Tag: M.W=100-150

I found the field of Chemistry; Physics very interesting. Saw the article Catalyst- and acid-free Markovnikov hydration of alkynes in a sustainable H2O/ethyl lactate system published in 2021. Product Details of 123-11-5, Reprint Addresses Dandia, A; Parewa, V (corresponding author), Univ Rajasthan, Ctr Adv Studies, Dept Chem, Jaipur, Rajasthan, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

An efficient and sustainable protocol for the hydration of alkynes has been developed under metal/acid/catalyst/ ligand-free conditions in a water/ethyl lactate mixture. The hydrogen-bond network in the ethyl lactate and water mixture plays a crucial and decisive role in activating the alkynes for hydration to afford the corresponding methyl ketones. This strategy gives the Markovnikov (ketone) addition product selectively over other possible products. The essential role of hydrogen bonding has been confirmed by experimental and theoretical techniques. A probable mechanism has been suggested by various control tests. The efficacy of the method has been further explored for the competent production of value-added alpha,beta-unsaturated carbonyl compounds through the reaction of aldehydes with alkynes as ketonic surrogates. The environmentally benign hydration method takes place under mild conditions, has broad functional-group compatibility, and uses the ethyl lactate/water (1:3) medium as a green alternative in the absence of any hazardous, harmful, or expensive substances. (C) 2021 Elsevier B.V. All rights reserved.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Dandia, A; Saini, P; Chithra, MJ; Vennapusa, SR; Parewa, V or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Slaghenaufi, D; Luzzini, G; Solis, JS; Forte, F; Ugliano, M in [Slaghenaufi, Davide; Luzzini, Giovanni; Samaniego Solis, Jessica; Forte, Filippo; Ugliano, Maurizio] Univ Verona, Dept Biotechnol, Via Pieve 70, I-37029 San Pietro In Cariano, Italy published Two Sides to One Story-Aroma Chemical and Sensory Signature of Lugana and Verdicchio Wines in 2021.0, Cited 86.0. COA of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Lugana and Verdicchio are two Italian white wines with a Protected Designation of Origin (PDO) label. These two wine types are produced in different regions using the same grape variety. The aim of this work is to investigate the existence of volatile chemical markers that could help to elucidate differences between Lugana and Verdicchio wines both at chemical and sensory levels. Thirteen commercial wine samples were analyzed by Gas Chromatography-Mass Spectrometry (GC-MS), and 76 volatile compounds were identified and quantified. Verdicchio and Lugana had been differentiated on the basis of 19 free and glycosidically bound compounds belonging to the chemical classes of terpenes, benzenoids, higher alcohols, C-6 alcohols and norisoprenoids. Samples were assessed by means of a sorting task sensory analysis, resulting in two clusters formed. These results suggested the existence of 2 product types with specific sensory spaces that can be related, to a good extend, to Verdicchio and Lugana wines. Cluster 1 was composed of six wines, 4 of which were Lugana, while Cluster 2 was formed of 7 wines, 5 of which were Verdicchio. The first cluster was described as fruity, and fresh/minty, while the second as fermentative and spicy. An attempt was made to relate analytical and sensory data, the results showed that damascenone and the sum of 3 of esters the ethyl hexanoate, ethyl octanoate and isoamyl acetate, was characterizing Cluster 1. These results highlighted the primary importance of geographical origin to the volatile composition and perceived aroma of Lugana and Verdicchio wines.

About Benzyl Alcohol, If you have any questions, you can contact Slaghenaufi, D; Luzzini, G; Solis, JS; Forte, F; Ugliano, M or concate me.. COA of Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. Walczak, M; Chryplewicz, A; Olewinska, S; Psurski, M; Winiarski, L; Torzyk, K; Oleksyszyn, J; Sienczyk, M in [Walczak, Maciej; Chryplewicz, Agnieszka; Olewinska, Sandra; Winiarski, Lukasz; Torzyk, Karolina; Oleksyszyn, Jozef; Sienczyk, Marcin] Wroclaw Univ Sci & Technol, Dept Organ & Med Chem, Fac Chem, Wybrzeze Wyspianskiego 27, PL-50370 Wroclaw, Poland; [Psurski, Mateusz] Polish Acad Sci, Hirszfeld Inst Immunol & Expt Therapy, Dept Expt Oncol, Weigla 12, PL-53114 Wroclaw, Poland published Phosphonic Analogs of Alanine as Acylpeptide Hydrolase Inhibitors in 2021, Cited 54. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5.

Acylpeptide hydrolase is a serine protease, which, together with prolyl oligopeptidase, dipeptidyl peptidase IV and oligopeptidase B, belongs to the prolyl oligopeptidase family. Its primary function is associated with the removal of N-acetylated amino acid residues from proteins and peptides. Although the N-acylation occurs in 50-90 % of eukaryotic proteins, the precise functions of this modification remains unclear. Recent findings have indicated that acylpeptide hydrolase participates in various events including oxidized proteins degradation, amyloid beta-peptide cleavage, and response to DNA damage. Considering the protein degradation cycle cross-talk between acylpeptide hydrolase and proteasome, inhibition of the first enzyme resulted in down-regulation of the ubiquitin-proteasome system and induction of cancer cell apoptosis. Acylpeptide hydrolase has been proposed as an interesting target for the development of new potential anticancer agents. Here, we present the synthesis of simple derivatives of (1-aminoethyl)phosphonic acid diaryl esters, phosphonic analogs of alanine diversified at the N-terminus and ester rings, as inhibitors of acylpeptide hydrolase and discuss the ability of the title compounds to induce apoptosis of U937 and MV-4-11 tumor cell lines.

Category: indole-building-block. About Mequinol, If you have any questions, you can contact Walczak, M; Chryplewicz, A; Olewinska, S; Psurski, M; Winiarski, L; Torzyk, K; Oleksyszyn, J; Sienczyk, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Synthesis, characterization, DNA/BSA interactions and in vitro cytotoxicity study of palladium(II) complexes of hispolon derivatives WOS:000502686300016 published article about NUCLEOPHILIC-SUBSTITUTION REACTIONS; CELL-CYCLE ARREST; DNA-BINDING; ANTICANCER AGENTS; CRYSTAL-STRUCTURE; THIOREDOXIN REDUCTASE; INTERACTION MECHANISM; SPECTRAL PROPERTIES; COPPER(II) COMPLEX; ANTITUMOR-ACTIVITY in [Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui] Hebei Univ, Key Lab Med Chem & Mol Diag, Minist Educ, Baoding 071002, Peoples R China; [Wei, Xiaonan; Yang, Yaxing; Ge, Jiangfeng; Lin, Xue; Liu, Dandan; Wang, Shuxiang; Zhang, Jinchao; Zhou, Guoqiang; Li, Shenghui] Hebei Univ, Coll Chem & Environm Sci, Key Lab Chem Biol Hebei Prov, Baoding 071002, Peoples R China in 2020.0, Cited 90.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Product Details of 100-83-4

Thirteen novel palladium(II) complexes of the general formula [Pd(bipy)(O,O’-dkt)](PF6), (where bipy is 2,2′-bipyridine and O,O’-dkt is beta-diketonate ligand hispolon or its derivative) have been prepared through a metal-ligand coordination method that involves spontaneous formation of the corresponding diketonate scaffold. The obtained palladium(II) complexes have been characterized by NMR spectroscopy, ESI-mass spectrometry as well as elemental analysis. The cytotoxicity analysis indicates that most of the obtained palladium(II) complexes show promising growth inhibition in three human cancer cell lines. Flow cytometry analysis shows complex 3e could promote intracellular reactive oxygen species (ROS) accumulation and lead cancer cell death. And the suppression of ROS accumulation and the rescue of cell viability in HeLa cells by N-acetyl-L-cysteine (NAC) suggest the possible link between the increase in ROS generation and cytotoxicity of complex 3e. Flow cytometry analysis also reveal that complex 3e cause cell cycle arrest in the G2/M phase and collapse of the mitochondrial membrane potential, promote the generation of ROS and lead to tumor cell apoptosis. The interactions of complex Be with calf thymus DNA (CT-DNA) have been evaluated by UV-Vis spectroscopy, fluorescence quenching experiments and viscosity measurements, which reveal that the complex interact with CT-DNA through minor groove binding and/or electrostatic interactions. Further, the results of fluorescence titration and site marker competitive experiment on bovine serum albumin (BSA) suggest that complex 3e can quench the fluorescence of BSA via a static quenching process and bind to BSA in Sudlow’s site II.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wei, XN; Yang, YX; Ge, JF; Lin, X; Liu, DD; Wang, SX; Zhang, JC; Zhou, GQ; Li, SH or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Green Approach for Preparation of New Hybrids of 5-Substituted-1H-Tetrazoles Using Novel Recyclable Nanocatalyst based on Copper(II) Anchored onto Glucosamine Grafted to Fe3O4@SiO2 WOS:000625488000005 published article about CRYSTAL-STRUCTURE; DOCKING in [Eslahi, Hassan; Reza Sardarian, Ali] Shiraz Univ, Dept Chem, Coll Sci, Shiraz 7194684795, Iran; [Esmaeilpour, Mohsen] Niroo Res Inst, Chem & Proc Engn Dept, Tehran 1468617151, Iran in 2021, Cited 82. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. HPLC of Formula: C8H8O2

The novel copper(II) ions decorated Fe3O4@SiO2 composite magnetic spheres were synthesized by grafting copper(II) ions onto glucosamine modified Fe3O4@SiO2 NPs. The magnetic Fe3O4@SiO2-TCT-GA-Cu(II) catalyst were characterized by varies physicochemical techniques such as FT-IR, FE-SEM, TEM, DLS, XRD, EDX, VSM, TGA, VSM, ICP, and UV-Vis. The catalytic performance of this novel catalyst was studied in the green preparation of 5-substituted 1H-tetrazole based hybrids via three-component and one-pot reaction of sodium azide, hydroxylamine hydrochloride, and various aldehydes in water and ethylene glycol, as a green solvent mixture. This green protocol provides significant advantages such as non-vigorous conditions, short reaction times, outstanding yield of desired tetrazoles, minimizing of chemical waste, wide-ranging substrate, quick and efficient work-up procedure and using environmentally benign, durable, cost effective, magnetically separable, reusable nanocatalyst.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Eslahi, H; Sardarian, AR; Esmaeilpour, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Zhao, TJ; Zhang, JJ; Wang, HH; Su, J; Li, XH; Chen, JS in [Zhao, Tian-Jian; Zhang, Jun-Jun; Wang, Hong-Hui; Su, Juan; Li, Xin-Hao; Chen, Jie-Sheng] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Shanghai 200240, Peoples R China; [Su, Juan] Jilin Univ, Coll Chem, State Key Lab Inorgan Synth & Preparat Chem, Changchun 130012, Peoples R China published Biomimetic Design of a 3 D Transition Metal/Carbon Dyad for the One-Step Hydrodeoxygenation of Vanillin in 2020.0, Cited 36.0. Name: Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Enzyme catalysts always show an excellent catalytic selectivity, which is important in biochemistry, especially in catalytic synthesis and biopharming. This selectivity is achieved by combining the binding effect induced by the electrostatic effect of the enzyme to attract a specific substrate and then the prearrangement of the substrates inside the enzyme pocket. Herein, we report a proof-of-concept application of an interfacial electrostatic field induced by constructing Schottky heterojunctions to mimic the electrostatic catalysis of an enzyme. In combination with the 3 D structure, a transition metal/carbon dyad was designed by nanoconfinement methods to promote the differential binding effect and the space-induced organization of the reaction intermediate (vanillyl alcohol) to develop a new one-step hydrogenolysis of vanillin for the production of 2-methoxy-4-methylphenol with a remarkably high selectivity (>99 %).

About Benzyl Alcohol, If you have any questions, you can contact Zhao, TJ; Zhang, JJ; Wang, HH; Su, J; Li, XH; Chen, JS or concate me.. Name: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 BIOORG MED CHEM LETT published article about OXIDATIVE STRESS; MECHANISMS; APOPTOSIS; AIF in [Selvaraj, Baskar; Huh, Gyewon; Lee, Jae Wook] Korea Inst Sci & Technol KIST, Nat Prod Res Ctr, 679 Saimdang Ro, Kangnung 25451, Gangwon Do, South Korea; [Selvaraj, Baskar; Bae, Ae Nim; Lee, Jae Wook] Korea Inst Sci & Technol KIST, Convergent Res Ctr Diag Treatment & Care Syst Dem, Seoul 02792, South Korea; [Uyen Tran Tu Nguyen; Kang, Kyungsu] Korea Inst Sci & Technol KIST, Nat Prod Informat Res Ctr, Kangnung 25451, South Korea; [Duc Hung Nguyen] Vietnam Korea Inst Sci & Technol VKIST, Dept Biotechnol, Hanoi, Vietnam; [Mok, Il-Kyoon] Seoul Natl Univ, Inst Food Industrializat, Inst Green Bio Sci & Technol, Gangwon Do 25354, South Korea; [Mok, Il-Kyoon] Seoul Natl Univ, Grad Sch Int Agr Technol, Gangwon Do 25354, South Korea; [Lee, Heesu] Gangnueng Wonju Natl Univ GWNU, Coll Dent, Dept Anat, Kangnung 25457, South Korea; [Kim, Dae Won] Gangneung Wonju Natl Univ GWNU, Coll Dent, Dept Biochem & Mol Biol, Kangnung 25457, South Korea; [Selvaraj, Baskar; Huh, Gyewon; Kang, Kyungsu; Bae, Ae Nim; Lee, Jae Wook] Univ Sci & Technol UST, Div Biomed Sci & Technol, Daejun 34113, South Korea in 2020.0, Cited 24.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4. Application In Synthesis of 3-Hydroxybenzaldehyde

Seventeen chalcone analogues were synthesized from 7-methoxy-3,4-dihydronaphthalen1(2H)-one and various aromatic aldehydes under basic conditions and their therapeutic properties were studied in mouse hippocampal cell line HT-22 against neuronal cell death induced by glutamate. From this study, we selected an analogue C01 as a active compound which showed significantly high neuroprotection. This compound inhibited Ca2+ influx and reactive oxygen species (ROS) accumulation inside cells. The glutamate-induced cell death was analyzed by flow cytometry and it showed that C01 significantly reduced apoptotic or dead cell induced by 5 mM glutamate. Western blot analysis indicates that glutamate-mediated activation of MAPKs were inhibited by compound C01 treatment. In addition, the C01enhanced Bcl-2 and decreased Bax, the anti and pro apoptotic proteins respectively. Further analysis showed that, C01 prevented the nuclear translocation of AIF (apoptosis inducing factor) and inhibited neuronal cell death. Taken together, compound C01 treatment resulted in decreased neurotoxicity induced by 5 mM of glutamate. Our finding confirmed that compound C01 has neuro-therapeutic potential against glutamate-mediated neurotoxicity.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Selvaraj, B; Nguyen, UTT; Huh, G; Nguyen, DH; Mok, IK; Lee, H; Kang, K; Bae, AN; Kim, DW; Lee, JW or concate me.. Application In Synthesis of 3-Hydroxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Quantum chemical study on the ozonolysis mechanism of guaiacol and the structure-reactivity relationship of phenols with hydroxyl, methoxy, and methyl substituents WOS:000664254400002 published article about ORGANIC AEROSOL FORMATION; GAS-PHASE OZONOLYSIS; KINETICS; OXIDATION; 2-METHOXYPHENOL; ATMOSPHERE; COMPOUND; PRODUCTS; RADICALS; PRIORITY in [Cao, Haijie; Wang, Kuikui; Yang, Zhengqiang; Wu, Shijie] Qingdao Univ, Coll Mat Sci & Engn, Inst Mat Energy & Environm, Qingdao 266071, Peoples R China; [Han, Dandan] Heze Univ, Sch Chem & Chem Engn, Heze 274015, Peoples R China in 2021.0, Cited 37.0. Recommanded Product: m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Quantum chemical calculations with the M06-2X method were performed to uncover the ozonolysis mechanism of guaiacol and several hydroxylated, methoxylated, and methylated phenols to improve the understanding of the ozone-induced attenuation of phenolic compounds. The detailed kinetic properties were obtained by the transition state theory (TST) and the Rice – Ramsperger – Kassel – Marcus (RRKM) theory. Results confirm that the primary ozonides originated from guaiacol occupy considerably long retention time than the short-lived primary ozonides formed from vinyl-type compounds in the air. The TST rate constant of guaiacol ozonolysis is calculated with a value of 8.81 x 10-20 cm3 molecule-1 s-1 at room temperature. The RRKM results prove that the rate constant is positively dependent on temperature but shows no relation with pressure. The reactivity of substituted phenols exhibits a strong correlation with the ozone affinity of carbon atoms and the orbital energy difference (ELo-Hac) between the lowest unoccupied molecular orbital of O3 and the highest occupied molecular orbital of phenols. The substituents can reduce the value of ELo-Hac and improve the phenols’ reactivity, especially when they locate at the ortho- and para-position. The substituents also improve the ozone affinity of carbon atoms due to the electron-withdrawing effect. The methyl group delivers a moderate impact on the reactivity compared to hydroxyl and methoxy groups.

Recommanded Product: m-Methoxyphenol. About m-Methoxyphenol, If you have any questions, you can contact Cao, HJ; Wang, KK; Yang, ZQ; Wu, SJ; Han, DD or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

COA of Formula: C7H8O2. Authors Song, CY; Nie, JQ; Ma, C; Lu, CF; Wang, FY; Yang, GC in ELSEVIER published article about in [Song, Chaoyang; Nie, Junqi; Ma, Chao; Lu, Cuifen; Wang, Feiyi; Yang, Guichun] Hubei Univ, Coll Chem & Chem Engn, Hubei Collaborat Innovat Ctr Adv Organ Chem Mat, Minist Educ Key Lab Synth & Applicat Organ Funct, Wuhan 430062, Peoples R China in 2021, Cited 71. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

1,2,3-Triazole contained conjugated porous polymers (CPPs) have recently emerged as a new class of efficient photocatalysts. To gain more insight into the excellent photocatalytic activity of this kind of CPPs, herein, we report the design and preparation of a series of 1,2,3-triazole-based CPPs via oxidative coupling polymerization to study their photocatalytic performance. These CPPs have donor-acceptor properties and 1,2,3-triazole serves as an electron acceptor. The resulting CPPs with thiophene, carbazole and diphenylamine as electron donor units, respectively, have distinct porosities and optoelectronic properties, and showed effective photocatalytic performance towards oxidative hydroxylation of arylboric acids and alkylation of vinylarenes with diethyl bromomalonate or bromoacetonitrile. The thiophene contained CPP was a more efficient photocatalyst for the catalytic reactions, which can be attributed to its smaller optical band gap and greater charge separation effi-ciency. Furthermore, PTPT has shown reliable recyclability with no significant loss in its catalytic activity.

COA of Formula: C7H8O2. About Mequinol, If you have any questions, you can contact Song, CY; Nie, JQ; Ma, C; Lu, CF; Wang, FY; Yang, GC or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Novel uric acid-based nano organocatalyst with phosphorous acid tags: Application for synthesis of new biologically-interest pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation published in 2021.0. HPLC of Formula: C8H8O2, Reprint Addresses Zarei, M; Zolfigol, MA (corresponding author), Bu Ali Sina Univ, Fac Chem, Dept Organ Chem, POB 6517838683, Hamadan, Hamadan, Iran.; Shi, H (corresponding author), Shanxi Univ, Sch Chem & Chem Engn, Inst Mol Sci, Taiyuan 030006, Peoples R China.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

In this study, we have designed, synthesized and full characterized a novel biological based acidic nano organocatalyst via condensations reaction of uric acid and phosphorous acid. The obtained compound was named theacrine tetrakis(phosphonic acid) (TTPA) and prepared under refluxing ethanol. This new nano organocatalyst was applied as an efficient and recyclable catalyst for the preparation of novel pyridines with indole moieties via a cooperative vinylogous anomeric based oxidation with good to excellent yields.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kalhor, S; Zarei, M; Sepehrmansourie, H; Zolfigol, MA; Shi, H; Wang, JP; Arjomandi, J; Hasani, M; Schirhagl, R or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles