Tag: M.W=100-150

An article Exploring the potential of wine industry by-products as source of additives to improve the quality of aquafeed WOS:000527371500101 published article about VITIS-VINIFERA L.; VOLATILE COMPOUNDS; ACID-COMPOSITION; GRAPE; EXTRACT; POMACE; WASTE; FOOD in [Camara, Jose S.; Silva, Catarina; Perestrelo, Rosa] Univ Madeira, CQM, Campus Penteada, P-9020105 Funchal, Portugal; [Camara, Jose S.] Univ Madeira, Fac Ciencias Exatas & Engn, Dept Quim, Campus Univ Penteada, P-9020105 Funchal, Portugal; [Lourenco, Silvia] Inst Politecn Leiria, MARE Marine & Environm Sci Ctr, Av Porto de Pesca, P-2520641 Peniche, Portugal; [Lourenco, Silvia; Andrade, Carlos] Univ Porto, Ctr Interdisciplinar Invest Marinha & Ambiental, CIIMAR CIMAR, Av Gen Norton de Matos S-N, P-4450208 Matosinhos, Portugal; [Lopes, Andre; Andrade, Carlos] OOM, Edificio Madeira Tecnopolo,Piso0, P-9020105 Funchal, Portugal; [Lopes, Andre] Univ Algarve, CCMAR Ctr Ciencias Mar, Campus Gamhelas, P-8005139 Faro, Portugal in 2020.0, Cited 41.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

The recent growing concern driven by consumer interest in the safety and quality of seafood, has boosted the search for healthy and functional aquafeeds. The current study represents the first approach to assess the potential of volatile composition of the wine industry by products (e.g., grape pomace, grape stems, lees), as additives for improving the quality of fish feeds in terms of organoleptic characteristics (e.g., aroma and flavor) and health benefits. Headspace solid-phase microextraction followed by gas chromatography-mass spectrometry (HS-SPME/GC-MS) was used to establish the volatile profile of wine industry by-products. A total of 153 volatile organic compounds (VOCs), which belong to different chemical families, comprising 36 esters, 31 carbonyl compound, 20 alcohols, 18 terpenoids, 17 acids, 11 furanic compounds, four volatile phenols, two lactones, and 14 miscellaneous, were identified. Esters and terpenoids showed a positive contribution to the aquafeeds aroma with fruity, sweet, green, fresh, and berry notes, whereas some acids (e.g., hexanoic acid) and terpenoids (e.g., limonene) could be used as antimicrobial, antioxidant and antiproliferative agents. Our findings confirmed the potential of wine industry by-products as a rich source of essential compounds to enhance the quality of aquafeeds towards the valorization of winery waste based on the concept of circular economy. Further investigation on the extraction, isolation and purification of VOCs from a natural bio-source will guarantee the safety of the aquafeed and compliance with the requirements of the animal feed industry.

Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Camara, JS; Lourenco, S; Silva, C; Lopes, A; Andrade, C; Perestrelo, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about NONFERROUS METALS; CARBON-STEEL; M HCL; ADSORPTION; BEHAVIOR; COMPOUND; DFT, Saw an article supported by the AICTE, New Delhi; TEQIP-II of VSSUT, Burla, India. Published in ELSEVIER in AMSTERDAM ,Authors: Upadhyay, A; Purohit, AK; Mahakur, G; Dash, S; Kar, PK. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde. Formula: C8H8O2

Corrosion inhibition of mild steel (MS) by a series of 4-aminoantipyrine-based Schiff base has been studied in 1 N HCl aqueous medium adopting electrochemical method at different concentration (10(-2)-10(-5) M) and temperature (303-333 K). All of the inhibitors were found to be dominated by cathodic/anodic in nature (mixed type). Electrochemical impedence and polarization studies were in agreement with each other. The surface morphology (smoothness and roughness) was characterized by SEM, which indicates the formation of protective layer on the MS surface. The substituents on the Schiff bases influence their corrosion inhibition properties. Schiff bases having -OCH3, -OH and -NMe2 substituents exhibit more inhibition tendency as compared to other substituents. The role of cross conjugation in electron donating as well as accepting properties by heteroatom (N, O) and pi-electrons in corrosion inhibition was clearly observed from DFT calculations. Monolayer formation on the MS surface has been confirmed from the Langmuir isotherm fitting. Thermodynamic modeling has been done to understand the nature of adsorption. The values of Delta G (>-30 kJ/mol/K) indicate the existence of both physical and chemical interactions between the Schiff base molecules and metal surface. (C) 2021 Elsevier B.V. All rights reserved.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Upadhyay, A; Purohit, AK; Mahakur, G; Dash, S; Kar, PK or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: Benzyl Alcohol. Recently I am researching about BIOLOGICAL EVALUATION; INHIBITORS; NUCLEOTIDE; ISOFLAVONES; ANALOGS; T-705, Saw an article supported by the National Science Foundation for Young Scientists of China [21502209]; China Postdoctoral Science FoundationChina Postdoctoral Science Foundation [2016T90395]. Published in PERGAMON-ELSEVIER SCIENCE LTD in OXFORD ,Authors: Guo, S; Xu, MS; Guo, Q; Zhu, FQ; Jiang, XR; Xie, YC; Shen, JS. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

To explore the application potential of dual prodrug strategies in the development of anti-HCV agents, a variety of sofosbuvir derivatives with modifications at the C4 or N3 position of the uracil moiety were designed and synthesized. Some compounds exhibited potent anti-HCV activities, such as 4e and 8a-8c with similar EC50 values (0.20-0.22 mu M) comparative to that of sofosbuvir (EC50= 0.18 mu M) in a genotype 1b based replicon Huh7 cell line. Moreover, 8b displayed a good human plasma stability profile, and was easily metabolized in human liver microsomes expectantly. On the other hand, aiming to discover novel anti-HCV nucleosides, pyrazin-2(1H)-one nucleosides and their phosphoramidate prodrugs were investigated. Several active compounds were discovered, such as 25e (EC50= 7.3 mu M) and S-29b (EC50= 19.5 mu M). This kind of nucleosides were interesting and would open a new avenue for the development of antiviral agents.

Name: Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Guo, S; Xu, MS; Guo, Q; Zhu, FQ; Jiang, XR; Xie, YC; Shen, JS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Effects of anise, clove and thyme essential oils supplementation on rumen fermentation, blood metabolites, milk yield and milk composition in lactating goats WOS:000612162700024 published article about VITRO GAS-PRODUCTION; BERRY ESSENTIAL OILS; RUMINAL FERMENTATION; NUTRIENT DIGESTIBILITY; MICROBIAL FERMENTATION; GROWTH-PERFORMANCE; CONTINUOUS-CULTURE; DAIRY-COWS; METHANE EMISSION; LIPID-SYNTHESIS in [El-Essawy, Abeer M.; Abdel-Wahed, A. M.; Abdou, Ahlam R.] Desert Res Ctr, Anim & Poultry Nutr Dept, Cairo 11753, Egypt; [Anele, U. Y.] North Carolina Agr & Tech State Univ, Greensboro, NC 27411 USA; [Khattab, I. M.] Matrouh Univ, Fac Desert & Environm Agr, Dept Anim & Fish Prod, Matrouh 51744, Egypt in 2021.0, Cited 76.0. Category: indole-building-block. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The present study evaluated the effects of essential oil (EO) from anise (AO), clove (CO) and thyme (TO) on the performance of lactating Shame goats. Eight lactating Shame goats with average body weight 34.90 +/- 0.9 kg and 3 years old were randomly assigned to four treatments in a duplicated 4 x 4 Latin square design, with four periods of 22 days. In each period, the goats were adapted to the treatments for 15 days and the remaining 7 days was used for sample collection. Goats were fed a basal diet without supplementation (control) or supplemented with anise (AO), thyme (TO) or clove (CO) at a daily dose of 2 mL/head/d. Feed intake was not affected by EO supplementations. Digestibility of organic matter, ether extract and acid detergent fibre was higher (P < 0.05) with EO supplementations when compared with the control. Supplementations of EO had no effect on milk (g/d) yield, protein and lactose, as well as the composition (g/kg) of protein and lactose. Fat yield (g/d) and fat content (g/kg) were greater (P < 0.05) in EO supplemented goats versus those on the control diet. Compared with control, ruminal ammonia-N was not affected whereas, ruminal pH was increased (P = 0.02) with EO supplementations. Rumen total volatile fatty acid concentration and molar proportion of acetate (C2) were higher (P < 0.05) in goats fed CO and TO compared to control, whereas propionate (C3) and butyrate (C4) and C2:C3 proportions were unchanged with EO inclusion. With the exception of a decrease (P = 0.05) in blood urea nitrogen (BUN) with EO supplementations, other blood parameters were not affected. Milk C8 and C12 fatty acids (FA) were lower (P < 0.05) with EO supplementations compared with control. Composition of unsaturated and monounsaturated FA was higher (P < 0.05) and polyunsaturated FA was decreased (P < 0.05) with EO supplementations compared with control. Proportions of C18:1 n-9 C18:3 n-3 and n-3 FA were increased (P < 0.05) and proportions of C18:3 n-6 C20:4 n-6 and n-6 FA were decreased (P < 0.05) in goats fed EO compared to the control group. Overall, all three EOs tested in this study had beneficial effects on digestion, rumen fermentation parameters and milk composition including milk FA profile. Supplementation of CO and TO tended to increase PUFA concentration in the milk which supports their recommendation in the diet of lactating ruminants. Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact El-Essawy, AM; Anele, UY; Abdel-Wahed, AM; Abdou, AR; Khattab, IM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Solid Base Bi24O31Br10(OH) with Active Lattice Oxygen for the Efficient Photo-Oxidation of Primary Alcohols to Aldehydes WOS:000471976400020 published article about SELECTIVE OXIDATION; VISIBLE-LIGHT; BENZYL ALCOHOL; PHOTOCATALYTIC ACTIVITY; AEROBIC OXIDATION; CATALYSTS; GLYCEROL; NANOPARTICLES; PD; DEHYDROGENATION in [Dai, Yitao; Ren, Pengju; Li, Yaru; Shen, Yanbin; Li, Yongwang; Niemantsverdriet, Hans; Xiang, Hongwei; Wen, Xiaodong; Su, Ren] Synfuels China Technol Co Ltd, SynCat Beijing, Leyuan South St 2,1 Yanqi Econ Dev Zone C, Beijing 101407, Peoples R China; [Dai, Yitao; Besenbacher, Flemming; Lock, Nina] Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Gustav Wieds Vej 14, DK-8000 Aarhus C, Denmark; [Hao, Weichang] Beihang Univ, Dept Phys, Ctr Mat Phys & Chem, Beijing 100191, Peoples R China; [Lv, Dongdong; Niemantsverdriet, Hans] Syngaschem BV, SynCat DIFFER, NL-6336 HH Eindhoven, Netherlands; [Li, Yaru; Xiang, Hongwei; Wen, Xiaodong; Lewis, James P.] Chinese Acad Sci, Inst Coal Chem, State Key Lab Coal Convers, Taiyuan 030001, Shanxi, Peoples R China; [Lewis, James P.] West Virginia Univ, Dept Phys & Astron, Morgantown, WV 26506 USA in 2019.0, Cited 60.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. HPLC of Formula: C7H8O

The selective oxidation of primary alcohols to aldehydes by O-2 instead of stoichiometric oxidants (for example, Mn-VII, Cr-VI, and Os-IV) is an important but challenging process. Most heterogeneous catalytic systems (thermal and photocatalysis) require noble metals or harsh reaction conditions. Here we show that the Bi24O31Br10(OH) photocatalyst is very efficient in the selective oxidation of a series of aliphatic (carbon chain from C-1 to C-10) and aromatic alcohols to their corresponding aldehydes/ketones under visible-light irradiation in air at room temperature, which would be challenging for conventional thermal and light-driven processes. High quantum efficiencies (71% and 55% under 410 and 450nm irradiation) are reached in a representative reaction, the oxidation of isopropanol. We propose that the outstanding performance of the Bi24O31Br10(OH) photocatalyst is associated with basic surface sites and active lattice oxygen that boost the dehydrogenation step in the photo-oxidation of alcohols.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Dai, YT; Ren, PJ; Li, YR; Lv, DD; Shen, YB; Li, YW; Niemantsverdriet, H; Besenbacher, F; Xiang, HW; Hao, WC; Lock, N; Wen, XD; Lewis, JP; Su, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2021 ACS CATAL published article about NITROGEN-HETEROCYCLES; ELECTRONIC-STRUCTURES; COMPLEXES; OXIDATION; HYDROGENATION; REACTIVITY in [Das, Siuli; Mondal, Rakesh; Chakraborty, Gargi; Guin, Amit Kumar; Paul, Nanda D.] Indian Inst Engn Sci & Technol, Dept Chem, Howrah 711103, India; [Das, Abhishek] Indian Assoc Cultivat Sci, Sch Chem Sci, Kolkata 700032, India in 2021, Cited 79. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Category: indole-building-block

Herein we report an exclusively ligand-centered redox controlled approach for the dehydrogenation of a variety of N-heterocycles using a Zn(II)-stabilized azo-anion radical complex as the catalyst. A simple, easy-to-prepare, and bench-stable Zn(II)-complex (1b) featuring the tridentate arylazo pincer, 2-((4-chlorophenyl)diazenyl)-1,10-phenanthroline, in the presence of zinc-dust, undergoes reduction to form the azo-anion radical species [1b]which efficiently dehydrogenates various saturated N-heterocycles such as 1,2,3,4-tetrahydro-2-methylquinoline, 1,2,3,4-tetrahydro-isoquinoline, indoline, 2-phenyl-2,3-dihydro-1H-benzoimidazole, 2,3-dihydro-2-phenylquinazolin-4(1H)-one, and 1,2,3,4-tetrahydro-2-phenylquinazolines, among others, under air. The catalyst has further been found to be compatible with the cascade synthesis of these N-heterocycles via dehydrogenative coupling of alcohols with other suitable coupling partners under air. Mechanistic investigation reveals that the dehydrogenation reactions proceed via a one-electron hydrogen atom transfer (HAT) pathway where the zinc-stabilized azo-anion radical ligand abstracts the hydrogen atom from the organic substrate(s), and the whole catalytic cycle proceeds via the exclusive involvement of the ligand-centered redox events where the zinc acts only as the template.

Category: indole-building-block. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Das, S; Mondal, R; Chakraborty, G; Guin, AK; Das, A; Paul, ND or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 3-Hydroxybenzaldehyde. Recently I am researching about H BOND ACTIVATION; SUBSTITUTED ANTHRAQUINONES; MERGING PHOTOREDOX; DERIVATIVES; ACID; CYCLIZATION; ARYL; ANTHRACYCLINE; BIOSYNTHESIS; ARYLATION, Saw an article supported by the Department of Science and Technology-Science and Engineering Research Board (DST-SERB), New Delhi [SB/S1/OC-39/2014]; MHRD. Published in GEORG THIEME VERLAG KG in STUTTGART ,Authors: Suchand, B; Satyanarayana, G. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A bis-acylation strategy to access functionalized anthraquinones via one-pot relay process, is presented. The first acylation was feasible under [Pd]-catalyzed intermolecular direct acylation reaction, while, the second acylation was accomplished by using intramolecular Friedel-Crafts acylation. Notably, benchtop aldehydes have been utilized as non-toxic acylation agents in the key [Pd]-catalyzed acylation.

Recommanded Product: 3-Hydroxybenzaldehyde. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Suchand, B; Satyanarayana, G or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Atom Transfer Oxidative Radical Cascade of Aryl Alkynoates towards 1,1-Dichalcogenide Olefins WOS:000477143100001 published article about METAL-FREE; STEREOSELECTIVE-SYNTHESIS; ALKENE DERIVATIVES; ACTIVATED ALKYNES; CYCLIZATION; MIGRATION; ACIDS; DIFUNCTIONALIZATION; COUMARINS; BOND in [Sahoo, Harekrishna; Ramakrishna, Isai; Mandal, Anup; Baidya, Mahiuddin] Indian Inst Technol Madras, Dept Chem, Chennai 600036, Tamil Nadu, India in 2019, Cited 70. Recommanded Product: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

An oxidative trifunctionalization of aryl alkynoates has been devised via the chalcogenide radical triggered intramolecular 1,4-aryl migration/decarboxylation cascade to prepare 1,1-dichalcogenide tetrasubstituted alkenes in high yields (up to 98 %). This operationally simple reaction proceeds under metal-free conditions, can be executed on gram scale, and highlights formal 1,1-difunctionalization of alkynes. Synthetic potential of this protocol was demonstrated through a twofold cascade rearrangement to access highly conjugated tetra-selenylated alkenes along with a cross-dehydrogenative annulation to prepare fluorene derivative.

Recommanded Product: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Sahoo, H; Ramakrishna, I; Mandal, A; Baidya, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 MED CHEM RES published article about VIRUS NEURAMINIDASE; HOMO-LUMO in [Cui, Man-Ying; Nie, Jian-Xia; Yan, Zhong-Zhong; Xiao, Meng-Wu; Lin, Ding; Ye, Jiao; Hu, Ai-Xi] Hunan Univ, Coll Chem & Chem Engn, Changsha 410082, Hunan, Peoples R China in 2019.0, Cited 28.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Safety of 4′-Hydroxyacetophenone

Three series of thiazolylhydrazone derivatives were designed, synthesized, and evaluated for their neuraminidase (NA) inhibitory activity against influenza virus H1N1 in vitro. Compounds 1 and 2 were synthesized via the one-pot reaction and compound 3 was synthesized in two steps. Pharmacological results showed that the majority of the target compounds 1, 2, and 3 exhibited moderate-to-good influenza NA inhibitory activity. The NA inhibitory activity of the most active compound 2g (IC50=7.12g/ml) is better than that of the lead compound A. Molecular docking was performed to study the possible interactions between compound 2g and the active site of NA. On the basis of biological results, a preliminary structure-activity relationship (SAR) was derived and discussed. Moreover, density functional theory (DFT) calculation was also performed to explain why the thiazolylhydrazone skeleton has NA inhibitory activity, especially compound 2g with the most potent inhibitory activity.

Safety of 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Cui, MY; Nie, JX; Yan, ZZ; Xiao, MW; Lin, D; Ye, J; Hu, AX or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis and biological evaluation of novel carbamates as potential inhibitors of acetylcholinesterase and butyrylcholinesterase published in 2020.0. Product Details of 99-93-4, Reprint Addresses Tan, W (corresponding author), Guangdong Univ Technol, Inst Biomed & Pharmaceut Sci, Guangzhou 510006, Peoples R China.; Tan, W (corresponding author), Monash Univ Malaysia, Jeffrey Cheah Sch Med & Hlth Sci, Bandar Sunway 47500, Selangor Darul, Malaysia.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

Rivastigmine, a dual inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), has been approved by U.S. Food and Drug Administration to treat Alzheimer’s disease (AD) and Parkinson’s disease (PD) dementia. In the current work, a bambuterol derivative lacking one of the carbamoyloxy groups on the benzene ring (BMC-1) and its analogues were synthesized using 1-(3-hydroxyphenyl) ethan-1-one and 1-(4-hydroxyphenyl) ethan-1-one as starting materials. In-vitro cholinesterase assay established that nine compounds were more potent to inhibit both electric eel AChE and equine serum BChE than rivastigmine under the same experimental conditions. Further study confirmed that among the nine carbamates, BMC-3 (IC50(AChE) = 792 nM, IC50(BChE) = 2.2 nM) and BMC-16 (IC50(AChE) = 266 nM, IC50(BChE) = 10.6 nM) were excellent cholinesterase inhibitors with potential of permeating through the blood-brain barrier. These carbamates could be used as potential dual inhibitors of AChE and BChE and to discover novel drugs for the treatment of AD and PD dementia.

Product Details of 99-93-4. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Wu, J; Pistolozzi, M; Liu, SY; Tan, W or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles