Tag: M.W=100-150

Safety of 4-Methoxybenzaldehyde. Authors Rej, S; Chatani, N in AMER CHEMICAL SOC published article about in [Rej, Supriya; Chatani, Naoto] Osaka Univ, Dept Appl Chem, Fac Engn, Suita, Osaka 5650871, Japan in 2021, Cited 51. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

Organoboron reagents are important synthetic intermediates and have wide applications in synthetic organic chemistry. The selective borylation strategies that are currently in use largely rely on the use of transition-metal catalysts. Hence, identifying much milder conditions for transition-metal-free borylation would be highly desirable. We herein present a unified strategy for the selective C-H borylation of electron-deficient benzaldehyde derivatives using a simple metal-free approach, utilizing an imine transient directing group. The strategy covers a wide spectrum of reactions and (i) even highly sterically hindered C-H bonds can be borylated smoothly, (ii) despite the presence of other potential directing groups, the reaction selectively occurs at the o-C-H bond of the benzaldehyde moiety, and (iii) natural products appended to benzaldehyde derivatives can also give the appropriate borylated products. Moreover, the efficacy of the protocol was confirmed by the fact that the reaction proceeds even in the presence of a series of external impurities.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Rej, S; Chatani, N or concate me.. Safety of 4-Methoxybenzaldehyde

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 123-11-5. Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N in [Milovic, Emilija; Petronijevic, Jelena; Joksimovic, Nenad] Univ Kragujevac, Fac Sci, Dept Chem, Radoja Domanovica 12, Kragujevac 34000, Serbia; [Jankovic, Nenad] Univ Kragujevac, Inst Informat Technol Kragujevac, Dept Sci, Kragujevac 34000, Serbia; [Bogdanovic, Goran A.] Univ Belgrade, VINCA Inst Nucl Sci, Natl Inst Republ Serbia, POB 522, Belgrade 11001, Serbia published On water synthesis of the novel 2-oxo-1,2,3,4-tetrahydropyrimidines in 2021, Cited 30. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5.

A simple on water approach for the synthesis of novel tetrahydropyrimidine (THPM) derivatives has been developed under a green and sustainable fashion. For the first time, a deuterated Biginelli’s hybrid was synthesized. Novel THPMs are suitable for further derivatization and could be an excellent toolkit for lead-oriented synthesis and/or cross-coupling reactions. (C) 2020 Elsevier Ltd. All rights reserved.

About 4-Methoxybenzaldehyde, If you have any questions, you can contact Milovic, E; Jankovic, N; Bogdanovic, GA; Petronijevic, J; Joksimovic, N or concate me.. SDS of cas: 123-11-5

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about MUKAIYAMA ALDOL REACTION; REACTION 40YEARS; DRUG DISCOVERY; HETEROCYCLES; EXPANSIONS; REAGENTS; LACTONES; ACCESS, Saw an article supported by the NSFCNational Natural Science Foundation of China (NSFC) [91956114]; Hong Kong RGCHong Kong Research Grants Council [16302318]; Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology [BM2012110]; Jiangsu specially appointed professors program. Published in WILEY-V C H VERLAG GMBH in WEINHEIM ,Authors: Huang, H; Zhang, TY; Sun, JW. The CAS is 150-76-5. Through research, I have a further understanding and discovery of Mequinol. Name: Mequinol

Mild oxetane opening by soft carbon nucleophiles has been developed for efficient C-C bond formation. In the presence of LiNTf2 or TBSNTf2 as catalyst, silyl ketene acetals were found to be effective nucleophiles to generate a wide range of highly oxygenated molecules, which are key substructure in natural products like polyketides. Furthermore, intramolecular oxetane opening by a styrene-based carbon nucleophile via a Prins-type process was also achieved with Sc(OTf)(3) as catalyst, leading to efficient formation of the useful 2,3-dihydrobenzo[b]oxepine skeleton.

Name: Mequinol. About Mequinol, If you have any questions, you can contact Huang, H; Zhang, TY; Sun, JW or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

SDS of cas: 150-19-6. Recently I am researching about BETA-SCISSION REACTIONS; MULTIREFERENCE PERTURBATION-THEORY; CENTERED RADICAL-ADDITION; REACTION-RATE PREDICTION; BENZENE PLUS OH; ACTIVATION-ENERGIES; BIO-OILS; REACTION-MECHANISM; ANISOLE PYROLYSIS; THERMAL-CRACKING, Saw an article supported by the The Computational Chemistry Consortium (C3); C3 consortium. Published in ROYAL SOC CHEMISTRY in CAMBRIDGE ,Authors: Maffei, LP; Faravelli, T; Cavallotti, C; Pelucchi, M. The CAS is 150-19-6. Through research, I have a further understanding and discovery of m-Methoxyphenol

The recent interest in bio-oils combustion and the key role of mono-aromatic hydrocarbons (MAHs) in existing kinetic frameworks, both in terms of poly-aromatic hydrocarbons growth and surrogate fuels formulation, motivates the current systematic theoretical investigation of one of the relevant reaction classes in MAHs pyrolysis and oxidation:ipsosubstitution by hydrogen. State-of-the-art theoretical methods and protocols implemented in automatized computational routines allowed to investigate 14 different potential energy surfaces involving MAHs with hydroxy and methyl single (phenol and toluene) and double (o-,m-,p-C6H4(OH)(2),o-,m-,p-CH3C6H4OH, ando-,m-,p-C6H4(CH3)(2)) substituents, providing rate constants for direct implementation in existing kinetic models. The accuracy of the adopted theoretical method was validated by comparison of the computed rate constants with the available literature data. Systematic trends in energy barriers, pre-exponential factors, and temperature dependence of the Arrhenius parameters were found, encouraging the formulation of rate rules for ipsosubstitutions on MAHs. The rules here proposed allow to extrapolate from a reference system the necessary activation energy and pre-exponential factor corrections for a large number of reactions from a limited set of electronic structure calculations. We were able to estimate rate constants for other 63 ipsoaddition-elimination reactions on di-substituted MAHs, reporting in total 75 rate constants for ipsosubstitution reactionso-,m-,p-R ‘ C6H4R + -> C6H5R + ‘, with R,R ‘ = OH/CH3/OCH3/CHO/C2H5, in the 300-2000 K range. Additional calculations performed for validation showed that the proposed rate rules are in excellent agreement with the rate constants calculated using the full computational protocol in the 500-2000 K range, generally with errors below 20%, increasing up to 40% in a few cases. The main results of this work are the successful application of automatized electronic structure calculations for the derivation of accurate rate constants for ipsosubstitution reactions on MAHs, and an efficient and innovative approach for rate rules formulation for this reaction class.

SDS of cas: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Maffei, LP; Faravelli, T; Cavallotti, C; Pelucchi, M or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FRIEDEL-CRAFTS REACTIONS; ONE-POT SYNTHESIS; COUPLING REACTIONS; ALKYL-HALIDES; OXIDATIVE ADDITION; ZINC REAGENTS; ARYL HALIDES; DIARYLMETHANES; BROMIDES; ETHERS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [21772072, 22071084]. Published in AMER CHEMICAL SOC in WASHINGTON ,Authors: Guo, P; Wang, K; Jin, WJ; Xie, H; Qi, LL; Liu, XY; Shu, XZ. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol. COA of Formula: C7H8O

Catalytic transformation of alcohols via metal-catalyzed cross-coupling reactions is very important, but it typically relies on a multistep procedure. We here report a dynamic kinetic cross-coupling approach for the direct functionalization of alcohols. The feasibility of this strategy is demonstrated by a nickel-catalyzed cross-electrophile arylation reaction of benzyl alcohols with (hetero)aryl electrophiles. The reaction proceeds with a broad substrate scope of both coupling partners. The electron-rich, electron-poor, and ortho-/meta-/para-substituted (hetero)aryl electrophiles (e.g., Ar-OTf, Ar-I, Ar-Br, and inert Ar-Cl) all coupled well. Most of the functionalities, including aldehyde, ketone, amide, ester, nitrile, sulfone, furan, thiophene, benzothiophene, pyridine, quinolone, Ar-SiMe3, Ar-Bpin, and Ar-SnBu3, were tolerated. The dynamic nature of this method enables the direct arylation of benzylic alcohol in the presence of various nucleophilic groups, including nonactivated primary/secondary/tertiary alcohols, phenols, and free indoles. It thus offers a robust alternative to existing methods for the precise construction of diarylmethanes. The synthetic utility of the method was demonstrated by a concise synthesis of biologically active molecules and by its application to peptide modification and conjugation. Preliminary mechanistic studies revealed that the reaction of in situ formed benzyl oxalates with nickel, possibly via a radical process, is an initial step in the reaction with aryl electrophiles.

COA of Formula: C7H8O. About Benzyl Alcohol, If you have any questions, you can contact Guo, P; Wang, K; Jin, WJ; Xie, H; Qi, LL; Liu, XY; Shu, XZ or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Pertschi, R; Weibel, JM; Pale, P; Blanc, A in AMER CHEMICAL SOC published article about GOLD; CYCLIZATION; COMPLEXES; ENTRY; RING in [Pertschi, Romain; Weibel, Jean-Marc; Pale, Patrick; Blanc, Aurelien] Univ Strasbourg, Lab Synth React Organ & Catalyse, Inst Chim, CNRS,UMR 7177, 4 Rue Blaise Pascal, F-67070 Strasbourg, France in 2019.0, Cited 39.0. Category: indole-building-block. The Name is Benzyl Alcohol. Through research, I have a further understanding and discovery of 100-51-6

The synthesis of benzosultams has been achieved through a gold(I)-catalyzed ammonium formation strategy. Starting from easily available N-(2-alkynyl)-phenylsulfonyl azetidine derivatives, a cyclization reaction generated a spiroammonium gold intermediate that was ring-opened by nucleophilic alcohol or indole. This new methodology is compatible with the large variation in the substrates and nucleophiles and allowed the formation of benzosultams in high yield (18-98, 20 examples). This strategy also allowed the preparation of benzosultam analogs via iododeauration and subsequent cross-coupling reactions.

Category: indole-building-block. About Benzyl Alcohol, If you have any questions, you can contact Pertschi, R; Weibel, JM; Pale, P; Blanc, A or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Authors Gokkaya, DS; Sert, M; Saglam, M; Yuksel, M; Ballice, L in ELSEVIER published article about SUPERCRITICAL WATER GASIFICATION; HOT-COMPRESSED WATER; HYDROGEN-RICH GAS; BIOMASS GASIFICATION; CATALYTIC GASIFICATION; CELLULOSE; LIGNIN; GLUCOSE; TEMPERATURE; CONVERSION in [Gokkaya, Dilek Selvi; Sert, Murat; Saglam, Mehmet; Yuksel, Mithat; Ballice, Levent] Ege Univ, Engn Fac, Dept Chem Engn, Izmir, Turkey in 2020.0, Cited 51.0. Recommanded Product: 150-19-6. The Name is m-Methoxyphenol. Through research, I have a further understanding and discovery of 150-19-6

Hydrothermal gasification of isolated hemicellulose from the white poplar (Populus alba L.) and white poplar sawdust were studied to evaluate the effects of temperature (in the range of 300-600 degrees C) and the catalyst on the yield of the products. Hydrothermal gasification of poplar sawdust represents a future alternative to the waste management of agricultural residues, and industry waste. Hydrothermal gasification of isolated hemicellulose was helpful to understand and analyze the catalytic gasification characteristics of natural biomass material with high hemicellulose composition. The results indicated that hemicellulose isolated from poplar produced more gaseous products than poplar sawdust. The hemicellulose isolated from poplar wood left lower amount of ingasified solid residue than the biomass studied. Also yields of xylose, which is commercially available as hemicellulosic fraction and was studied in our previous study, was compared with isolated hemicellulose and real biomass. Among them, isolated hemicellulose had the highest yield in gasification. (C) 2020 Elsevier B.V. All rights reserved.

Recommanded Product: 150-19-6. About m-Methoxyphenol, If you have any questions, you can contact Gokkaya, DS; Sert, M; Saglam, M; Yuksel, M; Ballice, L or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Recently I am researching about FATTY-ACID COMPOSITIONS; ENZYMATIC EXTRACTION; VOLATILE COMPOUNDS; OLEIFERA ABEL.; SEED OIL; PHYSICOCHEMICAL PROPERTIES; TRITERPENOID SAPONINS; TEA SAPONIN; PROTEIN; PHOSPHOLIPIDS, Saw an article supported by the National Natural Science Foundation of ChinaNational Natural Science Foundation of China (NSFC) [31560464]; Innovation Fund Designated for Graduate Students of Jiangxi Province [YC2015-B015]. Quality Control of Benzyl Alcohol. Published in WILEY in HOBOKEN ,Authors: Yang, JY; Li, J; Wang, M; Zou, XG; Peng, B; Yin, YL; Deng, ZY. The CAS is 100-51-6. Through research, I have a further understanding and discovery of Benzyl Alcohol

Emulsion is inevitable during the aqueous extraction of oil from oilseeds. In this study, a new aqueous extraction method for camellia oil is investigated. During the extraction, the emulsified oil is collected, frozen, and thawed, and the free oil is obtained (AEEF). The optimal processing conditions are as follows: three times as much water as camellia seed powder (w/w), grinding at 70 degrees C for 6 min, repeating 2 cycles to collect the emulsified oil; then the emulsified oil is frozen (-20 degrees C) /thawed (50 degrees C) for 2 cycles. The yield of camellia oil is 89.37 +/- 0.51%, which is significantly higher (p < 0.05) than that of microwave-assisted aqueous enzymatic extraction (MAAEE, 83.05 +/- 1.14%), and is similar to that of cold press extraction (CPE, 90.85 +/- 2.05%), as well as solvent extraction (SE) coupled with refining. Additionally, the total oxidation value (TOTOX) of the free oil extracted by using AEEF (AEEF-Oil, 6.82 +/- 0.12%) is significantly lower (p < 0.05) than those of MAAEE, CEP, or SE. In comparison to SE-Oil and CEP-Oil, AEEF-Oil has higher (p < 0.05) contents of alpha-tocopherol and squalene, and lower (p < 0.05) benzo(a)pyrene contents, and contains more favorable natural volatile compounds. The results indicate that the novel AEEF may be a promising aqueous extraction method. Practical Application: The novel aqueous extraction method for camellia oil by emulsified oil - frozen/thawed has acceptable oil yields. The obtained camellia oil has high levels of bioactive components, low contents of hazardous substances, and more characteristic volatile flavor compounds. AEEF is an improved aqueous extraction technology for edible oil without refining and using n-hexane, which could be potentially applied in industrial production of camellia oil due to its safety, nutrition, and environment-friendly treatments. Quality Control of Benzyl Alcohol. About Benzyl Alcohol, If you have any questions, you can contact Yang, JY; Li, J; Wang, M; Zou, XG; Peng, B; Yin, YL; Deng, ZY or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

An article An efficient and green synthesis of 1,4-dihydropyridine derivatives through multi-component reaction in subcritical EtOH WOS:000671550500009 published article about ONE-POT SYNTHESIS; HANTZSCH 1,4-DIHYDROPYRIDINES; OXIDATIVE DEALKYLATION; MICROWAVE IRRADIATION; SOLVENT; CATALYST; CHEMISTRY; ETHANOL; ABSENCE; SERIES in [Ersatir, Mehmet; Giray, Elife Sultan] Cukurova Univ, Arts & Sci Fac, Dept Chem, TR-01330 Adana, Turkey; [Turk, Murat] Cukurova Univ, Vocat Sch Ceyhan, Dept Property Protect & Secur, Adana, Turkey in 2021, Cited 41. Product Details of 123-11-5. The Name is 4-Methoxybenzaldehyde. Through research, I have a further understanding and discovery of 123-11-5

A simple, environmentally friendly and highly efficient method has been developed for the synthesis of 1,4-dihydropyridine compounds. A number of aromatic aldehydes, ethylaceto acetate and urea converted into corresponding in l,4Dihydropyridine derivatives via one-pot multicomponent reaction in sub-critical ethanol. This study shown that 1,4-dihyropyridines can be synthesized in sub-critical ethanol and has the advantage of excellent yields, short reaction time, and simple work-up conditions.

Product Details of 123-11-5. About 4-Methoxybenzaldehyde, If you have any questions, you can contact Ersatir, M; Turk, M; Giray, ES or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles

Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM in [Helwa, Amira A.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Organ Pharmaceut Chem, POB 77, 6th Of October City, Egypt; [El-Dydamony, Nehad M.] Misr Univ Sci & Technol, Coll Pharmaceut Sci & Drug Mfg, Dept Pharmaceut Chem, 6th Of October City, Egypt; [Radwan, Rasha A.] Sinai Univ, Fac Pharm & Pharmaceut Ind, Dept Biochem, Kantara Branch, New City, El Ismailia, Egypt; [Abdelraouf, Sahar M.] Misr Int Univ, Fac Pharm, Dept Biochem, Cairo, Egypt; [Abdelnaby, Rana M.] Heliopolis Univ, Fac Pharm, Dept Pharmaceut Chem, Cairo, Egypt published Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking in 2020.0, Cited 46.0. COA of Formula: C7H6O2. The Name is 3-Hydroxybenzaldehyde. Through research, I have a further understanding and discovery of 100-83-4.

Two series of novel morpholinopyrimidine derivatives were synthesized and screened for their in-vitro cytotoxic activity against 60 tumor cell line by the National Cancer Institute, USA. The in-vitro cytotoxic IC50 values for the most active compounds 6e, 6g, and 6l against the most sensitive cell line leukemia SR were estimated (IC50 = 0.76, 13.59, and 4.37 uM, respectively). To investigate their PI3K enzyme inhibition activity, the assay was done on Class IA (alpha, beta, & delta) isoforms. The IC50 values were very promising: compound [6e = 11.73 (alpha), 6.09 (beta), 11.18 (delta)], compound [6g = 8.43 (alpha), 15.84 (beta), 30.62 (delta)], and compound [6l = 13.98 (alpha), 7.22 (beta), 10.94 (delta)], compared to the reference compound LY294002 = 6.28 (alpha), 4.51 (beta), 4.60 (delta) uM, respectively. Moreover, cell cycle analysis and annexin V-FITC staining were done on Leukemia SR, there was arrest at G2/M phase and apoptosis was induced. Finally, docking study was performed to analyze the interactive mode of these derivatives in PI3K alpha ATP-binding site. These outcomes proved that compounds 6e, 6g, and 6l are potential leads for further optimization as antileukemic agents.

COA of Formula: C7H6O2. About 3-Hydroxybenzaldehyde, If you have any questions, you can contact Helwa, AA; El-Dydamony, NM; Radwan, RA; Abdelraouf, SM; Abdelnaby, RM or concate me.

Reference:
Indole alkaloid derivatives as building blocks of natural products from Bacillus thuringiensis and Bacillus velezensis and their antibacterial and antifungal activity study,
,Preparation of Indole Containing Building Blocks for the Regiospecific Construction of Indole Appended Pyrazoles and Pyrroles