Tag: M.W=100-150

In 2021.0 APPL CLAY SCI published article about KNOEVENAGEL CONDENSATION; PALLADIUM-CATALYSTS; GOLD NANOPARTICLES; EFFICIENT; REDUCTION; LDH; FABRICATION; GRAPHENE; NANOCOMPOSITES; COMPOSITES in [Yang, Yu] Hebei Normal Univ, Element Educ Dept, Shijiazhuang 050024, Hebei, Peoples R China; [Yang, Yu; Zhu, Wenjing; Cui, Donghui; Lu, Changli] Northeast Normal Univ, Coll Chem, Changchun 130024, Peoples R China in 2021.0, Cited 52.0. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Quality Control of 4-Methoxybenzaldehyde

A novel type of multicomponent nanocomposite of LDH@PDA@PNIPAM@Pd/carbon dots (CDs) was successfully constructed for highly efficient heterogeneous catalytic reduction from two-dimensional layer double hydroxide (LDH) nanosheet functionalized with thermo-responsive PNIPAM polymer brushes based on the mussel-inspired chemistry. CDs were used as a reductant and stabilizer by in situ loading metal Pd onto LDH@PDA@PNIPAM. Compared with LDH@PDA@PNIPAM@Pd catalyst without CDs modification, the designed LDH@PDA@PNIPAM@Pd/CDs nanohybrid catalyst had better catalytic reduction ability for various dyes and nitrophenol thanks to the synergistic catalytic effect between metal active center and CDs, LDH and their high dispersion stability. Especially, a good catalytic reduction activity was demonstrated for methylene blue (MB) with a high TOF (545.2 min(-1)). Furthermore, the nanohybrid presented interesting thermo-responsive catalytic property due to the existence of PNIPAM polymer chains. In addition, the prepared catalyst also exhibited outstanding catalytic property for the Knoevenagel condensation reaction. Our study provides a new way for the composite preparation of organic-inorganic hybrid materials by polymer and inorganic materials, and shows great potential in the field of catalytic applications.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Yang, Y; Zhu, WJ; Cui, DH; Lu, CL or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Zinc(II)-Catalyzed Synthesis of Secondary Amides from Ketones via Beckmann Rearrangement Using Hydroxylamine-O-sulfonic Acid in Aqueous Media WOS:000579422600014 published article about KETOXIMES; LACTAMS; REAGENT; OXIME; MILD in [Verma, Saumya; Kumar, Puneet; Chandra, Dinesh; Yadav, Ajay K.; Jat, Jawahar L.] Babasaheb Bhimrao Ambedkar Univ Cent Univ, Dept Chem, Lucknow, Uttar Pradesh, India; [Khatana, Anil K.; Tiwari, Bhoopendra] Ctr Biomed Res, Div Mol Synth & Drug Discovery, SGPGIMS Campus,Raebareli Rd, Lucknow, Uttar Pradesh, India in 2020.0, Cited 56.0. Category: indole-building-block. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4

A zinc(II)-catalyzed single-step protocol for the Beckmann rearrangement using hydroxylamine-O-sulfonic acid (HOSA) as the nitrogen source in water was developed. This direct method efficiently produces secondary amides under open atmosphere in a pure form after basic aqueous workup. It is environmentally benign and operationally simple.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Verma, S; Kumar, P; Khatana, AK; Chandra, D; Yadav, AK; Tiwari, B; Jat, JL or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ACTIVATED RECEPTORS ALPHA; FREE FATTY-ACIDS; BIOLOGICAL EVALUATION; ANTIDIABETIC ACTIVITY; GENE-EXPRESSION; MANNICH BASES; PPAR; THIAZOLIDINEDIONE; DESIGN; SILICO, Saw an article supported by the Department of Science and technology, New Delhi, India (DST), India [DST/Inspire Fellow/2014/266, DST/Inspire Fellow/2014/258]. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. HPLC of Formula: C7H6O2

A new series of octadec-9-enoic acid schiff base entities (S1-S30) were designed and synthesized targeting peroxisome proliferator activated receptor-gamma for agonist action. Molinspiration software (online) was used to estimate drug like molecular properties of the metabolites. Docking disquisition on co-crystallized protein of PPAR-gamma (PDB ID 1FM9) was carried out which showed S21, S10 and S7 as best situated in the vital sites of receptor having docking scores – 9.19, – 8.68 and – 8.64 respectively. Free binding energy measured using model of Maestro 9.0 and was in range of from – 40.01 and – 80.54 kcal/mol, significant when compared with pioglitazone (- 51.58 Kcal/mol). Seven best docked derivatives were assessed for in-vivo oral glucose tolerance on normal rats and anti-hyperglycaemic activity by streptozotocin induced diabetes model. S21 unveiled to be the best measured analogue among all the synthesized entities. Encouraging outcomes motivates fatty acids for further development of more effective and safer compounds.

HPLC of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kapoor, G; Pathak, DP; Bhutani, R; Husain, A; Jain, S; Iqbal, MA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Chemistry very interesting. Saw the article Design, synthesis, and bioactivity of dihydropyrimidine derivatives as kinesin spindle protein inhibitors published in 2019.0. COA of Formula: C7H8O, Reprint Addresses Tawfik, HO (corresponding author), Tanta Univ, Fac Pharm, Dept Pharmaceut Chem, El Giesh St, Tanta 31527, Egypt.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

A series of twenty-one 3,4-dihydropyrimidine derivatives bearing the heterocyclic 1,3-benzodioxole at position 4 in addition to different substituents at positions 2, 3 and 5 were designed and synthesized as monastrol analogs. The novel synthesized compounds were screened for their cytotoxic activity towards 60 cancer cell lines according to NCI (USA) protocol. Compounds 10b and 15 showed the best antitumor activity against most cell lines. Compound 15 was subsequently tested in 5-doses mode and displayed high selectivity towards CNS, prostate and leukemia subpanel with selectivity ratios of 22.30, 15.38 and 12.56, respectively at GI(50) level. The IC50 of compounds 9d, 10b, 12, 15 and 16 against kinesin enzyme were 3.86 +/- 0.12, 10.70 +/- 0.35, 3.95 +/- 0.12, 4.36 +/- 0.14, and 14.07 +/- 0.45 mu M respectively, while the prototype compound, monastrol, reported IC50 value of 20 +/- 0.42 mu M. The safest compound among test compounds against normal cell line (HEK 293) is 10b with IC50 value of 62.02 +/- 2.42 mu M/ml in comparison to doxorubicin (IC50 = 11.34 +/- 0.44 mu M/ml). Cell cycle analysis of SNB-75 cells treated with compound 15 showed cell cycle arrest at G2/M phase. Further, the assay of levels of active caspase-3 and caspase-9 was investigated. Moreover, Molecular docking of compounds, 9d, 10b, 12, 15, 16, monastrol and mon-97 was performed to study the interaction between inhibitors and the kinesin spindle protein allosteric binding site.

COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Tawfik, HO; El-Hamamsy, MH; Sharafeldin, NA; El-Moselhy, TF or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article The preparation and photocatalytic activity of Ag-Pd/g-C3N4 for the coupling reaction between benzyl alcohol and aniline WOS:000488661800014 published article about G-C3N4; NANOPARTICLES; COMPOSITES; EVOLUTION; DRIVEN; CARBON; TIO2 in [Ma, Jingjing; Yu, Xiujuan; Liu, Xiaoling; Li, Haiying; Hao, Xueli; Li, Jingyi] Inner Mongolia Univ, Coll Chem & Chem Engn, Hohhot 010021, Inner Mongolia, Peoples R China; [Yu, Xiujuan] Hebei North Univ, Hebei Key Lab Neuropharmacol, Zhangiakou 075000, Hebei, Peoples R China in 2019.0, Cited 25.0. Quality Control of Benzyl Alcohol. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

In this study, the carrier g-C3N4 was prepared by melamine, and the Ag-Pd/g-C3N4 catalyst was synthesized by the NaBH4 reduction method. Different characterization techniques, including SEM, TEM, XRD, UV-vis DRS, XPS, photoluminescence spectra (PL) and BET, were employed to investigate the morphology and optical properties of the as-prepared samples. The Ag-Pd/g-C3N4 catalyst was used for the synthesis of imine from a benzyl alcohol and aniline. The results show that when the total loading of Ag and Pd is 2 wt%, and the mass ratio of Ag and Pd is 1:1, the activity of the catalyst is the highest (The highest conversion of aniline is 86.7% and the product selectivity is > 99%.). The reaction is optimized by changing the type of solvent, the type and amount of base, the type of catalyst, and the amount of reactants. The optimal reaction conditions are 6 ml of n-hexane, 1.4 mmol of Cs2CO3, 50 mg of the Ag-Pd/g-C3N4 (2 wt%, 1:1), and 2:1 mol ratio of benzyl alcohol and aniline. Under optimal reaction conditions, alcohol derivatives and amine derivatives were investigated to determine the suitable range of the catalyst for alcohols and amines. Then, the effects of different light intensities and wavelengths on the reaction were explored. Additionally, the catalyst’s recycling ability was tested, and it was found to be relatively stable. The effect of reactive groups on the mechanism shows that the reaction is mainly achieved by the synergy between h(+), e(-) and center dot O-2(-).

Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Ma, JJ; Yu, XJ; Liu, XL; Li, HY; Hao, XL; Li, JY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. In 2020 ORG CHEM FRONT published article about SUZUKI-MIYAURA; ALKYL-HALIDES; ASYMMETRIC 1,4-ADDITION; ADDRESSING CHALLENGES; OXIDATIVE ADDITION; GRIGNARD-REAGENTS; CHLORIDES; TOSYLATES; BROMIDES; SECONDARY in [Lee, Hang Wai; So, Chau Ming; Yuen, On Ying; Wong, Wing Tak; Kwong, Fuk Yee] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Kowloon, Hong Kong, Peoples R China; [Lee, Hang Wai; So, Chau Ming; Wong, Wing Tak] Hong Kong Polytech Univ, Shenzhen Res Inst SZRI, Shenzhen, Peoples R China; [Yuen, On Ying; Kwong, Fuk Yee] Chinese Univ Hong Kong, Dept Chem, Shatin, Peoples R China in 2020, Cited 72. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6.

The first palladium-catalyzed cross-coupling reaction of aryl/heteroaryl and alkenyl mesylates and tosylates with aryl titanium as the multi-functional reagent is reported. Using the catalyst system of Pd(OAc)(2) associated with the new NMe2-CM-Phos (L14), a broad range of electron-rich, electron-neutral, electron-deficient, and sterically hindered aryl/heteroaryl and alkenyl mesylates and tosylates are well coupled with aryl titanium reagents to give the corresponding products in good to excellent yields. The catalyst loading down to 0.2 mol% Pd and the reaction time shortening to 10 min can be achieved. The reaction can be easily scaled up to the gram scale without diminishing the product yield.

About m-Methoxyphenol, If you have any questions, you can contact Lee, HW; So, CM; Yuen, OY; Wong, WT; Kwong, FY or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Quality Control of (E)-2-Methylbut-2-enoic acid. Gu, HP; Foong, SY; Lam, SS; Yue, XC; Yang, J; Peng, WX in [Gu, Haiping; Lam, Su Shiung; Yue, Xiaochen; Yang, Jun; Peng, Wanxi] Henan Agr Univ, Henan Prov Engn Res Ctr Biomass Value Added Prod, Zhengzhou 450002, Peoples R China; [Foong, Shin Ying; Lam, Su Shiung] Univ Malaysia Terengganu, Inst Trop Aquaculture & Fisheries Akuatrop, Pyrolysis Technol Res Grp, Terengganu 21030, Malaysia published Characterization and potential utilization of extracts and pyrolyzates from Jasminum nudiflorum Lindl. Bark in 2021, Cited 75. The Name is (E)-2-Methylbut-2-enoic acid. Through research, I have a further understanding and discovery of 80-59-1.

Utilization of lignocellulosic biomass is increasingly important. Jasminum nudiflorum Lindl. (JNL) is a widely cultivated landscape plant in China. To evaluate the chemical components, pyrolysis characteristics as well as the potential values of JNL bark for utilization, the components were extracted using methanol, ethanol, and benzene/ethanol (2:1, v/v) and pyrolyzed from room temperature to 300 ?C, respectively. Many components were detected in the extracts and the pyrolyzates of JNL bark and their chemical properties were analyzed. The compounds identified in the extracts and the pyrolyzates of JNL bark included acids, aldehydes, alcohols, esters, ketones, aromatics, saccharides, olefins, and nitrogen-containing compounds. Some of the identified compounds, such as urs-12-en-28-al, 3-(acetyloxy)-, (3.beta.)-, 5-hydroxymethylfurfural, and vanillin, are widely used in the medical, energy, and food industries. The pyrolysis of JNL bark using thermogravimetric (TG) analyzer showed the highest reaction rate occurred at between 200 and 300 ?C where the maximum mass loss was observed. According to the Coats-Redfern method, the calculated apparent activation energy (E) and pre-exponential factor (A) of the pyrolysis process of JNL bark were 52.04 kJ mol- 1 and 3.14 ? 105 min-1, respectively. This research provides information on the components and pyrolysis characteristics of JNL bark, which shows great potential for application in medical, food, and chemical industries.

About (E)-2-Methylbut-2-enoic acid, If you have any questions, you can contact Gu, HP; Foong, SY; Lam, SS; Yue, XC; Yang, J; Peng, WX or concate me.. Quality Control of (E)-2-Methylbut-2-enoic acid

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about ONE-POT SYNTHESIS; EFFICIENT HETEROGENEOUS CATALYST; AEROBIC OXIDATION; ADSORPTION PROPERTIES; EN-ROUTE; ONE-STEP; ALDEHYDES; AMIDATION; COPPER; CO2, Saw an article supported by the . Recommanded Product: Benzyl Alcohol. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Anbardan, SZ; Mokhtari, J; Yari, A; Bozcheloei, AH. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Oxidative dehydrogenative homo-coupling of amines to imines and cross-coupling of amines with alcohols to amides was achieved with high to moderate yields at room temperature in THF using Cu-MOF as an efficient and recyclable heterogeneous catalyst under mild conditions. Different primary benzyl amines and alcohols could be utilized for the synthesis of a wide variety of amides and imines. The Cu-MOF catalyst could be recycled and reused four times without loss of catalytic activity.

About Benzyl Alcohol, If you have any questions, you can contact Anbardan, SZ; Mokhtari, J; Yari, A; Bozcheloei, AH or concate me.. Recommanded Product: Benzyl Alcohol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Nickel-Catalyzed Ipso-Borylation of Silyloxyarenes via C-O Bond Activation published in 2021.0. Recommanded Product: 150-76-5, Reprint Addresses Montgomery, J (corresponding author), Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA.. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol

The conversion of silyloxyarenes to boronic acid pinacol esters via nickel catalysis is described. In contrast to other borylation protocols of inert C-O bonds, the method is competent in activating the carbon-oxygen bond of silyloxyarenes in isolated aromatic systems lacking a directing group. The catalytic functionalization of benzyl silyl ethers was also achieved under these conditions. Sequential cross-coupling reactions were achieved by leveraging the orthogonal reactivity of silyloxyarenes, which could then be functionalized subsequently.

About Mequinol, If you have any questions, you can contact Pein, WL; Wiensch, EM; Montgomery, J or concate me.. Recommanded Product: 150-76-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article The Pretreatment of the Seeds Affects the Quality and Physicochemical Characteristics of Watermelon Oil and Its By-Products WOS:000463024300009 published article about MELON SEED; OXIDATIVE STABILITY; ANTIOXIDANT in [Ok, Selcuk; Yilmaz, Emin] Canakkale Onsekiz Mart Univ, Dept Food Engn, Fac Engn, TR-17020 Canakkale, Turkey in 2019.0, Cited 56.0. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6. Product Details of 100-51-6

The aims of this study were to produce cold-pressed oils from watermelon seeds, which were previously treated with seed boiling and roasting, and to characterize the oils and press cakes. The watermelon seeds were found as rich sources of protein, oil, and minerals. Seed boiling pretreatment resulted in a higher oil recovery (51.31%) than seed preroasting (44.21%). Seed pretreatments did not cause any difference in the fatty acid (FA), sterol, and tocopherol compositions. Linoleic acid (LNA) was the major FA (54.57 and 54.62%) with higher contents of total unsaturated (74.41 and 75.52%) FA. beta-Sitosterol (202.79 mg/100 g oil and 202.90 mg/100 g oil) and gamma-tocopherol (361.45 mg kg(-1) oil and 365.98 mg kg(-1) oil) were the major components. The oils started to crystallize at around 1.80 and 1.75 degrees C, and completely crystallized oils melted at around -35.66 and -35.78 degrees C, respectively. Seed boiling pretreatment reduced the quantity of the most phenolic compounds in the oil (51.54 and 22.74 mg kg(-1) total phenolics). The oxidative induction times of the oils were 11.91 and 11.49 min. In these cold-pressed oils, volatile compounds associated with roasted/nutty and vegetable/herbal aroma descriptions were predominantly detected. Sensory descriptive analysis indicated that the oils are poor in terms of different sensory terms. Consumer tests showed that these oils are acceptable for direct consumption. Hence, this raw material could be used to produce edible oils.

About Benzyl Alcohol, If you have any questions, you can contact Ok, S; Yilmaz, E or concate me.. Product Details of 100-51-6

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles