Tag: M.W=100-150

Product Details of 100-83-4. In 2020.0 EUR J MED CHEM published article about OXIDOREDUCTASE 1 NQO1; DT-DIAPHORASE; OXIDATIVE STRESS; CANCER; CYTOTOXICITY; EXPRESSION; SENSITIVITY; METABOLISM; APOPTOSIS; REDUCTASE in [Wu, Li-Qiang; Liu, Zhao-Peng] Shandong Univ, Sch Pharmaceut Sci, Dept Med Chem, Key Lab Chem Biol,Minist Educ, Jinan 250012, Peoples R China; [Wu, Li-Qiang; Ma, Xin; Zhang, Chong] Xinxiang Med Univ, Sch Pharm, Xinxiang 453003, Henan, Peoples R China in 2020.0, Cited 44.0. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

A novel series of 4-substituted-3,4-dihydrobenzo[h]quinoline-2,5,6(1H)-triones as NQO1-directed anti-tumor agents were designed, synthesized, biologically evaluated. Compounds 3n, 3o and 3j proved to be good NQO1 substrates that showed increased metabolic rates relative to that of beta-lapachone. In addition, 3n, 3o and 3j potently inhibited the growth of NQO1-rich breast cancer MCF-7 cell, liver hepatocellular HepG2 cell, and lung cancer A549 cell. In cellular mechanistic studies, the representative compound 3o triggered ROS generation depending on the NQO1 dose, and induce HepG2 cell apoptosis by the generated oxidative stress. In HepG2 xenografts mouse model, at the dose of 20 mg/kg, 3o remarkably suppressed the tumor growth without affecting the animal weights. (C) 2020 Elsevier Masson SAS. All rights reserved.

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Wu, LQ; Ma, X; Zhang, C; Liu, ZP or concate me.. Product Details of 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Discovery of a novel series of substituted quinolines acting as anticancer agents and selective EGFR blocker: Molecular docking study published in 2021. HPLC of Formula: C8H8O2, Reprint Addresses Prashanth, MK (corresponding author), BNM Inst Technol, Dept Chem, Bengaluru 560070, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A Ta2O5-anchored-piperidine-4-carboxylic acid (PPCA) nanoparticle has been synthesized and characterized. It was then used as a highly effective nanocatalyst for the synthesis of quinolin-2(1H)-one derivatives through C-O bond functionalization. The special advantage of this heterogeneous solid catalyst is the reusability of the catalyst for up to five cycles without any noticeable reduction in product yields. In comparison, healthy reaction profiles, wide substrate scope, excellent yields and easy workup conditions are the notable highlights of this approach. All the compounds were tested for their anticancer activity against MCF-7 (human breast), HepG2 (human liver), HCT116 (human colorectal), and PC-3 (human prostate) cancer cell lines with the MTT assay. All the compounds were shown to have moderate to good inhibitory effects on tested cancer cell lines. Besides, compounds 5b, 5c and 5d showed good selectivity against epidermal growth factor receptor-tyrosine kinase (EGFR-TK). Molecular docking results showed that active compounds showed a good affinity towards EGFR kinase (PDB ID: 6V6O) by forming two hydrogen bonds with Cys-797 and Tyr-801. All the compounds were screened for computational ADMET and Lipinski analysis.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Kumar, CBP; Raghu, MS; Prathibha, BS; Prashanth, MK; Kanthimathi, G; Kumar, KY; Parashuram, L; Alharthi, FA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Authors Sorrentino, JP; Orsi, DL; Altman, RA in AMER CHEMICAL SOC published article about in [Sorrentino, Jacob P.] Univ Kansas, Dept Med Chem, Lawrence, KS 66045 USA; [Orsi, Douglas L.] Broad Inst Harvard & MIT, Cambridge, MA 02142 USA; [Altman, Ryan A.] Purdue Univ, Dept Med Chem & Mol Pharmacol, W Lafayette, IN 47906 USA; [Altman, Ryan A.] Purdue Univ, Dept Chem, W Lafayette, IN 47906 USA in 2021.0, Cited 35.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

The substitution of hydrogen atoms with fluorine in bioactive molecules can greatly impact physicochemical, pharmacokinetic, and pharmacodynamic properties. However, current synthetic methods cannot readily access many fluorinated motifs, which impedes utilization of these groups. Thus, the development of new methods to introduce fluorinated functional groups is critical for developing the next generation of biological probes and therapeutic agents. The synthesis of one such substructure, the alpha,alpha-difluoroalkylthioether, typically requires specialized conditions that necessitate early-stage installation. A late-stage and convergent approach to access alpha,alpha-difluoroalkylthioethers could involve nucleophilic addition of thiols across gem-difluorostyrenes. Unfortunately, under basic conditions, nucleophilic addition to gem-difluorostyrenes generates an anionic intermediate that can undergo facile elimination of fluoride to generate alpha-fluorovinylthioethers. To overcome this decomposition, we herein exploit an acid-based catalyst system to facilitate simultaneous nucleophilic addition and protonation of the unstable intermediate. Ultimately, the optimized mild conditions afford the desired alpha,alpha-difluoroalkylthioethers in high selectivity and moderate to excellent yields. These alpha,alpha-difluoroalkylthioethers are less nucleophilic and more oxidatively stable relative to nonfluorinated thioethers, suggesting the potential application of this unexplored functional group in biological probes and therapeutic agents.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sorrentino, JP; Orsi, DL; Altman, RA or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 150-76-5. Authors Lu, GH; Huang, TC; Hsueh, HC; Yang, SC; Cho, TW; Chou, HH in ROYAL SOC CHEMISTRY published article about in [Lu, Guan-Han; Huang, Tzu-Chia; Hsueh, Hsiao-Chin; Yang, Shin-Cherng; Cho, Ting-Wei; Chou, Ho-Hsuan] Natl Cheng Kung Univ, Dept Chem, Tainan 701, Taiwan in 2021, Cited 58. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

A novel universal N-transfer reagent for direct and effective transformation of alpha-amino ketones, acetamides, and esters to the corresponding alpha-diazo products under mild basic conditions has been developed. This one-step synthetic approach not only allows for generation of alpha-substituted-alpha-diazo carbonyl compounds from alpha-amino acid derivatives but also permits preparation of alpha-diazo dipeptides from N-terminal dipeptides (32 examples, up to 91%).

Recommanded Product: 150-76-5. About Mequinol, If you have any questions, you can contact Lu, GH; Huang, TC; Hsueh, HC; Yang, SC; Cho, TW; Chou, HH or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 ACS OMEGA published article about SOLVENT-FREE SYNTHESIS; SOLID ACID CATALYST; ONE-POT SYNTHESIS; RECYCLABLE CATALYST; EFFICIENT; DERIVATIVES; NANOCOMPOSITES; KNOEVENAGEL; TRIFLATE; REAGENT in [Jadhav, Nirajkumar H.; Rasal, Nishant K.; Pawar, Ramdas A.] PDEAs Baburaoji Gholap Coll, Dept Chem, Pune 411027, Maharashtra, India; [Sakate, Sachin S.] PE Soc Modern Coll Arts Sci & Commerce, Pune 411005, Maharashtra, India; [Shinde, Dnyaneshwar R.; Pawar, Ramdas A.] PDEAs Prof Ramkrishna More Coll, Pune 411044, Maharashtra, India; [Jadhav, Nirajkumar H.] Dr DY Patil Sch Engn, Pune 412105, Maharashtra, India in 2019.0, Cited 59.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6. Application In Synthesis of m-Methoxyphenol

A novel heterogeneous catalytic method was developed for the synthesis of coumarin and its derivatives using the Ti(IV)-doped ZnO matrix forming catalyst Zn0.925Ti0.075O having a high surface area and good Lewis acidity. The catalyst shows high activity toward a broad spectrum of the substituted phenols with beta-ketoesters such as ethyl acetoacetate, ethyl butyryl acetate, ethyl benzoyl acetate, and so forth in good yields over short reaction times during the synthesis of coumarins. The methodology was further extended for the synthesis of ayapin molecules. The catalyst also shows recycle activity up to seven cycles with very good stability.

About m-Methoxyphenol, If you have any questions, you can contact Jadhav, NH; Sakate, SS; Rasal, NK; Shinde, DR; Pawar, RA or concate me.. Application In Synthesis of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Efficient one-pot synthesis of polyhydroquinoline derivatives through the Hantzsch condensation using IRMOF-3 as heterogeneous and reusable catalyst published in 2021. HPLC of Formula: C8H8O2, Reprint Addresses Lande, MK (corresponding author), Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde

A mesoporous Zn-based 2-amino terephthalate metal organic framework (IRMOF-3) catalyst was prepared using the solvothermal method. The synthesized catalyst was characterized by powder X-ray diffraction (XRD), thermogravimetric analysis (TGA), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDAX), and Brunauer-Emmett-Teller surface area analysis (BET). It was applied as an effective heterogeneous catalyst for the synthesis of one-pot four-component polyhydroquinoline derivatives via the Hantzsch condensation. The present method offers several advantages over other reported methods such as easy separation, mild reaction condition, and excellent yield of desired product. Furthermore, the catalyst can be reused without loss in activity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rathod, VN; Bansode, ND; Thombre, PB; Lande, MK or concate me.. HPLC of Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Name: 4-Methoxybenzaldehyde. Liu, J; Cremosnik, GS; Otte, F; Pahl, A; Sievers, S; Strohmann, C; Waldmann, H in [Liu, Jie; Cremosnik, Gregor S.; Pahl, Axel; Sievers, Sonja; Waldmann, Herbert] Max Planck Inst Mol Physiol, Dept Chem Biol, Otto Hahn Str 1, D-44227 Dortmund, Germany; [Liu, Jie; Waldmann, Herbert] Tech Univ Dortmund, Fac Chem, Chem Biol, Otto Hahn Str 6, D-44221 Dortmund, Germany; [Otte, Felix; Strohmann, Carsten] Tech Univ Dortmund, Fac Chem, Inorgan Chem, Otto Hahn Str 6, D-44221 Dortmund, Germany; [Pahl, Axel; Sievers, Sonja] Compound Management & Screening Ctr, Dortmund, Germany published Design, Synthesis, and Biological Evaluation of Chemically and Biologically Diverse Pyrroquinoline Pseudo Natural Products in 2021.0, Cited 44.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Natural product (NP) structures are a rich source of inspiration for the discovery of new biologically relevant chemical matter. In natural product inspired pseudo-NPs, NP-derived fragments are combined de novo in unprecedented arrangements. Described here is the design and synthesis of a 155-member pyrroquinoline pseudo-NP collection in which fragments characteristic of the tetrahydroquinoline and pyrrolidine NP classes are combined with eight different connectivities and regioisomeric arrangements. Cheminformatic analysis and biological evaluation of the compound collection by means of phenotyping in the morphological cell painting assay followed by principal component analysis revealed that the pseudo-NP classes are chemically diverse and that bioactivity patterns differ markedly, and are dependent on connectivity and regioisomeric arrangement of the fragments.

Name: 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Liu, J; Cremosnik, GS; Otte, F; Pahl, A; Sievers, S; Strohmann, C; Waldmann, H or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of m-Methoxyphenol. In 2020.0 CHEM COMMUN published article about TO-TAIL DIMERIZATION; DRUG DISCOVERY; BAYLIS-HILLMAN; IN-SITU; ACRYLONITRILE; SULFONAMIDES; INHIBITORS; FLUOROSULFONYLVINYLATION; CYCLOADDITION; DERIVATIVES in [Li, Chen; Zheng, Yujie; Rakesh, K. P.; Qin, Hua-Li] Wuhan Univ Technol, Sch Chem Chem Engn & Life Sci, State Key Lab Silicate Mat Architectures, 205 Luoshi Rd, Wuhan 430070, Peoples R China in 2020.0, Cited 65.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

A versatile selectively addressable SuFEx click chemistry hub, but-3-ene-1,3-disulfonyl difluoride (BDF) was designed and synthesized through head-to-tail dimerization of ethenesulfonyl fluoride (ESF). BDF possesses three active sites to selectively participate in the construction of 4-membered, 5-membered and 6-membered cyclic sulfonamide (sultams) bearing aliphatic sulfonyl fluoride moieties for further manipulations in a fast, efficient and practical manner.

About m-Methoxyphenol, If you have any questions, you can contact Li, C; Zheng, YJ; Rakesh, KP; Qin, HL or concate me.. Application In Synthesis of m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

In 2019.0 CATAL TODAY published article about LARGE-SCALE SYNTHESIS; SOLVOTHERMAL SYNTHESIS; ORGANIC-SYNTHESIS; BENZYL ALCOHOL; ZNO; WATER; OXIDATION; TIO2; PERFORMANCE; BENZALDEHYDE in [Fernandes, Raquel A.; Sampaio, Maria J.; Da Silva, Eliana S.; Faria, Joaquim L.; Silva, Claudia G.] Univ Porto, Fac Engn, LCM, LSRE, Rua Dr Roberto Frias S-N, P-4200465 Porto, Portugal; [Serp, Philippe] Univ Toulouse, CNRS, UPR 8241, UPS,INP LCC,Lab Chim Coordinat,Composante ENSIACE, 4 Allee Emile Monso,BP 44362, F-31030 Toulouse 4, France in 2019.0, Cited 48.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Formula: C7H8O

Zinc oxide (ZnO) prepared by chemical vapor deposition was combined with different amounts of carbon nanofibers (CNF) to obtain hybrid materials, which were thoroughly characterized using several techniques. The photocatalytic performance was evaluated towards the photocatalytic synthesis of vanillin (VAD) starting from vanillyl alcohol (VA). The incorporation of the carbon phase in ZnO (from 5% to 20% wt.) was found to increase the surface area and the photocatalytic performance of the materials. The latter was attributed to the efficient separation of charge carriers generated on the optical semiconductor. With the best performing material, the one containing 10% of CNF, the selectivity of the synthesis towards vanillin generation was increased by a factor of 2.5 compared to previous studies, with the additional advantage of carrying the reaction in aqueous medium. The same photocatalyst was successfully applied to the selective synthesis of other aromatic aldehydes, namely anisaldehyde, piperonal, and benzaldehyde. A relationship between the efficiency of the photocatalytic oxidation of the alcohols and the activating nature of their aromatic ring substituents was proposed.

About Benzyl Alcohol, If you have any questions, you can contact Fernandes, RA; Sampaio, MJ; Da Silva, ES; Serp, P; Faria, JL; Silva, CG or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 100-51-6. I found the field of Polymer Science very interesting. Saw the article Mechanistic Insight into the Ring-Opening Polymerization of epsilon-Caprolactone and L-Lactide Using Ketiminate-Ligated Aluminum Catalysts published in 2019.0, Reprint Addresses Lin, YF (corresponding author), Kaohsiung Med Univ, Dept Fragrance & Cosmet Sci, Kaohsiung 80708, Taiwan.; Lin, YF (corresponding author), Kaohsiung Med Univ, Dept Med & Appl Chem, Kaohsiung 80708, Taiwan.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol.

The reactivity and the reaction conditions of the ring-opening polymerization of epsilon-caprolactone (epsilon-CL) and L-lactide (LA) initiated by aluminum ketiminate complexes have been shown differently. Herein, we account for the observation by studying the mechanisms on the basis of density functional theory (DFT) calculations. The calculations show that the ring-opening polymerization of epsilon-CL and LA are rate-determined by the benzoxide insertion and the C-O bond cleavage step, respectively. Theoretical computations suggest that the reaction temperature of L-LA polymerization should be higher than that of epsilon-CL one, in agreement with the experimental data. To provide a reasonable interpretation of the experimental results and to give an insight into the catalyst design, the influence of the electronic, steric, and thermal effects on the polymerization behaviors will be also discussed in this study.

About Benzyl Alcohol, If you have any questions, you can contact Lin, YF; Jheng, NY or concate me.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles