Tag: M.W=100-150

In 2019.0 BIOCHEMISTRY-US published article about BINUCLEAR METAL CENTER; SP STRAIN TCM1; FLAME RETARDANTS; ACTIVE-SITE; HYDROLYSIS; ENZYME; TOXICITY; PHOSPHORYL; MECHANISM in [Bigley, Andrew N.; Xiang, Dao Feng; Narindoshvili, Tamari; Raushel, Frank M.] Texas A&M Univ, Dept Chem, College Stn, TX 77843 USA; [Burgert, Charlie W.; Hengge, Alvan C.] Utah State Univ, Dept Chem & Biochem, Logan, UT 84322 USA in 2019.0, Cited 38.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Recommanded Product: 99-93-4

Organophosphorus flame retardants are stable toxic compounds used in nearly all durable plastic products and are considered major emerging pollutants. The phosphotriesterase from Sphingobium sp. TCM1 (Sb-PTE) is one of the few enzymes known to be able to hydrolyze organophosphorus flame retardants such as triphenyl phosphate and tris(2-chloroethyl) phosphate. The effectiveness of Sb-PTE for the hydrolysis of these organophosphates appears to arise from its ability to hydrolyze unactivated alkyl and phenolic esters from the central phosphorus core. How Sb-PTE is able to catalyze the hydrolysis of the unactivated substituents is not known. To interrogate the catalytic hydrolysis mechanism of Sb-PTE, the pH dependence of the reaction and the effects of changing the solvent viscosity were determined. These experiments were complemented by measurement of the primary and secondary 18-oxygen isotope effects on substrate hydrolysis and a determination of the effects of changing the pK(a) of the leaving group on the magnitude of the rate constants for hydrolysis. Collectively, the results indicated that a single group must be ionized for nucleophilic attack and that a separate general acid is not involved in protonation of the leaving group. The Bronsted analysis and the heavy atom kinetic isotope effects are consistent with an early associative transition state with subsequent proton transfers not being rate limiting. A novel binding mode of the substrate to the binuclear metal center and a catalytic mechanism are proposed to explain the unusual ability of Sb-PTE to hydrolyze unactivated esters from a wide range of organophosphate substrates.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Bigley, AN; Xiang, DF; Narindoshvili, T; Burgert, CW; Hengge, AC; Raushel, FM or concate me.. Recommanded Product: 99-93-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C7H8O2. Authors Kawamoto, Y; Kobayashi, T; Ito, H in AMER CHEMICAL SOC published article about in [Kawamoto, Yuichiro; Kobayashi, Toyoharu; Ito, Hisanaka] Tokyo Univ Pharm & Life Sci, Sch Life Sci, Tokyo 1920392, Japan in 2021.0, Cited 22.0. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Stachyodin A, possessing a unique spirotetrahydrofuran ring system, was isolated from the roots of Indigofera stachyodes in 2018. The first total synthesis of racemic stachyodin A was accomplished in 14 steps. The efficient stereoselective synthetic route involved one-pot Suzuki coupling and stereocontrolled epoxidation followed by reductive opening and spirocyclization.

About m-Methoxyphenol, If you have any questions, you can contact Kawamoto, Y; Kobayashi, T; Ito, H or concate me.. HPLC of Formula: C7H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

HPLC of Formula: C8H8O2. Authors Jain, H; Sutradhar, D; Roy, S; Desiraju, GR in WILEY-V C H VERLAG GMBH published article about in [Jain, Harsh; Sutradhar, Dipankar; Roy, Sourav; Desiraju, Gautam R.] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Higher cocrystal synthesis depends acutely on a knowledge of supramolecular synthons. We report three synthetic approaches towards ternary halogen bonded cocrystals that illustrate specificity and generality. Electrophilicity/nucleophilicity differences are needed among alternative sites of halogen bond formation. The two halogen bonds AB and BC in a halogen bonded ternary cocrystal ABC need to be of different strength. Interaction mimicry of hydrogen bonds by halogen bonds is a viable approach towards ternaries as illustrated with the pyrene structure. Finally, the crystal engineer should well be able to anticipate halogen bonds that are stronger than hydrogen bonds.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jain, H; Sutradhar, D; Roy, S; Desiraju, GR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article A novel Cu-nanowire@Quasi-MOF via mild pyrolysis of a bimetal-MOF for the selective oxidation of benzyl alcohol in air WOS:000493071600032 published article about METAL-ORGANIC FRAMEWORK; NANOPARTICLES; EFFICIENT; CATALYSTS; CONVERSION; POLYHEDRA; NANOCAGES; NANORODS; CO2 in [Shen, Yan; Bao, Li-Wei; Sun, Fang-Zhou; Hu, Tong-Liang] Nankai Univ, Sch Mat Sci & Engn, Natl Inst Adv Mat, Tianjin Key Lab Met & Mol Based Mat Chem, Tianjin 300350, Peoples R China; [Shen, Yan; Bao, Li-Wei; Sun, Fang-Zhou; Hu, Tong-Liang] Nankai Univ, Tianjin Key Lab Rare Earth Mat & Applicat, Tianjin 300350, Peoples R China; [Hu, Tong-Liang] Nankai Univ, Minist Educ, Key Lab Adv Energy Mat Chem, Tianjin 300071, Peoples R China in 2019.0, Cited 51.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Application In Synthesis of Benzyl Alcohol

The preparation of metal nanocomposite catalysts with MOFs as precursors has attracted extensive attention, as the design and preparation of catalysts by this method could maximize the advantages of the precursors and ensure the stability of the catalysts as much as possible. Here, a benzimidazole-modified Cu/Co bimetal-MOF as a precursor was used to synthesize a Cu-nanowire@Quasi-MOF material via a simple and low-cost thermal decomposition strategy for the first time. Experimental evaluation suggested that the Co-MOF part in Cu/Co bimetal-MOF was a morphology retainer, and the special channel composition of the Quasi-MOF played a space-confined role in the formation of the unique Cu-nanowires. Based on the detailed investigation, a possible formation mechanism was proposed. Furthermore, Cu-nanowire@Quasi-MOF exhibited excellent catalytic performance and good stability in the selective oxidation of benzyl alcohol in air. This study demonstrated that using MOFs as a precursor, by adjusting the calcination temperature and adding heteroatoms, can control the morphology of metal nanoparticles (MNPs) in MOF derivatives, reduce agglomeration and enhance catalytic activity, which will be a promising approach to in situ preparation of complex metal nanocomposites.

About Benzyl Alcohol, If you have any questions, you can contact Shen, Y; Bao, LW; Sun, FZ; Hu, TL or concate me.. Application In Synthesis of Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Jain, H; Sutradhar, D; Roy, S; Desiraju, GR in WILEY-V C H VERLAG GMBH published article about in [Jain, Harsh; Sutradhar, Dipankar; Roy, Sourav; Desiraju, Gautam R.] Indian Inst Sci, Solid State & Struct Chem Unit, Bangalore 560012, Karnataka, India in 2021, Cited 51. COA of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Higher cocrystal synthesis depends acutely on a knowledge of supramolecular synthons. We report three synthetic approaches towards ternary halogen bonded cocrystals that illustrate specificity and generality. Electrophilicity/nucleophilicity differences are needed among alternative sites of halogen bond formation. The two halogen bonds AB and BC in a halogen bonded ternary cocrystal ABC need to be of different strength. Interaction mimicry of hydrogen bonds by halogen bonds is a viable approach towards ternaries as illustrated with the pyrene structure. Finally, the crystal engineer should well be able to anticipate halogen bonds that are stronger than hydrogen bonds.

COA of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jain, H; Sutradhar, D; Roy, S; Desiraju, GR or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of 4-Methoxybenzaldehyde. In 2021 RSC ADV published article about PHOTOCHEMICAL-SYNTHESIS; DERIVATIVES; EFFICIENT; DEGRADATION; COUMARINS; ACETYLCHOLINESTERASE; PHOTOCATALYSIS; NANOCATALYST; BLUE in [Jarrahi, Mahbube; Tayebee, Reza; Maleki, Behrooz] Hakim Sabzevari Univ, Sch Sci, Dept Chem, Sabzevar 9617976487, Iran; [Salimi, Alireza] Ferdowsi Univ Mashhad, Fac Sci, Dept Chem, Mashhad, Razavi Khorasan, Iran in 2021, Cited 57. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Histaminium tetrachlorozincate nanoparticles are prepared, characterized and applied as an effective and recoverable photocatalyst in the one-pot, green and multi-component synthesis of various chromenes by the reaction of dimedone and/or 1,3-cyclohexanedione, arylaldehyde and 4-hydroxycoumarin in high yields under solventless conditions at ambient temperature. This new catalyst is characterized by FT-IR, XRD, EDX, NMR, SEM and TEM techniques. The incorporation of histaminium ions into the framework of ZnCl42- significantly affected the photocatalytic activity of tetrachlorozincate such that good reusability and recyclability are attained. Moreover, reactive species such as O-2(-) and hydroxyl radicals have proved to be active species in the presented photocatalytic reaction. In addition, the hot filtration test confirms enough stability of the photocatalyst and no significant leaching and destruction of the framework in the course of the reaction. The major advantages of the presented methodology include easy work-up, cost effectiveness, nontoxic nature, broad substrate scope, 100% atom economy, ease of separation, and environment friendly reaction conditions. Finally, the catalyst could be reused many times without significant loss of activity.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Jarrahi, M; Tayebee, R; Maleki, B; Salimi, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recommanded Product: 123-11-5. Authors Nikitas, NF; Apostolopoulou, MK; Skolia, E; Tsoukaki, A; Kokotos, CG in WILEY-V C H VERLAG GMBH published article about in [Nikitas, Nikolaos F.; Apostolopoulou, Mary K.; Skolia, Elpida; Tsoukaki, Anna; Kokotos, Christoforos G.] Natl & Kapodistrian Univ Athens, Dept Chem, Organ Chem Lab, Athens 15771, Greece in 2021, Cited 133. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A cheap, facile and metal-free photochemical protocol for the activation of aromatic aldehydes has been developed. Utilizing thioxanthen-9-one as the photocatalyst and cheap household lamps as the light source, a variety of aromatic aldehydes have been activated and subsequently converted in a one-pot reaction into amides, hydroxamic acids and esters in good to high yields. The applicability of this method was highlighted in the synthesis of Moclobemide, a drug against depression and social anxiety. Extended and detailed mechanistic studies have been conducted, in order to determine a plausible mechanism for the reaction.

Recommanded Product: 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Nikitas, NF; Apostolopoulou, MK; Skolia, E; Tsoukaki, A; Kokotos, CG or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Facile access to chiral beta-homoglutamic acid from 3-cyclohexene-carboxylic acid WOS:000560967300001 published article about AMINO-ACID; ENANTIOSELECTIVE SYNTHESIS; CURTIUS REARRANGEMENT; PEPTIDE; ANALOGS in [Xu, Jing; Zhang, Xuebo] Fujian Normal Univ, Coll Chem & Mat Sci, Fuzhou, Peoples R China; [Xu, Jing; Zhang, Xuebo; Chen, Zhongxiang; Sun, Zhaofeng; Bian, Guangling; Song, Ling] Chinese Acad Sci, Fujian Inst Res Struct Matter, Key Lab Coal Ethylene Glycol & Its Related Techno, Fuzhou 350002, Fujian, Peoples R China; [Chen, Zhongxiang; Sun, Zhaofeng; Bian, Guangling; Song, Ling] Univ Chinese Acad Sci, Beijing, Peoples R China in 2020.0, Cited 26.0. HPLC of Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

A convenient, safe, and effective synthetic protocol for the synthesis of chiral beta-homoglutamic acid was described. The strategy started from 3-cyclohexenecarboxylic acid, followed by three steps classic reaction including Curtius Rearrangement, oxidative cleavage of alkene, and debenzylation by catalytic hydrogenation. The chiral beta-homoglutamic acid was prepared with a high yield and high enantiomeric excess. [GRAPHICS] .

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Xu, J; Zhang, XB; Chen, ZX; Sun, ZF; Bian, GL; Song, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Hellwig, PS; Guedes, JS; Barcellos, AM; Perin, G; Lenardao, EJ in MDPI published article about in [Hellwig, Paola S.; Guedes, Jonatan S.; Barcellos, Angelita M.; Perin, Gelson; Lenardao, Eder J.] Univ Fed Pelotas UFPel, LASOL CCQFA, POB 354, BR-96010900 Pelotas, RS, Brazil in 2021.0, Cited 61.0. Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

We describe herein an alternative transition-metal-free procedure to access 3,4-bis(butylselanyl)selenophenes and the so far unprecedented 3-(butylselanyl)-4-alkoxyselenophenes. The protocol involves the 5-endo-dig electrophilic cyclization of 1,3-diynes promoted by electrophilic organoselenium species, generated in situ through the oxidative cleavage of the Se-Se bond of dibutyl diselenide using Oxone(R) as a green oxidant. The selective formation of the title products was achieved by controlling the solvent identity and the amount of dibutyl diselenide. By using 4.0 equiv of dibutyl diselenide and acetonitrile as solvent at 80 degrees C, four examples of 3,4-bis(butylselanyl)selenophenes were obtained in moderate to good yields (40-78%). When 3.0 equiv of dibutyl diselenide were used, in the presence of aliphatic alcohols as solvent/nucleophiles under reflux, 10 3-(butylselanyl)-4-alkoxyselenophenes were selectively obtained in low to good yields (15-80%).

Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Hellwig, PS; Guedes, JS; Barcellos, AM; Perin, G; Lenardao, EJ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Computed Properties of C8H8O2. In 2019.0 MOL DIVERS published article about BENZAMIDE; DISCOVERY; ALPHA; ACIDS in [Nian, Si-Yun; Jiang, Zheng-Li] Taizhou Hosp Zhejiang Prov, Dept Clin Pharm, Xi Men St 150, Linhai 317000, Zhejiang, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping; Xiao, Ying] China State Inst Pharmaceut Ind, Shanghai Inst Pharmaceut Ind, Shanghai 201203, Peoples R China; [Nian, Si-Yun; Wang, Guo-Ping] Aurisco Pharmaceut Yangzhou Co Ltd, Yangzhou 225100, Jiangsu, Peoples R China; [Huang, Mo-Han; Zhou, Yi-Huan; Tan, Xiang-Duan] Guilin Med Univ, Coll Pharm, Guilin 541004, Peoples R China in 2019.0, Cited 21.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

Most of reported steroidal FXR antagonists are restricted due to low potency. We described the design and synthesis of novel nonsteroidal scaffold SIPI-7623 derivatives as FXR antagonists. The most potent compound A-11 (IC50 = 7.8 +/- 1.1 mu M) showed better activity compared to SIPI-7623 (IC50 = 40.8 +/- 1.7 mu M) and guggulsterone (IC50 = 45.9 +/- 1.1 mu M). Docking of A-11 in FXR’s ligand-binding domain was also studied.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Nian, SY; Wang, GP; Jiang, ZL; Xiao, Y; Huang, MH; Zhou, YH; Tan, XD or concate me.. Computed Properties of C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles