Tag: M.W=100-150

An article Mechanistic insights into the non-bifunctional hydrogenation of esters by Co(ii) pincer complexes: a DFT study WOS:000493493400034 published article about HOMOGENEOUS CATALYTIC-HYDROGENATION; ELECTROCATALYTIC CO2 REDUCTION; SELECTIVE HYDROGENATION; TRANSFORMATIONS; THERMOCHEMISTRY; MANGANESE; ENERGIES; ALCOHOLS; CYCLES in [Chowdhury, Animesh; Biswas, Santu; Pramanik, Anup; Sarkar, Pranab] Visva Bharati Univ, Dept Chem, Santini Ketan 731235, W Bengal, India in 2019.0, Cited 54.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Computed Properties of C7H8O

A recent experiment has revealed that additive free ester hydrogenation by Co-pincer complexes might follow an unusual non-bifunctional mechanism, however, the detailed mechanistic pathway is missing. It has been predicted that several intermediates and transition states are involved, having their essential role in the catalytic performances. Detailed theoretical studies are therefore essential in this regard for achieving more efficient ester hydrogenation catalysts. On the basis of first principles calculations, performed over Co(PNP)/(PNN) complexes, we present here the energetics and mechanistic details, showing the distinct orientations of different possible intermediates and transition states, and find the minimum energy pathway for the conversion of esters to alcohols. In the way, we find that some intermediates must undergo structural distortion for achieving the lowest potential energy barrier which must have a severe impact on the catalytic turnover frequency.

Computed Properties of C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Chowdhury, A; Biswas, S; Pramanik, A; Sarkar, P or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Stereoselective Synthesis of Ribofuranoid exo-Glycals by One-Pot Julia Olefination Using Ribofuranosyl Sulfones WOS:000606840200054 published article about C-GLYCOSYLIDENE DERIVATIVES; RAMBERG-BACKLUND REACTION; PROTECTED SUGAR LACTONES; EFFICIENT SYNTHESIS; ENOL ETHERS; STEREOCONTROLLED SYNTHESIS; DEHYDROQUINATE SYNTHASE; CONVENIENT SYNTHESIS; SUBSTRATE-ANALOGS; FACILE SYNTHESIS in [Mori, Ayumi; Suzuki, Kanna; Ando, Kaori] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, Gifu 5011193, Japan; [Oka, Natsuhisa] Gifu Univ, Dept Chem & Biomol Sci, Fac Engn, Ctr Highly Adv Integrat Nano & Life Sci, Gifu 5011193, Japan; [Oka, Natsuhisa] Gifu Univ, Inst Glycocore Res iGCORE, Tokai Natl Higher Educ & Res Syst Furo Cho, Gifu 5011193, Japan in 2021, Cited 132. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Computed Properties of C8H8O2

One-pot Julia olefination using ribofuranosyl sulfones is described. The alpha-anomers of the ribofuranosyl sulfones were synthesized with complete alpha-selectivity via the glycosylation of heteroarylthiols using ribofuranosyl iodides as glycosyl donors and the subsequent oxidation of the resulting heteroaryl 1-thioribofuranosides with magnesium monoperphthalate (MMPP). The Julia olefination of the alpha-ribofuranosyl sulfones with aldehydes proceeded smoothly in one pot to afford the thermodynamically less stable (E)-exo-glycals with modest-to-excellent stereoselectivity (up to E/Z = 94:6) under the optimized conditions. The E selectivity was especially high for aromatic aldehydes. In contrast, the (Z)-exo-glycal was obtained as the main product with low stereoselectivity when the corresponding beta-ribofuranosyl sulfone was used (E/Z = 41:59). The remarkable impact of the anomeric configuration of the ribofuranosyl sulfones on the stereoselectivity of the Julia olefination has been rationalized using density functional theory (DFT) calculations. The protected ribose moiety of the resulting exo-glycals induced completely a-selective cyclopropanation on the exocyclic carbon-carbon double bond via the Simmons-Smith-Furukawa reaction. The 2-cyanoethyl group was found to be useful for the protection of the exo-glycals, as it could be removed without affecting the exocyclic C=C bond.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Oka, N; Mori, A; Suzuki, K; Ando, K or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Base-catalyzed stereoselective hydrophenoxylation and hydrothiolation of hexafluorobutyne WOS:000527103500020 published article about TERMINAL ALKYNES; VINYL SULFIDES; INTRAMOLECULAR HYDROALKOXYLATION; MEDIATED HYDROTHIOLATION; INTERNAL ALKYNES; C-O; GOLD; ACTIVATION; COMPLEXES; HYDROAMINATION in [Zhao Bo; Zeng Ji-Jun; Han Sheng; Tu Dong-Huai; Li Jiang-Wei; Zhang Wei; Lu Jian] Xian Modern Chem Res Inst, State Key Lab Fluorine & Nitrogen Chem, Xian 710065, Peoples R China in 2020.0, Cited 99.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Product Details of 99-93-4

Novel base-catalyzed hydrophenoxylation and hydrothiolation of hexafluorobutyne are described. By using an easily available base, a variety of vinyl ethers as well as sulfides are prepared at room temperature through two-phase nucleophilic addition reaction. Mechanistic study revealed that the stereoselectivity of vinyl ethers might depend on frontier orbital interaction under kinetic control. (C) 2020 Elsevier Ltd. All rights reserved.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Zhao, B; Zeng, JJ; Han, S; Tu, DH; Li, JW; Zhang, W; Lu, J or concate me.. Product Details of 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Authors Varzi, Z; Esmaeili, MS; Taheri-Ledari, R; Maleki, A in ELSEVIER published article about in [Varzi, Zahra; Esmaeili, Mir Saeed; Taheri-Ledari, Reza; Maleki, Ali] Iran Univ Sci & Technol, Dept Chem, Catalysts & Organ Synth Res Lab, Tehran 1684613114, Iran in 2021.0, Cited 55.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

In this study, an efficient hybrid nanocatalyst made of guar gum (guarana, as a natural basis), magnetic iron oxide nanoparticles, and copper(I) oxide nanoparticles (Cu2O NPs) is fabricated and suitably applied for catalyzing the multicomponent (three- and four-component) synthesis reactions of imidazole derivatives. Here, an easy preparation strategy for this novel catalytic system (Cu2O/Fe3O4@guarana) is presented. Then, the application of this catalytic system for the synthesis of imidazole derivatives is precisely investigated. For this purpose, ultrasonication is introduced as an efficient and fast method. In summary, the high catalytic efficiency of Cu2O/Fe3O4@guarana nanocomposite is well demonstrated by high reaction yields obtained in the presence of a small amount of this nanocomposite, under mild conditions. Wide active surface area, substantial magnetic behavior, excellent heterogeneity, suitable stability, well reusability, and etc. have distinguished this catalytic system as an instrumental tool for facilitating the complex synthetic reactions.

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Varzi, Z; Esmaeili, MS; Taheri-Ledari, R; Maleki, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Safety of 4-Methoxybenzaldehyde. In 2021 J MOL STRUCT published article about ANTIINFLAMMATORY DRUG INDOMETHACIN; IN-VITRO; COLON-CANCER; BIOLOGICAL EVALUATION; DIETARY ANTIOXIDANT; CELL-DEATH; INHIBITION; PROLIFERATION; CARCINOMA; DELPHINIDIN in [Harras, Marwa F.; Sabour, Rehab; Farrag, Amel M.; Eissa, Sally I.] Al Azhar Univ, Fac Pharm Girls, Dept Pharmaceut Chem, Cairo, Egypt; [Ammar, Yousry A.] Al Azhar Univ, Fac Sci Boys, Dept Organ Chem, Cairo, Egypt; [Mehany, Ahmed B. M.] Al Azhar Univ, Fac Sci Boys, Dept Zool, Cairo, Egypt; [Eissa, Sally I.] Almaarefa Univ, Coll Pharm, Riyadh, Saudi Arabia in 2021, Cited 48. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Indomethacin is a well-known nonsteroidal anti-inflammatory drug that has cytotoxic activity. In this study, a new series of structurally related indomethacin analogues was synthesized using simple chemical approaches, and their cytotoxic effects against five different human cancer cell lines (colon cancer cell lines HCT-116, HT-29 and Caco-2, hepatic cell line HepG-2 and breast cell line MCF-7) were evaluated. Most of the tested compounds displayed potent anti-cancer activity, especially against the three colon cancer cell lines. Among all tested derivatives, compound 12 demonstrated the most potent cytotoxic activity compared to the parent drug indomethacin and the reference compound 5-fluorouracil, with IC 50 values ranging 0.83-1.54 mu M. A mechanistic study of the most active compound against the HCT-116, HT-29 and Caco-2 cell lines revealed cell cycle arrest during the G2/M phase. Compound 12 was found to induce apoptosis through the up-regulation of Bax and p53 by 7.4 and 8.5-fold, respectively, and also the downregulation of Bcl-2 by 3.2-fold compared to the control. Western blot assay was performed on HCT-116 cells and demonstrated marked inhibition of CDK1 and Bcl-2 expression together with an increase in the expression of caspase-3, Bax and p53 in a concentration-dependent manner. Finally, a prediction of the chemo-informatic properties of compounds 11 and 12 indicated that they are orally bioavailable with no permeation of the blood-brain barrier. (C) 2020 Elsevier B.V. All rights reserved.

Safety of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Harras, MF; Sabour, R; Ammar, YA; Mehany, ABM; Farrag, AM; Eissa, SI or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2020.0 MEAT SCI published article about MEAT QUALITY; VOLATILE COMPOUNDS; PHYSICOCHEMICAL PROPERTIES; PALATABILITY EVALUATIONS; LONGISSIMUS MUSCLE; PROTEIN OXIDATION; SENSORY QUALITY; FROZEN STORAGE; SHEAR FORCE; DRIP LOSS in [da Silva Bernardo, Ana Paula; Muniz da Silva, Astrid Caroline; do Nascimento, Maristela da Silva; Pflanzer, Sergio Bertelli] Univ Estadual Campinas, Dept Food Technol, Rua Monteiro Lobato 80, BR-13083862 Campinas, SP, Brazil; [Francisco, Vanessa Cristina] Sao Paulo State Univ, Sch Pharmaceut Sci, UNESP, Rua Expedicionarios Brazil 1621, BR-14801902 Araraquara, SP, Brazil; [Nassu, Renata Tieko] Embrapa Pecuaria Sudeste, Rod Washington Luiz,Km 234, BR-13560970 Sao Carlos, SP, Brazil; [Ribeiro, Felipe A.; Calkins, Chris R.] Univ Nebraska, Dept Anim Sci, Anim Sci A213, Lincoln, NE 68583 USA in 2020.0, Cited 66.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Computed Properties of C7H8O

This study evaluated the effects of freezing, prior to and after dry aging, on the microbiological and physical-chemical quality of beef. Strip loins (n = 24) from 12 carcasses were assigned to four treatments: non-frozen dry aging (Dry); dry aging, steak fabrication, freezing and slow thawing (Dry + ST); freezing, fast thawing (FT; 20 degrees C/15 h) and dry aging (FT + Dry); freezing, slow thawing (ST; 4 degrees C/48 h) and dry aging (ST + Dry). Freezing conditions were – 20 degrees C/28 days and dry aging conditions were 2 degrees C/70% relative humidity, for 28 days. Freezing prior to dry aging did not affect the microbial counts compared to Dry. However, FT + Dry and ST + Dry increased (16%) total process loss (P < .05) compared to Dry and Dry + ST. Moreover, freezing changed volatile compounds profile. Thus, freezing prior to dry aging was not a feasible process due to increased process loss, while freezing after dry aging was considered a viable alternative to preserve the steaks without compromising beef physical-chemical traits. Computed Properties of C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Bernardo, APD; da Silva, ACM; Francisco, VC; Ribeiro, FA; Nassu, RT; Calkins, CR; do Nascimento, MD; Pflanzer, SB or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BISMUTH OXYHALIDES; DEGRADATION; NANOCOMPOSITES; FABRICATION; PERFORMANCE; HETEROJUNCTION; THICKNESS, Saw an article supported by the State Key Laboratory of Coal Mine Disaster Dynamics and Control in Chongqing University [2011DA105287-MS201802]. Published in ELSEVIER SCI LTD in OXFORD ,Authors: Jiang, Z; Xiao, C; Yin, XY; Xu, LJ; Liu, CL; Wang, HL. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone. Category: indole-building-block

In this wok, a novel Bi24O31Br10/nano-ZnO composite photocatalyst has been synthesized with solvothermal method. The photocatalytic ability of the composite photocatalyst is estimated through degrading Rhodomine B (RhB) under visible light. The RhB degradation rate exceeds 90% in 40 min for the Bi24O31Br10/nano-ZnO (5%) composite, showing the most remarkable photocatalytic abilities. The excellent photocatalytic performance can be explained by the successful detachment and motion of photo-induced electrons (e(-)) and holes (h(+)) in the composite photocatalyst. Additionally, a probable photo-catalytic principle of the Bi24O31Br10/nano-ZnO composite for RhB degradation is discussed. This study could provide an original visible light driven photocatalyst on efficiently purifying dye wastewaters.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Jiang, Z; Xiao, C; Yin, XY; Xu, LJ; Liu, CL; Wang, HL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Agriculture; Chemistry; Food Science & Technology very interesting. Saw the article Stereoselective Formation of beta-O-4 Structures Mimicking Softwood Lignin Biosynthesis: Effects of Solvent and the Structures of Quinone Methide Lignin Models published in 2019.0. Formula: C8H8O2, Reprint Addresses Akiyama, T (corresponding author), Forestry & Forest Prod Res Inst, Dept Forest Resource Chem, Wood Chem Lab, 1 Matsunosato, Tsukuba, Ibaraki 3058687, Japan.. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

p-Quinone methide (QM) is formed as an intermediate during lignin biosynthesis. The aromatization of the QM by the attack of a nucleophile at the a-position of its side chain generates a phenolic hydroxy group in a growing polymer and creates stereoisomeric forms in the side chain. A series of beta-O-4-aryl ether QMs was reacted with water at 25 degrees C to replicate the formation of p-hydro)ryphenyl (H) and guaiacyl (C) beta-O-4 structures in plant cell walls. Water addition occurred in 3-methoxy-substituted QMs (G-type QMs) with half-lives (t(1/2)) between 13 and 15 min, at pH 7, in 50% water solution (dioxane water, 1:1). The rate increased as the water concentration increased to 99% (t(1/2), 1.2-1.4 min). Similar solvent effects were observed for more reactive nonsubstituted QMs (H-type QMs with t(1/2) of <1 min). Consequently, t(1/2) of the H-type QMs was shorter than that of the G-type QMs under every solvent condition. Upon increasing the water concentration, the variation in the erythro/threo ratios of the four dimeric beta-O-4 products increased. Interestingly, the effect of pH on the stereopreference, which was observed in 50% water solution, was small and became imperceptible as the water concentration increased to 99%, suggesting that the effect of the solvent, as well as the effect of the pH, plays an important role in understanding the reaction conditions in cell walls during lignin biosynthesis. The threo isomer was preferentially formed in the four dimeric beta-O-4 structures, which is inconsistent with the structural features of compression wood lignin rich in H-units. However, the erythro-selective formation was attained in an H-type QM at every pH studied (pH 3.5-7) by introducing a biphenyl structure into the beta-etherified ring moiety. About 4'-Hydroxyacetophenone, If you have any questions, you can contact Zhu, XH; Akiyama, T; Yokoyama, T; Matsumoto, Y or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Jordan, A; Denton, RM; Sneddon, HF in AMER CHEMICAL SOC published article about WITTIG; CHLORIDES; REAGENT; OXIDE in [Jordan, Andrew; Denton, Ross M.] Univ Nottingham, GlaxoSmithKline Carbon Neutral Lab Sustainable Ch, Jubilee Campus, Nottingham NG7 2GA, England; [Sneddon, Helen F.] GSK, Med Res Ctr, Stevenage SG1 2NY, Herts, England in 2020.0, Cited 31.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

Herein, we report a green, chromatography-free Appel chlorination and bromination in both catalytic and stoichiometric form. Improved sustainability was achieved via the effective replacement of chlorinated solvents with dimethyl carbonate and the use of triphenylphosphine oxide (PPh3O) as a recyclable organocatalyst. The substrate scope of this halogenated solvent-free reaction was shown to be analogous to a contemporary methodology, and removal and recovery of PPh3O from the desired products were effectively demonstrated. Investigations into the catalytic cycle were conducted, and REACT-IR was demonstrated to be an effective method of reaction monitoring in situ. Optimized methodology was applied to the synthesis of 1-bromo-4-(1-bromoethyl)benzene, a key building block employed during the discovery of a GSK fatty acid synthase inhibitor.

About Benzyl Alcohol, If you have any questions, you can contact Jordan, A; Denton, RM; Sneddon, HF or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy very interesting. Saw the article The tyrosinase-inhibitory effects of 2-phenyl-1,4-naphthoquinone analogs: importance of the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type published in 2019.0. Recommanded Product: m-Methoxyphenol, Reprint Addresses Moon, HR (corresponding author), Pusan Natl Univ, Coll Pharm, Busan 609735, South Korea.; Chun, P (corresponding author), Inje Univ, Coll Pharm, Gimhae 50834, Gyeongnam, South Korea.; Chun, P (corresponding author), Inje Univ, Inje Inst Pharmaceut Sci & Res, Gimhae 50834, Gyeongnam, South Korea.. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

In order to investigate the effect of the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type on tyrosinase inhibition, 2-phenyl-1,4-naphthoquinone derivatives were synthesized by Michael addition of substituted benzenes to 1,4-naphthoquinone and subsequently an auto-oxidation. Most of the derivatives potently inhibited mushroom tyrosinase and four derivatives, including 1c (IC50=22.00 +/- 1.63M), more potently inhibited mushroom tyrosinase than kojic acid (IC50=37.86 +/- 2.21M). Cell-based assays using B16F10 cells (a melanoma cell line) showed 1c dose-dependently suppressed melanin production and more potently inhibited tyrosinase activity than kojic acid. Docking simulation results between 1c and tyrosinase and a kinetic study suggest that 1c is a competitive inhibitor that binds to the active site of tyrosinase. These results support that anti-melanogenic effect of naphthoquinone derivatives results from their tyrosinase inhibiting activity and the (E)–phenyl-,-unsaturated carbonyl scaffold of an endomethylene type can confer tyrosinase-inhibitory activity.

About m-Methoxyphenol, If you have any questions, you can contact Ullah, S; Akter, J; Kim, SJ; Yang, J; Park, Y; Chun, P; Moon, HR or concate me.. Recommanded Product: m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles