Tag: M.W=100-150

Recently I am researching about MOLECULAR DOCKING; BIOLOGICAL-ACTIVITIES; BEARING TRIAZOLE; DERIVATIVES; ANTIOXIDANT; OXADIAZOLE, Saw an article supported by the . Application In Synthesis of 4′-Hydroxyacetophenone. Published in WILEY in HOBOKEN ,Authors: Mentese, E; Sokmen, BB. The CAS is 99-93-4. Through research, I have a further understanding and discovery of 4′-Hydroxyacetophenone

A novel series of N ‘-(substituted benzylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides and N ‘-(1-(substituted phenyl)ethylidene)-2-(5,6-dichloro-2-methyl-1H-benzimidazol-1-yl)acetohydrazides were synthesized and then studied for their urease inhibitory activities using thiourea as a standard drug. All newly synthesized compounds were found to exhibit potent inhibitory properties against urease enzyme in the range of IC50 = 0.0155 +/- 0.0039-0.0602 +/- 0.0071 mu M, when compared with the thiourea as standard (IC50 = 0.5115 +/- 0.0233 mu M). All target molecules were characterized by H-1-NMR, C-13-NMR, IR, and electrospray ionization mass spectrometry.

About 4’-Hydroxyacetophenone, If you have any questions, you can contact Mentese, E; Sokmen, BB or concate me.. Application In Synthesis of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Formula: C8H8O2. Authors Zhang, F; Niu, YJ; Hong, DC; Ye, YL; Hua, YH; Ding, SH; Zhang, YD in ELSEVIER SCIENCE INC published article about in [Zhang, Yandong] Xiamen Univ, Dept Chem, iChEM, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China; Xiamen Univ, Key Lab Chem Biol Fujian Prov, iChEM, Coll Chem & Chem Engn, Xiamen 361005, Peoples R China in 2021, Cited 42. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Atkamine is a complex marine pyrroloiminoquinone alkaloid that comprises a heptacyclic scaffold bearing five different heterocycles and four contiguous stereocenters, and therefore it is a highly challenging target for synthetic chemists. We herein reported a modular synthetic strategy toward this alkaloid, featuring a formal [5 + 2] annulation and an asymmetric Michael addition. The efficient synthesis of the long-chain aliphatic aldehyde and chiral amino acetal fragments have been achieved. A simplified tetracyclic intermediate bearing the core structure of atkamine has been successfully constructed through the formal [5 + 2] annulation. (C) 2020 Chinese Chemical Society and Institute of Materia Medica, Chinese Academy of Medical Sciences. Published by Elsevier B.V. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Zhang, F; Niu, YJ; Hong, DC; Ye, YL; Hua, YH; Ding, SH; Zhang, YD or concate me.. Formula: C8H8O2

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 100-83-4. Recently I am researching about LIGHT-EMITTING-DIODES; CELL-CYCLE ARREST; QUINAZOLINE DERIVATIVES; STEREOSELECTIVE-SYNTHESIS; BIOLOGICAL EVALUATION; ONE-POT; DESIGN; DOCKING; HETEROCYCLES; INHIBITORS, Saw an article supported by the . Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Fares, IMZ; Mekky, AEM; Elwahy, AHM; Abdelhamid, IA. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

A novel series of bis(tetrahydro[1,2,4]triazolo[5,1-b]quinazolin-8-ones) and bis(tetrahydrobenzo[4,5]imidazo[2,1-b]quinazolinones) containing amide linkages were regionselectively prepared via a three-component reaction of bis(aldehydes) with dimedone and 3-amino-1,2,4-triazole (or 2-aminobenzimidazole) under conventional heating as well as under microwave irradiation.

Bye, fridends, I hope you can learn more about C7H6O2, If you have any questions, you can browse other blog as well. See you lster.. SDS of cas: 100-83-4

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Taha, I; Keshk, EM; Khalil, AGM; Fekri, A in [Taha, Israa; Keshk, Eman M.; Khalil, Abdel-Galil M.; Fekri, Ahmed] Mansoura Univ, Fac Sci, Chem Dept, 25 El Gomhouria St, Mansoura 35516, Dakahlia Govern, Egypt published Synthesis, characterization, antibacterial evaluation, 2D-QSAR modeling and molecular docking studies for benzocaine derivatives in 2021, Cited 47. Quality Control of 4-Methoxybenzaldehyde. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

Possible application of incorporating a well-known drug (benzocaine) with cyanoacetamide function to get a powerful synthon ethyl 4-cyanoacetamido benzoate. This synthetic intermediate was used as a precursor for the synthesis of triazine, pyridone, thiazolidinone, thiazole and thiophene scaffolds containing the benzocaine core. Facile coupling, Michael addition, condensation and nucleophilic attack reactions were used to synthesize our targets. The structural features of the synthesized scaffolds were characterized using IR,H-1 NMR,C-13 NMR and mass spectroscopy. The antibacterial activities against Gram-positive (Staphylococcus aureus,Bacillus subtilis) and Gram-negative bacteria (Escherichia coli,Pseudomonas aeruginosa) were evaluated using ampicillin as a reference drug. DNA/methyl-green colorimetric assay of the DNA-binding compounds was also performed. Theoretical studies of the newly synthesized compounds based on molecular docking and QSAR study were conducted. The molecular docking studies were screened by MOE software for the more potent antibacterial agent28band each native ligand against four ofS. aureusproteins 1jij, 2xct, 2w9s and 3t07. [GRAPHICS] .

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Taha, I; Keshk, EM; Khalil, AGM; Fekri, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article Water mediated and Baker’s yeast accelerated novel synthetic protocols for tetrahydrobenzo[a]xanthene-11-ones and pyrazolo[3,4-b]quinolines WOS:000650504700001 published article about ONE-POT SYNTHESIS; REUSABLE CATALYST; EFFICIENT; DERIVATIVES; XANTHENE; NANOPARTICLES; CONDENSATION; VALIDATION; ANALOGS; FE3O4 in [Chavan, Anusaya S.; Bhosle, Manisha R.; Dhumal, Sambhaji T.; Mane, Ramrao A.] Dr Babasaheb Ambedkar Marathwada Univ, Dept Chem, Aurangabad 431004, Maharashtra, India; [Kharat, Arun S.] Jawaharlal Nehru Univ, Sch Life Sci, Dept Microbiol, New Delhi, India in 2021, Cited 64. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5. Quality Control of 4-Methoxybenzaldehyde

Water mediated and baker’s yeast catalyzed, efficient synthetic routes have been first time developed for multicomponent cyclocondensations leading to bioactive tetrahydrobenzo[a]xanthene-11-ones (4a-h) and pyrazolo[3,4-b]quinolines (7a-i). The developed protocols are conducted at room temperature and gave better to excellent yields of the titled compounds. The biocatalytical resource, activated baker’s yeast is readily available, and biodegradable. These protocols are more convenient, scalable, and obey most of the green principles also. The developed protocols are cost effective and better in operation than existing ones.

Quality Control of 4-Methoxybenzaldehyde. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Chavan, AS; Kharat, AS; Bhosle, MR; Dhumal, ST; Mane, RA or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Lei, K; Li, P; Yang, XF; Wang, SB; Wang, XK; Hua, XW; Sun, B; Ji, LS; Xu, XH in AMER CHEMICAL SOC published article about ACID-DERIVATIVES; ANTIMICROBIAL ACTIVITY; CRYSTAL-STRUCTURE; TRIKETONE; ARABIDOPSIS; INHIBITORS; DISCOVERY in [Lei, Kang; Li, Pan; Wang, Shi-Ben; Wang, Xue-Kun; Hua, Xue-Wen; Sun, Bin; Ji, Lu-Sha] Liaocheng Univ, Sch Pharm, Liaocheng 252059, Shandong, Peoples R China; [Lei, Kang; Hua, Xue-Wen; Sun, Bin; Xu, Xiao-Hua] Nankai Univ, Inst Elementoorgan Chem, State Key Lab Elementoorgan Chem, Tianjin 300071, Peoples R China; [Yang, Xue-Fang] Shanxi Agr Univ, Coll Agr, Jinzhong 030800, Shanxi, Peoples R China in 2019.0, Cited 37.0. Recommanded Product: m-Methoxyphenol. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

In order to develop a novel herbicide containing the beta-triketone motif, a series of 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one derivatives were designed and synthesized. The bioassay results showed that compound II15 had good pre-emergent herbicidal activity even at a dosage of 187.5 g ha(-1). Moreover, compound II15 showed a broader spectrum of weed control when compared with a commercial herbicide 2,4-dichlorophenoxyacetic acid (2,4-D), and displayed good crop safety to Triticum aestivum L. and Zea mays Linn. when applied at 375 g ha(-1) under pre-emergence conditions, which indicated its great potential as a herbicide. More importantly, studying the molecular mode of action of compound II15 revealed that the novel triketone structure is a proherbicide of its corresponding phenoxyacetic acid auxin herbicide, which has a herbicidal mechanism similar to that of 2,4-D. The present work indicates that the 4-hydroxyl-3-(2-phenoxyacetyl)-pyran-2-one motif may be a potential lead structure for further development of novel auxin-type herbicides.

About m-Methoxyphenol, If you have any questions, you can contact Lei, K; Li, P; Yang, XF; Wang, SB; Wang, XK; Hua, XW; Sun, B; Ji, LS; Xu, XH or concate me.. Recommanded Product: m-Methoxyphenol

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Category: indole-building-block. I found the field of Chemistry very interesting. Saw the article Novel, Chiral, and Enantiopure C-2-Symmetric Thioureas Promote Asymmetric Protio-Pictet-Spengler Reactions by Anion-Binding Catalysis published in 2021.0, Reprint Addresses Piersanti, G (corresponding author), Univ Urbino Carlo Bo, Dipartimento Sci Biomol, Pzza Rinascimento 6, I-61029 Urbino, Italy.. The CAS is 123-11-5. Through research, I have a further understanding and discovery of 4-Methoxybenzaldehyde.

Although anion-binding processes are well-known for their crucial role in molecular recognition, they have only recently been utilized for catalysis. Herein, a new class of chiral, enantiopure C-2-symmetrical thioureas that, in combination with 4-methoxybenzoic acid, promotes the enantioselective protio-Pictet-Spengler reaction to provide unprotected tetrahydro-beta-carbolines in good yields (40-93 %) and moderate-to-high enantioselectivities (34-95 % ee) in one step from tryptamine and aldehyde derivatives is described. The formation of a chiral catalyst-anion complex was explored by H-1 NMR.

Category: indole-building-block. Bye, fridends, I hope you can learn more about C8H8O2, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Rapid, chemoselective and mild oxidation protocol for alcohols and ethers with recyclable N-chloro-N-(phenylsulfonyl)benzenesulfonamide published in 2021. SDS of cas: 100-51-6, Reprint Addresses Chaturbhuj, G (corresponding author), Inst Chem Technol, Mumbai 400019, Maharashtra, India.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Chlorine is the 20th most abundant element on the earth compared to bromine, iodine, and fluorine, a sulfonimide reagent, N-chloro-N-(phenylsulfonyl)benzenesulfonamide (NCBSI) was identified as a mild and selective oxidant. Without activation, the reagent was proved to oxidize primary and secondary alcohols as well as their symmetrical and mixed ethers to corresponding aldehydes and ketones. With recoverable PS-TEMPO catalyst, selective oxidation over chlorination of primary and secondary alcohols and their ethers with electron-donating substituents was achieved. The reagent precursor of NCBSI was recovered quantitatively and can be reused for synthesizing NCBSI. (C) 2021 Elsevier Ltd. All rights reserved.

SDS of cas: 100-51-6. Bye, fridends, I hope you can learn more about C7H8O, If you have any questions, you can browse other blog as well. See you lster.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about BIOLOGICAL EVALUATION; ANTITUMOR-ACTIVITY; DERIVATIVES BEARING; MULTIKINASE INHIBITOR; CLICK CHEMISTRY; DESIGN; CANCER; DISCOVERY; MOIETY; METASTASIS, Saw an article supported by the Institute for the Promotion of Teaching Science and Technology (IPST) [19/2558]; The Thailand Research FundThailand Research Fund (TRF) [RTA6280004]; Department of Chemistry, Faculty of Science, Silpakorn University; Center of Excellence in Hepatitis and Liver Cancer, Department of Biochemistry, Faculty of Medicine, Chulalongkorn University. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol. Safety of Mequinol

A series of 1,2,3-triazole-containing Sorafenib analogues, in which the aryl urea moiety of Sorafenib (1) was replaced with a 1,2,3-triazole ring linking a substituted phenoxy fragment, were prepared successfully via Huisgen 1,3-dipolar cycloaddition and nucleophilic aromatic substitution. The studies of cytotoxicity towards human hepatocellular carcinoma (HCC) cell lines, HepG2 and Huh7, indicated that p-tert-butylphenoxy analogue 2m showed significant inhibitory activity against Huh7 with IC50 = 5.67 +/- 0.57 mu M. More importantly, 2m showed low cytotoxicity against human embryonal lung fibroblast cell line, MRC-5, with IC50 > 100 mu M, suggesting its highly selective cytotoxic activity (SI > 17.6) towards Huh7 which is much superior to that of Sorafenib (SI = 6.73). The molecular docking studies revealed that the analogue 2m bound B-RAF near the binding position of Sorafenib, while it interacted VEGFR2 efficiently at the same binding position of Sorafenib. However, 2m exhibited moderate inhibitory activity toward B-RAF, implying that its anti-Huh7 effect might not strictly relate to inhibition of B-RAF. Wound healing and BrdU cell proliferation assays confirmed anti-cell migration and anti-cell proliferative activities towards Huh7. With its inhibitory efficiency and high safety profile, 2m has been identified as a promising candidate for the treatment of HCC.

Safety of Mequinol. Welcome to talk about 150-76-5, If you have any questions, you can contact Palakhachane, S; Ketkaew, Y; Chuaypen, N; Sirirak, J; Boonsombat, J; Ruchirawat, S; Tangkijvanich, P; Suksamrarn, A; Limpachayaporn, P or send Email.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Product Details of 150-76-5. Authors Bellotti, P; Koy, M; Gutheil, C; Heuvel, S; Glorius, F in ROYAL SOC CHEMISTRY published article about in [Bellotti, Peter; Koy, Maximilian; Gutheil, Christian; Heuvel, Steffen; Glorius, Frank] Westfal Wilhelms Univ Munster, Organ Chem Inst, Corrensstr 40, D-48149 Munster, Germany in 2021, Cited 66. The Name is Mequinol. Through research, I have a further understanding and discovery of 150-76-5

A highly modular radical cascade strategy based upon radical cyclisation/allylic substitution sequence between alkyl/aryl bromides, 1,3-dienes and nucleophiles ranging from sulfinates to amines, phenols and 1,3-dicarbonyls is described (>80 examples). Palladium phosphine complexes – which merge properties of photo- and cross coupling-catalysts – allow to forge three bonds with complete 1,4-selectivity and stereocontrol, delivering highly value added carbocyclic and heterocyclic motifs that can feature – inter alia – vicinal quaternary centers, free protic groups, gem-difluoro motifs and strained rings. Furthermore, a flow chemistry approach was for the first time applied in palladium-photocatalysed endeavors involving radicals.

Product Details of 150-76-5. About Mequinol, If you have any questions, you can contact Bellotti, P; Koy, M; Gutheil, C; Heuvel, S; Glorius, F or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles