Tag: M.W=100-150

An article Thermal Coursed Effect of Comprehensive Changes in the Flavor/Taste of Cynanchi wilfordii WOS:000488796100001 published article about TONGUE; NOSE in [Kim, Da-som; Lee, Jookyeong Tracy; Hong, Seong Jun; Cho, Jin-Ju; Shin, Eui-Cheol] Gyeongnam Natl Univ Sci & Technol, Dept Food Sci, Jinju 52725, South Korea in 2019.0, Cited 32.0. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4. Quality Control of 4′-Hydroxyacetophenone

This study aims to investigate alterations in volatile compounds and chemical components that may affect the sensory properties of Cynanchi wilfordii roasted at 120 degrees C and 180 degrees C for various durations of time (0 to 4 min). For volatile compound profiles, tridecane, tetradecane, and ethyl hexyl ether were detected as major compounds of the sample without roasting. As the roasting temperature increased, the types of volatile compounds increased, whereas the content decreased with an increase in heterocyclic compound generation. The sample roasted at 120 degrees C for 1 min showed a notably different profile pattern from the other roasted samples. For the sniffing test performed by trained panelists using gas chromatography olfactometry, naphthalene and nonanal, which induce spicy and raw C. wilfordii, respectively, were perceived most intensely throughout all the samples. In the electronic tongue analysis, the sample roasting at 180 degrees C showed an increased and decreased pattern in umami taste and saltiness, respectively, with increased roasting time. Electronic tongue analysis results showed that the sample roasted at 180 degrees C for 4 min would have the best sensory preference. Along with the volatile compound profiles, the sample roasted at 120 degrees C for 1 min had more sourness than the other samples, and would potentially have distinctive sensory characteristics. This study should provide baseline data on variations in the sensory properties and industrial applications of C. wilfordii upon roasting. Practical Application Various applications of food ingredients through changes in sensory characteristics by roasting will provide consumers more options for food selections. Accordingly, this study will be utilized by (1) individuals and food companies who are interested in functional foods, (2) individuals and food industries that seek optimum roasting conditions for proper sensory characteristics of foods, and (3) farmers and crop producers who seek for utilization the applications of Cynanchi wilfordii as a food ingredient.

About 4′-Hydroxyacetophenone, If you have any questions, you can contact Kim, DS; Lee, JT; Hong, SJ; Cho, JJ; Shin, EC or concate me.. Quality Control of 4′-Hydroxyacetophenone

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gein, VL; Pastukhova, EV in MAIK NAUKA/INTERPERIODICA/SPRINGER published article about in [Gein, V. L.; Pastukhova, E. V.] Perm State Pharmaceut Acad, Perm 614990, Russia in 2021, Cited 5. HPLC of Formula: C8H8O2. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A series of new 1-aminocarbonylmethyl-5-aryl-4-aroyl-3-hydroxy-3-pyrrolin-2-ones has been synthesized through a three-component reaction of aroylpyruvic acid methyl ester with a mixture of aromatic aldehyde and glycinamide hydrochloride in glacial acetic acid in the presence of anhydrous sodium bicarbonate.

HPLC of Formula: C8H8O2. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Gein, VL; Pastukhova, EV or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about PHARMACOKINETICS; ANESTHESIA; SAFETY, Saw an article supported by the Key Research AMP; Development Projects of the Department of Science AMP; Technology of Sichuan Province [2019YFS0093]. HPLC of Formula: C7H8O. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

In this work, a series of water-soluble propofol prodrugs were synthesized, and their propofol release rate and pharmacodynamic characteristics were measured. We found that inserting glycolic acid as a linker between propofol and the cyclic amino acid accelerated the release of propofol from prodrugs into the plasma while preserving its safety. In animal experiments, prodrugs (3e, 3g, and 3j) were significantly better than fospropofol (the only water-soluble propofol prodrug that has been used clinically) in terms of safety, onset, and duration time of anesthesia. Their molar dose, onset time, and anesthesia duration time were comparable to those of propofol, helping to maintain the clinical benefits of propofol. The experimental results showed the potential of such compounds as water-soluble prodrugs of propofol.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Liu, LQ; Hong, PX; Song, XH; Zhou, CC; Ling, R; Kang, Y; Qi, QR; Yang, J or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Reddy, VG; Jampaiah, D; Chalkidis, A; Sabri, YM; Mayes, ELH; Bhargava, SK in [Reddy, Velma Ganga; Jampaiah, Deshetti; Chalkidis, Anastasios; Sabri, Ylias M.; Bhargava, Suresh K.] RMIT Univ, Sch Sci, CAMIC, GPO Box 2476, Melbourne, Vic 3001, Australia; [Mayes, Edwin L. H.] RMIT Univ, RMMF, GPO Box 2476, Melbourne, Vic 3001, Australia published Highly dispersed cobalt oxide nanoparticles on manganese oxide nanotubes for aerobic oxidation of benzyl alcohol in 2019.0, Cited 34.0. Formula: C7H8O. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6.

Hybrid Co3O4/MnO2 nanotube-based catalysts were prepared by a simple hydrothermal synthesis method. The physico-chemical properties of Co3O4/MnO2 catalyst were then studied by different characterization techniques, namely, SEM, TEM and HR-TEM, XRD, BET surface area, XPS and H-2-TPR. The hybrid catalyst showed superior catalytic performance toward benzyl alcohol oxidation than pure MnO2 nanotubes and Co3O4 nanoparticles. The uniform dispersion of Co3O4 nanoparticles, good redox behaviour, the variable oxidation states of manganese and cobalt (Mn3+/4+ or Co3+/2+) as well as the abundance of active surface oxygen species were responsible for such a high catalytic activity.

About Benzyl Alcohol, If you have any questions, you can contact Reddy, VG; Jampaiah, D; Chalkidis, A; Sabri, YM; Mayes, ELH; Bhargava, SK or concate me.. Formula: C7H8O

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation published in 2020.0. HPLC of Formula: C7H8O, Reprint Addresses Wang, L; Xiao, FS (corresponding author), Zhejiang Univ, Key Lab Biomass Chem Engn, Minist Educ, Coll Chem & Biol Engn, Hangzhou 310027, Peoples R China.; Yang, B (corresponding author), ShanghaiTech Univ, Sch Phys Sci & Technol, Shanghai 201210, Peoples R China.; Xiao, FS (corresponding author), Zhejiang Univ, Key Lab Appl Chem Zhejiang Prov, Dept Chem, Hangzhou 310027, Peoples R China.; Xiao, FS (corresponding author), Beijing Univ Chem Technol, Beijing Adv Innovat Ctr Soft Matter Sci & Engn, Beijing 100029, Peoples R China.. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

There is a strong incentive for environmentally benign and sustainable production of organic nitriles to avoid the use of toxic cyanides. Here we report that manganese oxide nanorod-supported single-site Ru catalysts are active, selective, and stable for oxidative cyanation of various alcohols to give the corresponding nitriles with molecular oxygen and ammonia as the reactants. The very low amount of Ru (0.1 wt %) with atomic dispersion boosts the catalytic performance of manganese oxides. Experimental and theoretical results show how the Ru sites enhance the ammonia resistance of the catalyst, bolstering its performance in alcohol dehydrogenation and oxygen activation, the key steps in the oxidative cyanation. This investigation demonstrates the high efficiency of a single-site Ru catalyst for nitrile production.

HPLC of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Wang, H; Xu, DY; Guan, EJ; Wang, L; Zhang, J; Wang, CT; Wang, S; Xu, H; Meng, XJ; Yang, B; Gates, BC; Xiao, FS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about CYCLIC-NUCLEOTIDE PHOSPHODIESTERASE; ONE-POT SYNTHESIS; DERIVATIVES; EFFICIENT; INHIBITION; DIVERSITY; ALDEHYDES; ACID, Saw an article supported by the NIT Patna [EMR/2016/000960]; Department of Science and Technology, IndiaDepartment of Science & Technology (India) [EMR/2016/000960]. Published in SPRINGER in DORDRECHT ,Authors: Kumari, P; Bharti, R; Parvin, T. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde. Category: indole-building-block

An efficient, mild and environmentally benign protocol has been developed for the synthesis of aminouracil-tethered tri-substituted methane derivatives. The three-component reaction of 2-hydroxy-1,4-naphthaquinone, 6-amino-1,3-dimethyluracil and aldehydes in the presence of molecular iodine as catalyst under reflux conditions resulted in aminouracil-tethered tri-substituted methane derivatives 4 in aqueous medium. Similarly, the four-component reaction of 2-hydroxy-1,4-naphthaquinone, o-phenylenediamine, aldehydes and aminouracil derivatives resulted in aminouracil-tethered tri-substituted methane derivatives 6 under the same reaction conditions. The notable features of this protocol are simple experimental procedure, cheap catalyst, readily available starting materials, moderate-to-good yields of the products having biologically active important moieties such as aminouracil, hydroxy-naphthaquinone/benzophenazine. [GRAPHICS] .

About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Kumari, P; Bharti, R; Parvin, T or concate me.. Category: indole-building-block

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Application In Synthesis of Benzyl Alcohol. Recently I am researching about ACID PHENETHYL ESTER; REPERFUSION INJURY; PROPOLIS; HYPERURICEMIA; INTEGRASE; DISCOVERY, Saw an article supported by the National Institutes of HealthUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USA [5P20GM103436, 2R15GM084431-02A1]; NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCESUnited States Department of Health & Human ServicesNational Institutes of Health (NIH) – USANIH National Institute of General Medical Sciences (NIGMS) [P20GM103436] Funding Source: NIH RePORTER. Published in ACADEMIC PRESS INC ELSEVIER SCIENCE in SAN DIEGO ,Authors: Choi, W; Villegas, V; Istre, H; Heppler, B; Gonzalez, N; Brusman, N; Snider, L; Hogle, E; Tucker, J; Onate, A; Onate, S; Ma, LL; Paula, S. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Inhibitors of the enzyme xanthine oxidase (XO) with radical scavenging properties hold promise as novel agents against reperfusion injuries after ischemic events. By suppressing the formation of damaging reactive oxygen species (ROS) by XO or scavenging ROS from other sources, these compounds may prevent a buildup of ROS in the aftermath of a heart attack or stroke. To combine these two properties in a single molecule, we synthesized and characterized the non-purine XO inhibitor caffeic acid phenethylester (CAPE) and 19 derivatives using a convenient microwave-assisted Knoevenagel condensation protocol. Varying systematically the number and positions of the hydroxyl groups at the two phenyl rings, we derived structure-activity relationships based on experimentally determined XO inhibition data. Molecular docking suggested that critical enzyme/inhibitor interactions involved pi-pi interactions between the phenolic inhibitor ring and Tyr914, hydrogen bonds between inhibitor hydroxyl groups and Glu802, and hydrophobic interactions between the CAPE phenyl ring and nonpolar residues located at the entrance of the binding site. To effectively scavenge the stable radical DPPH, two hydroxyl groups in 1,2-or 1,4-position at the phenyl ring were required. Among all compounds tested, E-phenyl 3-(3,4-dihydroxyphenyl)acrylate, a CAPE analog without the ethyl tether, showed the most promising properties.

Application In Synthesis of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Choi, W; Villegas, V; Istre, H; Heppler, B; Gonzalez, N; Brusman, N; Snider, L; Hogle, E; Tucker, J; Onate, A; Onate, S; Ma, LL; Paula, S or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Ma, C; Zhao, CQ; Xu, XT; Li, ZM; Wang, XY; Zhang, K; Mei, TS in [Ma, Cong; Zhao, Chuan-Qi; Li, Zhao-Ming; Mei, Tian-Sheng] Chinese Acad Sci, Shanghai Inst Organ Chem, Ctr Excellence Mol Synth, State Key Lab Organometall Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China; [Xu, Xue-Tao; Wang, Xiang-Yang; Zhang, Kun] Wuyi Univ, Sch Chem & Environm Engn, Jiangmen 529020, Peoples R China published Nickel-Catalyzed Carboxylation of Aryl and Heteroaryl Fluorosulfates Using Carbon Dioxide in 2019, Cited 67. Name: 4′-Hydroxyacetophenone. The Name is 4′-Hydroxyacetophenone. Through research, I have a further understanding and discovery of 99-93-4.

The development of efficient and practical methods to construct carboxylic acids using CO2 as a C1 synthon is of great importance. Nickel-catalyzed carboxylation of aryl fluorosulfates and heteroaryl fluorosulfates with CO2 is described, affording arene carboxylic acids with good to excellent yields under mild conditions. In addition, a one-pot phenol fluorosulfation/carboxylation is developed.

Name: 4′-Hydroxyacetophenone. About 4′-Hydroxyacetophenone, If you have any questions, you can contact Ma, C; Zhao, CQ; Xu, XT; Li, ZM; Wang, XY; Zhang, K; Mei, TS or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

I found the field of Chemistry very interesting. Saw the article Sulfonated-polyvinyl amine coated on Fe3O4 nanoparticles: a high-loaded and magnetically separable acid catalyst for multicomponent reactions published in 2019.0. COA of Formula: C7H6O2, Reprint Addresses Koukabi, N (corresponding author), Semnan Univ, Dept Chem, POB 35195-363, Semnan, Iran.. The CAS is 100-83-4. Through research, I have a further understanding and discovery of 3-Hydroxybenzaldehyde

In this study, a PVAm-bearing SO3H groups/Fe3O4 nanocomposite was prepared via a simple and in situ polymerization of acrylamide onto the surface of magnetic nanoparticles without using organosilane precursors. In order to obtain amine-functionalized magnetic, Hofmann degradation was carried out. In the following, sulfonated-polyvinyl amine coated on Fe3O4 nanoparticles was prepared by covalent grafting of chlorosulfonic acid on amine groups. The introduction of polymer to the surface of magnetic nanoparticles increases the loading content with functional groups extremely. The resulting hybrid material was effectively employed as an unprecedented acid magnetic catalyst for the one-pot synthesis of 2,4,5-trisubstituted and 1,2,4,5-tetrasubstituted imidazoles under solvent-free conditions. High yields, mild reaction conditions, short reaction times, operational simplicity with reusability are the notable features of the catalyst. The structure of the newly developed catalyst was characterized using TGA, FT-IR, SEM, TEM, VSM, EDX, CHNS, and XRD analysis. Magnetic separation and recycling of the catalyst for at least 8 runs is possible without any significant deterioration in catalytic activity. This work is the first report of employing PVAm as a linker for immobilizing liquid acid on a support.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Arghan, M; Koukabi, N; Kolvari, E or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Sun, YY; Gao, PP; Zhu, L; Li, ZX; Zhao, RY; Li, CY; Shan, LH in ELSEVIER SCIENCE INC published article about ABIRATERONE ACETATE; NECROPTOSIS; PYRIDINES; INHIBITOR; CHEMISTRY; DESIGN in [Sun, Yingying; Gao, Peipei; Li, Zhaoxiang; Zhao, Ruiyun; Shan, Lihong] Zhengzhou Univ, Sch Pharmaceut Sci, Key Lab Adv Drug Preparat Technol, Minist Educ, Zhengzhou 450001, Peoples R China; [Sun, Yingying; Gao, Peipei; Li, Zhaoxiang; Zhao, Ruiyun; Shan, Lihong] Collaborat Innovat Ctr New Drug Res & Safety Eval, Zhengzhou, Henan, Peoples R China; [Zhu, Li] Shanxi Med Univ, Taiyuan Cent Hosp, 5 Dong San Dao Xiang, Taiyuan 030009, Peoples R China; [Li, Congyu] Zhengzhou Univ, Henan Canc Hosp, Affiliated Canc Hosp, Zhengzhou, Peoples R China in 2021.0, Cited 34.0. Recommanded Product: 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A series of new 17-cyanopyridine derivatives of pregnenolone have been synthesized, and their anti-proliferative activities against different human cancer cell lines were tested. The extensive structure-activity relationship (SAR) data suggested that the introduction of 2-amino-4-aryl-3-cyanopyridine to the D ring of pregnenolone may increase the anti-cancer activity. Among the products, the most potent compound 4j exhibited good growth inhibition against all the tested cells especially for PC- 3 cells with an IC50 value of 2.0 mu M. Further mechanistic studies showed that 4j inhibited the formation of cell colonies and migration, increased the level of reactive oxygen species (ROS) in PC-3 cells in a concentration-dependent manner, and induced necroptosis through the phosphorylation of receptor interacting protein 1/3 (P-RIP1/3) and phosphorylation of mixed lineage kinase domain-like protein (P-MLKL) pathway. The 17-pregnenolone cyanopyridine derivatives hold promising potential as anti-proliferative agents, and the most potent compound could be used as a starting point for the development of new steroidal heterocycles with improved anticancer potency and selectivity.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Sun, YY; Gao, PP; Zhu, L; Li, ZX; Zhao, RY; Li, CY; Shan, LH or concate me.. Recommanded Product: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles