-10 showed cell arrest at G2/M phase of the cell cycle while HK-13 inhibited cell growth at the G1/G0 phase. All the three compounds showed cell death induced through apoptosis. In the docking studies, HK-2, HK-10 and HK-13 were found to fit well in the colchicine binding site of the tubulin. Some of the compounds in the current series were found to be promising against all the three cancer cell lines and may act as potent leads for further development.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Dwivedi, AR; Kumar, V; Kaur, H; Kumar, N; Yadav, RP; Poduri, R; Baranwal, S; Kumar, V or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A simple, direct synthesis of 3-vinylindoles from the carbocation-catalysed dehydrative cross-coupling of ketones and indoles. A combined experimental and computational study WOS:000456353200005 published article about SUBSTITUTED CARBAZOLES; ORGANOBORON REAGENTS; DENSITY FUNCTIONALS; PRACTICAL SYNTHESIS; ACID; ALKYLATION; EFFICIENT; HYDROARYLATION; SOLVATION; CHLORIDE in [Barbero, Margherita; Dughera, Stefano; Alberti, Sara; Ghigo, Giovanni] Univ Torino, Dipartimento Chim, Via P Giuria 7, I-10125 Turin, Italy in 2019.0, Cited 84.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Computed Properties of C7H8O2

A straightforward synthesis of a library of largely new 3-vinylindoles via a clean dehydrative coupling reaction between ketones and indoles has been developed. Highly stable, non-nucleophilic aryl(2-methylindol-3-yl)methylium salts have been used as efficient Lewis acid catalysts. The advantages of the reaction are the use of equimolar amounts of inexpensive and easily available reagents, the low catalyst amount, high atom efficiency, the production of only one molecule of water as a by-product and the mild reaction conditions. Computational studies of two specific reaction mechanism instances show that both steric and electronic effects heavily influence the nature of the final products, whether a methyl group in position 2 of the indole is present or absent. (C) 2018 Elsevier Ltd. All rights reserved.

About m-Methoxyphenol, If you have any questions, you can contact Barbero, M; Dughera, S; Alberti, S; Ghigo, G or concate me.. Computed Properties of C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Ibrahim, JJ; Reddy, CB; Zhang, SC; Yang, Y in WILEY-V C H VERLAG GMBH published article about ASYMMETRIC TRANSFER HYDROGENATION; IRIDIUM-CATALYZED ALKYLATION; EFFICIENT; COMPLEX; AMINES; AUTOTRANSFER; REDUCTION; STRATEGY in [Ibrahim, Jessica Juweriah; Reddy, C. Bal; Zhang, Shaochun; Yang, Yong] Chinese Acad Sci, Qingdao Inst Bioenergy & Bioproc Technol, Qingdao 266101, Shandong, Peoples R China; [Ibrahim, Jessica Juweriah] Univ Chinese Acad Sci, Beijing 100049, Peoples R China in 2019.0, Cited 52.0. COA of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

In this study, we present a facile, cost-effective and expedient hydrogen-borrowing strategy to perform alpha-alkylation of ketones with primary alcohols using FeCl2 as the catalyst. A set of both ketones and alcohols could be efficiently alkylated to produce their corresponding ketones in good to high yields.

About Benzyl Alcohol, If you have any questions, you can contact Ibrahim, JJ; Reddy, CB; Zhang, SC; Yang, Y or concate me.. COA of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Efficient solvent- and temperature-tuned access to aldoxime ethers and phenolic functions by Pd-catalyzed C-O cross-coupling of aldoximes with aryl bromides and bromo-chalcones WOS:000509895700019 published article about ARYLOXIME ETHERS; OXIME ETHERS; PHENYLBORONIC ACIDS; REARRANGEMENT; BENZOFURANS; CYCLIZATION; ARYLATION; DERIVATIVES; COMPLEX in [Reeta; Kaushik, Kumar; Singh, Raj Pal] DRDO, Ctr Fire Explos & Environm Safety, Delhi, India; [Reeta] Univ Delhi, Dept Chem, Delhi, India; [Rangarajan, T. M.; Singh, Rishi Pal] Univ Delhi, Sri Venkateswara Coll, Dept Chem, New Delhi, India; [Singh, Manjula] Univ Delhi, Shivaji Coll, Dept Chem, New Delhi, India in 2020.0, Cited 69.0. HPLC of Formula: C8H8O2. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A single method with a functionality switching option was developed for the first time for the Pd-catalyzed C-O cross-coupling of aryl bromides and bromo-chalcones with aldoximes. The ligand tBuXPhos (L2) was found to be an effective supporting ligand for the Pd-catalyzed coupling of aldoximes with bromo coupling partners. The functionality switching from oxime ethers to a phenolic or hydroxy group was driven by solvent or temperature. This method offers the products in good to excellent yields in short reaction times.

HPLC of Formula: C8H8O2. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Reeta; Rangarajan, TM; Kaushik, K; Singh, RP; Singh, M; Singh, RP or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Heteroleptic copper(I) complexes as energy transfer photocatalysts for the intermolecular [2+2] photodimerization of chalcones, cinnamates and cinnamamides WOS:000650994000030 published article about CYCLOBUTANE; CYCLOADDITION; PHOTOCYCLOADDITION; DERIVATIVES; REDUCTION; FLOW in [Wu, Qing-An; Ren, Chen-Chao; Chen, Feng; Wang, Tian-Qi; Zhang, Yu; Luo, Shu-Ping] Zhejiang Univ Technol, State Key Lab Breeding Base Green Chem Synth Tech, Chaowang Rd 18, Hangzhou 310014, Peoples R China; [Liu, Xue-Fen] Hangzhou Normal Univ, Qianjiang Coll, Hangzhou 310006, Peoples R China; [Chen, Jian-Bin] Qilu Univ Technol, Sch Chem & Chem Engn, Shandong Prov Key Lab Mol Engn, Shandong Acad Sci, Jinan 250353, Peoples R China in 2021.0, Cited 41.0. Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The [2 + 2] photodimerization of chalcones, cinnamates and cinnamamides can be effectively catalyzed by heteroleptic copper(I) complexes. The reactions were carried out under mild reaction conditions and the products were obtained in 20-72% yield under visible light irradiation. The copper-based photocatalyst comprised of the rigid phenanthroline ligand with substituents at the 2,9-positions and the 4,7-positions showed high activity in the photodimerization via an energy transfer pathway. (C) 2021 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Wu, QA; Ren, CC; Chen, F; Wang, TQ; Zhang, Y; Liu, XF; Chen, JB; Luo, SP or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Rao, RN; Chanda, K in ROYAL SOC CHEMISTRY published article about in [Rao, Ramdas Nishanth; Chanda, Kaushik] Vellore Inst Technol, Sch Adv Sci, Dept Chem, Vellore 632014, Tamil Nadu, India in 2021, Cited 30. Computed Properties of C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

An expeditious microwave assisted one-pot sequential route to synthesize pyrido fused imidazo[4,5-c]quinolines via the Pictet-Spengler cyclization strategy has been developed. In this study, substituted 2-amino pyridines are condensed with 2-bromo-2 ‘-nitroacetophenone to generate imidazo[1,2-a]pyridines with nitro group functionality at C-2 position. Reduction of nitro group to its amine congener in green media followed by the Pictet-Spengler cyclization strategy with substituted aldehydes led to the formation of new C-C and C-N bonds in a one-pot sequential manner. The cyclization proceeds through the CO(carbonyl)-C(H) cleavage of the aldehyde group via oxidative cross-coupling, transamination, cyclization and aromatization steps. Low cost reagents and a green solvent were used to facilitate the architecturally beautiful pyrido fused imidazo[4,5-c]quinoline scaffolds in high yields. The key features of this synthetic protocol are the use of microwave-assisted mild reaction conditions, one-pot sequential pathway, broad substrate scope and green media, which make it feasible for the synthesis of fused polyheterocycles. Moreover, the synthetic manipulation proceeded well with heteroaromatic and aliphatic aldehydes also in good yields.

Computed Properties of C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rao, RN; Chanda, K or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Rapid and green synthesis of 4H-benzo[b]pyrans using triethanolamine as an efficient homogeneous catalyst under ambient conditions published in 2020.0. Product Details of 100-83-4, Reprint Addresses Moradi, L (corresponding author), Univ Kashan, Dept Organ Chem, Fac Chem, POB 8731753153, Kashan, Iran.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

4H-benzo[b]pyrans were obtained rapidly in high yields using triethanolamine as an efficient, eco-friendly and low-cost basic catalyst. One-pot three-component condensation reaction of a series of aldehydes, malononitrile and 1,3-diketones was performed at room temperature. All the products were obtained in high-to-excellent yields and characterized in detail. Green, rapid and mild process, very short reaction times (1-12 min) and simple workup are some of the advantages of this method.

Product Details of 100-83-4. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Rahnamafa, R; Moradi, L; Khoobi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2021 ORG BIOMOL CHEM published article about ASSISTED ONE-POT; MULTICOMPONENT SYNTHESIS; ULTRASOUND; WATER; NANOPARTICLES; DERIVATIVES; SCAFFOLDS; CHEMISTRY; PYRAZOLE; DESIGN in [Nazeri, Mohammad Taghi; Shaabani, Ahmad; Notash, Behrouz] Shahid Beheshti Univ, Fac Chem, GC, POB 19396-4716, Tehran, Iran; [Shaabani, Ahmad] RUDN Univ, Peoples Friendship Univ Russia, 6 Miklukho Maklaya St, Moscow 117198, Russia in 2021, Cited 74. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Small-ring heterocycles comprising pyrrole and pyrazole are well known for their rich biological properties. In this article, an efficient green sonochemical approach was designed for the synthesis of novel, fully substituted pyrroles connected to pyrazole scaffolds via a one-pot, four-component isocyanide-based sequential reaction. This reaction was carried out using various 5-amino-pyrazoles, aldehydes, dialkyl acetylenedicarboxylates and isocyanides for the synthesis of fully functionalized pyrroles with high chemoselectivity in the presence of a catalytic amount of PTSA center dot H2O, in good to excellent yields under ultrasound irradiation. This waste-free (-H2O) reaction exhibited a high atom economy and step economy via creating four new bonds, including two C-N and two C-C bonds, and the formation of two five-member heterocycles which are connected in a single operation. The mechanism of this four-component domino process involved sequential imination-dipolar cyclization-[1,5]-H shift reactions. The synthesized compounds possess interesting fluorescence features, and the bioactive scaffolds might attract great interest in the fields of clinical diagnostics and biomedical research in the future.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nazeri, MT; Shaabani, A; Notash, B or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Zhang, ZW; Rakesh, KP; Liu, J; Qin, HL; Tang, HL in ROYAL SOC CHEMISTRY published article about FDA-APPROVED DRUGS; CATALYZED FLUOROSULFONYLVINYLATION; HYDROLYSIS; SUFEX in [Qin, Hua-Li; Tang, Haolin] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, Wuhan 430070, Peoples R China; Wuhan Univ Technol, State Key Lab Adv Technol Mat Synth & Proc, Wuhan 430070, Peoples R China in 2021.0, Cited 40.0. Formula: C7H8O2. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

Both cis and trans relative configurations of functionalized cyano cyclopropane bearing sulfonyl fluoride moiety were accessed by Corey-Chaykovsky cyclopropanation reactions. This protocol used mild conditions, and obtained good yields with excellent functional group compatibility. Further application of this class of compounds in SuFEx reactions and cyano reductions were also successfully achieved in good yields.

Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Zhang, ZW; Rakesh, KP; Liu, J; Qin, HL; Tang, HL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles